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Aliases for UNK Gene
Aliases for UNK Gene
External Ids for UNK Gene
- HGNC: 29369
- Entrez Gene: 85451
- Ensembl: ENSG00000132478
- OMIM: 616375
- UniProtKB: Q9C0B0
Previous HGNC Symbols for UNK Gene
- ZC3HDC5
- ZC3H5
Previous GeneCards Identifiers for UNK Gene
- GC17P071293
- GC17P073780
- GC17P069206
Summaries for UNK Gene
GeneCards Summary for UNK Gene
UNK (Unk Zinc Finger) is a Protein Coding gene. Diseases associated with UNK include Thalamic Neoplasm and Bestiality. An important paralog of this gene is UNKL.
UniProtKB/Swiss-Prot Summary for UNK Gene
-
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).
Additional gene information for UNK Gene
- HGNC(29369)
- Entrez Gene(85451)
- Ensembl(ENSG00000132478)
- OMIM(616375)
- UniProtKB(Q9C0B0)
- Open Targets Platform(ENSG00000132478)
- Search for UNK at DataMed
- Search for UNK at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UNK Gene
Genomics for UNK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UNK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UNK on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the UNK gene promoter:
-
- AML1a
- AP-4
- Arnt
- Egr-4
- HSF2
- MRF-2
- Pax-3
- Sox5
Genomic Locations for UNK Gene
Genomic Locations for UNK Gene
- chr17:75,784,771-75,825,799
- (GRCh38/hg38)
- Size:
- 41,029 bases
- Orientation:
- Plus strand
- chr17:73,780,681-73,821,886
- (GRCh37/hg19)
- Size:
- 41,206 bases
- Orientation:
- Plus strand
Genomic View for UNK Gene
Genes around UNK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
UNK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UNK Gene
Proteins for UNK Gene
-
Protein details for UNK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0B0-UNK_HUMAN
- Recommended name:
- RING finger protein unkempt homolog
- Protein Accession:
- Q9C0B0
Protein attributes for UNK Gene
- Size:
- 810 amino acids
- Molecular mass:
- 88084 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH53362.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB21844.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for UNK Gene
Post-translational modifications for UNK Gene
Other Protein References for UNK Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for UNK
- Novus Biologicals Antibodies for UNK
-
Abcam antibodies for UNK
- Invitrogen Antibodies for UNK (AFLGC-UNK)
- antibodies-online: Show 9 available UNK Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for UNK
- Search Origene for MassSpec and Protein Over-expression Lysates for UNK
- Origene Custom Protein Services for UNK
- Novus Biologicals proteins for UNK
- antibodies-online: Search results for available UNK related products ranked by validation data
No data available for DME Specific Peptides for UNK Gene
Domains & Families for UNK Gene
Gene Families for UNK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UNK Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- Zn-finger, C-x8-C-x5-C-x3-H type
- ProtoNet:
Suggested Antigen Peptide Sequences for UNK Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger CCCH domain-containing protein 5 (UNK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9C0B0- Family:
-
- Belongs to the unkempt family.
Function for UNK Gene
Molecular function for UNK Gene
- UniProtKB/Swiss-Prot Function:
- Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).
Phenotypes From GWAS Catalog for UNK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:1905538 | polysome binding | IEA | -- |
| GO:1990715 | mRNA CDS binding | IDA | 25737280 |
Phenotypes for UNK Gene
- MGI mutant phenotypes for UNK:
-
inferred from 1 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- hematopoietic system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for UNK:
Animal Models for UNK Gene
- MGI Knock Outs for UNK:
-
- Unk Unk<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UNK - Select products 50% OFF >
- * UNK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UNK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UNK
-
Santa Cruz Biotechnology (SCBT) CRISPR for UNK
miRNA for UNK Gene
- miRTarBase miRNAs that target UNK
-
- mmu-miR-9-5p (MIRT015532)
- hsa-miR-760 (MIRT036720)
- hsa-miR-186-5p (MIRT044930)
- hsa-miR-17-3p (MIRT050757)
- hsa-let-7a-5p (MIRT052613)
- hsa-miR-17-5p (MIRT078810)
- hsa-miR-20a-5p (MIRT078811)
- hsa-miR-93-5p (MIRT078812)
- hsa-miR-106a-5p (MIRT078813)
- hsa-miR-106b-5p (MIRT078815)
- hsa-miR-302a-3p (MIRT078816)
- hsa-miR-302b-3p (MIRT078817)
- hsa-miR-302c-3p (MIRT078818)
- hsa-miR-302d-3p (MIRT078819)
- hsa-miR-372-3p (MIRT078820)
- hsa-miR-373-3p (MIRT078821)
- hsa-miR-20b-5p (MIRT078822)
- hsa-miR-520e (MIRT078824)
- hsa-miR-520f-3p (MIRT078825)
