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UNC119B (Unc-119 Lipid Binding Chaperone B) is a Protein Coding gene. Diseases associated with UNC119B include Joubert Syndrome 22 and Retinitis Pigmentosa 2. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is UNC119.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 22085962 |
GO:0008289 | lipid binding | IBA,IDA | 22085962 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005929 | cilium | IBA,TAS | -- |
GO:0035869 | ciliary transition zone | IDA | 22085962 |
GO:0042995 | cell projection | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cargo trafficking to the periciliary membrane | ||
2 | Organelle biogenesis and maintenance |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007399 | nervous system development | IBA | 21873635 |
GO:0015031 | protein transport | IEA | -- |
GO:0030030 | cell projection organization | IEA | -- |
GO:0042953 | lipoprotein transport | IDA | 22085962 |
GO:0060271 | cilium assembly | IBA,IMP | 22085962 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||
SP2: | |||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UNC119B 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | UNC119B 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UNC119B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | UNC119B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Unc119b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Unc119b 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | UNC119B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | UNC119B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | UNC119B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | unc119b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | unc119.1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | unc-119 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | unc-119 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11065 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2658765 | CNV | deletion | 23128226 |
esv3630930 | CNV | loss | 21293372 |
nsv1143712 | CNV | deletion | 24896259 |
nsv521928 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
joubert syndrome 22 |
|
|
retinitis pigmentosa 2 |
|
|
optic disk drusen |
|
|
joubert syndrome 1 |
|
|
nephronophthisis |
|
|