This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018] See more...

Aliases for UNC45A Gene

Aliases for UNC45A Gene

  • Unc-45 Myosin Chaperone A 2 3 5
  • Smooth Muscle Cell Associated Protein-1 2 3
  • Protein Unc-45 Homolog A 3 4
  • GCUNC-45 3 4
  • SMAP-1 3 4
  • SMAP1 3 4
  • Smooth Muscle Cell-Associated Protein 1 4
  • Unc-45 Homolog A (C. Elegans) 2
  • General Cell UNC45 3
  • Unc-45 Homolog A 3
  • IRO039700 3
  • GC-UNC45 3
  • GCUNC45 3
  • UNC-45A 3
  • Unc-45A 4

External Ids for UNC45A Gene

Previous GeneCards Identifiers for UNC45A Gene

  • GC15P089275
  • GC15P091473
  • GC15P067584

Summaries for UNC45A Gene

Entrez Gene Summary for UNC45A Gene

  • This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018]

GeneCards Summary for UNC45A Gene

UNC45A (Unc-45 Myosin Chaperone A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and Hsp90 protein binding. An important paralog of this gene is UNC45B.

UniProtKB/Swiss-Prot Summary for UNC45A Gene

  • Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

Gene Wiki entry for UNC45A Gene

Additional gene information for UNC45A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UNC45A Gene

Genomics for UNC45A Gene

GeneHancer (GH) Regulatory Elements for UNC45A Gene

Promoters and enhancers for UNC45A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNC45A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UNC45A

Top Transcription factor binding sites by QIAGEN in the UNC45A gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E47
  • Hand1

Genomic Locations for UNC45A Gene

Genomic Locations for UNC45A Gene
chr15:90,930,008-90,954,093
(GRCh38/hg38)
Size:
24,086 bases
Orientation:
Plus strand
chr15:91,473,410-91,497,323
(GRCh37/hg19)
Size:
23,914 bases
Orientation:
Plus strand

Genomic View for UNC45A Gene

Genes around UNC45A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC45A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC45A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC45A Gene

Proteins for UNC45A Gene

  • Protein details for UNC45A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3U1-UN45A_HUMAN
    Recommended name:
    Protein unc-45 homolog A
    Protein Accession:
    Q9H3U1
    Secondary Accessions:
    • A8K6F7
    • Q7L3Y6
    • Q9H3U8
    • Q9NSE8
    • Q9NSE9

    Protein attributes for UNC45A Gene

    Size:
    944 amino acids
    Molecular mass:
    103077 Da
    Quaternary structure:
    • Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.

    Three dimensional structures from OCA and Proteopedia for UNC45A Gene

    Alternative splice isoforms for UNC45A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UNC45A Gene

Post-translational modifications for UNC45A Gene

  • Ubiquitination at Lys142, Lys190, Lys329, Lys411, and Lys707
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UNC45A Gene

Domains & Families for UNC45A Gene

Gene Families for UNC45A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UNC45A Gene

Suggested Antigen Peptide Sequences for UNC45A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77677 (A8K6F7_HUMAN)
  • Smooth muscle cell-associated protein 1 (UN45A_HUMAN)
genes like me logo Genes that share domains with UNC45A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UNC45A Gene

Function for UNC45A Gene

Molecular function for UNC45A Gene

UniProtKB/Swiss-Prot Function:
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).

Phenotypes From GWAS Catalog for UNC45A Gene

Gene Ontology (GO) - Molecular Function for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0045296 cadherin binding HDA 25468996
GO:0051879 Hsp90 protein binding IBA 21873635
genes like me logo Genes that share ontologies with UNC45A: view
genes like me logo Genes that share phenotypes with UNC45A: view

Animal Models for UNC45A Gene

MGI Knock Outs for UNC45A:
  • Unc45a Unc45a<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UNC45A Gene

Localization for UNC45A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC45A Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region. Little protein in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC45A gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with UNC45A: view

Pathways & Interactions for UNC45A Gene

PathCards logo

SuperPathways for UNC45A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UNC45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA --
GO:0061077 chaperone-mediated protein folding IBA 21873635
genes like me logo Genes that share ontologies with UNC45A: view

No data available for Pathways by source and SIGNOR curated interactions for UNC45A Gene

Drugs & Compounds for UNC45A Gene

No Compound Related Data Available

Transcripts for UNC45A Gene

mRNA/cDNA for UNC45A Gene

6 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC45A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for UNC45A Gene

GeneLoc Exon Structure for
UNC45A

Expression for UNC45A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UNC45A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UNC45A Gene

This gene is overexpressed in Bone (42.4) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UNC45A Gene



Protein tissue co-expression partners for UNC45A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UNC45A

SOURCE GeneReport for Unigene cluster for UNC45A Gene:

Hs.389461

mRNA Expression by UniProt/SwissProt for UNC45A Gene:

Q9H3U1-UN45A_HUMAN
Tissue specificity: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.

Evidence on tissue expression from TISSUES for UNC45A Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Heart(4.2)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with UNC45A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC45A Gene

Orthologs for UNC45A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UNC45A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC45A 31 30
  • 95.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UNC45A 31 30
  • 91.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UNC45A 31 30
  • 90.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Unc45a 30
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Unc45a 17 31 30
  • 88.84 (n)
oppossum
(Monodelphis domestica)
Mammalia UNC45A 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC45A 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC45A 31 30
  • 74.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC45A 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia unc45a 30
  • 67.85 (n)
zebrafish
(Danio rerio)
Actinopterygii unc45a 31
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-45 31
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-45 31
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 31
  • 16 (a)
ManyToMany
TOM71 31
  • 13 (a)
ManyToMany
Species where no ortholog for UNC45A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC45A Gene

ENSEMBL:
Gene Tree for UNC45A (if available)
TreeFam:
Gene Tree for UNC45A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UNC45A: view image

Paralogs for UNC45A Gene

(1) SIMAP similar genes for UNC45A Gene using alignment to 1 proteins:

  • UN45A_HUMAN
genes like me logo Genes that share paralogs with UNC45A: view

Variants for UNC45A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UNC45A Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
721695 Benign: not provided 90,945,029(+) G/A MISSENSE_VARIANT
774501 Likely Benign: not provided 90,948,653(+) G/T SPLICE_ACCEPTOR_VARIANT
rs8041035 - p.Thr796Met

Additional dbSNP identifiers (rs#s) for UNC45A Gene

Structural Variations from Database of Genomic Variants (DGV) for UNC45A Gene

Variant ID Type Subtype PubMed ID
nsv515661 CNV loss 19592680
nsv833089 CNV loss 17160897
nsv833090 CNV loss 17160897

Variation tolerance for UNC45A Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC45A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC45A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC45A Gene

Disorders for UNC45A Gene

Additional Disease Information for UNC45A

No disorders were found for UNC45A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC45A Gene

Publications for UNC45A Gene

  1. UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation. (PMID: 25444911) Jilani Y … Chadli A (Cancer letters 2015) 2 3 54
  2. UCS proteins: chaperones for myosin and co-chaperones for Hsp90. (PMID: 25487020) Ni W … Odunuga OO (Sub-cellular biochemistry 2015) 2 3 54
  3. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. (PMID: 17872978) Bazzaro M … Roden RB (The American journal of pathology 2007) 3 23 54
  4. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. (PMID: 16478993) Chadli A … Toft D (Molecular and cellular biology 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for UNC45A Gene