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Aliases for UGT2B28 Gene

Aliases for UGT2B28 Gene

  • UDP Glucuronosyltransferase Family 2 Member B28 2 3 5
  • EC 4 56
  • UDP Glycosyltransferase 2 Family, Polypeptide B28 2
  • UDPGT 2B28 4

External Ids for UGT2B28 Gene

Previous GeneCards Identifiers for UGT2B28 Gene

  • GC04M070372
  • GC04P070194
  • GC04P070396
  • GC04P070461
  • GC04P070327
  • GC04P065944

Summaries for UGT2B28 Gene

Entrez Gene Summary for UGT2B28 Gene

  • This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]

GeneCards Summary for UGT2B28 Gene

UGT2B28 (UDP Glucuronosyltransferase Family 2 Member B28) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B11.

UniProtKB/Swiss-Prot for UGT2B28 Gene

  • UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Additional gene information for UGT2B28 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2B28 Gene

Genomics for UGT2B28 Gene

GeneHancer (GH) Regulatory Elements for UGT2B28 Gene

Promoters and enhancers for UGT2B28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I069280 Promoter 0.5 EPDnew 550.8 0.0 -12 0.1 UGT2B28 LOC100533845
GH04I069095 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 12.7 -183.5 -183506 3.8 FOXA2 MLX ARID4B SIN3A DMAP1 ETS1 YY1 ATF7 FOS RXRA UGT2B7 UGT2B28 LOC105377267 UGT2A3 PIR54134 ENSG00000248763
GH04I068946 Promoter/Enhancer 1.9 EPDnew FANTOM5 ENCODE dbSUPER 10.3 -329.8 -329757 7.8 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 ATF7 PAF1 RXRA UGT2A3 LOC105377267 UGT2B7 UGT2B28 UGT2B11 UGT2B15 UGT2B10 LOC101927264
GH04I069053 Enhancer 1.1 Ensembl ENCODE 11.5 -223.4 -223413 7.5 ELF3 PKNOX1 FOXA2 SMAD1 ARID4B DMAP1 BATF THRB RAD21 ZBTB40 LOC105377265 UGT2B7 UGT2B28 LOC105377267 UGT2A3 CSN1S1 ENSG00000248763
GH04I068903 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.8 -372.8 -372791 7.5 CTCF TAL1 CEBPG RAD21 ETS1 POLR2A CBFA2T2 NFE2 SMARCE1 TRIM22 ENSG00000272626 ENSG00000249985 UGT2A3 UGT2B28 UGT2B7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UGT2B28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UGT2B28 gene promoter:

Genomic Locations for UGT2B28 Gene

Genomic Locations for UGT2B28 Gene
14,583 bases
Plus strand

Genomic View for UGT2B28 Gene

Genes around UGT2B28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B28 Gene

Proteins for UGT2B28 Gene

  • Protein details for UGT2B28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronosyltransferase 2B28
    Protein Accession:
    Secondary Accessions:
    • B5BUM0
    • Q9BY62
    • Q9BY63

    Protein attributes for UGT2B28 Gene

    529 amino acids
    Molecular mass:
    60906 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK31809.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for UGT2B28 Gene


neXtProt entry for UGT2B28 Gene

Selected DME Specific Peptides for UGT2B28 Gene


Post-translational modifications for UGT2B28 Gene

  • Glycosylation at posLast=315315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B28 Gene

Domains & Families for UGT2B28 Gene

Gene Families for UGT2B28 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for UGT2B28 Gene

Suggested Antigen Peptide Sequences for UGT2B28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glycosyltransferase family.
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B28: view

Function for UGT2B28 Gene

Molecular function for UGT2B28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Enzyme Numbers (IUBMB) for UGT2B28 Gene

Phenotypes From GWAS Catalog for UGT2B28 Gene

Gene Ontology (GO) - Molecular Function for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B28: view
genes like me logo Genes that share phenotypes with UGT2B28: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B28 Gene

