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Aliases for UHRF2 Gene

Aliases for UHRF2 Gene

  • Ubiquitin Like With PHD And Ring Finger Domains 2 2 3 5
  • Np95-Like Ring Finger Protein 2 3 4
  • Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin Protein Ligase 2 3
  • Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 2 3 4
  • Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase UHRF2 3 4
  • Np95/ICBP90-Like RING Finger Protein 3 4
  • RING Finger Protein 107 3 4
  • Nuclear Protein 97 3 4
  • RNF107 3 4
  • NIRF 3 4
  • Ubiquitin-Like, Containing PHD And RING Finger Domains, 2 3
  • E3 Ubiquitin-Protein Ligase UHRF2 3
  • Nuclear Zinc Finger Protein NP97 3
  • Nuclear Zinc Finger Protein Np97 4
  • EC 2.3.2.27 4
  • EC 6.3.2 56
  • TDRD23 3
  • URF2 3

External Ids for UHRF2 Gene

Previous GeneCards Identifiers for UHRF2 Gene

  • GC00U990683
  • GC09P006404

Summaries for UHRF2 Gene

Entrez Gene Summary for UHRF2 Gene

  • This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

GeneCards Summary for UHRF2 Gene

UHRF2 (Ubiquitin Like With PHD And Ring Finger Domains 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and histone binding. An important paralog of this gene is UHRF1.

UniProtKB/Swiss-Prot for UHRF2 Gene

  • E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

Gene Wiki entry for UHRF2 Gene

Additional gene information for UHRF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UHRF2 Gene

Genomics for UHRF2 Gene

GeneHancer (GH) Regulatory Elements for UHRF2 Gene

Promoters and enhancers for UHRF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I006411 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 583 +0.6 601 4 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 ZNF207 UHRF2 RIC1 AK4P4 ENSG00000233367 KDM4C
GH09I006755 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 58.6 +344.9 344852 4.5 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 KDM4C UHRF2 GLDC AK4P4 ENSG00000236924 SNRPEP2 PIR49656
GH09I006006 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.2 -405.2 -405205 3.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A YY1 ZNF213 ZNF207 KLF13 SP3 KIAA2026 MIR4665 UHRF2 RIC1 AK4P4 PDSS1P1 ERMP1
GH09I005830 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.4 -580.6 -580605 3.4 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 DEK NFYC MXD4 ERMP1 RIC1 AK4P4 UHRF2 PDSS1P1 PIR31344
GH09I005435 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.4 -975.6 -975579 3.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 PLGRKT RIC1 UHRF2 AK4P4 PDSS1P1 PDCD1LG2 GC09M005431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UHRF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UHRF2 gene promoter:

Genomic Locations for UHRF2 Gene

Genomic Locations for UHRF2 Gene
chr9:6,413,148-6,507,056
(GRCh38/hg38)
Size:
93,909 bases
Orientation:
Plus strand
chr9:6,413,151-6,507,054
(GRCh37/hg19)

Genomic View for UHRF2 Gene

Genes around UHRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UHRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UHRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UHRF2 Gene

Proteins for UHRF2 Gene

  • Protein details for UHRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PU4-UHRF2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UHRF2
    Protein Accession:
    Q96PU4
    Secondary Accessions:
    • Q5VYR1
    • Q5VYR3
    • Q659C8
    • Q8TAG7

    Protein attributes for UHRF2 Gene

    Size:
    802 amino acids
    Molecular mass:
    89985 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides. Interacts with H3: the interaction has a preference for the Lys-9 trimethylated form of H3 (H3K9me3) (By similarity). Interacts with PCNP, HDAC1 and CDK2 (inactive form). Component of a complex at least composed of UHRF2, CDK2 and CCNE1. Interacts directly with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1 phosphorylation. Interacts with CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1 phosphorylation. Interacts with p53/TP53 and RB1. Interacts with UBE2I.
    SequenceCaution:
    • Sequence=CAH74120.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13295.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UHRF2 Gene

    Alternative splice isoforms for UHRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UHRF2 Gene

Selected DME Specific Peptides for UHRF2 Gene

Q96PU4:
  • HNVCKDCL
  • EGNRYDGIYKVVKYWPE
  • VWRYLLRRDD
  • GIHGRSNDGAYSLVLAGG
  • GVHRPHV
  • QRLFYRGKQ
  • WRFRVQVSE
  • AQVFSCPACR

Post-translational modifications for UHRF2 Gene

Other Protein References for UHRF2 Gene

Domains & Families for UHRF2 Gene

Gene Families for UHRF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UHRF2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UHRF2: view

No data available for UniProtKB/Swiss-Prot for UHRF2 Gene

Function for UHRF2 Gene

Molecular function for UHRF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
UniProtKB/Swiss-Prot Induction:
Up-regulated in proliferating fetal lung fibroblasts and in U-937 myeloid leukemia cells. Down-regulated in these cells by growth arrest and differentiation. In other cell types which cannot leave the cell cycle, such as tumoral HT-1080 and Hep-G2, levels are consistently up-regulated.

