Aliases for UGT2B11 Gene

Aliases for UGT2B11 Gene

  • UDP Glucuronosyltransferase Family 2 Member B11 2 3 5
  • UDP Glycosyltransferase 2 Family, Polypeptide B11 2 3
  • UDP-Glucuronosyltransferase 2B11 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 2B11 3 4
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B11 3
  • UDP Glycosyltransferase 2 Family Protein 3
  • UGT2B11 5

External Ids for UGT2B11 Gene

Previous GeneCards Identifiers for UGT2B11 Gene

  • GC04M069976
  • GC04M070114
  • GC04M070315
  • GC04M070185
  • GC04M070187
  • GC04M070051
  • GC04M069905
  • GC04M069871
  • GC04M065861
  • GC04M069005

Summaries for UGT2B11 Gene

GeneCards Summary for UGT2B11 Gene

UGT2B11 (UDP Glucuronosyltransferase Family 2 Member B11) is a Protein Coding gene. Diseases associated with UGT2B11 include Fascioliasis and Crigler-Najjar Syndrome, Type I. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B28.

UniProtKB/Swiss-Prot Summary for UGT2B11 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT2B11 Gene

Genomics for UGT2B11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT2B11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT2B11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT2B11

Top Transcription factor binding sites by QIAGEN in the UGT2B11 gene promoter:
  • C/EBPalpha
  • FAC1
  • FOXD1
  • FOXO1
  • FOXO1a
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Nkx2-5

Genomic Locations for UGT2B11 Gene

Latest Assembly
chr4:69,199,951-69,224,980
(GRCh38/hg38)
Size:
25,030 bases
Orientation:
Minus strand

Previous Assembly
chr4:70,065,669-70,080,466
(GRCh37/hg19 by Entrez Gene)
Size:
14,798 bases
Orientation:
Minus strand

chr4:70,065,669-70,080,449
(GRCh37/hg19 by Ensembl)
Size:
14,781 bases
Orientation:
Minus strand

Genomic View for UGT2B11 Gene

Genes around UGT2B11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B11 Gene

Proteins for UGT2B11 Gene

  • Protein details for UGT2B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75310-UDB11_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2B11
    Protein Accession:
    O75310
    Secondary Accessions:
    • Q3KNV9

    Protein attributes for UGT2B11 Gene

    Size:
    529 amino acids
    Molecular mass:
    61038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UGT2B11 Gene

Selected DME Specific Peptides for UGT2B11 Gene

O75310:
  • DLLNALK
  • GHPKTRAFITH
  • AFITHGG
  • FPHPFLPN
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • FWLYFSQ
  • CKDVVSNK
  • AAHDLTW
  • KPLDRAVFWIE
  • KLQESRFD
  • WMNMKTIL
  • YEAIYHG
  • RGHEVTVL
  • MTFMERV
  • CGKVLVW
  • QYHSLDV
  • TMSSTDL
  • DVIGFLL
  • KKWDQFYSEVLGRPTTL
  • WIPQNDLLG
  • FLLACVA
  • NALKTVINDP
  • IPQKVLW
  • NTRLYKW
  • DQPDNIAHMK
  • THGGANG
  • ERVKNMIY

Post-translational modifications for UGT2B11 Gene

  • Glycosylation at Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B11 Gene

Domains & Families for UGT2B11 Gene

Gene Families for UGT2B11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT2B11 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT2B11 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 2B11 (UDB11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75310

UniProtKB/Swiss-Prot:

UDB11_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B11: view

Function for UGT2B11 Gene

Molecular function for UGT2B11 Gene

UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;.

Enzyme Numbers (IUBMB) for UGT2B11 Gene

Phenotypes From GWAS Catalog for UGT2B11 Gene

Gene Ontology (GO) - Molecular Function for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008194 UDP-glycosyltransferase activity IEA,IBA 21873635
GO:0015020 glucuronosyltransferase activity IEA,IDA 8333863
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B11: view
genes like me logo Genes that share phenotypes with UGT2B11: view

miRNA for UGT2B11 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2B11

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B11 Gene

Localization for UGT2B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B11 Gene

Microsome membrane. Single-pass membrane protein. Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B11 gene
Compartment Confidence
peroxisome 3
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with UGT2B11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2B11 Gene

Pathways & Interactions for UGT2B11 Gene

genes like me logo Genes that share pathways with UGT2B11: view

Pathways by source for UGT2B11 Gene

2 BioSystems pathways for UGT2B11 Gene
1 GeneGo (Thomson Reuters) pathway for UGT2B11 Gene
  • Estradiol metabolism

Gene Ontology (GO) - Biological Process for UGT2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS 8333863
GO:0008210 estrogen metabolic process IDA 8333863
GO:0052697 xenobiotic glucuronidation IDA 8333863
genes like me logo Genes that share ontologies with UGT2B11: view

No data available for SIGNOR curated interactions for UGT2B11 Gene

Drugs & Compounds for UGT2B11 Gene

(17) Drugs for UGT2B11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma 98
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1160
Estriol Approved, Investigational, Vet_approved Pharma 0
Estrone Approved Pharma Estrogenic hormone 24
Morphine Approved, Investigational Pharma 1511

(78) Additional Compounds for UGT2B11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-alpha-Estradiol-3-glucuronide
  • 17-a-Estradiol-3-glucuronide
  • 17-Α-estradiol-3-glucuronide
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide)
  • Estradiol 17beta-glucuronide 3-sulfate
  • Estradiol 17b-glucuronide 3-sulfate
  • Estradiol 17b-glucuronide 3-sulfuric acid
  • Estradiol 17b-glucuronide 3-sulphate
  • Estradiol 17b-glucuronide 3-sulphuric acid
genes like me logo Genes that share compounds with UGT2B11: view

Transcripts for UGT2B11 Gene

mRNA/cDNA for UGT2B11 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2B11

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B11 Gene

No ASD Table

Relevant External Links for UGT2B11 Gene

GeneLoc Exon Structure for
UGT2B11

Expression for UGT2B11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2B11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B11 Gene

This gene is overexpressed in Liver (x21.4), Breast - Mammary Tissue (x10.4), and Kidney - Cortex (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT2B11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT2B11

SOURCE GeneReport for Unigene cluster for UGT2B11 Gene:

Hs.339811

mRNA Expression by UniProt/SwissProt for UGT2B11 Gene:

O75310-UDB11_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for UGT2B11 Gene

  • Liver(2.9)
genes like me logo Genes that share expression patterns with UGT2B11: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B11 Gene

Orthologs for UGT2B11 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2B11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UGT2B11 29
  • 97.42 (n)
-- 30
  • 96 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 81 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia RGD1559459 29
  • 74.86 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 70 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 64 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ugt2b37 30
  • 63 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6475 29 31
  • 47.38 (n)
Ugt86Da 31
  • 35 (a)
Ugt86Dg 31
  • 34 (a)
Ugt35b 31
  • 32 (a)
CG11289 31
  • 32 (a)
Ugt37a1 31
  • 31 (a)
Ugt86Dd 31
  • 31 (a)
Ugt35a 31
  • 30 (a)
CG15661 31
  • 29 (a)
Ugt36Bb 31
  • 28 (a)
Ugt36Bc 31
  • 27 (a)
Ugt86Dj 31
  • 26 (a)
CG5999 31
  • 26 (a)
Ugt37b1 31
  • 26 (a)
CG10170 31
  • 25 (a)
CG10168 31
  • 24 (a)
Worm
(Caenorhabditis elegans)
Secernentea M88.1 31
  • 29 (a)
F39G3.1 31
  • 28 (a)
F35H8.6 31
  • 27 (a)
C18C4.3 31
  • 26 (a)
C03A7.11 31
  • 25 (a)
Y37E11AR.5 31
  • 25 (a)
C08B6.1 31
  • 25 (a)
C44H9.1 31
  • 25 (a)
T03D3.1 31
  • 25 (a)
F56B3.7 31
  • 25 (a)
R04B5.9 31
  • 24 (a)
T19H12.11 31
  • 23 (a)
Species where no ortholog for UGT2B11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for UGT2B11 Gene

ENSEMBL:
Gene Tree for UGT2B11 (if available)
TreeFam:
Gene Tree for UGT2B11 (if available)
Alliance of Genome Resources:
Additional Orthologs for UGT2B11

Paralogs for UGT2B11 Gene

(27) SIMAP similar genes for UGT2B11 Gene using alignment to 2 proteins:

  • UDB11_HUMAN
  • Q4W5B9_HUMAN
genes like me logo Genes that share paralogs with UGT2B11: view

Variants for UGT2B11 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT2B11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT2B11 Gene

Variant ID Type Subtype PubMed ID
dgv17n31 CNV gain 19718026
dgv844e201 CNV deletion 23290073
esv2670036 CNV deletion 23128226
esv2671471 CNV deletion 23128226
esv2727775 CNV deletion 23290073
esv2727780 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv28328 CNV gain+loss 19812545
esv3600894 CNV gain 21293372
esv3893950 CNV gain 25118596
esv3893952 CNV loss 25118596
nsv1002753 CNV loss 25217958
nsv1002926 CNV loss 25217958
nsv1013269 CNV gain 25217958
nsv10524 CNV gain+loss 18304495
nsv1067929 OTHER inversion 25765185
nsv1130819 CNV deletion 24896259
nsv482088 CNV gain 20164927
nsv519544 CNV gain+loss 19592680
nsv594584 CNV loss 21841781
nsv980214 CNV duplication 23825009
nsv999654 CNV gain 25217958

Variation tolerance for UGT2B11 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2B11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2B11
Leiden Open Variation Database (LOVD)
UGT2B11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT2B11 Gene

Disorders for UGT2B11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT2B11 Gene - From: COP

Disorder Aliases PubMed IDs
fascioliasis
  • fasciola hepatica infection
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT2B11

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT2B11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT2B11 Gene

Publications for UGT2B11 Gene

  1. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11. (PMID: 9675083) Beaulieu M … Bélanger A (Biochemical and biophysical research communications 1998) 2 3 4
  2. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J … Hall P (Breast cancer research : BCR 2010) 3 40
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 40
  4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for UGT2B11 Gene

Sources for UGT2B11 Gene