Aliases for UNK Gene

Aliases for UNK Gene

  • Unk Zinc Finger 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 5 3 4
  • Zinc Finger CCCH-Type Domain Containing 5 2 3
  • RING Finger Protein Unkempt Homolog 3 4
  • Zinc Finger CCCH-Type Containing 5 2 3
  • Unk Family Zinc Finger 2 3
  • ZC3HDC5 3 4
  • ZC3H5 3 4
  • Unkempt Homolog (Drosophila) 2
  • Unkempt Family Zinc Finger 3
  • Unkempt Homolog 3
  • KIAA1753 4
  • UNKEMPT 3

External Ids for UNK Gene

Previous HGNC Symbols for UNK Gene

  • ZC3HDC5
  • ZC3H5

Previous GeneCards Identifiers for UNK Gene

  • GC17P071293
  • GC17P073780
  • GC17P069206

Summaries for UNK Gene

GeneCards Summary for UNK Gene

UNK (Unk Zinc Finger) is a Protein Coding gene. An important paralog of this gene is UNKL.

UniProtKB/Swiss-Prot Summary for UNK Gene

  • Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

Additional gene information for UNK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UNK Gene

Genomics for UNK Gene

GeneHancer (GH) Regulatory Elements for UNK Gene

Promoters and enhancers for UNK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J075776 Promoter/Enhancer 2.8 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 913.1 -2.9 -2916 11.6 PPP1R10 E2F8 SIN3A SP1 CTCF SREBF1 SIX5 LCORL MLX SMARCE1 UNK H3-3B NUP85 SRSF2 NT5C ENSG00000267342 TRIM65 ENSG00000266980 GGA3 METTL23
GH17J076734 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 175.3 +952.5 952453 7.8 E2F8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 ZBTB6 SMARCE1 SRSF2 MFSD11 MIR636 NONHSAG022835.2 lnc-JMJD6-1 UNK ENSG00000267342 TRIM65 SEPTIN9 ENSG00000266980
GH17J076258 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 130.4 +483.2 483169 19.6 FOXK2 SIN3A ZNF24 SP1 ZBTB40 ZBTB6 MLX RBPJ SMARCE1 POLR2A UBALD2 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 EXOC7 MFSD11 TSEN54
GH17J075031 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 112.7 -750.2 -750185 5.8 GTF3C2 ZNF785 SIN3A ZNF24 ZBTB40 ZBTB6 LCORL MLX SMARCE1 RBPJ KCTD2 AJ535831-003 AJ535831-004 TRR-CCT1-1 TRR-CCT2-1 TRR-TCG3-1 piR-30855-001 NUP85 UNK ENSG00000266980
GH17J075507 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 84.6 -271.3 -271258 11.8 PPP1R10 SIN3A ZNF24 ZBTB40 SP1 CTCF ZBTB6 FOXA1 LCORL MLX TSEN54 CASKIN2 UNK NUP85 ENSG00000266980 ENSG00000267342 NT5C GGA3 NAT9 EXOC7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UNK gene promoter:
  • AML1a
  • AP-4
  • Arnt
  • Egr-4
  • HSF2
  • MRF-2
  • Pax-3
  • Sox5

Genomic Locations for UNK Gene

Genomic Locations for UNK Gene
chr17:75,784,806-75,825,805
(GRCh38/hg38)
Size:
41,000 bases
Orientation:
Plus strand
chr17:73,780,681-73,821,886
(GRCh37/hg19)
Size:
41,206 bases
Orientation:
Plus strand

Genomic View for UNK Gene

Genes around UNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNK Gene

Proteins for UNK Gene

  • Protein details for UNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B0-UNK_HUMAN
    Recommended name:
    RING finger protein unkempt homolog
    Protein Accession:
    Q9C0B0

    Protein attributes for UNK Gene

    Size:
    810 amino acids
    Molecular mass:
    88084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH53362.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UNK Gene

Post-translational modifications for UNK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UNK Gene

Domains & Families for UNK Gene

Gene Families for UNK Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UNK Gene

Suggested Antigen Peptide Sequences for UNK Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger CCCH domain-containing protein 5 (UNK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9C0B0

UniProtKB/Swiss-Prot:

UNK_HUMAN :
  • Belongs to the unkempt family.
Family:
  • Belongs to the unkempt family.
genes like me logo Genes that share domains with UNK: view

