Aliases for UNC93B1 Gene
External Ids for UNC93B1 Gene
Previous GeneCards Identifiers for UNC93B1 Gene
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]
GeneCards Summary for UNC93B1 Gene
UNC93B1 (Unc-93 Homolog B1, TLR Signaling Regulator) is a Protein Coding gene. Diseases associated with UNC93B1 include Encephalopathy, Acute, Infection-Induced 1 and Herpes Simplex Encephalitis. Among its related pathways are Activated TLR4 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include Toll-like receptor binding. An important paralog of this gene is UNC93A.
UniProtKB/Swiss-Prot Summary for UNC93B1 Gene
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.