The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an importan... See more...

Aliases for ULBP3 Gene

Aliases for ULBP3 Gene

  • UL16 Binding Protein 3 2 3 5
  • RAET1N 2 3 4
  • Retinoic Acid Early Transcript 1N 3 4
  • UL16-Binding Protein 3 3 4
  • NKG2D Ligand 3 3 4
  • ALCAN-Gamma 3 4
  • NKG2DL3 3 4
  • N2DL-3 3 4
  • ULBP3 5
  • N2DL3 4

External Ids for ULBP3 Gene

Previous GeneCards Identifiers for ULBP3 Gene

  • GC06M149946
  • GC06M150281
  • GC06M150416
  • GC06M150477
  • GC06M147951

Summaries for ULBP3 Gene

Entrez Gene Summary for ULBP3 Gene

  • The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

GeneCards Summary for ULBP3 Gene

ULBP3 (UL16 Binding Protein 3) is a Protein Coding gene. Diseases associated with ULBP3 include Alopecia Areata and Alopecia Universalis Congenita. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1G.

UniProtKB/Swiss-Prot Summary for ULBP3 Gene

  • Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene Wiki entry for ULBP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ULBP3 Gene

Genomics for ULBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ULBP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J150068 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 610.7 +0.0 27 1.8 BRCA1 CTCF PRDM10 ZNF629 RFX1 ZNF692 ZIC2 PATZ1 SP1 ZNF501 ULBP3 ARL4AP5 ENSG00000219553 piR-61810-013 RAET1L
GH06J150070 Promoter 0.4 Ensembl 600.7 -1.3 -1280 0.4 PRDM10 ULBP3 HSALNG0054296 PPP1R14C
GH06J150071 Enhancer 0.8 ENCODE 11.3 -3.2 -3180 1 HNRNPL CREB1 ZNF692 TARDBP JUND PKNOX1 PATZ1 ZNF600 SCRT2 NRF1 ULBP3 PPP1R14C IYD HSALNG0054296
GH06J150059 Enhancer 0.3 Ensembl 11.5 +8.9 8920 0.8 NR2F1 BHLHE40 ULBP3 ENSG00000219553 piR-61810-013 RAET1L
GH06J150076 Enhancer 0.5 Ensembl 7.2 -7.4 -7380 1 CTCF ZNF600 ZBTB20 ZNF16 TRIM28 RNF2 ZSCAN21 LATS1 NUP43 KATNA1 PPP1R14C ULBP3 HSALNG0054296
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ULBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ULBP3

Top Transcription factor binding sites by QIAGEN in the ULBP3 gene promoter:
  • aMEF-2
  • Evi-1
  • FOXD3
  • MEF-2A
  • RSRFC4
  • Sox9
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ULBP3 Gene

Genomic Locations for ULBP3 Gene
chr6:150,061,053-150,069,121
(GRCh38/hg38)
Size:
8,069 bases
Orientation:
Minus strand
chr6:150,384,286-150,390,231
(GRCh37/hg19)
Size:
5,946 bases
Orientation:
Minus strand

Genomic View for ULBP3 Gene

Genes around ULBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP3 Gene

Proteins for ULBP3 Gene

  • Protein details for ULBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM4-ULBP3_HUMAN
    Recommended name:
    UL16-binding protein 3
    Protein Accession:
    Q9BZM4
    Secondary Accessions:
    • Q5VY82
    • Q8IZX5
    • Q8TE75

    Protein attributes for ULBP3 Gene

    Size:
    244 amino acids
    Molecular mass:
    27949 Da
    Quaternary structure:
    • Interacts with KLRK1/NKG2D (PubMed:11491531, PubMed:11777960, PubMed:11754823). Does not bind to beta2-microglobulin (By similarity).
    • (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16 and UL142; this interaction causes ULBP3 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
    Miscellaneous:
    • UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.

    Three dimensional structures from OCA and Proteopedia for ULBP3 Gene

neXtProt entry for ULBP3 Gene

Post-translational modifications for ULBP3 Gene

  • Glycosylation at Asn37, Thr209, and Thr213
  • Modification sites at PhosphoSitePlus

Other Protein References for ULBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ULBP3 Gene

Domains & Families for ULBP3 Gene

Gene Families for ULBP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ULBP3 Gene

InterPro:
Blocks:
  • MHC class I signature
ProtoNet:

Suggested Antigen Peptide Sequences for ULBP3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51255, moderately similar to NKG2D ligand 3 (B4DN91_HUMAN)
  • Retinoic acid early transcript 1N (N2DL3_HUMAN)
  • cDNA, FLJ96287, Homo sapiens UL16 binding protein 3 (ULBP3), mRNA (Q5VY82_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZM4

UniProtKB/Swiss-Prot:

ULBP3_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with ULBP3: view

Function for ULBP3 Gene

Molecular function for ULBP3 Gene

UniProtKB/Swiss-Prot Function:
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Phenotypes From GWAS Catalog for ULBP3 Gene

Gene Ontology (GO) - Molecular Function for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11754823
GO:0046703 natural killer cell lectin-like receptor binding IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view
genes like me logo Genes that share phenotypes with ULBP3: view

Animal Model Products

CRISPR Products

miRNA for ULBP3 Gene

miRTarBase miRNAs that target ULBP3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ULBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULBP3 Gene

Localization for ULBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP3 Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULBP3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ULBP3: view

Pathways & Interactions for ULBP3 Gene

genes like me logo Genes that share pathways with ULBP3: view

Pathways by source for ULBP3 Gene

Gene Ontology (GO) - Biological Process for ULBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006955 immune response IBA 21873635
GO:0016032 viral process IEA --
GO:0030101 natural killer cell activation IDA 11239445
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
genes like me logo Genes that share ontologies with ULBP3: view

No data available for SIGNOR curated interactions for ULBP3 Gene

Drugs & Compounds for ULBP3 Gene

(1) Drugs for ULBP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with ULBP3: view

Transcripts for ULBP3 Gene

mRNA/cDNA for ULBP3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ULBP3

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for ULBP3 Gene

GeneLoc Exon Structure for
ULBP3

Expression for ULBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ULBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP3 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ULBP3 Gene

This gene is overexpressed in Serum (57.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ULBP3 Gene



Protein tissue co-expression partners for ULBP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ULBP3

SOURCE GeneReport for Unigene cluster for ULBP3 Gene:

Hs.326556

Evidence on tissue expression from TISSUES for ULBP3 Gene

  • Spleen(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ULBP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ULBP3 Gene

Orthologs for ULBP3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ULBP3 30 31
  • 98.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC101903261 30
  • 69.41 (n)
-- 31
  • 48 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 31 (a)
OneToMany
Species where no ortholog for ULBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ULBP3 Gene

ENSEMBL:
Gene Tree for ULBP3 (if available)
TreeFam:
Gene Tree for ULBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ULBP3: view image

Paralogs for ULBP3 Gene

(9) SIMAP similar genes for ULBP3 Gene using alignment to 1 proteins:

  • N2DL3_HUMAN
genes like me logo Genes that share paralogs with ULBP3: view

Variants for ULBP3 Gene

Additional dbSNP identifiers (rs#s) for ULBP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ULBP3 Gene

Variant ID Type Subtype PubMed ID
esv2664929 CNV deletion 23128226
esv2678333 CNV deletion 23128226
esv2732878 CNV deletion 23290073
esv3611222 CNV loss 21293372
esv3890963 CNV loss 25118596
esv7375 CNV loss 19470904
nsv1026236 CNV loss 25217958
nsv517022 CNV gain+loss 19592680

Variation tolerance for ULBP3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ULBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ULBP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ULBP3 Gene

Disorders for ULBP3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ULBP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alopecia areata
  • aa
alopecia universalis congenita
  • alunc
telogen effluvium
polyomavirus-associated nephropathy
  • polyomavirus associated nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search ULBP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ULBP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ULBP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ULBP3 Gene

Publications for ULBP3 Gene

  1. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A … Briggs DC (Human immunology 2010) 3 23 41
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk AV … Leelayuwat C (Immunogenetics 2009) 3 23 41
  3. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M … Bahram S (Genomics 2002) 2 3 4
  4. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D … Chalupny NJ (Immunity 2001) 2 3 4
  5. Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus. (PMID: 20530255) Bennett NJ … Wills MR (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 4

Products for ULBP3 Gene

  • Boster Bio Antibodies for ULBP3
  • Boster Bio ELISA Kits for ULBP3
  • Biorbyt antibodies for ULBP3

Sources for ULBP3 Gene