Aliases for UGT2B7 Gene
External Ids for UGT2B7 Gene
Previous GeneCards Identifiers for UGT2B7 Gene
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
GeneCards Summary for UGT2B7 Gene
UGT2B7 (UDP Glucuronosyltransferase Family 2 Member B7) is a Protein Coding gene. Diseases associated with UGT2B7 include Hepatocellular Adenoma and Neonatal Abstinence Syndrome. Among its related pathways are Drug metabolism - cytochrome P450 and Carvedilol Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B10.
UniProtKB/Swiss-Prot Summary for UGT2B7 Gene
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).