Enzyme Numbers (IUBMB) for UHRF2 Gene

Phenotypes From GWAS Catalog for UHRF2 Gene

Gene Ontology (GO) - Molecular Function for UHRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 14741369
GO:0005515 protein binding IPI 12176013
GO:0016740 transferase activity IEA --
GO:0042393 histone binding IEA,ISS --
genes like me logo Genes that share ontologies with UHRF2: view
genes like me logo Genes that share phenotypes with UHRF2: view

Animal Models for UHRF2 Gene

MGI Knock Outs for UHRF2:

Animal Model Products

CRISPR Products

miRNA for UHRF2 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UHRF2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UHRF2 Gene

Localization for UHRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UHRF2 Gene

Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UHRF2 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UHRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12176013
GO:0005654 nucleoplasm IDA --
GO:0005720 nuclear heterochromatin ISS,IEA --
genes like me logo Genes that share ontologies with UHRF2: view

Pathways & Interactions for UHRF2 Gene

SuperPathways for UHRF2 Gene

No Data Available

UniProtKB/Swiss-Prot Q96PU4-UHRF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UHRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation IEP 12176013
GO:0010216 maintenance of DNA methylation IBA --
GO:0016567 protein ubiquitination IDA 14741369
GO:0030154 cell differentiation IEP 12176013
genes like me logo Genes that share ontologies with UHRF2: view

No data available for Pathways by source and SIGNOR curated interactions for UHRF2 Gene

Drugs & Compounds for UHRF2 Gene

No Compound Related Data Available

Transcripts for UHRF2 Gene

Unigene Clusters for UHRF2 Gene

Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UHRF2

Alternative Splicing Database (ASD) splice patterns (SP) for UHRF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:

ExUns: 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for UHRF2 Gene

GeneLoc Exon Structure for
UHRF2
ECgene alternative splicing isoforms for
UHRF2

Expression for UHRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UHRF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UHRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.1), Blymphocyte (9.7), and Heart (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UHRF2 Gene



Protein tissue co-expression partners for UHRF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UHRF2 Gene:

UHRF2

SOURCE GeneReport for Unigene cluster for UHRF2 Gene:

Hs.493401

Evidence on tissue expression from TISSUES for UHRF2 Gene

  • Nervous system(4.6)
  • Kidney(3.2)
genes like me logo Genes that share expression patterns with UHRF2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UHRF2 Gene

Orthologs for UHRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UHRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UHRF2 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia UHRF2 33 34
  • 92.05 (n)
cow
(Bos Taurus)
Mammalia UHRF2 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uhrf2 33 16 34
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Uhrf2 33
  • 87.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UHRF2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves UHRF2 33 34
  • 75.81 (n)
lizard
(Anolis carolinensis)
Reptilia UHRF2 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124801 33
  • 69.55 (n)
zebrafish
(Danio rerio)
Actinopterygii UHRF2 (2 of 3) 34
  • 78 (a)
OneToMany
UHRF2 (3 of 3) 34
  • 57 (a)
OneToMany
CABZ01073380.1 34
  • 45 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8721 33
Species where no ortholog for UHRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UHRF2 Gene

ENSEMBL:
Gene Tree for UHRF2 (if available)
TreeFam:
Gene Tree for UHRF2 (if available)

Paralogs for UHRF2 Gene

Paralogs for UHRF2 Gene

(2) SIMAP similar genes for UHRF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for UHRF2 Gene

genes like me logo Genes that share paralogs with UHRF2: view

Variants for UHRF2 Gene

Sequence variations from dbSNP and Humsavar for UHRF2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs147971931 A colorectal cancer sample 6,421,018(+) T/A/C 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000030437 -- 6,501,740(+) G/A intron_variant
rs1000071316 -- 6,443,655(+) A/T intron_variant
rs1000092506 -- 6,438,849(+) A/T intron_variant
rs1000106101 -- 6,466,864(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UHRF2 Gene

Variant ID Type Subtype PubMed ID
dgv7386n100 CNV gain 25217958
esv2535857 CNV deletion 19546169
esv2761298 CNV gain 21179565
esv3619403 CNV loss 21293372
esv3619404 CNV gain 21293372
esv6811 CNV gain 19470904
nsv1023419 CNV loss 25217958
nsv1029665 CNV gain 25217958
nsv1029766 CNV gain 25217958
nsv1140952 CNV deletion 24896259
nsv824839 CNV gain 20364138
nsv831497 CNV gain 17160897
nsv831498 CNV loss 17160897

Variation tolerance for UHRF2 Gene

Residual Variation Intolerance Score: 7.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UHRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UHRF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UHRF2 Gene

Disorders for UHRF2 Gene

UniProtKB/Swiss-Prot

UHRF2_HUMAN
  • Note=Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.

Additional Disease Information for UHRF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UHRF2 Gene.

No data available for MalaCards and Genatlas for UHRF2 Gene

Publications for UHRF2 Gene

  1. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. (PMID: 14741369) Mori T … Kochi H (FEBS letters 2004) 3 4 22 58
  2. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. (PMID: 12176013) Mori T … Kochi H (Biochemical and biophysical research communications 2002) 2 3 4 58
  3. The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory. (PMID: 28115522) Chen R … Wong J (The Journal of biological chemistry 2017) 2 3 58
  4. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. (PMID: 23404503) Oh Y … Chung KC (The Journal of biological chemistry 2013) 3 4 58
  5. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. (PMID: 21952639) Mori T … Kochi H (Cell cycle (Georgetown, Tex.) 2011) 3 4 58

Products for UHRF2 Gene

  • Addgene plasmids for UHRF2

Sources for UHRF2 Gene

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