This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of re... See more...

Aliases for UNC5C Gene

Aliases for UNC5C Gene

  • Unc-5 Netrin Receptor C 2 3 5
  • Unc5 (C.Elegans Homolog) C 2 3
  • Protein Unc-5 Homolog 3 3 4
  • Protein Unc-5 Homolog C 3 4
  • Netrin Receptor UNC5C 3 4
  • UNC5H3 3 4
  • Unc-5 Homolog C (C. Elegans) 2
  • Unc-5 Homolog 3 3
  • Unc-5 Homolog C 3
  • UNC5C 5

External Ids for UNC5C Gene

Previous GeneCards Identifiers for UNC5C Gene

  • GC04M096436
  • GC04M096548
  • GC04M096446
  • GC04M096308
  • GC04M096083
  • GC04M091820

Summaries for UNC5C Gene

Entrez Gene Summary for UNC5C Gene

  • This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

GeneCards Summary for UNC5C Gene

UNC5C (Unc-5 Netrin Receptor C) is a Protein Coding gene. Diseases associated with UNC5C include Alzheimer Disease. Among its related pathways are Guidance Cues and Growth Cone Motility and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include netrin receptor activity. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot Summary for UNC5C Gene

  • Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

Gene Wiki entry for UNC5C Gene

Additional gene information for UNC5C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UNC5C Gene

Genomics for UNC5C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UNC5C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J095546 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.4 1409 6.4 CTCF PRDM10 ZNF629 LARP7 PRDM1 ZIC2 ZSCAN4 RAD21 RCOR1 ZNF501 ENSG00000271474 LOC105377335 UNC5C piR-43105-501 BMPR1B
GH04J095288 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.8 +257.9 257909 5.8 LEF1 IKZF1 JUND DDX20 REST NR2C1 IKZF2 ZNF24 DPF2 HDAC1 UNC5C piR-43105-501 piR-38352-424 BMPR1B
GH04J095599 Enhancer 0.7 FANTOM5 Ensembl 7.5 -51.6 -51569 1.6 IKZF2 RELB JUNB BATF TBX21 ATF7 MTA2 IKZF1 UNC5C ENSG00000271474 lnc-UNC5C-2 RPL30P6 LOC105377337 PDHA2
GH04J095317 Enhancer 0.8 Ensembl CraniofacialAtlas dbSUPER 4.5 +231.1 231084 2.2 RCOR1 YY1 SMARCA4 CHD2 GATA2 UNC5C piR-43105-501 piR-38352-424 BMPR1B
GH04J095408 Enhancer 0.7 Ensembl dbSUPER 5.1 +140.0 140009 0.8 GABPA SP1 JUND FOXA2 FOSL2 JUN ZNF384 UNC5C piR-43105-501 ENSG00000271474 BMPR1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNC5C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UNC5C

Top Transcription factor binding sites by QIAGEN in the UNC5C gene promoter:
  • AP-1
  • c-Fos
  • FosB
  • Lmo2
  • POU2F1
  • POU2F1a
  • RORalpha1
  • TBP
  • TFIID
  • Zic1

Genomic Locations for UNC5C Gene

Genomic Locations for UNC5C Gene
chr4:95,162,504-95,549,210
(GRCh38/hg38)
Size:
386,707 bases
Orientation:
Minus strand
chr4:96,083,655-96,470,361
(GRCh37/hg19)
Size:
386,707 bases
Orientation:
Minus strand

Genomic View for UNC5C Gene

Genes around UNC5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5C Gene

Proteins for UNC5C Gene

  • Protein details for UNC5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95185-UNC5C_HUMAN
    Recommended name:
    Netrin receptor UNC5C
    Protein Accession:
    O95185
    Secondary Accessions:
    • Q8IUT0

    Protein attributes for UNC5C Gene

    Size:
    931 amino acids
    Molecular mass:
    103146 Da
    Quaternary structure:
    • Interacts with DCC (via cytoplasmic domain) (By similarity). Interacts (tyrosine phosphorylated form) with PTPN11 (By similarity). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity). Interacts (via Ig-like C2-type domain) with DSCAM (via extracellular domain) (PubMed:22685302). Interacts (via death domain) with DAPK1 (PubMed:27068745). Interacts (via cytoplasmic domain) with TUBB3; this interaction is decreased by NTN1/Netrin-1 (PubMed:28483977).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

