This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016] See more...

Aliases for UGT2B15 Gene

Aliases for UGT2B15 Gene

  • UDP Glucuronosyltransferase Family 2 Member B15 2 3 5
  • UGT2B8 2 3 4
  • UDP-Glucuronosyltransferase 2B15 3 4
  • UDP-Glucuronosyltransferase 2B8 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 2B8 3 4
  • HLUG4 3 4
  • Uridine Diphosphate Glucuronosyltransferase 2 Family, Member B8 3
  • Uridine Diphosphate Glycosyltransferase 2 Family, Member B15 3
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B15 3
  • UDP Glycosyltransferase 2 Family, Polypeptide B15 2
  • UDP Glucuronosyltransferase 2 Family, Member 15 3
  • UDP Glucuronosyltransferase 2 Family, Member B8 3
  • UDP-Glucuronyltransferase, Family 2, Beta-15 3
  • UDP Gycosyltransferase 2 Family, Member B15 3
  • UDP-Glucuronosyltransferase UGT2B15 3
  • UDP Glycosyltransferase 2B15 3
  • UDPGT 2B15 4
  • UDPGT2B15 3
  • UDPGTh-3 4
  • EC 2.4.1 50
  • UDPGTH3 3
  • UGT2B15 5

External Ids for UGT2B15 Gene

Previous GeneCards Identifiers for UGT2B15 Gene

  • GC04M069423
  • GC04M069561
  • GC04M069762
  • GC04M069827
  • GC04M069407
  • GC04M069693
  • GC04M065308
  • GC04M068538

Summaries for UGT2B15 Gene

Entrez Gene Summary for UGT2B15 Gene

  • This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016]

GeneCards Summary for UGT2B15 Gene

UGT2B15 (UDP Glucuronosyltransferase Family 2 Member B15) is a Protein Coding gene. Diseases associated with UGT2B15 include Estrogen-Receptor Positive Breast Cancer and Acetaminophen Metabolism. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B17.

UniProtKB/Swiss-Prot Summary for UGT2B15 Gene

  • UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity).

Gene Wiki entry for UGT2B15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT2B15 Gene

Genomics for UGT2B15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT2B15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J068670 Promoter 0.8 EPDnew 250.7 0.0 -20 0.1 CEBPA YY1 CUX1 FOXA1 DPF2 ATF2 NCOA3 CREB1 HLF TAF1 HSALNG0034933 UGT2B15 piR-53360-007 UGT2B10
GH04J068671 Enhancer 0.6 ENCODE 250.7 -0.1 -146 0.2 CEBPA YY1 CUX1 FOXA1 DPF2 ATF2 NCOA3 CREB1 HLF TAF1 HSALNG0034933 UGT2B15 piR-53360-007 UGT2B10
GH04J068673 Enhancer 0.5 Ensembl 250.7 -0.7 -652 0.6 CTCF FOXA1 RAD21 NCOA3 CREB1 FOS HSALNG0034933 UGT2B15 piR-53360-007 UGT2B10
GH04J068451 Enhancer 0.7 Ensembl ENCODE 8.5 +219.0 218951 4.6 NFIC NFE2 NFIB SIX5 POU5F1 NANOG FOS TMPRSS11BNL UGT2B15 UGT2B17 TMPRSS11E HSALNG0034926
GH04J067880 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 4.2 +787.4 787352 8.6 JUND NFE2 SPI1 MAFK BHLHE40 NFE2L2 EP300 FOS TMPRSS11D lnc-TMPRSS11A-5 TMPRSS11GP ENSG00000227725 UGT2B15 piR-32810-081 GNRHR UBA6-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT2B15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT2B15

Top Transcription factor binding sites by QIAGEN in the UGT2B15 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • FOXO1a
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for UGT2B15 Gene

Latest Assembly
chr4:68,646,597-68,670,652
(GRCh38/hg38)
Size:
24,056 bases
Orientation:
Minus strand

Previous Assembly
chr4:69,512,315-69,536,370
(GRCh37/hg19 by Entrez Gene)
Size:
24,056 bases
Orientation:
Minus strand

chr4:69,512,348-69,536,346
(GRCh37/hg19 by Ensembl)
Size:
23,999 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr4(ALT_REF_LOCI_1):222,964-247,007 (-)

Genomic View for UGT2B15 Gene

Genes around UGT2B15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B15 Gene

Proteins for UGT2B15 Gene

  • Protein details for UGT2B15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54855-UDB15_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B15
    Protein Accession:
    P54855
    Secondary Accessions:
    • A6NDX0
    • A6NNJ4
    • A8K054
    • P23765
    • Q9UK63

