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Aliases for UNCX Gene

Aliases for UNCX Gene

  • UNC Homeobox 2 3 5
  • Homeobox Protein Uncx4.1 3 4
  • UNCX4.1 3 4
  • Truncated UNCX Homeobox Protein 3
  • Homeobox Protein Unc-4 Homolog 3
  • UNC Homeobox Protein 3
  • Unc4.1 Homeobox 3

External Ids for UNCX Gene

Previous GeneCards Identifiers for UNCX Gene

  • GC07P001241
  • GC07P001189
  • GC07P001272

Summaries for UNCX Gene

Entrez Gene Summary for UNCX Gene

  • This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]

GeneCards Summary for UNCX Gene

UNCX (UNC Homeobox) is a Protein Coding gene. Diseases associated with UNCX include Conotruncal Heart Malformations. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is OTX1.

UniProtKB/Swiss-Prot for UNCX Gene

  • Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).

Additional gene information for UNCX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNCX Gene

Genomics for UNCX Gene

GeneHancer (GH) Regulatory Elements for UNCX Gene

Promoters and enhancers for UNCX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I001232 Promoter 0.8 EPDnew 550.8 -0.1 -54 0.1 POLR2A SUZ12 CREB1 EZH2 UNCX GC07P001203
GH07I001233 Enhancer 0.6 UCNEbase 550.8 -0.5 -495 0.2 PKNOX1 SUZ12 EZH2 UNCX GC07P001203
GH07I001231 Enhancer 0.4 ENCODE 550.8 -1.3 -1317 0.1 SUZ12 EZH2 UNCX GC07P001203
GH07I001323 Enhancer 0.5 ENCODE 11.7 +90.7 90669 0.4 CTBP1 LEF1 PKNOX1 ZIC2 ZFX UNCX ENSG00000233082 MICALL2
GH07I001230 Enhancer 0.5 FANTOM5 2.6 -2.1 -2133 0.4 RING1 SUZ12 EZH2 UNCX GC07P001203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UNCX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UNCX gene promoter:

Genomic Locations for UNCX Gene

Genomic Locations for UNCX Gene
chr7:1,232,907-1,237,318
(GRCh38/hg38)
Size:
4,412 bases
Orientation:
Plus strand
chr7:1,272,543-1,276,954
(GRCh37/hg19)

Genomic View for UNCX Gene

Genes around UNCX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNCX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNCX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNCX Gene

Proteins for UNCX Gene

  • Protein details for UNCX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJT0-UNC4_HUMAN
    Recommended name:
    Homeobox protein unc-4 homolog
    Protein Accession:
    A6NJT0
    Secondary Accessions:
    • A4D221

    Protein attributes for UNCX Gene

    Size:
    531 amino acids
    Molecular mass:
    53690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UNCX Gene

Post-translational modifications for UNCX Gene

No Post-translational modifications

Other Protein References for UNCX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNCX Gene

Domains & Families for UNCX Gene

Gene Families for UNCX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for UNCX Gene

Suggested Antigen Peptide Sequences for UNCX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJT0

UniProtKB/Swiss-Prot:

UNC4_HUMAN :
  • Belongs to the paired homeobox family. Unc-4 subfamily.
Family:
  • Belongs to the paired homeobox family. Unc-4 subfamily.
genes like me logo Genes that share domains with UNCX: view

Function for UNCX Gene

Molecular function for UNCX Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).

Phenotypes From GWAS Catalog for UNCX Gene

Gene Ontology (GO) - Molecular Function for UNCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with UNCX: view
genes like me logo Genes that share phenotypes with UNCX: view

Animal Models for UNCX Gene

MGI Knock Outs for UNCX:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNCX Gene

Localization for UNCX Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNCX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNCX gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UNCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with UNCX: view

Pathways & Interactions for UNCX Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNCX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with UNCX: view

No data available for Pathways by source and SIGNOR curated interactions for UNCX Gene

Drugs & Compounds for UNCX Gene

No Compound Related Data Available

Transcripts for UNCX Gene

mRNA/cDNA for UNCX Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UNCX Gene

UNC homeobox:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNCX Gene

No ASD Table

Relevant External Links for UNCX Gene

GeneLoc Exon Structure for
UNCX
ECgene alternative splicing isoforms for
UNCX

Expression for UNCX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNCX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNCX Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x24.1) and Brain - Cerebellum (x23.4).

