Aliases for UGT2B10 Gene

Aliases for UGT2B10 Gene

  • UDP Glucuronosyltransferase Family 2 Member B10 2 3 5
  • UDP-Glucuronosyltransferase 2B10 3 4
  • EC 4 50
  • UDPGT 2B10 3 4
  • UDP Glucuronosyltransferase 2 Family, Polypeptide B10 3
  • UDP Glycosyltransferase 2 Family, Polypeptide B10 2
  • UDPGT2B10 3
  • UGT2B10 5

External Ids for UGT2B10 Gene

Previous GeneCards Identifiers for UGT2B10 Gene

  • GC04P069592
  • GC04P069730
  • GC04P069931
  • GC04P069997
  • GC04P069862
  • GC04P065477

Summaries for UGT2B10 Gene

GeneCards Summary for UGT2B10 Gene

UGT2B10 (UDP Glucuronosyltransferase Family 2 Member B10) is a Protein Coding gene. Diseases associated with UGT2B10 include Crigler-Najjar Syndrome, Type I and Gilbert Syndrome. Among its related pathways are Drug metabolism - cytochrome P450 and Imipramine/Desipramine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2B11.

UniProtKB/Swiss-Prot Summary for UGT2B10 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Wiki entry for UGT2B10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT2B10 Gene

Genomics for UGT2B10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT2B10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J068815 Promoter/Enhancer 1.2 EPDnew Ensembl 250.7 +0.4 406 1.2 SSRP1 KLF9 CEBPA MXD4 FOXA1 KLF11 ZFP64 HOMEZ KMT2B THAP11 UGT2B10 ENSG00000272626 HSALNG0034940 UGT2A3
GH04J068731 Enhancer 1.3 FANTOM5 Ensembl ENCODE 3.2 -81.7 -81730 5.9 SSRP1 CEBPA ATF3 YY1 HOMEZ THAP11 FOXA2 KDM6A MAFF SMAD4 ENSG00000250376 TMPRSS11E UGT2A3 UGT2B7 ENSG00000272626 UGT2B10 UGT2B11 UGT2B15 lnc-UGT2B15-1 LOC728811
GH04J068946 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 +134.7 134717 7.8 NCOR1 SSRP1 CEBPA ATF3 CHD4 YY1 KLF11 HOMEZ KMT2B THAP11 UGT2A3 LOC105377267 UGT2B7 UGT2B28 UGT2B11 UGT2B15 UGT2B10 piR-55194-259
GH04J068817 Enhancer 0.8 Ensembl 0.7 +2.3 2306 0.6 CEBPA YY1 HOMEZ FOXA2 RXRA SAP130 TEAD3 ZSCAN9 CREM FOXP1 UGT2B10 HSALNG0034940 UGT2A3
GH04J068863 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.3 +49.5 49478 3.7 NCOR1 CEBPA NFIC YY1 NONO REST FOXA1 KLF11 HES1 BHLHE40 piR-30791-070 piR-30876-085 UGT2A3 ENSG00000272626 ENSG00000251529 lnc-UGT2A3-8 LOC101930041 UGT2B10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT2B10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT2B10

Top Transcription factor binding sites by QIAGEN in the UGT2B10 gene promoter:
  • AML1a
  • C/EBPbeta
  • FOXD1
  • FOXO1
  • FOXO1a
  • Meis-1
  • Meis-1a
  • Pax-4a

Genomic Locations for UGT2B10 Gene

Latest Assembly
16,045 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
16,030 bases
Plus strand

(GRCh37/hg19 by Ensembl)
15,204 bases
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr4(ALT_REF_LOCI_1):392,013-408,042 (+)

Genomic View for UGT2B10 Gene

Genes around UGT2B10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2B10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2B10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2B10 Gene

Proteins for UGT2B10 Gene

  • Protein details for UGT2B10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronosyltransferase 2B10
    Protein Accession:
    Secondary Accessions:
    • A8K9M3
    • B4DPP1
    • Q14CR8

