Aliases for UGT2B4 Gene
External Ids for UGT2B4 Gene
Previous GeneCards Identifiers for UGT2B4 Gene
GeneCards Summary for UGT2B4 Gene
UGT2B4 (UDP Glucuronosyltransferase Family 2 Member B4) is a Protein Coding gene. Diseases associated with UGT2B4 include Autosomal Dominant Non-Syndromic Intellectual Disability 3 and Leber Congenital Amaurosis. Among its related pathways are Drug metabolism - cytochrome P450 and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B10.
UniProtKB/Swiss-Prot Summary for UGT2B4 Gene
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.