Function for UNK Gene

Molecular function for UNK Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

Phenotypes From GWAS Catalog for UNK Gene

Gene Ontology (GO) - Molecular Function for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0046872 metal ion binding IEA --
GO:1905538 polysome binding IEA --
GO:1990715 mRNA CDS binding IDA 25737280
genes like me logo Genes that share ontologies with UNK: view
genes like me logo Genes that share phenotypes with UNK: view

Animal Models for UNK Gene

MGI Knock Outs for UNK:
  • Unk Unk<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for UNK Gene

miRTarBase miRNAs that target UNK

Clone Products

  • Addgene plasmids for UNK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNK Gene

Localization for UNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNK gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IDA 25737280
genes like me logo Genes that share ontologies with UNK: view

Pathways & Interactions for UNK Gene

PathCards logo

SuperPathways for UNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001764 neuron migration IEA --
GO:0006417 regulation of translation IEA --
GO:0048667 cell morphogenesis involved in neuron differentiation IMP 25737280
GO:2000766 negative regulation of cytoplasmic translation IMP 25737280
genes like me logo Genes that share ontologies with UNK: view

No data available for Pathways by source and SIGNOR curated interactions for UNK Gene

Drugs & Compounds for UNK Gene

No Compound Related Data Available

Transcripts for UNK Gene

mRNA/cDNA for UNK Gene

CRISPR Products

Clone Products

  • Addgene plasmids for UNK

Alternative Splicing Database (ASD) splice patterns (SP) for UNK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - -
SP2: - - - - - - - - - -
SP3:
SP4: - -
SP5: - - - - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10: -

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for UNK Gene

GeneLoc Exon Structure for
UNK
ECgene alternative splicing isoforms for
UNK

Expression for UNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNK Gene

This gene is overexpressed in CD4 Tcells (13.4), Placenta (7.9), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UNK Gene



Protein tissue co-expression partners for UNK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNK Gene:

UNK

SOURCE GeneReport for Unigene cluster for UNK Gene:

Hs.584768

Evidence on tissue expression from TISSUES for UNK Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with UNK: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNK Gene

Orthologs for UNK Gene

This gene was present in the common ancestor of animals.

Orthologs for UNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNK 33 32
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UNK 33 32
  • 92.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UNK 33 32
  • 91.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Unk 17 33 32
  • 91.32 (n)
rat
(Rattus norvegicus)
Mammalia Unk 32
  • 90.52 (n)
oppossum
(Monodelphis domestica)
Mammalia UNK 33
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 65 (a)
OneToMany
-- 33
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves UNK 33 32
  • 79.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNK 33
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unk 32
  • 73.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398497 32
zebrafish
(Danio rerio)
Actinopterygii unk 33 32
  • 66.5 (n)
OneToOne
zgc55407 32
fruit fly
(Drosophila melanogaster)
Insecta unk 33
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34D10.2 33
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
OneToMany
Cin.1907 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1907 32
Species where no ortholog for UNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNK Gene

ENSEMBL:
Gene Tree for UNK (if available)
TreeFam:
Gene Tree for UNK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UNK: view image

Paralogs for UNK Gene

Paralogs for UNK Gene

(1) SIMAP similar genes for UNK Gene using alignment to 6 proteins:

  • UNK_HUMAN
  • K7EIZ1_HUMAN
  • K7ELF5_HUMAN
  • K7EMB1_HUMAN
  • K7EQ93_HUMAN
  • K7EQJ1_HUMAN
genes like me logo Genes that share paralogs with UNK: view

Variants for UNK Gene

Sequence variations from dbSNP and Humsavar for UNK Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000085815 -- 75,788,397(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000110712 -- 75,794,586(+) C/T 5_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000114933 -- 75,788,668(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000168647 -- 75,787,942(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000171098 -- 75,818,528(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UNK Gene

Variant ID Type Subtype PubMed ID
esv2716246 CNV deletion 23290073
esv2716247 CNV deletion 23290073
esv2716248 CNV deletion 23290073
esv2716249 CNV deletion 23290073
esv2743244 CNV deletion 23290073
nsv470606 CNV loss 18288195
nsv510728 CNV deletion 20534489
nsv833545 CNV gain 17160897

Variation tolerance for UNK Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNK Gene

Disorders for UNK Gene

No disorders were found for UNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNK Gene

Publications for UNK Gene

  1. Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. (PMID: 26641712) Murn J … Patel DJ (Nature structural & molecular biology 2016) 2 3 56
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 56
  5. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. (PMID: 29053956) Tan P … Wang RF (Molecular cell 2017) 3 56

Products for UNK Gene

Sources for UNK Gene