Aliases for UGT3A2 Gene

Aliases for UGT3A2 Gene

  • UDP Glycosyltransferase Family 3 Member A2 2 3 5
  • UDP Glycosyltransferase 3 Family, Polypeptide A2 2 3
  • UDP-Glucuronosyltransferase 3A2 3 4
  • UDPGT 3A2 3 4
  • EC 2.4.1.17 4
  • UGT3A2 5

External Ids for UGT3A2 Gene

Previous GeneCards Identifiers for UGT3A2 Gene

  • GC05M036071
  • GC05M035985

Summaries for UGT3A2 Gene

GeneCards Summary for UGT3A2 Gene

UGT3A2 (UDP Glycosyltransferase Family 3 Member A2) is a Protein Coding gene. Diseases associated with UGT3A2 include Fusariosis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT3A1.

UniProtKB/Swiss-Prot Summary for UGT3A2 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT3A2 Gene

Genomics for UGT3A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT3A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT3A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT3A2

Top Transcription factor binding sites by QIAGEN in the UGT3A2 gene promoter:
  • ARP-1
  • C/EBPalpha

Genomic Locations for UGT3A2 Gene

Latest Assembly
chr5:36,035,021-36,071,358
(GRCh38/hg38)
Size:
36,338 bases
Orientation:
Minus strand

Previous Assembly
chr5:36,035,123-36,066,984
(GRCh37/hg19 by Entrez Gene)
Size:
31,862 bases
Orientation:
Minus strand

chr5:36,035,119-36,071,460
(GRCh37/hg19 by Ensembl)
Size:
36,342 bases
Orientation:
Minus strand

Genomic View for UGT3A2 Gene

Genes around UGT3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT3A2 Gene

Proteins for UGT3A2 Gene

  • Protein details for UGT3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY77-UD3A2_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 3A2
    Protein Accession:
    Q3SY77
    Secondary Accessions:
    • B4DUQ7
    • E9PFK7
    • Q6UXC4
    • Q8NBP2

    Protein attributes for UGT3A2 Gene

    Size:
    523 amino acids
    Molecular mass:
    59547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT3A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT3A2 Gene

Post-translational modifications for UGT3A2 Gene

  • Glycosylation at Asn52
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT3A2 Gene

No data available for DME Specific Peptides for UGT3A2 Gene

Domains & Families for UGT3A2 Gene

Gene Families for UGT3A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UGT3A2 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT3A2 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 3A2 (UD3A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3SY77

UniProtKB/Swiss-Prot:

UD3A2_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT3A2: view

Function for UGT3A2 Gene

Molecular function for UGT3A2 Gene

UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;.

Enzyme Numbers (IUBMB) for UGT3A2 Gene

Phenotypes From GWAS Catalog for UGT3A2 Gene

Gene Ontology (GO) - Molecular Function for UGT3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IDA 22621930
GO:0015020 glucuronosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT3A2: view
genes like me logo Genes that share phenotypes with UGT3A2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT3A2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT3A2 Gene

Localization for UGT3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT3A2 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT3A2 gene
Compartment Confidence
golgi apparatus 2
extracellular 1
nucleus 1
endoplasmic reticulum 1
plasma membrane 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UGT3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with UGT3A2: view

Pathways & Interactions for UGT3A2 Gene

genes like me logo Genes that share pathways with UGT3A2: view

Pathways by source for UGT3A2 Gene

Gene Ontology (GO) - Biological Process for UGT3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071412 cellular response to genistein IDA 22621930
genes like me logo Genes that share ontologies with UGT3A2: view

No data available for SIGNOR curated interactions for UGT3A2 Gene

Drugs & Compounds for UGT3A2 Gene

(2) Drugs for UGT3A2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine 5'-diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with UGT3A2: view

Transcripts for UGT3A2 Gene

mRNA/cDNA for UGT3A2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT3A2

Alternative Splicing Database (ASD) splice patterns (SP) for UGT3A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2:
SP3: - -

Relevant External Links for UGT3A2 Gene

GeneLoc Exon Structure for
UGT3A2

Expression for UGT3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT3A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT3A2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.4), Skin - Sun Exposed (Lower leg) (x16.1), and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for UGT3A2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT3A2 Gene



