Aliases for UNC5D Gene

Aliases for UNC5D Gene

  • Unc-5 Netrin Receptor D 2 3 5
  • Protein Unc-5 Homolog 4 2 3 4
  • Protein Unc-5 Homolog D 2 3 4
  • Netrin Receptor UNC5D 2 3 4
  • KIAA1777 2 4
  • Unc5h4 2 3
  • Unc-5 Homolog D (C. Elegans) 2
  • Netrin Receptor Unc5h4 3
  • Unc-5 Homolog 4 3
  • Unc-5 Homolog D 3
  • PRO34692 3
  • UNC5H4 4
  • UNC5D 5

External Ids for UNC5D Gene

Previous GeneCards Identifiers for UNC5D Gene

  • GC08P035183
  • GC08P035858
  • GC08P035459
  • GC08P035521
  • GC08P033626

Summaries for UNC5D Gene

GeneCards Summary for UNC5D Gene

UNC5D (Unc-5 Netrin Receptor D) is a Protein Coding gene. Diseases associated with UNC5D include Localized Chondrosarcoma and Anisometropia. Among its related pathways are Guidance Cues and Growth Cone Motility and Netrin-1 signaling. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot Summary for UNC5D Gene

  • Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UNC5D Gene

Genomics for UNC5D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UNC5D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J035235 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 608.3 +0.7 726 3.2 POLR2A SCRT2 RAD21 USF1 MYC TAF1 TBP EZH2 USF2 UNC5D ENSG00000279099
GH08J035328 Enhancer 0.6 Ensembl ENCODE 13.1 +91.7 91726 2 CTCF MNT ESR1 ZNF143 RAD21 UNC5D piR-34163-018 piR-50443-358
GH08J035303 Enhancer 0.5 Ensembl ENCODE 12 +68.3 68326 1.2 CTCF RAD21 UNC5D piR-34163-018 ENSG00000279099
GH08J035277 Enhancer 0.4 Ensembl 12.4 +42.2 42226 1 POLR2A USF1 RCOR1 CHD2 UNC5D ENSG00000279099 piR-34163-018
GH08J035411 Enhancer 0.7 FANTOM5 Ensembl ENCODE 7.8 +177.7 177661 2.5 POLR2A UNC5D piR-50443-358 piR-34163-018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNC5D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UNC5D

Top Transcription factor binding sites by QIAGEN in the UNC5D gene promoter:
  • aMEF-2
  • Arnt
  • C/EBPalpha
  • HEN1
  • MEF-2
  • MEF-2A
  • Nkx2-5
  • Sox5
  • TBP

Genomic Locations for UNC5D Gene

Genomic Locations for UNC5D Gene
chr8:35,235,475-35,796,550
(GRCh38/hg38)
Size:
561,076 bases
Orientation:
Plus strand
chr8:35,092,975-35,654,068
(GRCh37/hg19)
Size:
561,094 bases
Orientation:
Plus strand

Genomic View for UNC5D Gene

Genes around UNC5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5D Gene

Proteins for UNC5D Gene

  • Protein details for UNC5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ4-UNC5D_HUMAN
    Recommended name:
    Netrin receptor UNC5D
    Protein Accession:
    Q6UXZ4
    Secondary Accessions:
    • Q8WYP7

    Protein attributes for UNC5D Gene

    Size:
    953 amino acids
    Molecular mass:
    105880 Da
    Quaternary structure:
    • Interacts (via extracellular domain) with FLRT2 (via extracellular domain); the interaction is direct (By similarity). Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030).

    Alternative splice isoforms for UNC5D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5D Gene

Post-translational modifications for UNC5D Gene

  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Glycosylation at Asn117, Asn228, Asn353, and Asn376
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for UNC5D
  • Boster Bio Antibodies for UNC5D
  • Santa Cruz Biotechnology (SCBT) Antibodies for UNC5D

No data available for DME Specific Peptides for UNC5D Gene

Domains & Families for UNC5D Gene

Gene Families for UNC5D Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UNC5D Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin subtype
  • Death domain
  • Thrombospondin type 1 repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for UNC5D Gene

GenScript: Design optimal peptide antigens:
  • Protein unc-5 homolog D (UNC5D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UXZ4

UniProtKB/Swiss-Prot:

UNC5D_HUMAN :
  • Belongs to the unc-5 family.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5D: view

Function for UNC5D Gene

Molecular function for UNC5D Gene

UniProtKB/Swiss-Prot Function:
Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53 in response to DNA damage.

Phenotypes From GWAS Catalog for UNC5D Gene

Gene Ontology (GO) - Molecular Function for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005042 netrin receptor activity IEA,IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with UNC5D: view
genes like me logo Genes that share phenotypes with UNC5D: view

Animal Models for UNC5D Gene

MGI Knock Outs for UNC5D:

Animal Model Products

  • Taconic Biosciences Mouse Models for UNC5D

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNC5D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC5D Gene

Localization for UNC5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5D Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC5D gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UNC5D Gene

Pathways & Interactions for UNC5D Gene

PathCards logo

SuperPathways for UNC5D Gene

genes like me logo Genes that share pathways with UNC5D: view

Pathways by source for UNC5D Gene

1 KEGG pathway for UNC5D Gene
2 Qiagen pathways for UNC5D Gene
  • Guidance Cues and Growth Cone Motility
  • Netrin Signaling

Gene Ontology (GO) - Biological Process for UNC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance IBA 21873635
GO:0021859 pyramidal neuron differentiation IEA --
genes like me logo Genes that share ontologies with UNC5D: view

No data available for SIGNOR curated interactions for UNC5D Gene

Drugs & Compounds for UNC5D Gene

No Compound Related Data Available

Transcripts for UNC5D Gene

mRNA/cDNA for UNC5D Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNC5D

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: - -

Relevant External Links for UNC5D Gene

GeneLoc Exon Structure for
UNC5D

Expression for UNC5D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UNC5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5D Gene

This gene is overexpressed in Brain - Hypothalamus (x6.8), Brain - Frontal Cortex (BA9) (x6.1), Brain - Cortex (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.4), and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for UNC5D Gene

This gene is overexpressed in Liver (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UNC5D Gene



Protein tissue co-expression partners for UNC5D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UNC5D

SOURCE GeneReport for Unigene cluster for UNC5D Gene:

Hs.238889

Evidence on tissue expression from TISSUES for UNC5D Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with UNC5D: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC5D Gene

Orthologs for UNC5D Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UNC5D 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UNC5D 30 31
  • 92.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UNC5D 30 31
  • 91.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Unc5d 30
  • 90.68 (n)
Mouse
(Mus musculus)
Mammalia Unc5d 30 17 31
  • 90.36 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UNC5D 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia UNC5D 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves UNC5D 30 31
  • 79.54 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia UNC5D 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia unc5d 30
  • 75.86 (n)
Zebrafish
(Danio rerio)
Actinopterygii UNC5D (3 of 3) 31
  • 73 (a)
OneToMany
unc5db 31
  • 68 (a)
OneToMany
unc5da 30 31
  • 67.8 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea unc-5 32
  • 26 (a)
Species where no ortholog for UNC5D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UNC5D Gene

ENSEMBL:
Gene Tree for UNC5D (if available)
TreeFam:
Gene Tree for UNC5D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UNC5D: view image

Paralogs for UNC5D Gene

Paralogs for UNC5D Gene

(3) SIMAP similar genes for UNC5D Gene using alignment to 5 proteins:

  • UNC5D_HUMAN
  • C9J1I0_HUMAN
  • C9J2B6_HUMAN
  • E9PDS8_HUMAN
  • H7BXJ2_HUMAN
genes like me logo Genes that share paralogs with UNC5D: view

Variants for UNC5D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UNC5D Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
714379 Benign: not provided 35,568,111(+) C/T SYNONYMOUS_VARIANT
778358 Likely Benign: not provided 35,235,796(+) G/T SYNONYMOUS_VARIANT
rs35487923 - p.Arg728Lys

Additional dbSNP identifiers (rs#s) for UNC5D Gene

Structural Variations from Database of Genomic Variants (DGV) for UNC5D Gene

Variant ID Type Subtype PubMed ID
dgv12089n54 CNV loss 21841781
dgv1279e199 CNV deletion 23128226
esv1962769 CNV deletion 18987734
esv24068 CNV loss 19812545
esv2483846 CNV deletion 19546169
esv2530621 CNV deletion 19546169
esv2532641 CNV deletion 19546169
esv2632134 CNV insertion 19546169
esv2657552 CNV deletion 23128226
esv2663137 CNV deletion 23128226
esv2675242 CNV deletion 23128226
esv2736875 CNV deletion 23290073
esv275263 CNV loss 21479260
esv28759 CNV loss 19812545
esv3329938 CNV duplication 20981092
esv3432912 CNV insertion 20981092
esv3543350 CNV deletion 23714750
esv3543353 CNV deletion 23714750
esv3616881 CNV loss 21293372
esv3616884 CNV loss 21293372
esv3616886 CNV loss 21293372
esv3616887 CNV loss 21293372
esv3616888 CNV loss 21293372
esv3616890 CNV loss 21293372
nsv1075130 CNV deletion 25765185
nsv1109966 CNV deletion 24896259
nsv1109967 CNV deletion 24896259
nsv1115086 CNV deletion 24896259
nsv1128411 CNV deletion 24896259
nsv1148503 CNV duplication 26484159
nsv396482 CNV deletion 16902084
nsv520421 CNV gain 19592680
nsv6150 CNV insertion 18451855
nsv6151 CNV deletion 18451855
nsv6152 CNV insertion 18451855
nsv820115 CNV gain 19587683
nsv831284 CNV gain 17160897
nsv831285 CNV loss 17160897
nsv971297 CNV duplication 23825009

Variation tolerance for UNC5D Gene

Residual Variation Intolerance Score: 6.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC5D Gene

Human Gene Mutation Database (HGMD)
UNC5D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC5D

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5D Gene

Disorders for UNC5D Gene

MalaCards: The human disease database

(2) MalaCards diseases for UNC5D Gene - From: DISEASES

Disorder Aliases PubMed IDs
localized chondrosarcoma
anisometropia
- elite association - COSMIC cancer census association via MalaCards
Search UNC5D in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UNC5D

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UNC5D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UNC5D Gene

Publications for UNC5D Gene

  1. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. (PMID: 26235030) Lu YC … Araç D (Structure (London, England : 1993) 2015) 3 4
  2. Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell. (PMID: 24519068) Wang H … Hao L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 3 4
  3. Unc5D regulates p53-dependent apoptosis in neuroblastoma cells. (PMID: 24691657) Wang H … Hao L (Molecular medicine reports 2014) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. (PMID: 18402767) Wang H … Nakagawara A (Biochemical and biophysical research communications 2008) 2 3

Products for UNC5D Gene

Sources for UNC5D Gene