This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012] See more...

Aliases for UNC13A Gene

Aliases for UNC13A Gene

  • Unc-13 Homolog A 2 3 5
  • Munc13-1 2 3 4
  • Protein Unc-13 Homolog A 3 4
  • KIAA1032 2 4
  • Unc-13 Homolog A (C. Elegans) 2
  • UNC13A 5

External Ids for UNC13A Gene

Previous GeneCards Identifiers for UNC13A Gene

  • GC19M017575
  • GC19M017712
  • GC19M017276

Summaries for UNC13A Gene

Entrez Gene Summary for UNC13A Gene

  • This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012]

GeneCards Summary for UNC13A Gene

UNC13A (Unc-13 Homolog A) is a Protein Coding gene. Diseases associated with UNC13A include Amyotrophic Lateral Sclerosis 1 and Intermittent Squint. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and diacylglycerol binding. An important paralog of this gene is UNC13B.

UniProtKB/Swiss-Prot Summary for UNC13A Gene

  • Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UNC13A Gene

Genomics for UNC13A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UNC13A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J017685 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 600.7 +0.9 883 3.4 HNRNPL ATF7 TEAD4 REST TFE3 ZNF512 JUND POLR2A RXRB PATZ1 UNC13A piR-48325-083 COLGALT1
GH19J017845 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.3 -160.4 -160412 6.4 SP1 HNRNPL GATAD2A POLR2A BACH1 LARP7 STAT3 ZNF143 RELA RBFOX2 JAK3 lnc-JAK3-1 FCHO1 B3GNT3 INSL3 UNC13A RPL18A MAST3 NIBAN3 IL12RB1
GH19J017718 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.6 -32.2 -32186 3.9 SP1 GATAD2A HNRNPL PRDM10 ZNF629 POLR2A ZNF692 BACH1 JUND ZNF143 MAP1S HSALNG0124549 FCHO1 UNC13A B3GNT3 ENSG00000268112
GH19J017716 Promoter/Enhancer 1.2 Ensembl ENCODE 12.7 -29.1 -29077 1.1 ZNF512 LEF1 IKZF1 JUND ETV6 GABPA MTA2 MTA1 REST SP1 MAP1S UNC13A B3GNT3 piR-43105-332
GH19J018657 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.5 -971.1 -971090 4.6 RFX1 IKZF1 BACH1 JUND ZNF300 PRDM1 ZNF776 ZIC2 PKNOX1 PATZ1 lnc-CRTC1-1 MAU2 IQCN ENSG00000268030 UPF1 SUGP2 CRTC1 TSSK6 ENSG00000268938 UNC13A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNC13A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UNC13A

Top Transcription factor binding sites by QIAGEN in the UNC13A gene promoter:
  • aMEF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NRSF form 1
  • NRSF form 2
  • Sp1

Genomic Locations for UNC13A Gene

Genomic Locations for UNC13A Gene
chr19:17,601,328-17,688,365
(GRCh38/hg38)
Size:
87,038 bases
Orientation:
Minus strand
chr19:17,712,137-17,799,401
(GRCh37/hg19)
Size:
87,265 bases
Orientation:
Minus strand

Genomic View for UNC13A Gene

Genes around UNC13A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC13A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC13A Gene

Proteins for UNC13A Gene

  • Protein details for UNC13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW8-UN13A_HUMAN
    Recommended name:
    Protein unc-13 homolog A
    Protein Accession:
    Q9UPW8
    Secondary Accessions:
    • E5RHY9

    Protein attributes for UNC13A Gene

    Size:
    1703 amino acids
    Molecular mass:
    193014 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with the N-termini of STX1A and/or STX1B1 and DOC2A. Interacts with BSN. Interacts with RIMS1 which recruits UNC13A to the active zone. Forms homodimers via its first C2 domain. Also interacts via this domain with the zinc finger domain of RIMS2. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Also part of a complex consisting of UNC13A, RIMS2 and RAB3A (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity).

neXtProt entry for UNC13A Gene

Post-translational modifications for UNC13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UNC13A Gene

No data available for DME Specific Peptides for UNC13A Gene

Domains & Families for UNC13A Gene

Gene Families for UNC13A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UNC13A Gene