Protein differential expression in normal tissues from HIPED for UNCX Gene

This gene is overexpressed in Platelet (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNCX Gene



Protein tissue co-expression partners for UNCX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNCX Gene:

UNCX

SOURCE GeneReport for Unigene cluster for UNCX Gene:

Hs.232272
genes like me logo Genes that share expression patterns with UNCX: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNCX Gene

Orthologs for UNCX Gene

This gene was present in the common ancestor of animals.

Orthologs for UNCX Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UNCX 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNCX 33 34
  • 87.14 (n)
mouse
(Mus musculus)
Mammalia Uncx 33 16 34
  • 83.46 (n)
rat
(Rattus norvegicus)
Mammalia Uncx 33
  • 83.01 (n)
cow
(Bos Taurus)
Mammalia UNCX 34
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves UNCX 33 34
  • 76.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492016 33
  • 67.85 (n)
zebrafish
(Danio rerio)
Actinopterygii uncx4.1 33 34
  • 70.91 (n)
uncx 34
  • 52 (a)
OneToMany
UNCX (3 of 3) 34
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta unc-4 34
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-4 34
  • 29 (a)
OneToOne
Species where no ortholog for UNCX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNCX Gene

ENSEMBL:
Gene Tree for UNCX (if available)
TreeFam:
Gene Tree for UNCX (if available)

Paralogs for UNCX Gene

Paralogs for UNCX Gene

(1) SIMAP similar genes for UNCX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNCX: view

Variants for UNCX Gene

Sequence variations from dbSNP and Humsavar for UNCX Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000447305 -- 1,233,228(+) C/A coding_sequence_variant, missense_variant
rs1000675869 -- 1,237,423(+) CCCC/CCCCC downstream_transcript_variant
rs1000818604 -- 1,232,130(+) /A upstream_transcript_variant
rs1001026615 -- 1,236,970(+) T/G coding_sequence_variant, missense_variant
rs1001496337 -- 1,232,388(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UNCX Gene

Variant ID Type Subtype PubMed ID
dgv1084n67 CNV gain 20364138
dgv1085n67 CNV gain 20364138
esv23542 CNV loss 19812545
esv2673144 CNV deletion 23128226
esv2759499 CNV loss 17122850
nsv1032992 CNV gain 25217958
nsv1074467 CNV deletion 25765185
nsv1074468 CNV deletion 25765185
nsv1122153 CNV deletion 24896259
nsv1126767 CNV deletion 24896259
nsv1145121 CNV deletion 24896259
nsv471182 CNV loss 18288195
nsv823961 CNV gain 20364138
nsv830876 CNV loss 17160897
nsv830877 CNV loss 17160897
nsv950785 CNV deletion 24416366

Variation tolerance for UNCX Gene

Gene Damage Index Score: 1.07; 21.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNCX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNCX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNCX Gene

Disorders for UNCX Gene

MalaCards: The human disease database

(1) MalaCards diseases for UNCX Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • cthm
- elite association - COSMIC cancer census association via MalaCards
Search UNCX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UNCX

genes like me logo Genes that share disorders with UNCX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UNCX Gene

Publications for UNCX Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells. (PMID: 28411256) Daniele G … Storlazzi CT (Haematologica 2017) 3 58
  4. Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence. (PMID: 27581094) Garin-Muga A … Segura V (Journal of proteome research 2016) 3 58
  5. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y … Tanaka T (Nature genetics 2012) 3 58

Products for UNCX Gene

Sources for UNCX Gene

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