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Aliases for UNC5A Gene

Aliases for UNC5A Gene

  • Unc-5 Netrin Receptor A 2 3 5
  • Unc5 (C.Elegans Homolog) A 2 3
  • Protein Unc-5 Homolog 1 3 4
  • Protein Unc-5 Homolog A 3 4
  • UNC5H1 3 4
  • Unc-5 Homolog A (C. Elegans) 2
  • Netrin Receptor Unc5h1 3
  • Netrin Receptor UNC5A 3
  • Unc-5 Homolog 1 3
  • Unc-5 Homolog A 3
  • KIAA1976 4

External Ids for UNC5A Gene

Previous GeneCards Identifiers for UNC5A Gene

  • GC00U990540
  • GC05P176270
  • GC05P176170
  • GC05P171160
  • GC05P176237

Summaries for UNC5A Gene

Entrez Gene Summary for UNC5A Gene

  • UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

GeneCards Summary for UNC5A Gene

UNC5A (Unc-5 Netrin Receptor A) is a Protein Coding gene. Among its related pathways are Developmental Biology and Netrin-1 signaling. An important paralog of this gene is UNC5C.

UniProtKB/Swiss-Prot for UNC5A Gene

  • Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Gene Wiki entry for UNC5A Gene

Additional gene information for UNC5A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC5A Gene

Genomics for UNC5A Gene

GeneHancer (GH) Regulatory Elements for UNC5A Gene

Promoters and enhancers for UNC5A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I176810 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.1 124 0.4 NFIB KLF17 ZNF335 ZFHX2 GLIS2 PATZ1 VEZF1 SCRT2 FOS KLF13 UNC5A GC05M176812
GH05I176895 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 10.6 +88.6 88551 7.7 CTCF ZNF146 ZSCAN26 EBF1 BATF ZIC2 IRF4 ZBTB40 FOXK2 POLR2A HK3 ZNF346 FGFR4 UNC5A ZNF346-IT1 UIMC1 GC05M176812
GH05I176824 Enhancer 0.9 FANTOM5 ENCODE 13.4 +12.8 12810 0.3 KLF1 ZNF687 USF2 KLF17 ELF1 ZNF507 ZNF217 SCRT2 ZNF444 WT1 UNC5A HK3 SNCB EIF4E1B NSD1 GPRIN1 GC05M176812
GH05I176552 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 -256.7 -256669 3.5 BCOR ZNF449 SIN3A ZMYM3 BMI1 BATF ZIC2 ZKSCAN1 GLIS2 POLR2A FAF2 ENSG00000250909 NSD1 ENSG00000251414 ARL10 MIR1271 KIAA1191 UNC5A CDHR2 GC05M176548
GH05I176692 Enhancer 0.9 ENCODE 11.2 -117.4 -117352 0.9 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF213 TSHZ1 ZSCAN16 GLIS1 MYNN AEBP2 TSPAN17 UNC5A ENSG00000248484
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UNC5A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UNC5A gene promoter:

Genomic Locations for UNC5A Gene

Genomic Locations for UNC5A Gene
chr5:176,810,477-176,880,898
(GRCh38/hg38)
Size:
70,422 bases
Orientation:
Plus strand
chr5:176,237,478-176,307,899
(GRCh37/hg19)

Genomic View for UNC5A Gene

Genes around UNC5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC5A Gene

Proteins for UNC5A Gene

  • Protein details for UNC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN44-UNC5A_HUMAN
    Recommended name:
    Netrin receptor UNC5A
    Protein Accession:
    Q6ZN44
    Secondary Accessions:
    • B2RXE6
    • Q8TF26
    • Q96GP4

    Protein attributes for UNC5A Gene

    Size:
    842 amino acids
    Molecular mass:
    92932 Da
    Quaternary structure:
    • Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (By similarity).
    Miscellaneous:
    • Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.
    SequenceCaution:
    • Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UNC5A Gene

    Alternative splice isoforms for UNC5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC5A Gene

Post-translational modifications for UNC5A Gene

  • Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.

Other Protein References for UNC5A Gene

No data available for DME Specific Peptides for UNC5A Gene

Domains & Families for UNC5A Gene

Gene Families for UNC5A Gene

Suggested Antigen Peptide Sequences for UNC5A Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZN44

UniProtKB/Swiss-Prot:

UNC5A_HUMAN :
  • The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
  • Belongs to the unc-5 family.
Domain:
  • The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
Family:
  • Belongs to the unc-5 family.
genes like me logo Genes that share domains with UNC5A: view

Function for UNC5A Gene

Molecular function for UNC5A Gene

UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with UNC5A: view

Animal Models for UNC5A Gene

MGI Knock Outs for UNC5A:

miRNA for UNC5A Gene

miRTarBase miRNAs that target UNC5A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC5A Gene

