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UGT3A1 (UDP Glycosyltransferase Family 3 Member A1) is a Protein Coding gene. Diseases associated with UGT3A1 include Bile Acid Synthesis Defect, Congenital, 3. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT3A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008194 | UDP-glycosyltransferase activity | IDA | 22621930 |
GO:0015020 | glucuronosyltransferase activity | IDA | 22621930 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0016758 | transferase activity, transferring hexosyl groups | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IBA | 21873635 |
GO:0043541 | UDP-N-acetylglucosamine transferase complex | IDA | 22621930 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type | ||
2 | Porphyrin and chlorophyll metabolism |
.67
|
|
3 | Metabolism |
.40
|
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Kaempferol | Experimental | Pharma | Target | Apoptosis inducer;antioxidant;flavonoid | 0 | |
Quercetin | Experimental, Investigational | Pharma | Target | Antitumor agent, Non-selective PI 3-kinase inhibitor | 54 | |
UDP-alpha-D-glucuronic acid | Experimental | Pharma | 0 | |||
Uridine 5'-diphosphate | Experimental | Pharma | 0 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UGT3A1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | UGT3A1 30 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Ugt3a2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ugt3a2 30 17 31 |
|
ManyToMany | |
Ugt3a1 17 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | ugt5b4 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Ugt37c1 31 |
|
ManyToMany | |
Ugt35b 31 |
|
ManyToMany | |||
CG15661 31 |
|
ManyToMany | |||
CG10178 31 |
|
ManyToMany | |||
Ugt36Ba 31 |
|
ManyToMany | |||
CG4302 31 |
|
ManyToMany | |||
Ugt36Bb 31 |
|
ManyToMany | |||
Ugt37b1 31 |
|
ManyToMany | |||
CG11289 31 |
|
ManyToMany | |||
Ugt86Dc 31 |
|
ManyToMany | |||
CG6475 31 |
|
ManyToMany | |||
Ugt86Dg 31 |
|
ManyToMany | |||
CG17324 31 |
|
ManyToMany | |||
Ugt86Dd 31 |
|
ManyToMany | |||
CG17323 31 |
|
ManyToMany | |||
CG5724 31 |
|
ManyToMany | |||
Ugt86De 31 |
|
ManyToMany | |||
Ugt86Da 31 |
|
ManyToMany | |||
Ugt35a 31 |
|
ManyToMany | |||
Ugt36Bc 31 |
|
ManyToMany | |||
CG17322 31 |
|
ManyToMany | |||
CG30438 31 |
|
ManyToMany | |||
Ugt86Di 31 |
|
ManyToMany | |||
Ugt37a1 31 |
|
ManyToMany | |||
CG31002 31 |
|
ManyToMany | |||
CG5999 31 |
|
ManyToMany | |||
CG16732 31 |
|
ManyToMany | |||
Ugt86Dh 31 |
|
ManyToMany | |||
CG10168 31 |
|
ManyToMany | |||
CG10170 31 |
|
ManyToMany | |||
Dot 31 |
|
ManyToMany | |||
Ugt86Dj 31 |
|
ManyToMany | |||
CG3797 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ugt-58 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3756669 | - | p.Cys121Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
bile acid synthesis defect, congenital, 3 |
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