Aliases for ULBP1 Gene
External Ids for ULBP1 Gene
Previous GeneCards Identifiers for ULBP1 Gene
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for ULBP1 Gene
ULBP1 (UL16 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1L.
UniProtKB/Swiss-Prot Summary for ULBP1 Gene
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.