    Alternative splice isoforms for UNC5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5C Gene

Post-translational modifications for UNC5C Gene

  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
  • Glycosylation at Asn236 and Asn361
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UNC5C Gene

Domains & Families for UNC5C Gene

Gene Families for UNC5C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UNC5C Gene

InterPro:
Blocks:
  • Death domain
  • Thrombospondin type 1 repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for UNC5C Gene

GenScript: Design optimal peptide antigens:
  • Protein unc-5 homolog C (UNC5C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95185

UniProtKB/Swiss-Prot:

UNC5C_HUMAN :
  • Belongs to the unc-5 family.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5C: view

Function for UNC5C Gene

Molecular function for UNC5C Gene

UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
GENATLAS Biochemistry:
C elegans Unc5 and murine unc5hr homolog,involved in cell migration during cerebellum development,inducing repulsion in axon guidance through its cytoplasmic tail,expressed in brain,fetal heart

Phenotypes From GWAS Catalog for UNC5C Gene

Gene Ontology (GO) - Molecular Function for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005042 netrin receptor activity IEA,IBA 21873635
GO:0005043 netrin receptor activity involved in chemorepulsion ISS --
GO:0005515 protein binding IEA,IPI 22685302
GO:0015631 tubulin binding IPI 28483977
GO:0019901 protein kinase binding IPI 27068745
genes like me logo Genes that share ontologies with UNC5C: view
genes like me logo Genes that share phenotypes with UNC5C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNC5C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC5C Gene

Localization for UNC5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5C Gene

Cell membrane. Single-pass type I membrane protein. Cell surface. Cell junction, synapse, synaptosome. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC5C gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 25419706
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030027 lamellipodium ISS --
genes like me logo Genes that share ontologies with UNC5C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UNC5C Gene

Pathways & Interactions for UNC5C Gene

PathCards logo

SuperPathways for UNC5C Gene

genes like me logo Genes that share pathways with UNC5C: view

Pathways by source for UNC5C Gene

1 KEGG pathway for UNC5C Gene
2 Qiagen pathways for UNC5C Gene
  • Guidance Cues and Growth Cone Motility
  • Netrin Signaling

SIGNOR curated interactions for UNC5C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UNC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance TAS,IBA 21873635
GO:0007420 brain development TAS,IEA --
genes like me logo Genes that share ontologies with UNC5C: view

Drugs & Compounds for UNC5C Gene

No Compound Related Data Available

Transcripts for UNC5C Gene

mRNA/cDNA for UNC5C Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNC5C

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: -
SP3:

Relevant External Links for UNC5C Gene

GeneLoc Exon Structure for
UNC5C

Expression for UNC5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UNC5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC5C Gene

This gene is overexpressed in Adrenal (47.2) and Fetal Brain (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UNC5C Gene



Protein tissue co-expression partners for UNC5C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UNC5C

SOURCE GeneReport for Unigene cluster for UNC5C Gene:

Hs.388565

mRNA Expression by UniProt/SwissProt for UNC5C Gene:

O95185-UNC5C_HUMAN
Tissue specificity: Mainly expressed in brain (PubMed:9782087). Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer (PubMed:25419706). Also expressed in kidney (PubMed:9782087). Not expressed in developing or adult lung (PubMed:9782087).

Evidence on tissue expression from TISSUES for UNC5C Gene

  • Nervous system(4.8)
  • Lung(4.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with UNC5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC5C Gene

Orthologs for UNC5C Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC5C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UNC5C 30 31
  • 99.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UNC5C 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia UNC5C 30 31
  • 91.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UNC5C 30 31
  • 91.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Unc5c 30 17 31
  • 89.65 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Unc5c 30
  • 88.97 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Chicken
(Gallus gallus)
Aves UNC5C 30 31
  • 82.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia UNC5C 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia unc5c 30
  • 77.62 (n)
Zebrafish
(Danio rerio)
Actinopterygii unc5c 30 31
  • 72.35 (n)
OneToMany
UNC5C (1 of 2) 31
  • 64 (a)
OneToMany
Dr.14572 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009061 30
  • 45.47 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta unc-5 30 32
  • 44.27 (n)
Worm
(Caenorhabditis elegans)
Secernentea unc-5 32
  • 28 (a)
Species where no ortholog for UNC5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UNC5C Gene