    Protein attributes for UGT2B10 Gene

    528 amino acids
    Molecular mass:
    60774 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UGT2B10 Gene


neXtProt entry for UGT2B10 Gene

Selected DME Specific Peptides for UGT2B10 Gene


Post-translational modifications for UGT2B10 Gene

  • Glycosylation at Asn66, Asn314, and Asn481
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2B10 Gene

Antibodies for research

  • Abcam antibodies for UGT2B10
  • Boster Bio Antibodies for UGT2B10
  • Santa Cruz Biotechnology (SCBT) Antibodies for UGT2B10

Domains & Families for UGT2B10 Gene

Gene Families for UGT2B10 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT2B10 Gene

  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT2B10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54605, highly similar to UDP-glucuronosyltransferase 2B10 (EC (B4DPP1_HUMAN)
  • UDP-glucuronosyltransferase 2B10 (UDB10_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glycosyltransferase family.
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2B10: view

Function for UGT2B10 Gene

Molecular function for UGT2B10 Gene

UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=;.

Enzyme Numbers (IUBMB) for UGT2B10 Gene

Phenotypes From GWAS Catalog for UGT2B10 Gene

Gene Ontology (GO) - Molecular Function for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IEA,IBA 21873635
GO:0015020 NOT glucuronosyltransferase activity IDA 8333863
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2B10: view
genes like me logo Genes that share phenotypes with UGT2B10: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2B10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2B10 Gene

Localization for UGT2B10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2B10 Gene

Microsome membrane. Single-pass membrane protein. Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2B10 gene
Compartment Confidence
peroxisome 3
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
cytoskeleton 0

Gene Ontology (GO) - Cellular Components for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with UGT2B10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2B10 Gene

Pathways & Interactions for UGT2B10 Gene

genes like me logo Genes that share pathways with UGT2B10: view

Gene Ontology (GO) - Biological Process for UGT2B10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8333863
genes like me logo Genes that share ontologies with UGT2B10: view

No data available for SIGNOR curated interactions for UGT2B10 Gene

Drugs & Compounds for UGT2B10 Gene

(26) Drugs for UGT2B10 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amitriptyline Approved Pharma Enzyme, substrate, inhibitor 116
Cyclobenzaprine Approved Pharma Enzyme, substrate 51
Cyproheptadine Approved Pharma Enzyme, substrate 18
Ketotifen Approved Pharma Enzyme, substrate 30
Loratadine Approved, Investigational Pharma Enzyme Peripheral HH1R antagonist 83

(35) Additional Compounds for UGT2B10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
  • 17beta-Estradiol 3-(beta-D-glucuronide)
  • 17beta-Estradiol 3-glucuronide
  • Estradiol-3-glucuronide
  • 17b-Estradiol 3-(b-D-glucuronide)
  • 17β-estradiol 3-(β-D-glucuronide)
  • (3alpha,5alpha,17beta)-17-Hydroxyandrostan-3-yl-beta-D-glucopyranosiduronic acid
  • (3alpha,5alpha,17beta)-17-Hydroxyandrostan-3-yl-beta-delta-glucopyranosiduronic acid
  • 17-Hydroxyandrostane-3-glucuronoside
  • 17beta-Hydroxy-5alpha-androstan-3alpha-yl-glucosiduronic acid
  • Adiol 3-g
  • 2,2,2-Trichloro-1-ethanol
  • Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-ethanol
2-Methoxy-estradiol-17b 3-glucuronide
  • (17beta)-17-Hydroxy-2-methoxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid
  • 2-MeOE2 3g
  • 2-Methoxy-17beta-estradiol 3-beta-D-glucuronide
  • 2-Methoxy-17beta-estradiol 3-beta-glucuronide
  • 2-Methoxy-17beta-estradiol 3-glucosiduronic acid
genes like me logo Genes that share compounds with UGT2B10: view