Protein tissue co-expression partners for UGT3A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT3A2

SOURCE GeneReport for Unigene cluster for UGT3A2 Gene:

Hs.348941

Evidence on tissue expression from TISSUES for UGT3A2 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with UGT3A2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT3A2 Gene

Orthologs for UGT3A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UGT3A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UGT3A2 29
  • 99.81 (n)
Dog
(Canis familiaris)
Mammalia LOC489231 29
  • 82.68 (n)
-- 30
  • 75 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC537188 29
  • 79.8 (n)
UGT3A1 30
  • 74 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ugt3a2 30
  • 66 (a)
ManyToMany
Ugt3a1 30
  • 66 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 58 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 48 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ugt3a2 29
  • 57.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii ugt5e1 30
  • 26 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ugt35b 30
  • 28 (a)
ManyToMany
Ugt37c1 30
  • 27 (a)
ManyToMany
CG15661 30
  • 26 (a)
ManyToMany
Ugt86Dg 30
  • 26 (a)
ManyToMany
CG17324 30
  • 26 (a)
ManyToMany
CG10178 30
  • 26 (a)
ManyToMany
Ugt86Dd 30
  • 26 (a)
ManyToMany
Ugt86Dc 30
  • 26 (a)
ManyToMany
Ugt36Bb 30
  • 25 (a)
ManyToMany
Ugt35a 30
  • 25 (a)
ManyToMany
CG4302 30
  • 25 (a)
ManyToMany
Ugt36Ba 30
  • 25 (a)
ManyToMany
Ugt37a1 30
  • 25 (a)
ManyToMany
Ugt86Di 30
  • 25 (a)
ManyToMany
Ugt86De 30
  • 24 (a)
ManyToMany
CG17323 30
  • 24 (a)
ManyToMany
Ugt86Da 30
  • 24 (a)
ManyToMany
CG6475 30
  • 24 (a)
ManyToMany
Ugt37b1 30
  • 24 (a)
ManyToMany
CG30438 30
  • 24 (a)
ManyToMany
CG5724 30
  • 24 (a)
ManyToMany
CG31002 30
  • 23 (a)
ManyToMany
Ugt36Bc 30
  • 23 (a)
ManyToMany
CG17322 30
  • 23 (a)
ManyToMany
CG11289 30
  • 23 (a)
ManyToMany
CG5999 30
  • 23 (a)
ManyToMany
CG10168 30
  • 22 (a)
ManyToMany
CG16732 30
  • 22 (a)
ManyToMany
Ugt86Dh 30
  • 21 (a)
ManyToMany
Ugt86Dj 30
  • 20 (a)
ManyToMany
CG10170 30
  • 20 (a)
ManyToMany
Dot 30
  • 19 (a)
ManyToMany
CG3797 30
  • 18 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ugt-58 30
  • 22 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG26 32
Species where no ortholog for UGT3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UGT3A2 Gene

ENSEMBL:
Gene Tree for UGT3A2 (if available)
TreeFam:
Gene Tree for UGT3A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT3A2: view image
Alliance of Genome Resources:
Additional Orthologs for UGT3A2

Paralogs for UGT3A2 Gene

(26) SIMAP similar genes for UGT3A2 Gene using alignment to 4 proteins:

  • UD3A2_HUMAN
  • D6RDU1_HUMAN
  • D6RHY1_HUMAN
  • F5H377_HUMAN
genes like me logo Genes that share paralogs with UGT3A2: view

Variants for UGT3A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT3A2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs138640717 A colorectal cancer sample p.Arg515His
rs2197514 -- p.Tyr74Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT3A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT3A2 Gene

Variant ID Type Subtype PubMed ID
esv32711 CNV gain 17666407
esv3604707 CNV gain 21293372
esv3604711 CNV loss 21293372

Variation tolerance for UGT3A2 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT3A2
Leiden Open Variation Database (LOVD)
UGT3A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT3A2 Gene

Disorders for UGT3A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UGT3A2 Gene - From: COP

Disorder Aliases PubMed IDs
fusariosis
  • fusarium infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT3A2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT3A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT3A2 Gene

Publications for UGT3A2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 40
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for UGT3A2 Gene

Sources for UGT3A2 Gene