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Aliases for UGT2B4 Gene

Aliases for UGT2B4 Gene

  • UDP Glucuronosyltransferase Family 2 Member B4 2 3 5
  • Hyodeoxycholic Acid-Specific UDPGT 3 4
  • EC 2.4.1.17 4 56
  • UDPGT 2B4 3 4
  • UDPGTh-1 3 4
  • UGT2B11 3 4
  • HLUG25 3 4
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B4 3
  • UDP Glycosyltransferase 2 Family, Polypeptide B4 2
  • UDP-Glucuronyltransferase, Family 2, Beta-4 3
  • UDP-Glucuronosyltransferase 2B4 3
  • Hyodeoxycholic Acid 3
  • UDPGT2B4 3
  • UDPGTH1 3

External Ids for UGT2B4 Gene

Previous GeneCards Identifiers for UGT2B4 Gene

  • GC04P070172
  • GC04M070394
  • GC04M070595
  • GC04M070661
  • GC04M070186
  • GC04M070526
  • GC04M070345
  • GC04M066144

Summaries for UGT2B4 Gene

GeneCards Summary for UGT2B4 Gene

UGT2B4 (UDP Glucuronosyltransferase Family 2 Member B4) is a Protein Coding gene. Among its related pathways are Farnesoid X Receptor Pathway and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B10.

UniProtKB/Swiss-Prot for UGT2B4 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Gene Wiki entry for UGT2B4 Gene

Additional gene information for UGT2B4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B4 Gene

Genomics for UGT2B4 Gene

GeneHancer (GH) Regulatory Elements for UGT2B4 Gene

Promoters and enhancers for UGT2B4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I069495 Promoter 1.2 EPDnew 550.3 +30.1 30089 0.1 ELF3 FOXA2 ARID4B ZSCAN9 RAD21 ETS1 YY1 CREM THAP11 MIXL1 UGT2B4 UGT2A3P7 ENSG00000249686
GH04I069544 Enhancer 0.7 ENCODE 42.3 -20.1 -20147 2.9 TFAP4 FOXA2 TAF1 MAX RAD21 YY1 POLR2A HNF4G NFE2 MAFK UGT2B4 LOC100422024
GH04I069496 Enhancer 0.3 ENCODE 47 +28.6 28617 1.5 JUND UGT2B4 UGT2A3P7 ENSG00000249686
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UGT2B4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UGT2B4 gene promoter:

Genomic Locations for UGT2B4 Gene

Genomic Locations for UGT2B4 Gene
chr4:69,480,165-69,526,014
(GRCh38/hg38)
Size:
45,850 bases
Orientation:
Minus strand
chr4:70,345,883-70,391,732
(GRCh37/hg19)

Genomic View for UGT2B4 Gene

Genes around UGT2B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B4 Gene

Proteins for UGT2B4 Gene

  • Protein details for UGT2B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06133-UD2B4_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B4
    Protein Accession:
    P06133
    Secondary Accessions:
    • A6NCP7
    • B4DT75
    • G5E9X8
    • O60731
    • O60867
    • O75614
    • P36538
    • Q1HBF9
    • Q6QQX7

    Protein attributes for UGT2B4 Gene

    Size:
    528 amino acids
    Molecular mass:
    60513 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2B4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT2B4 Gene

Selected DME Specific Peptides for UGT2B4 Gene

P06133:
  • AFITHGG
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • AAHDLTW
  • KPLDRAVFWIE
  • KLQESRFD
  • SHWMNIKTILDEL
  • YEAIYHG
  • RGHEVTVL
  • FVGGLHC
  • KKWDQFYSEVLGRPTTL
  • PPSYVPV
  • WIPQNDLLG
  • FLLACVA
  • IPQKVLW
  • DQPDNIAHMK
  • THGGANG
  • DLLNALK
  • GHPKTRAFITH
  • VVFSLGSMV
  • LSRIHHDQP
  • VMRHKGA
  • CGKVLVW
  • QYHSLDV
  • TMSSTDL
  • NALKTVINDP
  • NTRLYKW
  • ERVKNMIY

Post-translational modifications for UGT2B4 Gene

Other Protein References for UGT2B4 Gene

Domains & Families for UGT2B4 Gene

Gene Families for UGT2B4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for UGT2B4 Gene

Graphical View of Domain Structure for InterPro Entry

P06133

UniProtKB/Swiss-Prot:

UD2B4_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B4: view

Function for UGT2B4 Gene

Molecular function for UGT2B4 Gene

GENATLAS Biochemistry:
UDP glucuronosyltransferase 2,liver,bile acid conjugating
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Enzyme Numbers (IUBMB) for UGT2B4 Gene

Phenotypes From GWAS Catalog for UGT2B4 Gene

Gene Ontology (GO) - Molecular Function for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IDA 18052087
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B4: view
genes like me logo Genes that share phenotypes with UGT2B4: view

Animal Model Products

miRNA for UGT2B4 Gene

miRTarBase miRNAs that target UGT2B4

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B4 Gene

Localization for UGT2B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B4 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B4 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
peroxisome 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2B4 Gene

