Aliases for ULBP3 Gene
External Ids for ULBP3 Gene
Previous GeneCards Identifiers for ULBP3 Gene
The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]
GeneCards Summary for ULBP3 Gene
ULBP3 (UL16 Binding Protein 3) is a Protein Coding gene. Diseases associated with ULBP3 include Alopecia Areata and Alopecia Universalis Congenita. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1G.
UniProtKB/Swiss-Prot Summary for ULBP3 Gene
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.