Aliases for ULBP1 Gene
External Ids for ULBP1 Gene
Previous GeneCards Identifiers for ULBP1 Gene
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for ULBP1 Gene
ULBP1 (UL16 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is RAET1L.
UniProtKB/Swiss-Prot Summary for ULBP1 Gene
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.