Aliases for UGT2B4 Gene
External Ids for UGT2B4 Gene
Previous GeneCards Identifiers for UGT2B4 Gene
GeneCards Summary for UGT2B4 Gene
UGT2B4 (UDP Glucuronosyltransferase Family 2 Member B4) is a Protein Coding gene. Diseases associated with UGT2B4 include Heart Defects, Congenital, And Other Congenital Anomalies and Autosomal Dominant Non-Syndromic Intellectual Disability 3. Among its related pathways are Drug metabolism - cytochrome P450 and Farnesoid X Receptor Pathway. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B10.
UniProtKB/Swiss-Prot Summary for UGT2B4 Gene
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).