    Protein attributes for UGT2B15 Gene

    Size:
    530 amino acids
    Molecular mass:
    61036 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UGT2B15 Gene

neXtProt entry for UGT2B15 Gene

Selected DME Specific Peptides for UGT2B15 Gene

P54855:
  • AFITHGG
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • KPLDRAVFWIE
  • IHHDQPMKPLD
  • YWDFEFPRP
  • AAHNLTW
  • YEAIYHG
  • RGHEVTVL
  • FVGGLHC
  • KKWDQFYSEVLGRPTTL
  • PPSYVPV
  • FLLACVA
  • IPQKVLW
  • KLQESKFD
  • ERIKNMI
  • DLLNALK
  • NMKTILEELV
  • LSRIHHDQP
  • VMRHKGA
  • CGKVLVW
  • QYHSLDV
  • KTILEEL
  • NTRLYKW
  • ELLAELFNIP

Post-translational modifications for UGT2B15 Gene

  • Glycosylation at Asn65, Asn316, and Asn483
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • UDB15_HUMAN (2087)

Other Protein References for UGT2B15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT2B15 Gene

Gene Families for UGT2B15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT2B15 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT2B15 Gene

GenScript: Design optimal peptide antigens:
  • UGT2B15 protein (B7ZW53_HUMAN)
  • UDP-glucuronosyltransferase UGT2B15 (Q9UHH3_HUMAN)
  • UDPGTh-3 (UDB15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54855

UniProtKB/Swiss-Prot:

UDB15_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B15: view

Function for UGT2B15 Gene

Molecular function for UGT2B15 Gene

UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:7835232, ECO:0000269|PubMed:9295060};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence={ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52924, ChEBI:CHEBI:15378, ChEBI:CHEBI:42156, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136882; Evidence={ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53000, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136914; Evidence={ECO:0000269|PubMed:16595710};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=26.1 uM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=90 uM for UDP-alpha-D-glucuronate (when assaying glucuronidation with eugenol and 4-methylumbelliferone as substrates) {ECO:0000269|PubMed:7835232}; KM=15 uM for 4-hydroxy-estrone {ECO:0000269|PubMed:7835232}; KM=15 uM for 5alpha-androstane-3alpha,17beta-diol {ECO:0000269|PubMed:7835232}; KM=28 uM for naringenin {ECO:0000269|PubMed:7835232}; KM=78 uM for 4-methylumbelliferone {ECO:0000269|PubMed:7835232}; KM=8 uM for eugenol {ECO:0000269|PubMed:7835232}; KM=180 uM for 4-nitrophenol {ECO:0000269|PubMed:7835232}; KM=30 uM for 4-hydroxybiphenyl {ECO:0000269|PubMed:7835232}; Vmax=350 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=5 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=10.1 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=88.1 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=9.4 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=349 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=12.3 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=388 pmol/min/mg enzyme for the formation of 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:16595710}; Vmax=14 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone glucuronide {ECO:0000269|PubMed:7835232}; Vmax=49 pmol/min/mg enzyme for the formation of 5alpha-androstane-3alpha,17beta-diol glucuronide {ECO:0000269|PubMed:7835232}; Vmax=72 pmol/min/mg enzyme for the formation of naringenin glucuronide {ECO:0000269|PubMed:7835232}; Vmax=5 pmol/min/mg enzyme for the formation of 4-methylumbelliferone glucuronide {ECO:0000269|PubMed:7835232}; Vmax=100 pmol/min/mg enzyme for the formation of eugenol glucuronide {ECO:0000269|PubMed:7835232}; Vmax=23 pmol/min/mg enzyme for the formation of 4-nitrophenol glucuronide {ECO:0000269|PubMed:7835232}; Vmax=55 pmol/min/mg enzyme for the formation of 4-hydroxybiphenyl glucuronide {ECO:0000269|PubMed:7835232}; Note=Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values. {ECO:0000305|PubMed:16595710, ECO:0000305|PubMed:18719240, ECO:0000305|PubMed:23288867};
GENATLAS Biochemistry:
UDP glucuronosyltransferase subfamily 2,liver specific,conjugating bile acid

Enzyme Numbers (IUBMB) for UGT2B15 Gene

Phenotypes From GWAS Catalog for UGT2B15 Gene

Gene Ontology (GO) - Molecular Function for UGT2B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0008194 UDP-glycosyltransferase activity IEA,IBA 21873635
GO:0015020 glucuronosyltransferase activity IEA,IDA 18719240
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B15: view
genes like me logo Genes that share phenotypes with UGT2B15: view

miRNA for UGT2B15 Gene

miRTarBase miRNAs that target UGT2B15

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2B15

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B15 Gene

Localization for UGT2B15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B15 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B15 gene
Compartment Confidence
peroxisome 3
plasma membrane 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UGT2B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with UGT2B15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2B15 Gene

