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Aliases for UGT3A2 Gene
Aliases for UGT3A2 Gene
External Ids for UGT3A2 Gene
- HGNC: 27266
- Entrez Gene: 167127
- Ensembl: ENSG00000168671
- OMIM: 616384
- UniProtKB: Q3SY77
Previous GeneCards Identifiers for UGT3A2 Gene
- GC05M036071
- GC05M035985
Summaries for UGT3A2 Gene
GeneCards Summary for UGT3A2 Gene
UGT3A2 (UDP Glycosyltransferase Family 3 Member A2) is a Protein Coding gene. Diseases associated with UGT3A2 include Fusariosis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT3A1.
UniProtKB/Swiss-Prot Summary for UGT3A2 Gene
-
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Additional gene information for UGT3A2 Gene
- HGNC(27266)
- Entrez Gene(167127)
- Ensembl(ENSG00000168671)
- OMIM(616384)
- UniProtKB(Q3SY77)
- Open Targets Platform(ENSG00000168671)
- Monarch Initiative
- Search for UGT3A2 at DataMed
- Search for UGT3A2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT3A2 Gene
Genomics for UGT3A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UGT3A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UGT3A2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT3A2
- Top Transcription factor binding sites by QIAGEN in the UGT3A2 gene promoter:
-
- ARP-1
- C/EBPalpha
Genomic Locations for UGT3A2 Gene
Genomic Locations for UGT3A2 Gene
- chr5:36,035,021-36,071,358
- (GRCh38/hg38)
- Size:
- 36,338 bases
- Orientation:
- Minus strand
- chr5:36,035,119-36,071,460
- (GRCh37/hg19)
- Size:
- 36,342 bases
- Orientation:
- Minus strand
Genomic View for UGT3A2 Gene
Genes around UGT3A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.2 by HGNC
- 5p13.2 by Entrez Gene
- 5p13.2 by Ensembl
UGT3A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UGT3A2 Gene
Proteins for UGT3A2 Gene
-
Protein details for UGT3A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q3SY77-UD3A2_HUMAN
- Recommended name:
- UDP-glucuronosyltransferase 3A2
- Protein Accession:
- Q3SY77
- B4DUQ7
- E9PFK7
- Q6UXC4
- Q8NBP2
Protein attributes for UGT3A2 Gene
- Size:
- 523 amino acids
- Molecular mass:
- 59547 Da
- Quaternary structure:
- No Data Available
Protein Expression for UGT3A2 Gene
Post-translational modifications for UGT3A2 Gene
Other Protein References for UGT3A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for UGT3A2
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- Invitrogen Antibodies for UGT3A2 (AFLGC-UGT3A2)
-
Biorbyt antibodies for UGT3A2
-
Boster Bio Antibodies for UGT3A2
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Protein Products
-
OriGene Purified Proteins for UGT3A2
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- antibodies-online: Show 3 available UGT3A2 Proteins ranked by validation data
- Compare Top UGT3A2 Proteins
-
Quality Products:
-
Abcam proteins for UGT3A2
No data available for DME Specific Peptides for UGT3A2 Gene
Domains & Families for UGT3A2 Gene
Gene Families for UGT3A2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for UGT3A2 Gene
- InterPro:
- Blocks:
-
- UDP-glucoronosyl/UDP-glucosyl transferase
- ProtoNet:
Suggested Antigen Peptide Sequences for UGT3A2 Gene
- GenScript: Design optimal peptide antigens:
-
- UDP-glucuronosyltransferase 3A2 (UD3A2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q3SY77- Family:
-
- Belongs to the UDP-glycosyltransferase family.
Function for UGT3A2 Gene
Molecular function for UGT3A2 Gene
- UniProtKB/Swiss-Prot Function:
- UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;.
Enzyme Numbers (IUBMB) for UGT3A2 Gene
Phenotypes From GWAS Catalog for UGT3A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008194 | UDP-glycosyltransferase activity | IDA | 22621930 |
| GO:0015020 | glucuronosyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0016758 | transferase activity, transferring hexosyl groups | IEA | -- |
Phenotypes for UGT3A2 Gene
- GenomeRNAi human phenotypes for UGT3A2:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
- Decreased Salmonella proliferation
- Increased cell number in G2M, increased number of polyploid cells, increased number of cells with high perimeter-to-area ratio nuclei
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UGT3A2 - Select products 50% OFF >
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-
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGT3A2
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Clone Products
- Applied Biological Materials (abm): Clones for UGT3A2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for UGT3A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGT3A2
Cell Line Products
-
Horizon Cell Lines for UGT3A2
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT3A2 Gene
Localization for UGT3A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UGT3A2 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 2 |
| extracellular | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| plasma membrane | 0 |
| peroxisome | 0 |
- Cytosol (2)
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IBA | 21873635 |
Pathways & Interactions for UGT3A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type | ||
| 2 | Porphyrin and chlorophyll metabolism |
.67
|
|
| 3 | Metabolism |
.40
|
|
Pathways by source for UGT3A2 Gene
4 Reactome pathways for UGT3A2 Gene
Interacting Proteins for UGT3A2 Gene
GPS-Prot Interaction Network for UGT3A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0071412 | cellular response to genistein | IDA | 22621930 |
No data available for SIGNOR curated interactions for UGT3A2 Gene
Transcripts for UGT3A2 Gene
mRNA/cDNA for UGT3A2 Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000282507 2342 nts (view in UCSC)
- ENST00000504685 1476 nts (view in UCSC)
- ENST00000504954 543 nts (view in UCSC)
- ENST00000513300 1924 nts (view in UCSC)
- ENST00000515131 572 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UGT3A2 - Select products 50% OFF >
- * UGT3A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UGT3A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UGT3A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for UGT3A2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGT3A2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT3A2
Clone Products
- Applied Biological Materials (abm): Clones for UGT3A2 - Select products 50% OFF >
- * UGT3A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UGT3A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGT3A2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - |
Relevant External Links for UGT3A2 Gene
- GeneLoc Exon Structure for
- UGT3A2
Expression for UGT3A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for UGT3A2 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.4), Skin - Sun Exposed (Lower leg) (x16.1), and Testis (x7.0).