Localization for UGT2B28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B28 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B28 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 11300766
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with UGT2B28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2B28 Gene

Pathways & Interactions for UGT2B28 Gene

genes like me logo Genes that share pathways with UGT2B28: view

Pathways by source for UGT2B28 Gene

Interacting Proteins for UGT2B28 Gene

Gene Ontology (GO) - Biological Process for UGT2B28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process IDA 11300766
GO:0008152 metabolic process IDA 11300766
genes like me logo Genes that share ontologies with UGT2B28: view

No data available for SIGNOR curated interactions for UGT2B28 Gene

Drugs & Compounds for UGT2B28 Gene

(15) Drugs for UGT2B28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 83
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estriol Approved, Investigational, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 22
Eugenol Approved Pharma Activator 0

(82) Additional Compounds for UGT2B28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2B28: view

Transcripts for UGT2B28 Gene

mRNA/cDNA for UGT2B28 Gene

Unigene Clusters for UGT2B28 Gene

UDP glucuronosyltransferase 2 family, polypeptide B28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B28 Gene

No ASD Table

Relevant External Links for UGT2B28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGT2B28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT2B28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B28 Gene

This gene is overexpressed in Bladder (x19.7), Liver (x11.1), Skin - Not Sun Exposed (Suprapubic) (x6.7), and Breast - Mammary Tissue (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT2B28 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT2B28 Gene:


SOURCE GeneReport for Unigene cluster for UGT2B28 Gene:


mRNA Expression by UniProt/SwissProt for UGT2B28 Gene:

Tissue specificity: Expressed in the liver, breast and kidney.
genes like me logo Genes that share expression patterns with UGT2B28: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B28 Gene

Orthologs for UGT2B28 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 94 (a)
UGT2B28 33
  • 93.7 (n)
(Canis familiaris)
Mammalia UGT2B31 34
  • 73 (a)
(Mus musculus)
Mammalia Ugt2b5 33 16
  • 72.34 (n)
Ugt2b34 34
  • 67 (a)
(Rattus norvegicus)
Mammalia Ugt2b 33
  • 70.83 (n)
(Bos Taurus)
Mammalia -- 34
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ugt86Dg 35
  • 34 (a)
Ugt35b 35
  • 33 (a)
Ugt86Dd 35
  • 31 (a)
CG15661 35
  • 30 (a)
Ugt35a 35
  • 30 (a)
Ugt86Di 35
  • 29 (a)
Ugt36Bb 35
  • 28 (a)
CG17323 35
  • 26 (a)
Ugt37b1 35
  • 26 (a)
Ugt36Bc 35
  • 25 (a)
CG10168 35
  • 24 (a)
CG10170 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea M88.1 35
  • 29 (a)
F39G3.1 35
  • 28 (a)
C18C4.3 35
  • 26 (a)
T25B9.7 35
  • 26 (a)
C03A7.11 35
  • 25 (a)
C44H9.1 35
  • 25 (a)
T03D3.1 35
  • 25 (a)
Y37E11AR.5 35
  • 25 (a)
F56B3.7 35
  • 24 (a)
T19H12.11 35
  • 24 (a)
ZC455.3 35
  • 23 (a)
Species where no ortholog for UGT2B28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UGT2B28 Gene

Gene Tree for UGT2B28 (if available)
Gene Tree for UGT2B28 (if available)

Paralogs for UGT2B28 Gene Pseudogenes for UGT2B28 Gene

genes like me logo Genes that share paralogs with UGT2B28: view

Variants for UGT2B28 Gene

Sequence variations from dbSNP and Humsavar for UGT2B28 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000077 -- 69,291,017(+) G/A intron_variant
rs1000114389 -- 69,284,310(+) G/A/C intron_variant
rs10002503 -- 69,291,286(+) G/A intron_variant
rs1000335510 -- 69,290,283(+) A/G intron_variant
rs1000436254 -- 69,291,119(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2B28 Gene

