Aliases for UNC5D Gene
External Ids for UNC5D Gene
Previous GeneCards Identifiers for UNC5D Gene
GeneCards Summary for UNC5D Gene
UNC5D (Unc-5 Netrin Receptor D) is a Protein Coding gene. Diseases associated with UNC5D include Localized Chondrosarcoma and Anisometropia. Among its related pathways are Guidance Cues and Growth Cone Motility and Netrin-1 signaling. An important paralog of this gene is UNC5B.
UniProtKB/Swiss-Prot Summary for UNC5D Gene
Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).