Pathways & Interactions for UGT2B15 Gene

genes like me logo Genes that share pathways with UGT2B15: view

Gene Ontology (GO) - Biological Process for UGT2B15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS 7835232
GO:0008202 steroid metabolic process TAS 7835232
GO:0008210 estrogen metabolic process IDA 18719240
GO:0052695 cellular glucuronidation IDA 18719240
genes like me logo Genes that share ontologies with UGT2B15: view

No data available for SIGNOR curated interactions for UGT2B15 Gene

Drugs & Compounds for UGT2B15 Gene

(52) Drugs for UGT2B15 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lorazepam Approved Pharma Enzyme, substrate 145
Estradiol Approved, Investigational, Vet_approved Pharma Enzyme, Enzyme, inducer, substrate Sex hormone 1160
Acetaminophen Approved Pharma Enzyme, substrate 1412
Oxazepam Approved Pharma Enzyme, substrate 11
Ezetimibe Approved Pharma Enzyme, substrate Cholesterol transport inhibitor 356

(84) Additional Compounds for UGT2B15 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-alpha-Estradiol-3-glucuronide
  • 17-a-Estradiol-3-glucuronide
  • 17-Α-estradiol-3-glucuronide
17-beta-Estradiol glucuronide
  • 17-b-Estradiol glucuronide
  • 17-Β-estradiol glucuronide
  • beta-Estradiol 17-beta-D-glucuronide
  • e(2)17g CPD
  • Estradiol-17 beta-glucuronide, monosodium salt
genes like me logo Genes that share compounds with UGT2B15: view

Transcripts for UGT2B15 Gene

mRNA/cDNA for UGT2B15 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2B15

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B15 Gene

No ASD Table

Relevant External Links for UGT2B15 Gene

GeneLoc Exon Structure for
UGT2B15

Expression for UGT2B15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2B15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B15 Gene

This gene is overexpressed in Liver (x28.8), Colon - Transverse (x11.7), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for UGT2B15 Gene

This gene is overexpressed in Liver (33.6) and Gallbladder (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT2B15 Gene



Protein tissue co-expression partners for UGT2B15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT2B15

SOURCE GeneReport for Unigene cluster for UGT2B15 Gene:

Hs.150207

mRNA Expression by UniProt/SwissProt for UGT2B15 Gene:

P54855-UDB15_HUMAN
Tissue specificity: Expressed in many tissues. Present in liver, prostate and testis.

Evidence on tissue expression from TISSUES for UGT2B15 Gene

  • Liver(4.8)
  • Intestine(2.3)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with UGT2B15: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B15 Gene

Orthologs for UGT2B15 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UGT2B15 29 30
  • 99.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 76 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Ugt2b37 29
  • 73.55 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 70 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ugt2b38 30
  • 67 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ugt35a 31
  • 36 (a)
Ugt86Dg 31
  • 35 (a)
CG6475 31
  • 35 (a)
Ugt86Dj 31
  • 34 (a)
Ugt86Di 31
  • 34 (a)
BEST:GH09393 31
  • 33 (a)
Ugt86Da 31
  • 33 (a)
Ugt35b 31
  • 31 (a)
CG11289 31
  • 31 (a)
CG15661 31
  • 30 (a)
Ugt37c1 31
  • 30 (a)
Ugt36Bc 31
  • 30 (a)
Ugt37a1 31
  • 30 (a)
Ugt86Dd 31
  • 30 (a)
BEST:GH06505 31
  • 30 (a)
Ugt86Dc 31
  • 29 (a)
Ugt36Ba 31
  • 29 (a)
Ugt36Bb 31
  • 28 (a)
Ugt37b1 31
  • 27 (a)
CG10178 31
  • 27 (a)
Ugt86De 31
  • 26 (a)
CG5999 31
  • 26 (a)
CG17323 31
  • 26 (a)
CG10168 31
  • 25 (a)
Ugt86Dh 31
  • 25 (a)
CG5724 31
  • 25 (a)
CG16732 31
  • 24 (a)
CG10170 31
  • 24 (a)
Dot 31
  • 24 (a)
Worm
(Caenorhabditis elegans)
Secernentea M88.1 31
  • 31 (a)
F39G3.1 31
  • 29 (a)
F35H8.6 31
  • 28 (a)
C33A12.6 31
  • 27 (a)
T19H12.11 31
  • 25 (a)
C44H9.1 31
  • 25 (a)
C17G1.3 31
  • 25 (a)
T07C5.1a 31
  • 24 (a)
Y37E11AR.5 31
  • 24 (a)
R04B5.9 31
  • 24 (a)
T03D3.1 31
  • 24 (a)
ZC455.3 31
  • 24 (a)
F56B3.7 31
  • 24 (a)
C08F11.8 31
  • 23 (a)
C08B6.1 31
  • 23 (a)
F01D4.1 31
  • 23 (a)
Species where no ortholog for UGT2B15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for UGT2B15 Gene

