UOX Gene (Pseudogene)

Urate Oxidase (Pseudogene)

GC01M084364
GIFtS:
17
Urate oxidase is an enzyme that catalyzes the oxidation of uric acid to allantoin. This gene has been inactivated by mutation and is nonfunctional in humans and some other primates. [provided by RefSeq, Jul 2008] See more...

Aliases for UOX Gene

Aliases for UOX Gene

  • Urate Oxidase (Pseudogene) 2 3 5
  • UOXP 2 3
  • Urate Oxidase 2
  • URICASE 3
  • UOX 5

External Ids for UOX Gene

Previous GeneCards Identifiers for UOX Gene

  • GC01U990181
  • GC01M084602
  • GC01M084830
  • GC01M082940

Summaries for UOX Gene

Entrez Gene Summary for UOX Gene

  • Urate oxidase is an enzyme that catalyzes the oxidation of uric acid to allantoin. This gene has been inactivated by mutation and is nonfunctional in humans and some other primates. [provided by RefSeq, Jul 2008]

GeneCards Summary for UOX Gene

UOX (Urate Oxidase (Pseudogene)) is a Pseudogene. Diseases associated with UOX include Urate Oxidase, Pseudogene.

Gene Wiki entry for UOX Gene

Additional gene information for UOX Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UOX Gene

Genomics for UOX Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

GeneHancers around UOX on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the UOX gene promoter:
  • AML1a
  • ATF6
  • C/EBPalpha
  • E47
  • Hand1
  • IRF-1
  • NRSF form 1
  • NRSF form 2
  • Sox5
  • STAT5B

Genomic Locations for UOX Gene

Genomic Locations for UOX Gene
chr1:84,363,706-84,397,831
(GRCh38/hg38)
Size:
34,126 bases
Orientation:
Minus strand
chr1:84,830,641-84,863,576
(GRCh37/hg19)
Size:
32,936 bases
Orientation:
Minus strand

Genomic View for UOX Gene

Genes around UOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UOX Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UOX Gene

Proteins for UOX Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for UOX Gene

No Post-translational modifications

No data available for DME Specific Peptides for UOX Gene

Domains & Families for UOX Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UOX Gene

Function for UOX Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for UOX Gene

GENATLAS Biochemistry:
urate-oxidase,rat sequence homolog (not expressed in humans)

Phenotypes From GWAS Catalog for UOX Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UOX Gene

Localization for UOX Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UOX Gene

Pathways & Interactions for UOX Gene

PathCards logo

SuperPathways for UOX Gene

No Data Available

Gene Ontology (GO) - Biological Process for UOX Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for UOX Gene

Drugs & Compounds for UOX Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for UOX Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for UOX Gene

8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for UOX Gene

No ASD Table

Relevant External Links for UOX Gene

GeneLoc Exon Structure for
UOX

Expression for UOX Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UOX Gene

mRNA expression in normal human tissues for UOX Gene
mRNA expression by GTEx for UOX Gene

mRNA differential expression in normal tissues according to GTEx for UOX Gene

This gene is overexpressed in Testis (x12.4) and Brain - Caudate (basal ganglia) (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UOX

SOURCE GeneReport for Unigene cluster for UOX Gene:

Hs.647646
genes like me logo Genes that share expression patterns with UOX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UOX Gene

Orthologs for UOX Gene

Evolution for UOX Gene

ENSEMBL:
Gene Tree for UOX (if available)
TreeFam:
Gene Tree for UOX (if available)

No data available for Orthologs for UOX Gene

Paralogs for UOX Gene

No data available for Paralogs for UOX Gene

Variants for UOX Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Structural Variations from Database of Genomic Variants (DGV) for UOX Gene

Variant ID Type Subtype PubMed ID
esv2677432 CNV deletion 23128226
esv3577990 CNV loss 25503493
nsv1744 CNV insertion 18451855
nsv830426 CNV gain 17160897
nsv830437 CNV gain+loss 17160897

Additional Variant Information for UOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UOX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for UOX Gene

Disorders for UOX Gene

MalaCards: The human disease database

(1) MalaCards diseases for UOX Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
urate oxidase, pseudogene
  • uox
- elite association - COSMIC cancer census association via MalaCards
Search UOX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UOX

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UOX Gene

Publications for UOX Gene

  1. Localization of the human urate oxidase gene (UOX) to 1p22. (PMID: 1395718) Yeldandi AV … Le Beau MM (Cytogenetics and cell genetics 1992) 2 3
  2. Two independent mutational events in the loss of urate oxidase during hominoid evolution. (PMID: 1556746) Wu XW … Caskey CT (Journal of molecular evolution 1992) 2 3
  3. Evolutionary history and metabolic insights of ancient mammalian uricases. (PMID: 24550457) Kratzer JT … Gaucher EA (Proceedings of the National Academy of Sciences of the United States of America 2014) 3
  4. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange CM … Swiss Hepatitis C Cohort Study Group (Hepatology (Baltimore, Md.) 2012) 3
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang ZD … Gerstein M (Genome biology 2010) 3

ExternalLinks

View latest publications for UOX gene in Mastermind

Products for UOX Gene

Sources for UOX Gene