Aliases for UNKL Gene
External Ids for UNKL Gene
Previous HGNC Symbols for UNKL Gene
Previous GeneCards Identifiers for UNKL Gene
This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
GeneCards Summary for UNKL Gene
UNKL (Unk Like Zinc Finger) is a Protein Coding gene. Diseases associated with UNKL include Mucolipidosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is UNK.
UniProtKB/Swiss-Prot Summary for UNKL Gene
May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.