ENSEMBL:
Gene Tree for UGT2B15 (if available)
TreeFam:
Gene Tree for UGT2B15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT2B15: view image
Alliance of Genome Resources:
Additional Orthologs for UGT2B15

Paralogs for UGT2B15 Gene

(31) SIMAP similar genes for UGT2B15 Gene using alignment to 3 proteins:

  • UDB15_HUMAN
  • B7ZW53_HUMAN
  • Q9UHH3_HUMAN

Pseudogenes.org Pseudogenes for UGT2B15 Gene

genes like me logo Genes that share paralogs with UGT2B15: view

Variants for UGT2B15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT2B15 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs146711063 Benign: not provided 68,647,117(-) T/C
NM_001076.4(UGT2B15):c.1580A>G (p.Lys527Arg)
MISSENSE
rs147164238 Likely Benign: not provided 68,647,289(-) G/A
NM_001076.4(UGT2B15):c.1408C>T (p.Arg470Cys)
MISSENSE
rs1902023 Drug Response: oxazepam response - Other; lorazepam response - Other 68,670,366(-) A/Cp.Tyr85Asp
NM_001076.4(UGT2B15):c.253T>G (p.Tyr85Asp)
MISSENSE
rs1993282 Benign: not provided 68,668,031(-) T/C
NM_001076.4(UGT2B15):c.873+9A>G
INTRON
rs74987674 Benign: not provided 68,670,445(-) A/C
NM_001076.4(UGT2B15):c.174T>G (p.Ser58=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT2B15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT2B15 Gene

Variant ID Type Subtype PubMed ID
dgv1491e212 CNV gain 25503493
dgv1495e212 CNV gain 25503493
dgv1496e212 CNV loss 25503493
dgv5242n100 CNV gain 25217958
dgv5251n100 CNV gain 25217958
dgv5264n100 CNV gain+loss 25217958
dgv5269n100 CNV gain 25217958
dgv5278n100 CNV gain+loss 25217958
dgv5279n100 CNV gain 25217958
dgv5289n100 CNV gain+loss 25217958
dgv843e201 CNV deletion 23290073
dgv9104n54 CNV loss 21841781
dgv9111n54 CNV gain 21841781
esv2669141 CNV deletion 23128226
esv2727770 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv28502 CNV gain 19812545
esv3569485 CNV loss 25503493
esv3569501 CNV loss 25503493
esv3600876 CNV loss 21293372
esv3600877 CNV gain 21293372
esv3893940 CNV gain+loss 25118596
esv3893946 CNV gain+loss 25118596
esv3893947 CNV loss 25118596
nsv1003250 CNV gain 25217958
nsv10516 CNV gain 18304495
nsv1073770 CNV deletion 25765185
nsv1119005 CNV deletion 24896259
nsv1122086 CNV deletion 24896259
nsv594577 CNV gain 21841781
nsv820369 CNV deletion 20802225
nsv822582 CNV loss 20364138
nsv964055 CNV duplication 23825009

Variation tolerance for UGT2B15 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2B15 Gene

Human Gene Mutation Database (HGMD)
UGT2B15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B15
Leiden Open Variation Database (LOVD)
UGT2B15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B15 Gene

Disorders for UGT2B15 Gene

MalaCards: The human disease database

(6) MalaCards diseases for UGT2B15 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
estrogen-receptor positive breast cancer
acetaminophen metabolism
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
prostate cancer
  • prostate cancer, somatic
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT2B15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT2B15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT2B15 Gene

Publications for UGT2B15 Gene

  1. A major genotype in UDP-glucuronosyltransferase 2B15. (PMID: 15618667) Toide K … Kamataki T (Drug metabolism and pharmacokinetics 2002) 3 4 22 40
  2. Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. (PMID: 19916996) He X … Court MH (British journal of clinical pharmacology 2009) 3 22 40
  3. Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes. (PMID: 18496127) Schulze JJ … Ekström L (Pharmacogenetics and genomics 2008) 3 22 40
  4. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PMID: 18161889) Berkhout M … Peters WH (The British journal of surgery 2008) 3 22 40
  5. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. (PMID: 17244352) Wegman P … Wingren S (Breast cancer research : BCR 2007) 3 22 40

Products for UGT2B15 Gene

Sources for UGT2B15 Gene