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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing pr... See more...
Aliases for UPF2 Gene
Aliases for UPF2 Gene
- UPF2 Regulator Of Nonsense Mediated MRNA Decay 2 3 5
- RENT2 2 3 4
- Regulator Of Nonsense Transcripts 2 3 4
- Up-Frameshift Suppressor 2 Homolog 3 4
- Nonsense MRNA Reducing Factor 2 3 4
- KIAA1408 2 4
- Smg-3 2 3
- Smg-3 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) 2
- UPF2 Regulator Of Nonsense Transcripts Homolog (Yeast) 2
External Ids for UPF2 Gene
- HGNC: 17854
- Entrez Gene: 26019
- Ensembl: ENSG00000151461
- OMIM: 605529
- UniProtKB: Q9HAU5
Previous GeneCards Identifiers for UPF2 Gene
- GC10M011925
- GC10M012112
- GC10M011966
- GC10M012002
- GC10M011879
- GC10M011962
Summaries for UPF2 Gene
-
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for UPF2 Gene
UPF2 (UPF2 Regulator Of Nonsense Mediated MRNA Decay) is a Protein Coding gene. Diseases associated with UPF2 include Pancreatic Adenosquamous Carcinoma and Metaphyseal Chondrodysplasia, Schmid Type. Among its related pathways are Gene Expression and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include RNA binding and binding.
UniProtKB/Swiss-Prot Summary for UPF2 Gene
-
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
Additional gene information for UPF2 Gene
- HGNC(17854)
- Entrez Gene(26019)
- Ensembl(ENSG00000151461)
- OMIM(605529)
- UniProtKB(Q9HAU5)
- Open Targets Platform(ENSG00000151461)
- Search for UPF2 at DataMed
- Search for UPF2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UPF2 Gene
Genomics for UPF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UPF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UPF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UPF2
- Top Transcription factor binding sites by QIAGEN in the UPF2 gene promoter:
-
- Egr-1
- MZF-1
- Pax-5
- POU2F1
- POU2F1a
Genomic Locations for UPF2 Gene
Genomic Locations for UPF2 Gene
- chr10:11,920,022-12,043,170
- (GRCh38/hg38)
- Size:
- 123,149 bases
- Orientation:
- Minus strand
- chr10:11,962,021-12,085,169
- (GRCh37/hg19)
- Size:
- 123,149 bases
- Orientation:
- Minus strand
Genomic View for UPF2 Gene
Genes around UPF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p14 by HGNC
- 10p14 by Entrez Gene
- 10p14 by Ensembl
UPF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UPF2 Gene
Proteins for UPF2 Gene
-
Protein details for UPF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HAU5-RENT2_HUMAN
- Recommended name:
- Regulator of nonsense transcripts 2
- Protein Accession:
- Q9HAU5
- A6NLJ5
- D3DRS0
- Q14BM1
- Q5W0J4
- Q8N8U1
- Q9H1J2
- Q9NWL1
- Q9P2D9
- Q9Y4M9
Protein attributes for UPF2 Gene
- Size:
- 1272 amino acids
- Molecular mass:
- 147810 Da
- Quaternary structure:
-
- Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1.
- SequenceCaution:
-
- Sequence=BAA92646.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC04721.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for UPF2 Gene
Post-translational modifications for UPF2 Gene
Other Protein References for UPF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-UPF2 (aa 1200-1272) polyclonal antibody
- Creative Biolabs Rabbit Anti-UPF2 Recombinant Antibody (D3B10) and Mouse Anti-UPF2 Recombinant Antibody (G-10)
-
Custom Antibody ServicesOriGene Antibodies for UPF2
- Novus Biologicals Antibodies for UPF2
-
Abcam antibodies for UPF2
- Invitrogen Antibodies for UPF2 (AFLGC-UPF2)
-
Boster Bio Antibodies for UPF2
-
Santa Cruz Biotechnology (SCBT) Antibodies for UPF2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for UPF2
- Origene Custom Protein Services for UPF2
- Novus Biologicals proteins for UPF2
- antibodies-online: Search results for available UPF2 related products ranked by validation data
No data available for DME Specific Peptides for UPF2 Gene
Domains & Families for UPF2 Gene
Gene Families for UPF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for UPF2 Gene
- InterPro:
- Blocks:
-
- Initiation factor eIF-4 gamma, middle
- ProtoNet:
Suggested Antigen Peptide Sequences for UPF2 Gene
- GenScript: Design optimal peptide antigens:
-
- UPF2 protein (Q5BKV2_HUMAN)
- Up-frameshift suppressor 2 homolog (RENT2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UPF2 Gene
Function for UPF2 Gene
Molecular function for UPF2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
Phenotypes From GWAS Catalog for UPF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 11163187 |
| GO:0042162 | telomeric DNA binding | IDA | 17916692 |
Phenotypes for UPF2 Gene
- MGI mutant phenotypes for UPF2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for UPF2:
Animal Models for UPF2 Gene
- MGI Knock Outs for UPF2:
-
- Upf2 Upf2<tm1.1Btp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UPF2 - Select products 50% OFF >
- * UPF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UPF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UPF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for UPF2
miRNA for UPF2 Gene
- miRTarBase miRNAs that target UPF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UPF2
- Browse OriGene Inhibitory RNA Products For UPF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UPF2
Clone Products
- Applied Biological Materials (abm): Clones for UPF2 - Select products 50% OFF >
- * UPF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UPF2
- Addgene plasmids for UPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UPF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UPF2 Gene
Localization for UPF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UPF2 Gene
- Cytoplasm, perinuclear region.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytoplasmic bodies (3)
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 14636577 |
| GO:0005737 | cytoplasm | IDA | 14636577 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005844 | polysome | IBA | 21873635 |
| GO:0035145 | exon-exon junction complex | IBA,IDA | 16601204 |
Pathways & Interactions for UPF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation | ||
| 2 | Translational Control | ||
| 3 | mRNA surveillance pathway | ||
| 4 | RNA transport | ||
| 5 | Gene Expression |
.48
|
|
Pathways by source for UPF2 Gene
3 Reactome pathways for UPF2 Gene
2 KEGG pathways for UPF2 Gene
1 Cell Signaling Technology pathway for UPF2 Gene
Interacting Proteins for UPF2 Gene
Selected Interacting proteins:
Q9HAU5-RENT2_HUMAN
ENSP00000348708
for UPF2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for UPF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IBA,TAS | 16488880 |
| GO:0001889 | liver development | IEA | -- |
| GO:0006406 | mRNA export from nucleus | TAS | 16488880 |
| GO:0031100 | animal organ regeneration | IEA | -- |
No data available for SIGNOR curated interactions for UPF2 Gene