- hsa-miR-520a-3p (MIRT078827)
- hsa-miR-526b-3p (MIRT078828)
- hsa-miR-520b (MIRT078830)
- hsa-miR-520c-3p (MIRT078831)
- hsa-miR-519d-3p (MIRT078832)
- hsa-miR-520d-3p (MIRT078833)
- hsa-miR-636 (MIRT078837)
- hsa-miR-1264 (MIRT078839)
- hsa-miR-302e (MIRT078840)
- hsa-miR-548t-5p (MIRT078841)
- hsa-miR-3184-3p (MIRT078842)
- hsa-miR-548az-5p (MIRT078846)
- hsa-miR-3151-5p (MIRT460170)
- hsa-miR-185-3p (MIRT460171)
- hsa-miR-4283 (MIRT460172)
- hsa-miR-4489 (MIRT460173)
- hsa-miR-5001-5p (MIRT460174)
- hsa-miR-762 (MIRT460175)
- hsa-miR-4498 (MIRT460176)
- hsa-miR-4492 (MIRT460177)
- hsa-miR-4745-5p (MIRT460178)
- hsa-miR-4481 (MIRT460179)
- hsa-miR-4726-3p (MIRT460180)
- hsa-miR-3934-5p (MIRT460181)
- hsa-miR-4433a-3p (MIRT460182)
- hsa-miR-4768-3p (MIRT460183)
- hsa-miR-4459 (MIRT460184)
- hsa-miR-1296-3p (MIRT460185)
- hsa-miR-4433b-3p (MIRT460186)
- hsa-miR-6795-5p (MIRT491972)
- hsa-miR-6887-5p (MIRT491973)
- hsa-miR-625-5p (MIRT491974)
- hsa-miR-6816-5p (MIRT491975)
- hsa-miR-3196 (MIRT491976)
- hsa-miR-3180-3p (MIRT491977)
- hsa-miR-3180 (MIRT491978)
- hsa-miR-6780b-5p (MIRT491979)
- hsa-miR-4725-3p (MIRT491980)
- hsa-miR-4271 (MIRT491981)
- hsa-miR-5196-5p (MIRT491982)
- hsa-miR-4747-5p (MIRT491983)
- hsa-miR-6787-5p (MIRT491984)
- hsa-miR-663a (MIRT491985)
- hsa-miR-4467 (MIRT491986)
- hsa-miR-1908-5p (MIRT491987)
- hsa-miR-4533 (MIRT491988)
- hsa-miR-8072 (MIRT491989)
- hsa-miR-3960 (MIRT491990)
- hsa-miR-423-5p (MIRT491991)
- hsa-miR-3184-5p (MIRT491992)
- hsa-miR-6889-5p (MIRT491993)
- hsa-miR-6777-5p (MIRT491994)
- hsa-miR-3169 (MIRT491995)
- hsa-miR-328-3p (MIRT509923)
- hsa-miR-6851-3p (MIRT509924)
- hsa-miR-6775-3p (MIRT509925)
- hsa-miR-1291 (MIRT509926)
- hsa-miR-4659b-3p (MIRT533329)
- hsa-miR-4659a-3p (MIRT533330)
- hsa-miR-4778-3p (MIRT533331)
- hsa-miR-1277-5p (MIRT707782)
- hsa-miR-5007-3p (MIRT707783)
- hsa-miR-190a-3p (MIRT707784)
- hsa-miR-466 (MIRT707785)
- hsa-miR-664a-3p (MIRT707786)
- hsa-miR-6074 (MIRT707787)
- hsa-miR-5011-5p (MIRT707788)
- hsa-miR-4643 (MIRT707789)
- hsa-miR-4789-3p (MIRT707790)
- hsa-miR-149-3p (MIRT762842)
- hsa-miR-4728-5p (MIRT771758)
- hsa-miR-4740-5p (MIRT771878)
- hsa-miR-6784-5p (MIRT779090)
- hsa-miR-6785-5p (MIRT779168)
- hsa-miR-6825-5p (MIRT779901)
- hsa-miR-6857-3p (MIRT780506)
- hsa-miR-6883-5p (MIRT780964)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UNK
- Browse OriGene Inhibitory RNA Products For UNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNK
Clone Products
- Applied Biological Materials (abm): Clones for UNK - Select products 50% OFF >
- * UNK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UNK
- Addgene plasmids for UNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UNK
Cell Line Products
-
Horizon Cell Lines for UNK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNK Gene
Localization for UNK Gene
Subcellular locations from UniProtKB/Swiss-Prot for UNK Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytoplasmic bodies (3)
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005844 | polysome | IDA | 25737280 |
Pathways & Interactions for UNK Gene
Interacting Proteins for UNK Gene
GPS-Prot Interaction Network for UNK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0048667 | cell morphogenesis involved in neuron differentiation | IMP | 25737280 |
| GO:2000766 | negative regulation of cytoplasmic translation | IMP | 25737280 |
No data available for Pathways by source and SIGNOR curated interactions for UNK Gene
Transcripts for UNK Gene
mRNA/cDNA for UNK Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000586217 651 nts (view in UCSC)
- ENST00000586527 1312 nts (view in UCSC)
- ENST00000587258 660 nts (view in UCSC)
- ENST00000587501 984 nts (view in UCSC)
- ENST00000589666 3890 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UNK - Select products 50% OFF >
- * UNK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UNK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UNK
-
Santa Cruz Biotechnology (SCBT) CRISPR for UNK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UNK
- Browse OriGene Inhibitory RNA Products For UNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNK
Clone Products
- Applied Biological Materials (abm): Clones for UNK - Select products 50% OFF >
- * UNK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UNK
- Addgene plasmids for UNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UNK
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - |
| ExUns: | 16 | ^ | 17 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: |
Relevant External Links for UNK Gene
- GeneLoc Exon Structure for
- UNK
