Aliases for UMPS Gene
External Ids for UMPS Gene
Previous GeneCards Identifiers for UMPS Gene
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for UMPS Gene
UMPS (Uridine Monophosphate Synthetase) is a Protein Coding gene. Diseases associated with UMPS include Orotic Aciduria and Pyrimidine Metabolic Disorder. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity and orotidine-5'-phosphate decarboxylase activity.