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Aliases for ULK3 Gene

Aliases for ULK3 Gene

  • Unc-51 Like Kinase 3 2 3 5
  • Unc-51-Like Kinase 3 (C. Elegans) 2
  • Unc-51-Like Kinase 3 4
  • EC 2.7.11.1 4

External Ids for ULK3 Gene

Previous GeneCards Identifiers for ULK3 Gene

  • GC15M072916
  • GC15M075128
  • GC15M051925

Summaries for ULK3 Gene

GeneCards Summary for ULK3 Gene

ULK3 (Unc-51 Like Kinase 3) is a Protein Coding gene. Among its related pathways are Signaling by Hedgehog and mTOR signalling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK1.

UniProtKB/Swiss-Prot for ULK3 Gene

  • Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

Additional gene information for ULK3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK3 Gene

Genomics for ULK3 Gene

GeneHancer (GH) Regulatory Elements for ULK3 Gene

Promoters and enhancers for ULK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 565.6 -0.5 -513 5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ULK3 SIN3A RPP25 EDC3 ENSG00000260274 ENSG00000203392 MPI SCAMP2 MAN2C1 SNX33
GH15I074775 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26 +55.2 55173 26 DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 CSK MIR4513 EDC3 SIN3A LOC441728 ULK3 ENSG00000260274 C15orf39 DNM1P35 ENSG00000203392
GH15I074770 Enhancer 1.4 Ensembl ENCODE dbSUPER 24.1 +72.0 72005 0.9 HDGF PKNOX1 ARNT ARID4B SIN3A GLI4 ZNF2 ZBTB7B IRF4 ZNF48 ULK3 CPLX3 SCAMP5 PPCDC CSK CYP1A2
GH15I074953 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.1 -113.3 -113310 5.4 PKNOX1 CLOCK SMAD1 ARNT SIN3A DMAP1 YY1 ZNF766 E2F8 ZNF207 RPP25 SCAMP5 MAN2C1 ENSG00000260274 FBXO22 ENSG00000203392 SIN3A FAM219B MPI ULK3
GH15I074613 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +227.0 227032 4.9 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 CLK3 ENSG00000260919 LOC102723750 SIN3A EDC3 MAN2C1 ENSG00000260274 PML UBL7-AS1 FAM219B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ULK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ULK3 gene promoter:

Genomic Locations for ULK3 Gene

Genomic Locations for ULK3 Gene
chr15:74,836,116-74,843,346
(GRCh38/hg38)
Size:
7,231 bases
Orientation:
Minus strand
chr15:75,128,457-75,135,687
(GRCh37/hg19)

Genomic View for ULK3 Gene

Genes around ULK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK3 Gene

Proteins for ULK3 Gene

  • Protein details for ULK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PHR2-ULK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK3
    Protein Accession:
    Q6PHR2
    Secondary Accessions:
    • B2RXK3
    • B4DFT0
    • B4DRQ7
    • D3DW68
    • Q9NPN5
    • Q9UFS4

    Protein attributes for ULK3 Gene

    Size:
    472 amino acids
    Molecular mass:
    53444 Da
    Quaternary structure:
    • Interacts (via protein kinase domain) with SUFU.
    SequenceCaution:
    • Sequence=CAB55955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ULK3 Gene

    Alternative splice isoforms for ULK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ULK3 Gene

Post-translational modifications for ULK3 Gene

  • Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
  • Ubiquitination at posLast=345345

No data available for DME Specific Peptides for ULK3 Gene

Domains & Families for ULK3 Gene

Gene Families for ULK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ULK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PHR2

UniProtKB/Swiss-Prot:

ULK3_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK3: view

Function for ULK3 Gene

Molecular function for ULK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
UniProtKB/Swiss-Prot Induction:
Up-regulated during senescence.

