Aliases for UNC5B Gene
External Ids for UNC5B Gene
Previous GeneCards Identifiers for UNC5B Gene
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for UNC5B Gene
UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Diseases associated with UNC5B include Hyperinsulinemic Hypoglycemia, Familial, 3. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Netrin-1 signaling. An important paralog of this gene is UNC5C.
UniProtKB/Swiss-Prot Summary for UNC5B Gene
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).