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Aliases for ULK1 Gene

Aliases for ULK1 Gene

  • Unc-51 Like Autophagy Activating Kinase 1 2 3 5
  • Autophagy-Related Protein 1 Homolog 3 4
  • HATG1 3 4
  • ATG1 3 4
  • ATG1 Autophagy Related 1 Homolog (S. Cerevisiae) 2
  • Serine/Threonine-Protein Kinase ULK1 3
  • Unc-51 (C. Elegans)-Like Kinase 1 2
  • Unc-51-Like Kinase 1 (C. Elegans) 2
  • ATG1 Autophagy Related 1 Homolog 3
  • Unc-51-Like Kinase 1 4
  • EC 2.7.11.1 4
  • KIAA0722 4
  • Unc51.1 3
  • ATG1A 3
  • UNC51 3

External Ids for ULK1 Gene

Previous GeneCards Identifiers for ULK1 Gene

  • GC12U990117
  • GC12M131722
  • GC12P132259
  • GC12P130873
  • GC12P131045
  • GC12P130945
  • GC12P132379
  • GC12P129276

Summaries for ULK1 Gene

GeneCards Summary for ULK1 Gene

ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK2.

UniProtKB/Swiss-Prot for ULK1 Gene

  • Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Gene Wiki entry for ULK1 Gene

Additional gene information for ULK1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULK1 Gene

Genomics for ULK1 Gene

GeneHancer (GH) Regulatory Elements for ULK1 Gene

Promoters and enhancers for ULK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J131893 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.5 1481 4.3 HDGF SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ULK1 ENSG00000279283 EP400 SFSWAP DDX51 NOC4L GOLGA3
GH12J131859 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -32.5 -32530 4.7 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF263 NFYC MEF2D SSRP1 ANKLE2 GOLGA3 EP400 SFSWAP NOC4L RPS11P5 ENSG00000255933 MMP17 RNU6-1017P DDX51
GH12J132162 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.7 +268.2 268150 1.2 KLF1 ZBTB6 KLF17 MAX ZIC2 GLIS2 ZNF23 ZNF366 PATZ1 SCRT2 LOC105370090 DDX51 ZNF84 ZNF605 ULK1 FBRSL1 SFSWAP GC12P132155
GH12J131871 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -22.1 -22069 2.8 PKNOX1 NFIB NEUROD1 SIN3A ZBTB7B ZNF280A FOS RCOR1 SMARCA5 SMARCC1 MMP17 PUS1 ENSG00000255992 EP400 RNU6-1017P SFSWAP ULK1 ENSG00000256955
GH12J131718 Enhancer 0.2 FANTOM5 4.7 -175.7 -175742 0.1 ULK1 SFSWAP ENSG00000255933
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ULK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ULK1 gene promoter:
  • SREBP-1b
  • SREBP-1a
  • SREBP-1c
  • Zic1
  • Sp1
  • CP1A
  • CBF(2)
  • CBF-A
  • CBF-B
  • NF-Y

Genomic Locations for ULK1 Gene

Genomic Locations for ULK1 Gene
chr12:131,894,651-131,923,167
(GRCh38/hg38)
Size:
28,517 bases
Orientation:
Plus strand
chr12:132,379,196-132,407,712
(GRCh37/hg19)
Size:
28,517 bases
Orientation:
Plus strand

Genomic View for ULK1 Gene

Genes around ULK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULK1 Gene

Proteins for ULK1 Gene

  • Protein details for ULK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75385-ULK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ULK1
    Protein Accession:
    O75385
    Secondary Accessions:
    • Q9UQ28

    Protein attributes for ULK1 Gene

    Size:
    1050 amino acids
    Molecular mass:
    112631 Da
    Quaternary structure:
    • Interacts with GABARAP and GABARAPL2 (PubMed:11146101). Interacts (via C-terminus) with ATG13 (PubMed:18936157). Part of a complex consisting of ATG13, ATG101, ULK1 and RB1CC1 (PubMed:19287211). Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation (PubMed:19211835, PubMed:21795849). Interacts with FEZ1; SCOC interferes with FEZ1-binding (PubMed:22354037). Interacts with TBC1D14 (PubMed:22613832). Interacts (phosphorylated form) with TRIM5 (PubMed:25127057). When phosphorylated at Ser-317, interacts with MEFV and BECN1 simultaneously (PubMed:26347139). Interacts with TRIM21 and IRF3, in the presence of TRIM21 (PubMed:26347139). Interacts with SESN2 (PubMed:25040165). Interacts with SQSTM1 (PubMed:25040165). Interacts with C9orf72 (PubMed:27334615).
    SequenceCaution:
    • Sequence=BAA34442.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ULK1 Gene

neXtProt entry for ULK1 Gene

Post-translational modifications for ULK1 Gene

  • Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated and activated by AMPK, leading to activate autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ULK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ULK1 Gene

Domains & Families for ULK1 Gene

Gene Families for ULK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ULK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75385

UniProtKB/Swiss-Prot:

ULK1_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
genes like me logo Genes that share domains with ULK1: view

Function for ULK1 Gene

Molecular function for ULK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
GENATLAS Biochemistry:
C elegans UNC51-like kinase 1,112.6kDa,ubiquitously expressed

Enzyme Numbers (IUBMB) for ULK1 Gene

Phenotypes From GWAS Catalog for ULK1 Gene

Gene Ontology (GO) - Molecular Function for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 11146101
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity TAS --
genes like me logo Genes that share ontologies with ULK1: view
genes like me logo Genes that share phenotypes with ULK1: view