Transcripts for UGT2B10 Gene

mRNA/cDNA for UGT2B10 Gene

6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2B10

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2B10 Gene

No ASD Table

Relevant External Links for UGT2B10 Gene

GeneLoc Exon Structure for

Expression for UGT2B10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2B10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2B10 Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for UGT2B10 Gene

This gene is overexpressed in Liver (43.8) and Gallbladder (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGT2B10 Gene

Protein tissue co-expression partners for UGT2B10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT2B10

SOURCE GeneReport for Unigene cluster for UGT2B10 Gene:


Evidence on tissue expression from TISSUES for UGT2B10 Gene

  • Liver(4.7)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with UGT2B10: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2B10 Gene

Orthologs for UGT2B10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UGT2B10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UGT2B10 29 30
  • 99.05 (n)
(Mus musculus)
Mammalia Ugt2b34 29 16
  • 76.9 (n)
Ugt2b5 30
  • 64 (a)
(Rattus norvegicus)
Mammalia Ugt2b10 29
  • 75.82 (n)
(Canis familiaris)
Mammalia -- 30
  • 73 (a)
(Bos Taurus)
Mammalia -- 30
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 64 (a)
Species where no ortholog for UGT2B10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for UGT2B10 Gene

Gene Tree for UGT2B10 (if available)
Gene Tree for UGT2B10 (if available)
Evolutionary constrained regions (ECRs) for UGT2B10: view image
Alliance of Genome Resources:
Additional Orthologs for UGT2B10

Paralogs for UGT2B10 Gene

(28) SIMAP similar genes for UGT2B10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UGT2B10: view

Variants for UGT2B10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT2B10 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs61750900 Drug Response: nicotine response - Metabolism/PK 68,816,218(+) G/T
NM_001075.6(UGT2B10):c.199G>T (p.Asp67Tyr)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT2B10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT2B10 Gene

Variant ID Type Subtype PubMed ID
dgv1004e214 CNV loss 21293372
dgv5291n100 CNV gain 25217958
dgv5292n100 CNV loss 25217958
dgv5293n100 CNV gain 25217958
esv21679 CNV gain 19812545
esv2421961 CNV duplication 20811451
esv2660681 CNV deletion 23128226
esv2672025 CNV deletion 23128226
esv2727775 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv2760902 CNV gain 21179565
esv3368609 OTHER inversion 20981092
esv3569505 CNV loss 25503493
esv3600886 CNV gain 21293372
esv3600887 CNV loss 21293372
esv3600890 CNV gain 21293372
esv3893952 CNV loss 25118596
nsv1001923 CNV gain 25217958
nsv1004225 CNV gain+loss 25217958
nsv10521 CNV loss 18304495
nsv1074180 CNV deletion 25765185
nsv1122086 CNV deletion 24896259
nsv1145032 CNV deletion 24896259
nsv441886 CNV gain 18776908
nsv461547 CNV loss 19166990
nsv594580 CNV loss 21841781
nsv594581 CNV loss 21841781
nsv594582 CNV loss 21841781
nsv829962 CNV gain 17160897
nsv980211 CNV duplication 23825009
nsv980213 CNV duplication 23825009
nsv999654 CNV gain 25217958

Variation tolerance for UGT2B10 Gene

Gene Damage Index Score: 4.78; 66.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2B10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2B10 Gene

Disorders for UGT2B10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UGT2B10 Gene - From: COP

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT2B10

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT2B10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT2B10 Gene

Publications for UGT2B10 Gene

  1. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. (PMID: 18300939) Chen G … Lazarus P (Pharmacogenetics and genomics 2008) 3 22 40
  2. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. (PMID: 17576790) Kaivosaari S … Finel M (Molecular pharmacology 2007) 3 22 25
  3. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. (PMID: 8333863) Jin CJ … Mackenzie PI (Biochemical and biophysical research communications 1993) 2 3 4
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for UGT2B10 Gene

Sources for UGT2B10 Gene