This gene is overexpressed in Testis (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT3A2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT3A2
SOURCE GeneReport for Unigene cluster for UGT3A2 Gene:
Hs.348941Evidence on tissue expression from TISSUES for UGT3A2 Gene
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for UGT3A2
-
OriGene qPCR primer pairs and template standards for UGT3A2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT3A2 Gene
Orthologs for UGT3A2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UGT3A2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LOC489231 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | LOC537188 30 |
|
||
| UGT3A1 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Ugt3a2 31 |
|
ManyToMany | |
| Ugt3a1 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ugt3a2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ugt5e1 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ugt35b 31 |
|
ManyToMany | |
| Ugt37c1 31 |
|
ManyToMany | |||
| CG15661 31 |
|
ManyToMany | |||
| Ugt86Dg 31 |
|
ManyToMany | |||
| CG17324 31 |
|
ManyToMany | |||
| CG10178 31 |
|
ManyToMany | |||
| Ugt86Dd 31 |
|
ManyToMany | |||
| Ugt86Dc 31 |
|
ManyToMany | |||
| Ugt36Bb 31 |
|
ManyToMany | |||
| Ugt35a 31 |
|
ManyToMany | |||
| CG4302 31 |
|
ManyToMany | |||
| Ugt36Ba 31 |
|
ManyToMany | |||
| Ugt37a1 31 |
|
ManyToMany | |||
| Ugt86Di 31 |
|
ManyToMany | |||
| Ugt86De 31 |
|
ManyToMany | |||
| CG17323 31 |
|
ManyToMany | |||
| Ugt86Da 31 |
|
ManyToMany | |||
| CG6475 31 |
|
ManyToMany | |||
| Ugt37b1 31 |
|
ManyToMany | |||
| CG30438 31 |
|
ManyToMany | |||
| CG5724 31 |
|
ManyToMany | |||
| CG31002 31 |
|
ManyToMany | |||
| Ugt36Bc 31 |
|
ManyToMany | |||
| CG17322 31 |
|
ManyToMany | |||
| CG11289 31 |
|
ManyToMany | |||
| CG5999 31 |
|
ManyToMany | |||
| CG10168 31 |
|
ManyToMany | |||
| CG16732 31 |
|
ManyToMany | |||
| Ugt86Dh 31 |
|
ManyToMany | |||
| Ugt86Dj 31 |
|
ManyToMany | |||
| CG10170 31 |
|
ManyToMany | |||
| Dot 31 |
|
ManyToMany | |||
| CG3797 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ugt-58 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG26 33 |
|
|
- Species where no ortholog for UGT3A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UGT3A2 Gene
- ENSEMBL:
- Gene Tree for UGT3A2 (if available)
- TreeFam:
- Gene Tree for UGT3A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UGT3A2: view image
Paralogs for UGT3A2 Gene
Paralogs for UGT3A2 Gene
(26) SIMAP similar genes for UGT3A2 Gene using alignment to 4 proteins:
- UD3A2_HUMAN
- D6RDU1_HUMAN
- D6RHY1_HUMAN
- F5H377_HUMAN
Variants for UGT3A2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT3A2 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138640717 | A colorectal cancer sample | p.Arg515His | |||
| rs2197514 | - | p.Tyr74Asn |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv32711 | CNV | gain | 17666407 |
| esv3604707 | CNV | gain | 21293372 |
| esv3604711 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.39;
27.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UGT3A2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UGT3A2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT3A2 Gene
Disorders for UGT3A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fusariosis |
|
|
Search UGT3A2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UGT3A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UGT3A2 Gene
Publications for UGT3A2 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
ExternalLinks
Products for UGT3A2 Gene
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- antibodies-online: Show 18 available UGT3A2 Antibodies ranked by validation data
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Sources for UGT3A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
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