InterPro:
Blocks:
  • C2 domain
  • Protein of unknown function DUF1041
ProtoNet:

Suggested Antigen Peptide Sequences for UNC13A Gene

GenScript: Design optimal peptide antigens:
  • Munc13-1 (UN13A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UPW8

UniProtKB/Swiss-Prot:

UN13A_HUMAN :
  • The C2 domains are not involved in calcium-dependent phospholipid binding.
  • Belongs to the unc-13 family.
Domain:
  • The C2 domains are not involved in calcium-dependent phospholipid binding.
  • The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity.
Family:
  • Belongs to the unc-13 family.
genes like me logo Genes that share domains with UNC13A: view

Function for UNC13A Gene

Molecular function for UNC13A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Phenotypes From GWAS Catalog for UNC13A Gene

Gene Ontology (GO) - Molecular Function for UNC13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005516 calmodulin binding ISS --
GO:0005543 phospholipid binding IEA --
GO:0017075 syntaxin-1 binding ISS --
GO:0019992 diacylglycerol binding IEA --
genes like me logo Genes that share ontologies with UNC13A: view
genes like me logo Genes that share phenotypes with UNC13A: view

Human Phenotype Ontology for UNC13A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for UNC13A Gene

MGI Knock Outs for UNC13A:

Animal Model Products

  • Taconic Biosciences Mouse Models for UNC13A

CRISPR Products

miRNA for UNC13A Gene

miRTarBase miRNAs that target UNC13A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNC13A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for UNC13A Gene

Localization for UNC13A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC13A Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane. Peripheral membrane protein. Cell junction, synapse, presynaptic active zone. Note=Translocated to the plasma membrane in response to phorbol ester binding. {ECO:0000250 UniProtKB:Q62768}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC13A gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3
cytoskeleton 2
endosome 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for UNC13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with UNC13A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UNC13A Gene

Pathways & Interactions for UNC13A Gene

PathCards logo

SuperPathways for UNC13A Gene

SuperPathway Contained pathways
1 Synaptic vesicle cycle
genes like me logo Genes that share pathways with UNC13A: view

Pathways by source for UNC13A Gene

1 BioSystems pathway for UNC13A Gene
1 KEGG pathway for UNC13A Gene

Gene Ontology (GO) - Biological Process for UNC13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001956 positive regulation of neurotransmitter secretion IEA --
GO:0006887 exocytosis IEA --
GO:0007268 chemical synaptic transmission IEA --
GO:0007269 neurotransmitter secretion ISS --
GO:0007528 neuromuscular junction development IEA,IBA 21873635
genes like me logo Genes that share ontologies with UNC13A: view

No data available for SIGNOR curated interactions for UNC13A Gene

Drugs & Compounds for UNC13A Gene

(1) Drugs for UNC13A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556

(5) Additional Compounds for UNC13A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with UNC13A: view

Transcripts for UNC13A Gene

mRNA/cDNA for UNC13A Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UNC13A

Alternative Splicing Database (ASD) splice patterns (SP) for UNC13A Gene

No ASD Table

Relevant External Links for UNC13A Gene

GeneLoc Exon Structure for
UNC13A

Expression for UNC13A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UNC13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UNC13A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.4), Brain - Cortex (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.3), Pituitary (x4.9), Brain - Cerebellar Hemisphere (x4.9), and Brain - Cerebellum (x4.6).

Protein differential expression in normal tissues from HIPED for UNC13A Gene

This gene is overexpressed in Frontal cortex (57.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UNC13A Gene



Protein tissue co-expression partners for UNC13A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UNC13A

SOURCE GeneReport for Unigene cluster for UNC13A Gene:

Hs.164502

mRNA Expression by UniProt/SwissProt for UNC13A Gene:

Q9UPW8-UN13A_HUMAN
Tissue specificity: Expressed in pancreatic islet cells (PubMed:12871971). Expressed in melanocytes (PubMed:23999003).

Evidence on tissue expression from TISSUES for UNC13A Gene

  • Nervous system(4.9)
  • Adrenal gland(2.4)
  • Pancreas(2.2)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC13A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with UNC13A: view

Orthologs for UNC13A Gene

This gene was present in the common ancestor of animals.

Orthologs for UNC13A Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 94 (a)
OneToMany
UNC13A 30
  • 90.21 (n)
Chimpanzee
(Pan troglodytes)
Mammalia UNC13A 31
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UNC13A 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia UNC13A 30 31
  • 91.43 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia UNC13A 31
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Unc13a 30 17 31
  • 88.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Unc13a 30
  • 87.68 (n)
Chicken
(Gallus gallus)
Aves UNC13A 31
  • 89 (a)
OneToOne
LOC430487 30
  • 85.32 (n)
Lizard
(Anolis carolinensis)
Reptilia UNC13A 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492289 30
  • 76.35 (n)
Str.17572 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29718 30
Zebrafish
(Danio rerio)
Actinopterygii CABZ01117756.1 31
  • 97 (a)
OneToMany
UNC13A (3 of 5) 31
  • 92 (a)
OneToMany
UNC13A (2 of 5) 31
  • 91 (a)
OneToMany
UNC13A (1 of 5) 31
  • 80 (a)
OneToMany
UNC13A (5 of 5) 31
  • 80 (a)
OneToMany
si:dkey-110c1.7 30
  • 76.47 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta unc-13 30 31
  • 62.36 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea unc-13 30 31
  • 56.07 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 61 (a)
OneToMany
Species where no ortholog for UNC13A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UNC13A Gene

ENSEMBL:
Gene Tree for UNC13A (if available)
TreeFam:
Gene Tree for UNC13A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UNC13A: view image

Paralogs for UNC13A Gene

Paralogs for UNC13A Gene

(3) SIMAP similar genes for UNC13A Gene using alignment to 6 proteins:

  • UN13A_HUMAN
  • F8VZH8_HUMAN
  • F8W059_HUMAN
  • F8W0P6_HUMAN
  • H7BXE5_HUMAN
  • J3KQI7_HUMAN
genes like me logo Genes that share paralogs with UNC13A: view

Variants for UNC13A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UNC13A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
691465 Likely Pathogenic: Pyloric stenosis; Esophageal atresia 17,621,849(-) C/T MISSENSE_VARIANT
708730 Benign: not provided 17,630,262(-) T/C SYNONYMOUS_VARIANT
710759 Benign: not provided 17,627,908(-) T/C SYNONYMOUS_VARIANT
710760 Benign: not provided 17,642,938(-) G/A SYNONYMOUS_VARIANT
711168 Benign: not provided 17,655,978(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for UNC13A Gene

Structural Variations from Database of Genomic Variants (DGV) for UNC13A Gene

Variant ID Type Subtype PubMed ID
dgv50n68 CNV loss 17160897
esv2718280 CNV deletion 23290073
esv3305310 CNV mobile element insertion 20981092
esv3397826 CNV insertion 20981092
esv3440250 CNV insertion 20981092
esv3556124 CNV deletion 23714750
esv999988 CNV deletion 20482838
nsv1072868 CNV deletion 25765185
nsv1109171 CNV deletion 24896259
nsv1113981 CNV deletion 24896259
nsv1123230 CNV deletion 24896259
nsv1124778 CNV duplication 24896259
nsv138145 CNV deletion 16902084
nsv138197 CNV deletion 16902084
nsv474157 CNV novel sequence insertion 20440878

Variation tolerance for UNC13A Gene

Residual Variation Intolerance Score: 1.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC13A Gene

Human Gene Mutation Database (HGMD)
UNC13A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UNC13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC13A Gene

Disorders for UNC13A Gene

MalaCards: The human disease database

(9) MalaCards diseases for UNC13A Gene - From: Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UNC13A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UNC13A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UNC13A Gene

Publications for UNC13A Gene

  1. Regulation of insulin exocytosis by Munc13-1. (PMID: 12871971) Sheu L … Gaisano HY (The Journal of biological chemistry 2003) 3 4 23
  2. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo JC … Yoon TJ (Journal of dermatological science 2013) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Analysis of the UNC13A gene as a risk factor for sporadic amyotrophic lateral sclerosis. (PMID: 20385924) Daoud H … Rouleau GA (Archives of neurology 2010) 3 41
  5. Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. (PMID: 19996097) Tada H … Okano H (The Journal of biological chemistry 2010) 3 23

Products for UNC13A Gene

Sources for UNC13A Gene