Animal Models for ULK1 Gene

MGI Knock Outs for ULK1:
  • Ulk1 Ulk1<tm1.1Thsn>

Animal Model Products

  • Taconic Biosciences Mouse Models for ULK1

miRNA for ULK1 Gene

miRTarBase miRNAs that target ULK1

Clone Products

  • Addgene plasmids for ULK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ULK1 Gene

Localization for ULK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULK1 Gene

Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULK1 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
cytosol 5
endosome 5
lysosome 3
nucleus 2
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IEA,IBA --
GO:0005737 cytoplasm NAS 9693035
GO:0005741 mitochondrial outer membrane TAS --
GO:0005776 autophagosome IDA 17595159
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with ULK1: view

Pathways & Interactions for ULK1 Gene

genes like me logo Genes that share pathways with ULK1: view

SIGNOR curated interactions for ULK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ULK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0006468 protein phosphorylation NAS 9693035
GO:0006914 autophagy ISS --
GO:0007165 signal transduction IEA --
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with ULK1: view

Drugs & Compounds for ULK1 Gene

(3) Drugs for ULK1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
SBI-0206965 Pharma ULK1 inhibitor 0

(1) Additional Compounds for ULK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with ULK1: view

Transcripts for ULK1 Gene

mRNA/cDNA for ULK1 Gene

Unigene Clusters for ULK1 Gene

Unc-51-like kinase 1 (C. elegans):
Representative Sequences:

Clone Products

  • Addgene plasmids for ULK1

Alternative Splicing Database (ASD) splice patterns (SP) for ULK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 21a · 21b ^ 22a · 22b · 22c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for ULK1 Gene

GeneLoc Exon Structure for
ULK1
ECgene alternative splicing isoforms for
ULK1

Expression for ULK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ULK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ULK1 Gene

This gene is overexpressed in Frontal cortex (20.6), Fetal gut (13.8), Adipocyte (11.6), Blymphocyte (11.1), and Heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ULK1 Gene



Protein tissue co-expression partners for ULK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ULK1 Gene:

ULK1

SOURCE GeneReport for Unigene cluster for ULK1 Gene:

Hs.47061

mRNA Expression by UniProt/SwissProt for ULK1 Gene:

O75385-ULK1_HUMAN
Tissue specificity: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Evidence on tissue expression from TISSUES for ULK1 Gene

  • Nervous system(4.8)
  • Muscle(3)
  • Liver(2.1)
  • Heart(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with ULK1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ULK1 Gene

Orthologs for ULK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ULK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ULK1 33
  • 92.73 (n)
cow
(Bos Taurus)
Mammalia ULK1 34 33
  • 88.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ULK1 34 33
  • 85.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ulk1 16 34 33
  • 83.73 (n)
rat
(Rattus norvegicus)
Mammalia Ulk1 33
  • 83.6 (n)
oppossum
(Monodelphis domestica)
Mammalia ULK1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ULK1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ULK1 34 33
  • 73.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ULK1 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ulk1 33
  • 67.18 (n)
zebrafish
(Danio rerio)
Actinopterygii ulk1b 34 33
  • 65.96 (n)
OneToMany
ulk1a 34
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Atg1 34
  • 39 (a)
OneToMany
CG8866 35
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-51 34 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG1 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3319 34
  • 25 (a)
ManyToMany
Species where no ortholog for ULK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ULK1 Gene

ENSEMBL:
Gene Tree for ULK1 (if available)
TreeFam:
Gene Tree for ULK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ULK1: view image

Paralogs for ULK1 Gene

Variants for ULK1 Gene

Sequence variations from dbSNP and Humsavar for ULK1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs370624303 An ovarian mucinous carcinoma sample 131,910,720(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_041280 A lung adenocarcinoma sample p.Ser784Cys
rs1000184016 -- 131,900,677(+) C/G intron_variant
rs1000200073 -- 131,896,000(+) C/G/T intron_variant
rs1000292485 -- 131,918,381(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ULK1 Gene

Variant ID Type Subtype PubMed ID
esv2274339 CNV deletion 18987734
esv2746906 CNV deletion 23290073
esv2751042 CNV gain 17911159
esv3427251 CNV insertion 20981092
esv3631281 CNV gain 21293372
esv3631282 CNV gain 21293372
esv990859 CNV deletion 20482838
nsv1069723 CNV deletion 25765185
nsv1112629 CNV deletion 24896259
nsv455803 CNV gain 19166990
nsv455804 CNV loss 19166990
nsv560927 CNV gain 21841781
nsv560928 CNV gain 21841781
nsv560930 CNV loss 21841781
nsv560931 CNV loss 21841781
nsv826561 CNV gain 20364138
nsv832555 CNV loss 17160897
nsv9045 CNV gain+loss 18304495
nsv942 CNV insertion 18451855

Variation tolerance for ULK1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ULK1 Gene

Human Gene Mutation Database (HGMD)
ULK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULK1 Gene

Disorders for ULK1 Gene

Additional Disease Information for ULK1

No disorders were found for ULK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULK1 Gene

Publications for ULK1 Gene

  1. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. (PMID: 9693035) Kuroyanagi H … Shirasawa T (Genomics 1998) 2 3 4 22 58
  2. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PMID: 18936157) Chan EY … Tooze SA (Molecular and cellular biology 2009) 3 4 22 58
  3. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer CA … Dennis PB (Autophagy 2009) 3 4 22 58
  4. The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. (PMID: 27334615) Webster CP … De Vos KJ (The EMBO journal 2016) 3 4 58
  5. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. (PMID: 26347139) Kimura T … Deretic V (The Journal of cell biology 2015) 3 4 58

Products for ULK1 Gene

Sources for ULK1 Gene

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