Aliases for UIMC1 Gene
External Ids for UIMC1 Gene
Previous GeneCards Identifiers for UIMC1 Gene
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for UIMC1 Gene
UIMC1 (Ubiquitin Interaction Motif Containing 1) is a Protein Coding gene. Diseases associated with UIMC1 include Riddle Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are DNA Double Strand Break Response and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include histone binding and K63-linked polyubiquitin modification-dependent protein binding.
UniProtKB/Swiss-Prot Summary for UIMC1 Gene
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.