Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UNC5CL Gene

Aliases for UNC5CL Gene

  • Unc-5 Family C-Terminal Like 2 3 5
  • ZU5 And Death Domain Containing 2 3
  • Protein Unc-5 Homolog C-Like 3 4
  • ZUD 3 4
  • ZU5 And Death Domain-Containing Protein 4
  • Unc-5 Homolog C (C. Elegans)-Like 2
  • Unc-5 Homolog C-Like 3
  • UNC5C-Like Protein 3
  • MUXA 3

External Ids for UNC5CL Gene

Previous GeneCards Identifiers for UNC5CL Gene

  • GC06M040996
  • GC06M041042
  • GC06M041043
  • GC06M041102
  • GC06M040712

Summaries for UNC5CL Gene

GeneCards Summary for UNC5CL Gene

UNC5CL (Unc-5 Family C-Terminal Like) is a Protein Coding gene. Among its related pathways are Netrin Signaling. Gene Ontology (GO) annotations related to this gene include peptidase activity. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot for UNC5CL Gene

  • Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.

Additional gene information for UNC5CL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5CL Gene

Genomics for UNC5CL Gene

GeneHancer (GH) Regulatory Elements for UNC5CL Gene

Promoters and enhancers for UNC5CL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I041036 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 558.9 +0.3 321 5.7 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 YY1 ZNF143 FOS ZNF263 RXRA UNC5CL APOBEC2 TSPO2 LOC101929555 OARD1
GH06I041070 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 -34.4 -34367 5.9 MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 NFYA OARD1 ADCY10P1 TAF8 FRS3 TSPO2 UNC5CL APOBEC2
GH06I040995 Enhancer 1.2 Ensembl ENCODE 11.9 +41.3 41262 5.3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 SLC30A9 ZNF416 ZNF143 FOS REST TSPO2 UNC5CL NFYA LOC101929555 GC06P042401
GH06I040936 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.9 +102.1 102054 2.1 MAX FOSL2 MNT FOS ZIC2 UNC5CL TSPO2 GC06P042401 LOC101929555
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UNC5CL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UNC5CL gene promoter:

Genomic Locations for UNC5CL Gene

Genomic Locations for UNC5CL Gene
12,317 bases
Minus strand

Genomic View for UNC5CL Gene

Genes around UNC5CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5CL Gene

Proteins for UNC5CL Gene

  • Protein details for UNC5CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UNC5C-like protein
    Protein Accession:
    Secondary Accessions:
    • Q5TGU1

    Protein attributes for UNC5CL Gene

    518 amino acids
    Molecular mass:
    57818 Da
    Quaternary structure:
    • Interacts with p65/RELA and NFKB1.

neXtProt entry for UNC5CL Gene

Post-translational modifications for UNC5CL Gene

No Post-translational modifications

Other Protein References for UNC5CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UNC5CL Gene

Domains & Families for UNC5CL Gene

Gene Families for UNC5CL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UNC5CL Gene

Suggested Antigen Peptide Sequences for UNC5CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unc-5 family.
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5CL: view

Function for UNC5CL Gene

Molecular function for UNC5CL Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.

Phenotypes From GWAS Catalog for UNC5CL Gene

Gene Ontology (GO) - Molecular Function for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IDA 22158417
genes like me logo Genes that share ontologies with UNC5CL: view
genes like me logo Genes that share phenotypes with UNC5CL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC5CL Gene

Localization for UNC5CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5CL Gene

Membrane; Single-pass type III membrane protein. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC5CL gene
Compartment Confidence
extracellular 3
cytoskeleton 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 22158417
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UNC5CL: view

Pathways & Interactions for UNC5CL Gene

SuperPathways for UNC5CL Gene

SuperPathway Contained pathways
1 Netrin Signaling
genes like me logo Genes that share pathways with UNC5CL: view

Pathways by source for UNC5CL Gene

1 Qiagen pathway for UNC5CL Gene

Gene Ontology (GO) - Biological Process for UNC5CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 22158417
GO:0046330 positive regulation of JNK cascade IDA 22158417
genes like me logo Genes that share ontologies with UNC5CL: view

No data available for SIGNOR curated interactions for UNC5CL Gene

Drugs & Compounds for UNC5CL Gene

No Compound Related Data Available

Transcripts for UNC5CL Gene

mRNA/cDNA for UNC5CL Gene

Unigene Clusters for UNC5CL Gene

Unc-5 homolog C (C. elegans)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5CL Gene

No ASD Table

Relevant External Links for UNC5CL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC5CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNC5CL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5CL Gene

This gene is overexpressed in Kidney - Cortex (x14.6), Liver (x10.7), and Pancreas (x7.3).

Protein differential expression in normal tissues from HIPED for UNC5CL Gene

This gene is overexpressed in Plasma (34.0), Islet of Langerhans (22.1), and Kidney (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5CL Gene

Protein tissue co-expression partners for UNC5CL Gene

NURSA nuclear receptor signaling pathways regulating expression of UNC5CL Gene:


SOURCE GeneReport for Unigene cluster for UNC5CL Gene:


mRNA Expression by UniProt/SwissProt for UNC5CL Gene:

Tissue specificity: Expressed in pancreas, liver and kidney.

Evidence on tissue expression from TISSUES for UNC5CL Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with UNC5CL: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC5CL Gene

Orthologs for UNC5CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for UNC5CL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UNC5CL 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia UNC5CL 33 34
  • 87.4 (n)
(Bos Taurus)
Mammalia UNC5CL 33 34
  • 86.68 (n)
(Mus musculus)
Mammalia Unc5cl 33 16 34
  • 82.88 (n)
(Rattus norvegicus)
Mammalia Unc5cl 33
  • 80.53 (n)
(Monodelphis domestica)
Mammalia UNC5CL 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
(Danio rerio)
Actinopterygii bai2 34
  • 11 (a)
Species where no ortholog for UNC5CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UNC5CL Gene

Gene Tree for UNC5CL (if available)
Gene Tree for UNC5CL (if available)

Paralogs for UNC5CL Gene

Paralogs for UNC5CL Gene

(1) SIMAP similar genes for UNC5CL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UNC5CL: view

Variants for UNC5CL Gene

Sequence variations from dbSNP and Humsavar for UNC5CL Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000039207 -- 41,039,841(-) C/T upstream_transcript_variant
rs1000303208 -- 41,030,247(-) T/G intron_variant
rs1000412179 -- 41,039,586(-) A/G upstream_transcript_variant
rs1000457588 -- 41,036,402(-) C/T intron_variant
rs1000639136 -- 41,031,454(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5CL Gene

Variant ID Type Subtype PubMed ID
nsv526577 CNV loss 19592680

Variation tolerance for UNC5CL Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC5CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5CL Gene

Disorders for UNC5CL Gene

Additional Disease Information for UNC5CL

No disorders were found for UNC5CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5CL Gene

Publications for UNC5CL Gene

  1. Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB. (PMID: 14769797) Zhang J … Shu HB (The Journal of biological chemistry 2004) 2 3 4 22 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours. (PMID: 26129866) Hu N … Abnet CC (Gut 2016) 3 58
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  5. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. (PMID: 22158417) Heinz LX … Tschopp J (Cell death and differentiation 2012) 3 58

Products for UNC5CL Gene

Sources for UNC5CL Gene

Loading form....