ENSEMBL:
Gene Tree for UNC5C (if available)
TreeFam:
Gene Tree for UNC5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UNC5C: view image

Paralogs for UNC5C Gene

Paralogs for UNC5C Gene

(4) SIMAP similar genes for UNC5C Gene using alignment to 4 proteins:

  • UNC5C_HUMAN
  • D6RE16_HUMAN
  • E0CX15_HUMAN
  • Q4W5H4_HUMAN
genes like me logo Genes that share paralogs with UNC5C: view

Variants for UNC5C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UNC5C Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
786040 Benign: not provided 95,169,360(-) G/A SYNONYMOUS_VARIANT
rs137875858 Alzheimer disease (AD) [MIM:104300] p.Thr835Met
rs2289043 - p.Met721Thr
rs2306715 - p.Gly37Val
rs34585936 - p.Ala841Thr

Additional dbSNP identifiers (rs#s) for UNC5C Gene

Structural Variations from Database of Genomic Variants (DGV) for UNC5C Gene

Variant ID Type Subtype PubMed ID
dgv2856n106 CNV deletion 24896259
dgv9175n54 CNV loss 21841781
dgv9176n54 CNV loss 21841781
esv1001867 CNV deletion 20482838
esv1143724 CNV insertion 17803354
esv1227332 CNV deletion 17803354
esv1489767 CNV insertion 17803354
esv1617018 CNV insertion 17803354
esv2041389 CNV deletion 18987734
esv25475 CNV loss 19812545
esv2577861 CNV deletion 19546169
esv2660811 CNV deletion 23128226
esv2661832 CNV deletion 23128226
esv2674923 CNV deletion 23128226
esv27157 CNV loss 19812545
esv2727993 CNV deletion 23290073
esv2727994 CNV deletion 23290073
esv2727996 CNV deletion 23290073
esv2763844 CNV loss 21179565
esv2808 CNV loss 18987735
esv3450367 CNV duplication 20981092
esv3564287 CNV deletion 23714750
esv3564288 CNV deletion 23714750
esv3564289 CNV deletion 23714750
esv3569613 CNV loss 25503493
esv3569614 CNV loss 25503493
esv3601464 CNV loss 21293372
esv3601466 CNV loss 21293372
nsv1005881 CNV gain 25217958
nsv1074200 CNV deletion 25765185
nsv1133345 CNV tandem duplication 24896259
nsv1151405 CNV deletion 26484159
nsv471768 CNV loss 16327809
nsv478904 CNV novel sequence insertion 20440878
nsv519986 CNV loss 19592680
nsv521417 CNV loss 19592680
nsv523039 CNV loss 19592680
nsv525953 CNV loss 19592680
nsv527705 CNV loss 19592680
nsv594907 CNV gain 21841781
nsv822655 CNV gain 20364138
nsv830011 CNV gain 17160897
nsv964075 CNV duplication 23825009

Variation tolerance for UNC5C Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.02; 96.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC5C Gene

Human Gene Mutation Database (HGMD)
UNC5C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC5C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5C Gene

Disorders for UNC5C Gene

MalaCards: The human disease database

(1) MalaCards diseases for UNC5C Gene - From: UniProtKB/Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search UNC5C in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

UNC5C_HUMAN
  • Alzheimer disease (AD) [MIM:104300]: Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death. {ECO:0000269 PubMed:25419706, ECO:0000269 PubMed:27068745}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for UNC5C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UNC5C: view

No data available for Genatlas for UNC5C Gene

Publications for UNC5C Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K … Mehlen P (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 23
  2. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. (PMID: 9782087) Ackerman SL … Knowles BB (Genomics 1998) 2 3 4 23
  3. Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. (PMID: 28483977) Shao Q … Liu G (The Journal of neuroscience : the official journal of the Society for Neuroscience 2017) 3 4
  4. An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling. (PMID: 27068745) Hashimoto Y … Matsuoka M (The Journal of biological chemistry 2016) 3 4
  5. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. (PMID: 25419706) Wetzel-Smith MK … Graham RR (Nature medicine 2014) 3 4

Products for UNC5C Gene

  • Signalway ELISA kits for UNC5C
  • Signalway Proteins for UNC5C

Sources for UNC5C Gene