Transcripts for UPF2 Gene
mRNA/cDNA for UPF2 Gene
- 2 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356352 5569 nts (view in UCSC)
- ENST00000357604 5168 nts (view in UCSC)
- ENST00000397053 5369 nts (view in UCSC)
- ENST00000460569 640 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UPF2 - Select products 50% OFF >
- * UPF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UPF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UPF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for UPF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UPF2
- Browse OriGene Inhibitory RNA Products For UPF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UPF2
Clone Products
- Applied Biological Materials (abm): Clones for UPF2 - Select products 50% OFF >
- * UPF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UPF2
- Addgene plasmids for UPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UPF2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - |
| ExUns: | 25 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: |
Relevant External Links for UPF2 Gene
- GeneLoc Exon Structure for
- UPF2
Expression for UPF2 Gene
This gene is overexpressed in Lymph node (7.1), Peripheral blood mononuclear cells (7.1), and CD8 Tcells (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UPF2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UPF2
SOURCE GeneReport for Unigene cluster for UPF2 Gene:
Hs.370689mRNA Expression by UniProt/SwissProt for UPF2 Gene:
Q9HAU5-RENT2_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for UPF2 Gene
- Nervous system(4.5)
- Heart(4.4)
- Blood(2.7)
- Muscle(2.5)
- Kidney(2.4)
- Liver(2.3)
- Skin(2.2)
- Spleen(2.2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for UPF2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UPF2 Gene
Orthologs for UPF2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UPF2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UPF2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UPF2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UPF2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Upf2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Upf2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | UPF2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UPF2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | upf2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14937 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | upf2 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000337 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Upf2 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | smg-3 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NMD2 30 31 33 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D13156g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR364C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G39260 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU05267 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | upf2 30 |
|
- Species where no ortholog for UPF2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UPF2 Gene
- ENSEMBL:
- Gene Tree for UPF2 (if available)
- TreeFam:
- Gene Tree for UPF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UPF2: view image
Paralogs for UPF2 Gene
No data available for Paralogs for UPF2 Gene
Variants for UPF2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UPF2 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714446 | Likely Benign: not provided | 11,943,060(-) | G/A | INTRON_VARIANT | |
| 714447 | Benign: not provided | 11,956,529(-) | A/T | INTRON_VARIANT | |
| 714448 | Benign: not provided | 11,959,276(-) | G/A | SYNONYMOUS_VARIANT | |
| 718772 | Benign: not provided | 12,035,070(-) | A/G | SYNONYMOUS_VARIANT | |
| 719186 | Benign: not provided | 12,029,317(-) | A/G | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
1.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.62;
56.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UPF2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPF2 Gene
Disorders for UPF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic adenosquamous carcinoma |
|
|
| metaphyseal chondrodysplasia, schmid type |
|
|
| retinitis pigmentosa 51 |
|
|
Search UPF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UPF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UPF2 Gene
Publications for UPF2 Gene
- Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). (PMID: 11113196) Serin G … Maquat LE (Molecular and cellular biology 2001) 2 3 4 23
- NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. (PMID: 18066079) Chamieh H … Le Hir H (Nature structural & molecular biology 2008) 3 4 23
- Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. (PMID: 16452507) Kashima I … Ohno S (Genes & development 2006) 3 4 23
- Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. (PMID: 16209946) Gehring NH … Kulozik AE (Molecular cell 2005) 3 4 23
- The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. (PMID: 15004547) Kadlec J … Cusack S (Nature structural & molecular biology 2004) 3 4 23
ExternalLinks
Products for UPF2 Gene
- Custom Antibody ServicesOriGene Antibodies for UPF2
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- OriGene qPCR primer pairs for UPF2
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- Browse OriGene miRNA Products For UPF2
- Sino Biological Human cDNA Clone for UPF2
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for UPF2
- Novus Biologicals proteins for UPF2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for UPF2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for UPF2 (AFLGC-UPF2)
- VectorBuilder Custom and pre-made DNA vectors for UPF2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for UPF2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for UPF2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for UPF2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UPF2
- Addgene plasmids for UPF2
- antibodies-online: Show 16 available UPF2 Antibodies ranked by validation data
- Compare Top UPF2 Antibodies
- antibodies-online: Search results for available UPF2 related products ranked by validation data
- antibodies-online: Search results for available UPF2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for UPF2
- Search Santa Cruz Biotechnology (SCBT) for UPF2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for UPF2
- Browse GeneCopoeia Cell Lines
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UPF2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UPF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UPF2
- Boster Bio Antibodies for UPF2
- Browse Boster Bio ELISA Kits
Sources for UPF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
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