Variant ID Type Subtype PubMed ID
dgv121e203 CNV gain+loss 21179565
dgv17n31 CNV gain 19718026
dgv195n111 CNV deletion 26073780
dgv2821n106 CNV deletion 24896259
dgv5295n100 CNV gain 25217958
dgv5296n100 CNV gain 25217958
dgv5297n100 CNV loss 25217958
dgv5298n100 CNV gain 25217958
dgv5299n100 CNV gain 25217958
dgv5300n100 CNV gain+loss 25217958
dgv5301n100 CNV loss 25217958
dgv5302n100 CNV gain+loss 25217958
dgv5303n100 CNV loss 25217958
dgv5304n100 CNV gain+loss 25217958
dgv5305n100 CNV loss 25217958
dgv5306n100 CNV gain+loss 25217958
dgv5307n100 CNV loss 25217958
dgv5308n100 CNV gain+loss 25217958
dgv5309n100 CNV gain 25217958
dgv5310n100 CNV loss 25217958
dgv5311n100 CNV loss 25217958
dgv5312n100 CNV loss 25217958
dgv5313n100 CNV loss 25217958
dgv5314n100 CNV loss 25217958
dgv844e201 CNV deletion 23290073
dgv845e201 CNV deletion 23290073
dgv878n67 CNV loss 20364138
dgv9113n54 CNV loss 21841781
dgv9114n54 CNV loss 21841781
dgv9115n54 CNV loss 21841781
dgv9116n54 CNV loss 21841781
dgv92n16 CNV deletion 17901297
dgv952e199 CNV deletion 23128226
esv2421696 CNV deletion 20811451
esv2670036 CNV deletion 23128226
esv2727775 CNV deletion 23290073
esv2727780 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv28328 CNV gain+loss 19812545
esv29954 CNV loss 18421352
esv33154 CNV loss 17666407
esv33234 CNV gain 17666407
esv3584807 CNV loss 24956385
esv3600896 CNV loss 21293372
esv3600897 CNV loss 21293372
esv3600898 CNV gain 21293372
esv3893949 CNV loss 25118596
esv3893950 CNV gain 25118596
esv3893951 CNV loss 25118596
nsv1002753 CNV loss 25217958
nsv1006071 CNV loss 25217958
nsv10524 CNV gain+loss 18304495
nsv1067929 OTHER inversion 25765185
nsv1073343 CNV deletion 25765185
nsv1130819 CNV deletion 24896259
nsv436676 OTHER inversion 17901297
nsv436948 CNV loss 16327808
nsv436949 CNV loss 16327808
nsv4374 CNV deletion 18451855
nsv437922 CNV loss 16468122
nsv442911 CNV loss 18776908
nsv469562 CNV loss 16826518
nsv471625 CNV loss 15918152
nsv499045 CNV loss 21111241
nsv510922 OTHER complex 20534489
nsv514224 CNV loss 21397061
nsv594584 CNV loss 21841781
nsv594586 CNV gain 21841781
nsv594594 CNV loss 21841781
nsv594598 CNV loss 21841781
nsv820690 CNV deletion 20802225
nsv822596 CNV loss 20364138
nsv822599 CNV gain 20364138
nsv964063 CNV duplication 23825009
nsv997506 CNV gain 25217958

Variation tolerance for UGT2B28 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.98; 98.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2B28 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B28 Gene

Disorders for UGT2B28 Gene

Additional Disease Information for UGT2B28

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UGT2B28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2B28 Gene

Publications for UGT2B28 Gene

  1. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. (PMID: 11300766) Lévesque E … Bélanger A (Biochemistry 2001) 2 3 4 22 58
  2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 44 58
  3. Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study. (PMID: 28882566) Habibi M … Pouresmaeili F (Gene 2017) 3 58
  4. The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression. (PMID: 26215610) Belledant A … Lévesque E (European urology 2016) 3 58
  5. Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study. (PMID: 21679149) Ohno S … Nakajin S (Drug metabolism letters 2011) 3 58

Products for UGT2B28 Gene

Sources for UGT2B28 Gene

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