Expression for UNK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in CD4 Tcells (13.4), Placenta (7.9), and Fetal Brain (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UNK Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UNK
SOURCE GeneReport for Unigene cluster for UNK Gene:
Hs.584768Evidence on tissue expression from TISSUES for UNK Gene
- Nervous system(4.7)
- Liver(4.4)
- Blood(2.8)
- Skin(2.7)
- Spleen(2.6)
- Lymph node(2.4)
- Muscle(2.3)
- Heart(2.3)
- Bone marrow(2.2)
- Intestine(2.2)
- Kidney(2.1)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for UNK
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNK Gene
Orthologs for UNK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UNK 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UNK 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UNK 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Unk 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Unk 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | UNK 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | UNK 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UNK 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | unk 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398497 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | unk 30 31 |
|
OneToOne | |
| zgc55407 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | unk 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C34D10.2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1907 30 |
|
- Species where no ortholog for UNK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UNK Gene
- ENSEMBL:
- Gene Tree for UNK (if available)
- TreeFam:
- Gene Tree for UNK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UNK: view image
Paralogs for UNK Gene
Variants for UNK Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2716246 | CNV | deletion | 23290073 |
| esv2716247 | CNV | deletion | 23290073 |
| esv2716248 | CNV | deletion | 23290073 |
| esv2716249 | CNV | deletion | 23290073 |
| esv2743244 | CNV | deletion | 23290073 |
| nsv470606 | CNV | loss | 18288195 |
| nsv510728 | CNV | deletion | 20534489 |
| nsv833545 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.46;
43.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UNK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UNK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNK Gene
Disorders for UNK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thalamic neoplasm |
|
|
| bestiality |
|
|
| diencephalic neoplasm |
|
|
| subacute lymphocytic thyroiditis |
|
|
| tinea unguium |
|
|
Search UNK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UNK
No data available for UniProtKB/Swiss-Prot and Genatlas for UNK Gene
Publications for UNK Gene
- Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. (PMID: 26641712) Murn J … Patel DJ (Nature structural & molecular biology 2016) 2 3
- Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
- The human cytoplasmic dynein interactome reveals novel activators of motility. (PMID: 28718761) Redwine WB … Reck-Peterson SL (eLife 2017) 3
ExternalLinks
Products for UNK Gene
- Custom Antibody ServicesOriGene Antibodies for UNK
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for UNK
- Search Origene for MassSpec and Protein Over-expression Lysates for UNK
- Origene Custom Protein Services for UNK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UNK
- Browse OriGene Inhibitory RNA Products For UNK
- OriGene qPCR primer pairs for UNK
- OriGene CRISPR knockouts for UNK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For UNK
- Sino Biological Human cDNA Clone for UNK
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for UNK
- Novus Biologicals proteins for UNK
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for UNK
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for UNK (AFLGC-UNK)
- VectorBuilder Custom and pre-made DNA vectors for UNK (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for UNK (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for UNK (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for UNK CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UNK
- Addgene plasmids for UNK
- antibodies-online: Show 9 available UNK Antibodies ranked by validation data
- antibodies-online: Search results for available UNK related products ranked by validation data
- antibodies-online: Search results for available UNK related products ranked by validation data
- Horizon Cell Lines for UNK
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UNK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UNK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UNK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNK
Sources for UNK Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB