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Aliases for ULBP2 Gene

Aliases for ULBP2 Gene

  • UL16 Binding Protein 2 2 3 5
  • Retinoic Acid Early Transcript 1H 3 4
  • NKG2D Ligand 2 3 4
  • ALCAN-Alpha 3 4
  • NKG2DL2 3 4
  • RAET1H 3 4
  • N2DL2 3 4
  • UL16-Binding Protein 2 3
  • N2DL-2 4

External Ids for ULBP2 Gene

Previous GeneCards Identifiers for ULBP2 Gene

  • GC06P149824
  • GC06P150158
  • GC06P150294
  • GC06P150355
  • GC06P150304
  • GC06P150263
  • GC06P147828
  • GC06P149935

Summaries for ULBP2 Gene

Entrez Gene Summary for ULBP2 Gene

  • This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

GeneCards Summary for ULBP2 Gene

ULBP2 (UL16 Binding Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1L.

UniProtKB/Swiss-Prot for ULBP2 Gene

  • Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene Wiki entry for ULBP2 Gene

Additional gene information for ULBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ULBP2 Gene

Genomics for ULBP2 Gene

GeneHancer (GH) Regulatory Elements for ULBP2 Gene

Promoters and enhancers for ULBP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I149941 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 562.6 +0.1 69 1.2 PKNOX1 ATF1 SIN3A GLI4 GLIS2 ZNF213 ZNF548 FOS ATF7 SP3 ULBP2 LATS1 PPIL4 KATNA1 NUP43 RPS18P9 ENSG00000233330 ENSG00000215094
GH06I149962 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 8.8 +22.3 22261 3.1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 ZNF302 ZNF548 ULBP1 LATS1 NUP43 PPIL4 KATNA1 RAET1K ENSG00000216906 ENSG00000233330 ULBP2 ENSG00000219298
GH06I150025 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11.3 +83.7 83721 1.3 KLF1 JUN KLF17 CC2D1A E2F1 FOSL1 CTBP1 GATA3 FOS FOSL2 RAET1L ULBP2 RAET1M
GH06I149937 Enhancer 1 Ensembl ENCODE 11 -3.4 -3396 1.4 SMAD1 ZFP64 BMI1 ZNF207 ATF7 ETV6 IKZF2 RUNX3 CBFB ZNF217 ULBP2 ULBP1 RAET1K LOC105378052
GH06I150014 Enhancer 0.7 Ensembl 13.3 +73.5 73532 1.2 HDAC1 MEIS2 NFRKB TAL1 FOSL1 TCF12 CC2D1A CTBP1 FOXK2 NCOR1 ULBP2 RAET1K RAET1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ULBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ULBP2 gene promoter:

Genomic Locations for ULBP2 Gene

Genomic Locations for ULBP2 Gene
7,298 bases
Plus strand

Genomic View for ULBP2 Gene

Genes around ULBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ULBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ULBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ULBP2 Gene

Proteins for ULBP2 Gene

  • Protein details for ULBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UL16-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5VUN4

    Protein attributes for ULBP2 Gene

    246 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710).
    • (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP2 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
    • UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.

neXtProt entry for ULBP2 Gene

Post-translational modifications for ULBP2 Gene

  • Glycosylation at isoforms=68 and posLast=8282
  • Modification sites at PhosphoSitePlus

Other Protein References for ULBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ULBP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for ULBP2

No data available for DME Specific Peptides for ULBP2 Gene

Domains & Families for ULBP2 Gene

Gene Families for ULBP2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ULBP2 Gene

Suggested Antigen Peptide Sequences for ULBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MHC class I family.
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with ULBP2: view

Function for ULBP2 Gene

Molecular function for ULBP2 Gene

UniProtKB/Swiss-Prot Function:
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene Ontology (GO) - Molecular Function for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19424970
GO:0046703 natural killer cell lectin-like receptor binding IDA 11239445
genes like me logo Genes that share ontologies with ULBP2: view
genes like me logo Genes that share phenotypes with ULBP2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ULBP2 Gene

Localization for ULBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ULBP2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Secreted. Note=In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. {ECO:0000269 PubMed:12782710}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ULBP2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18676862
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 18676862
genes like me logo Genes that share ontologies with ULBP2: view

Pathways & Interactions for ULBP2 Gene

genes like me logo Genes that share pathways with ULBP2: view

SIGNOR curated interactions for ULBP2 Gene


Gene Ontology (GO) - Biological Process for ULBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0016032 viral process IEA --
GO:0030101 natural killer cell activation IDA 11239445
GO:0042267 natural killer cell mediated cytotoxicity IDA 11239445
genes like me logo Genes that share ontologies with ULBP2: view

Drugs & Compounds for ULBP2 Gene

(1) Drugs for ULBP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with ULBP2: view

Transcripts for ULBP2 Gene

mRNA/cDNA for ULBP2 Gene

Unigene Clusters for ULBP2 Gene

UL16 binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ULBP2 Gene

No ASD Table

Relevant External Links for ULBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ULBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ULBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ULBP2 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.6).

Protein differential expression in normal tissues from HIPED for ULBP2 Gene

This gene is overexpressed in Amniocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ULBP2 Gene

Protein tissue co-expression partners for ULBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ULBP2 Gene:


SOURCE GeneReport for Unigene cluster for ULBP2 Gene:


mRNA Expression by UniProt/SwissProt for ULBP2 Gene:

Tissue specificity: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.

Evidence on tissue expression from TISSUES for ULBP2 Gene

  • Skin(4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with ULBP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ULBP2 Gene

Orthologs for ULBP2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ULBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ULBP2 33
  • 96.88 (n)
-- 34
  • 93 (a)
-- 34
  • 91 (a)
(Bos Taurus)
Mammalia ULBP3 34
  • 34 (a)
(Canis familiaris)
Mammalia -- 34
  • 32 (a)
Species where no ortholog for ULBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ULBP2 Gene

Gene Tree for ULBP2 (if available)
Gene Tree for ULBP2 (if available)

Paralogs for ULBP2 Gene

Paralogs for ULBP2 Gene

(9) SIMAP similar genes for ULBP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ULBP2: view

Variants for ULBP2 Gene

Sequence variations from dbSNP and Humsavar for ULBP2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000120528 -- 149,947,692(+) C/G intron_variant
rs1000385896 -- 149,942,066(+) G/A 5_prime_UTR_variant
rs1000669629 -- 149,943,068(+) G/A intron_variant
rs1000847299 -- 149,948,872(+) T/C 3_prime_UTR_variant
rs1000991586 -- 149,942,961(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ULBP2 Gene

Variant ID Type Subtype PubMed ID
esv2732866 CNV deletion 23290073
esv3611217 CNV loss 21293372
esv3890963 CNV loss 25118596
nsv517022 CNV gain+loss 19592680
nsv969456 CNV duplication 23825009

Variation tolerance for ULBP2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ULBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ULBP2 Gene

Disorders for ULBP2 Gene

Additional Disease Information for ULBP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ULBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ULBP2 Gene

Publications for ULBP2 Gene

  1. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A … Briggs DC (Human immunology 2010) 3 22 44 58
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk AV … Leelayuwat C (Immunogenetics 2009) 3 22 44 58
  3. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. (PMID: 11239445) Cosman D … Chalupny NJ (Immunity 2001) 2 3 4 58
  4. Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. (PMID: 19089914) Schwinn N … Paschen A (International journal of cancer 2009) 3 22 58
  5. Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain. (PMID: 19424970) Wittenbrink M … Steinle A (European journal of immunology 2009) 3 22 58

Products for ULBP2 Gene

Sources for ULBP2 Gene

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