Pathways & Interactions for UGT2B4 Gene

genes like me logo Genes that share pathways with UGT2B4: view

Gene Ontology (GO) - Biological Process for UGT2B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006711 estrogen catabolic process IDA 8333863
GO:0006805 xenobiotic metabolic process IDA 8333863
GO:0008152 metabolic process IDA,IEA 8333863
GO:0052695 cellular glucuronidation IDA 20056724
genes like me logo Genes that share ontologies with UGT2B4: view

No data available for SIGNOR curated interactions for UGT2B4 Gene

Drugs & Compounds for UGT2B4 Gene

(41) Drugs for UGT2B4 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist, Enzyme, substrate 83
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 1100
Flurbiprofen Approved, Investigational Pharma Channel blocker, Enzyme, substrate 56
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 594
Canagliflozin Approved Pharma Inhibition, Inhibitor, Enzyme, substrate SGLT2 inhibitor,potent and selective 116

(140) Additional Compounds for UGT2B4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-beta-delta-Glucopyranosiduronate
  • Taurolithocholic acid 3-glucuronide
99794-82-8
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
(3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid
  • Glycocholic acid 3-glucuronide
99794-78-2
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
genes like me logo Genes that share compounds with UGT2B4: view

Transcripts for UGT2B4 Gene

Unigene Clusters for UGT2B4 Gene

UDP glucuronosyltransferase 2 family, polypeptide B4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B4 Gene

No ASD Table

Relevant External Links for UGT2B4 Gene

GeneLoc Exon Structure for
UGT2B4
ECgene alternative splicing isoforms for
UGT2B4

Expression for UGT2B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT2B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B4 Gene

This gene is overexpressed in Liver (x50.5).

Protein differential expression in normal tissues from HIPED for UGT2B4 Gene

This gene is overexpressed in Liver (39.2) and Gallbladder (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT2B4 Gene



Protein tissue co-expression partners for UGT2B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT2B4 Gene:

UGT2B4

SOURCE GeneReport for Unigene cluster for UGT2B4 Gene:

Hs.285887

Evidence on tissue expression from TISSUES for UGT2B4 Gene

  • Liver(4.8)
genes like me logo Genes that share expression patterns with UGT2B4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B4 Gene

Orthologs for UGT2B4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2B4 33 34
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 75 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ugt2b7 33
  • 72.41 (n)
mouse
(Mus musculus)
Mammalia Ugt2b1 34
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007374 33
  • 44.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ugt86Dg 35
  • 35 (a)
CG6475 35
  • 33 (a)
BEST:GH09393 35
  • 31 (a)
Ugt35b 35
  • 31 (a)
CG15661 35
  • 30 (a)
Ugt35a 35
  • 30 (a)
Ugt86Dd 35
  • 30 (a)
Ugt86De 35
  • 28 (a)
CG10170 35
  • 25 (a)
Ugt86Dh 35
  • 25 (a)
CG10168 35
  • 23 (a)
worm
(Caenorhabditis elegans)
Secernentea F39G3.1 35
  • 30 (a)
M88.1 35
  • 30 (a)
C44H9.1 35
  • 26 (a)
Y37E11AR.5 35
  • 26 (a)
F56B3.7 35
  • 25 (a)
T03D3.1 35
  • 24 (a)
Species where no ortholog for UGT2B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B4 Gene

ENSEMBL:
Gene Tree for UGT2B4 (if available)
TreeFam:
Gene Tree for UGT2B4 (if available)

Paralogs for UGT2B4 Gene

Variants for UGT2B4 Gene

Sequence variations from dbSNP and Humsavar for UGT2B4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000049786 -- 69,513,347(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000141981 -- 69,510,655(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000185556 -- 69,501,964(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000187125 -- 69,513,669(-) T/A/C genic_upstream_transcript_variant, intron_variant
rs1000348008 -- 69,518,726(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B4 Gene

Variant ID Type Subtype PubMed ID
nsv967760 CNV duplication 23825009
nsv967759 CNV duplication 23825009
nsv594611 CNV gain 21841781
nsv510892 OTHER complex 20534489
nsv470045 CNV gain 18288195
nsv461548 CNV gain 19166990
esv3893958 CNV gain 25118596
esv3600913 CNV loss 21293372
esv3600909 CNV gain 21293372
esv3600908 CNV gain 21293372
esv2759258 CNV gain+loss 17122850
esv2727783 CNV deletion 23290073
esv2671739 CNV deletion 23128226
dgv5317n100 CNV gain 25217958
dgv1498e212 CNV loss 25503493

Variation tolerance for UGT2B4 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B4 Gene

Disorders for UGT2B4 Gene

Additional Disease Information for UGT2B4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UGT2B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B4 Gene

Publications for UGT2B4 Gene

  1. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PMID: 18161889) Berkhout M … Peters WH (The British journal of surgery 2008) 3 22 44 58
  2. Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol. (PMID: 16849011) Takekuma Y … Sugawara M (Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2006) 3 22 44 58
  3. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (PMID: 15319348) Saeki M … Sawada J (Drug metabolism and disposition: the biological fate of chemicals 2004) 3 22 44 58
  4. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. (PMID: 15318931) Sparks R … McTiernan A (Breast cancer research : BCR 2004) 3 22 44 58
  5. Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. (PMID: 10376768) Lévesque E … Bélanger A (Pharmacogenetics 1999) 3 4 22 58

Products for UGT2B4 Gene

Sources for UGT2B4 Gene

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