Aliases for UIMC1 Gene
External Ids for UIMC1 Gene
Previous GeneCards Identifiers for UIMC1 Gene
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for UIMC1 Gene
UIMC1 (Ubiquitin Interaction Motif Containing 1) is a Protein Coding gene. Diseases associated with UIMC1 include Riddle Syndrome and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are DNA Double-Strand Break Repair and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include histone binding and K63-linked polyubiquitin modification-dependent protein binding.
UniProtKB/Swiss-Prot Summary for UIMC1 Gene
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.