Enzyme Numbers (IUBMB) for ULK3 Gene

Phenotypes From GWAS Catalog for ULK3 Gene

Gene Ontology (GO) - Molecular Function for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 20643644
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ULK3: view
genes like me logo Genes that share phenotypes with ULK3: view

Animal Model Products

miRNA for ULK3 Gene

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULK3 Gene

Localization for ULK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK3 Gene

Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULK3 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site TAS 19279323
GO:0005737 cytoplasm IDA,IEA 19878745
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with ULK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ULK3 Gene

Pathways & Interactions for ULK3 Gene

genes like me logo Genes that share pathways with ULK3: view

Pathways by source for ULK3 Gene

1 GeneTex pathway for ULK3 Gene
1 BioSystems pathway for ULK3 Gene

Gene Ontology (GO) - Biological Process for ULK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006914 autophagy TAS 19279323
GO:0016310 phosphorylation IEA --
GO:0045879 negative regulation of smoothened signaling pathway IDA 20643644
GO:0045880 positive regulation of smoothened signaling pathway IDA 19878745
genes like me logo Genes that share ontologies with ULK3: view

No data available for SIGNOR curated interactions for ULK3 Gene

Drugs & Compounds for ULK3 Gene

(2) Drugs for ULK3 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for ULK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ULK3: view

Transcripts for ULK3 Gene

Unigene Clusters for ULK3 Gene

Unc-51-like kinase 3 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULK3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12: -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ULK3 Gene

GeneLoc Exon Structure for
ULK3
ECgene alternative splicing isoforms for
ULK3

Expression for ULK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ULK3 Gene

Protein differential expression in normal tissues from HIPED for ULK3 Gene

This gene is overexpressed in Cerebrospinal fluid (37.8) and Lung (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ULK3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ULK3 Gene:

ULK3

SOURCE GeneReport for Unigene cluster for ULK3 Gene:

Hs.513034

mRNA Expression by UniProt/SwissProt for ULK3 Gene:

Q6PHR2-ULK3_HUMAN
Tissue specificity: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.

Evidence on tissue expression from TISSUES for ULK3 Gene

  • Nervous system(4.8)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ULK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ULK3 Gene

Orthologs for ULK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK3 33 34
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia ULK3 33 34
  • 91.24 (n)
dog
(Canis familiaris)
Mammalia ULK3 33 34
  • 90.58 (n)
rat
(Rattus norvegicus)
Mammalia Ulk3 33
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Ulk3 33 16 34
  • 88.06 (n)
oppossum
(Monodelphis domestica)
Mammalia ULK3 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves ULK3 33 34
  • 77.14 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk3 33
  • 68.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22122 33
zebrafish
(Danio rerio)
Actinopterygii ulk3 33 34
  • 68.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000098 33
  • 55.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8866 33 34
  • 51.93 (n)
worm
(Caenorhabditis elegans)
Secernentea T07F12.4 34
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14602 33
Species where no ortholog for ULK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK3 Gene

ENSEMBL:
Gene Tree for ULK3 (if available)
TreeFam:
Gene Tree for ULK3 (if available)

Paralogs for ULK3 Gene

Paralogs for ULK3 Gene

genes like me logo Genes that share paralogs with ULK3: view

Variants for ULK3 Gene

Sequence variations from dbSNP and Humsavar for ULK3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000002101 -- 74,840,877(-) C/A intron_variant
rs1000445894 -- 74,839,816(-) T/C intron_variant
rs1001813679 -- 74,844,831(-) G/C upstream_transcript_variant
rs1002150646 -- 74,843,489(-) C/T upstream_transcript_variant
rs1002531826 -- 74,843,230(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ULK3 Gene

Variant ID Type Subtype PubMed ID
nsv833055 CNV loss 17160897
nsv569992 CNV loss 21841781
nsv1121512 CNV deletion 24896259
esv2749887 CNV deletion 23290073
esv1231258 CNV deletion 17803354

Variation tolerance for ULK3 Gene

Gene Damage Index Score: 10.26; 90.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ULK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK3 Gene

Disorders for ULK3 Gene

Additional Disease Information for ULK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ULK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK3 Gene

Publications for ULK3 Gene

  1. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. (PMID: 19878745) Maloverjan A … Osterlund T (Experimental cell research 2010) 3 4 58
  2. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PMID: 20959405) Kim DH … Lipton JH (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 44 58
  3. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. (PMID: 20643644) Maloverjan A … Kogerman P (The Journal of biological chemistry 2010) 3 4 58
  4. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PMID: 20479155) Takeuchi F … Kato N (Circulation 2010) 3 44 58
  5. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PMID: 19141860) Kim DH … Lipton JH (Blood 2009) 3 44 58

Products for ULK3 Gene

Sources for ULK3 Gene

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