Localization for UNC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC5A Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell projection. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. Detected in neurites. {ECO:0000250 UniProtKB:O08721}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC5A gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane ISS --
GO:0032589 neuron projection membrane ISS --
genes like me logo Genes that share ontologies with UNC5A: view

Pathways & Interactions for UNC5A Gene

genes like me logo Genes that share pathways with UNC5A: view

SIGNOR curated interactions for UNC5A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UNC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance TAS --
GO:0031175 neuron projection development ISS --
genes like me logo Genes that share ontologies with UNC5A: view

Drugs & Compounds for UNC5A Gene

No Compound Related Data Available

Transcripts for UNC5A Gene

Unigene Clusters for UNC5A Gene

Unc-5 homolog A (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for UNC5A Gene

GeneLoc Exon Structure for
UNC5A
ECgene alternative splicing isoforms for
UNC5A

Expression for UNC5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC5A Gene

This gene is overexpressed in Brain - Cortex (x10.1), Brain - Cerebellum (x7.3), Brain - Frontal Cortex (BA9) (x7.0), Brain - Cerebellar Hemisphere (x6.1), and Brain - Anterior cingulate cortex (BA24) (x5.3).

Protein differential expression in normal tissues from HIPED for UNC5A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UNC5A Gene



Protein tissue co-expression partners for UNC5A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNC5A Gene:

UNC5A

SOURCE GeneReport for Unigene cluster for UNC5A Gene:

Hs.33191

Evidence on tissue expression from TISSUES for UNC5A Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with UNC5A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC5A Gene

Orthologs for UNC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for UNC5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC5A 33 34
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia UNC5A 33 34
  • 92.12 (n)
dog
(Canis familiaris)
Mammalia UNC5A 33 34
  • 92 (n)
mouse
(Mus musculus)
Mammalia Unc5a 33 16 34
  • 88.4 (n)
rat
(Rattus norvegicus)
Mammalia Unc5a 33
  • 87.33 (n)
oppossum
(Monodelphis domestica)
Mammalia UNC5A 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC5A 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC5A 33 34
  • 79.05 (n)
lizard
(Anolis carolinensis)
Reptilia UNC5A 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc5a 33
  • 68.5 (n)
zebrafish
(Danio rerio)
Actinopterygii unc5a 33 34
  • 69.57 (n)
Species where no ortholog for UNC5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UNC5A Gene

ENSEMBL:
Gene Tree for UNC5A (if available)
TreeFam:
Gene Tree for UNC5A (if available)

Paralogs for UNC5A Gene

Paralogs for UNC5A Gene

(4) SIMAP similar genes for UNC5A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UNC5A: view

Variants for UNC5A Gene

Sequence variations from dbSNP and Humsavar for UNC5A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000028597 -- 176,852,878(+) G/A intron_variant
rs1000043108 -- 176,822,338(+) T/C intron_variant
rs1000122169 -- 176,816,024(+) C/T intron_variant
rs1000143 -- 176,857,900(+) A/C/G intron_variant
rs1000144 -- 176,857,712(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UNC5A Gene

Variant ID Type Subtype PubMed ID
nsv950724 CNV deletion 24416366
nsv600353 CNV loss 21841781
nsv600352 CNV loss 21841781
nsv513275 CNV loss 21212237
nsv509100 CNV insertion 20534489
nsv462562 CNV loss 19166990
nsv462557 CNV loss 19166990
nsv328116 CNV deletion 16902084
nsv1124013 CNV deletion 24896259
nsv1119053 CNV deletion 24896259
nsv1112891 CNV deletion 24896259
nsv1074890 CNV deletion 25765185
esv3607674 CNV gain 21293372
esv2763524 CNV gain 21179565
esv2731183 CNV deletion 23290073
esv2731182 CNV deletion 23290073
esv2731181 CNV deletion 23290073
esv2731180 CNV deletion 23290073
esv2670396 CNV deletion 23128226
esv2666951 CNV deletion 23128226
esv21826 CNV gain 19812545
esv1776918 CNV deletion 17803354
esv1663529 CNV insertion 17803354
esv1379063 CNV deletion 17803354
esv1176499 CNV deletion 17803354
esv1004326 CNV deletion 20482838
dgv732n27 CNV loss 19166990
dgv362n21 CNV loss 19592680
dgv3429e59 CNV duplication 20981092
dgv10181n54 CNV loss 21841781
dgv10180n54 CNV loss 21841781

Variation tolerance for UNC5A Gene

Residual Variation Intolerance Score: 9.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC5A Gene

Disorders for UNC5A Gene

Additional Disease Information for UNC5A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UNC5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC5A Gene

Publications for UNC5A Gene

  1. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PMID: 12655055) Thiebault K … Mehlen P (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. (PMID: 20372800) Miyamoto Y … Arakawa H (International journal of oncology 2010) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for UNC5A Gene

Sources for UNC5A Gene

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