Aliases for ULBP2 Gene
External Ids for ULBP2 Gene
Previous GeneCards Identifiers for ULBP2 Gene
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
GeneCards Summary for ULBP2 Gene
ULBP2 (UL16 Binding Protein 2) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1L.
UniProtKB/Swiss-Prot Summary for ULBP2 Gene
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.