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Aliases for UOX Gene

Aliases for UOX Gene

  • Urate Oxidase (Pseudogene) 2 3 5
  • Urate Oxidase 2
  • URICASE 3
  • UOXP 3

External Ids for UOX Gene

Previous GeneCards Identifiers for UOX Gene

  • GC01U990181
  • GC01M084602
  • GC01M084830
  • GC01M082940

Summaries for UOX Gene

Entrez Gene Summary for UOX Gene

  • Urate oxidase is an enzyme that catalyzes the oxidation of uric acid to allantoin. This gene has been inactivated by mutation and is nonfunctional in humans and some other primates. [provided by RefSeq, Jul 2008]

GeneCards Summary for UOX Gene

UOX (Urate Oxidase (Pseudogene)) is a Pseudogene. Diseases associated with UOX include Urate Oxidase, Pseudogene.

Gene Wiki entry for UOX Gene

Additional gene information for UOX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UOX Gene

Genomics for UOX Gene

GeneHancer (GH) Regulatory Elements for UOX Gene

Promoters and enhancers for UOX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I084297 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 +96.8 96817 6.8 HDGF SMAD1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF143 KLF13 SAMD13 ENSG00000271576 BCL10 DNASE2B UOX RPF1 ENSG00000199959 ENSG00000249237 GC01M084160
GH01I084364 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 +31.8 31758 2.9 ATF1 RAD21 RFX5 ZEB1 ZNF366 RCOR1 FOS SMARCC1 CEBPB SP1 DNASE2B UOX RPF1 GC01M084160 GC01M084333 SAMD13
GH01I084432 Enhancer 0.9 Ensembl ENCODE 11.1 -36.6 -36633 3.3 CTCF PKNOX1 ZNF384 RAD21 RFX5 CC2D1A ZNF213 POLR2A SCRT2 ZNF143 GC01M084333 DNASE2B GNG5 SPATA1 UOX SAMD13 RPF1 ENSG00000199959
GH01I084270 Enhancer 0.9 Ensembl ENCODE 9.8 +125.7 125727 3.2 PKNOX1 KLF1 SIN3A POLR2A BCLAF1 MAFK RUNX3 IKZF2 EZH2 ELF1 UOX DNASE2B RPF1 SYDE2 SAMD13 GC01P084245 GC01M084160
GH01I084374 Enhancer 0.7 ENCODE dbSUPER 11.7 +21.3 21336 3.4 JUND CBFA2T3 ATF7 FOS ATF2 DNASE2B UOX ENSG00000199959 RPF1 GC01M084160 GC01M084333 SAMD13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UOX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UOX gene promoter:

Genomic Locations for UOX Gene

Genomic Locations for UOX Gene
chr1:84,363,706-84,397,893
(GRCh38/hg38)
Size:
34,188 bases
Orientation:
Minus strand
chr1:84,830,641-84,863,576
(GRCh37/hg19)

Genomic View for UOX Gene

Genes around UOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UOX Gene

Proteins for UOX Gene

Post-translational modifications for UOX Gene

No Post-translational modifications

No data available for DME Specific Peptides for UOX Gene

Domains & Families for UOX Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for UOX Gene

Function for UOX Gene

Molecular function for UOX Gene

GENATLAS Biochemistry:
urate-oxidase,rat sequence homolog (not expressed in humans)

Phenotypes From GWAS Catalog for UOX Gene

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UOX Gene

Localization for UOX Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UOX Gene

Pathways & Interactions for UOX Gene

No Data Available

Interacting Proteins for UOX Gene

Gene Ontology (GO) - Biological Process for UOX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UOX Gene

Drugs & Compounds for UOX Gene

No Compound Related Data Available

Transcripts for UOX Gene

mRNA/cDNA for UOX Gene

(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UOX Gene

Urate oxidase, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UOX Gene

No ASD Table

Relevant External Links for UOX Gene

GeneLoc Exon Structure for
UOX
ECgene alternative splicing isoforms for
UOX

Expression for UOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UOX Gene

mRNA differential expression in normal tissues according to GTEx for UOX Gene

This gene is overexpressed in Testis (x12.4) and Brain - Caudate (basal ganglia) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of UOX Gene:

UOX

SOURCE GeneReport for Unigene cluster for UOX Gene:

Hs.647646
genes like me logo Genes that share expression patterns with UOX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UOX Gene

Orthologs for UOX Gene

Evolution for UOX Gene

ENSEMBL:
Gene Tree for UOX (if available)
TreeFam:
Gene Tree for UOX (if available)

No data available for Orthologs for UOX Gene

Paralogs for UOX Gene

No data available for Paralogs for UOX Gene

Variants for UOX Gene

Sequence variations from dbSNP and Humsavar for UOX Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000018842 -- 84,374,484(-) C/G intron_variant
rs1000069766 -- 84,374,224(-) C/T intron_variant
rs1000201272 -- 84,369,262(-) C/T intron_variant
rs1000253686 -- 84,368,989(-) C/T intron_variant
rs1000429613 -- 84,375,823(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UOX Gene

Variant ID Type Subtype PubMed ID
nsv830437 CNV gain+loss 17160897
nsv830426 CNV gain 17160897
nsv1744 CNV insertion 18451855
esv3577990 CNV loss 25503493
esv2677432 CNV deletion 23128226

Additional Variant Information for UOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UOX Gene

Disorders for UOX Gene

MalaCards: The human disease database

(1) MalaCards diseases for UOX Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
urate oxidase, pseudogene
  • uox
- elite association - COSMIC cancer census association via MalaCards
Search UOX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UOX

genes like me logo Genes that share disorders with UOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UOX Gene

Publications for UOX Gene

  1. Two independent mutational events in the loss of urate oxidase during hominoid evolution. (PMID: 1556746) Wu XW … Caskey CT (Journal of molecular evolution 1992) 2 3 58
  2. Localization of the human urate oxidase gene (UOX) to 1p22. (PMID: 1395718) Yeldandi AV … Le Beau MM (Cytogenetics and cell genetics 1992) 2 3 58
  3. Evolutionary history and metabolic insights of ancient mammalian uricases. (PMID: 24550457) Kratzer JT … Gaucher EA (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58
  4. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange CM … Swiss Hepatitis C Cohort Study Group (Hepatology (Baltimore, Md.) 2012) 3 58
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang ZD … Gerstein M (Genome biology 2010) 3 58

Products for UOX Gene

Sources for UOX Gene

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