Aliases for UGT8 Gene
External Ids for UGT8 Gene
Previous HGNC Symbols for UGT8 Gene
Previous GeneCards Identifiers for UGT8 Gene
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for UGT8 Gene
UGT8 (UDP Glycosyltransferase 8) is a Protein Coding gene. Diseases associated with UGT8 include Niemann-Pick Disease, Type A and Metachromatic Leukodystrophy. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.
UniProtKB/Swiss-Prot Summary for UGT8 Gene
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity).