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Aliases for UGT2A3 Gene

Aliases for UGT2A3 Gene

  • UDP Glucuronosyltransferase Family 2 Member A3 2 3 5
  • EC 2.4.1.17 4 56
  • UDP Glucuronosyltransferase 2 Family, Polypeptide A3 2
  • UDPGT 2A3 4

External Ids for UGT2A3 Gene

Previous GeneCards Identifiers for UGT2A3 Gene

  • GC04M069975
  • GC04M069828
  • GC04M065589

Summaries for UGT2A3 Gene

GeneCards Summary for UGT2A3 Gene

UGT2A3 (UDP Glucuronosyltransferase Family 2 Member A3) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot for UGT2A3 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Additional gene information for UGT2A3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT2A3 Gene

Genomics for UGT2A3 Gene

GeneHancer (GH) Regulatory Elements for UGT2A3 Gene

Promoters and enhancers for UGT2A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I068946 Promoter/Enhancer 1.9 EPDnew FANTOM5 ENCODE dbSUPER 560 +1.1 1087 7.8 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 ATF7 PAF1 RXRA UGT2A3 LOC105377267 UGT2B7 UGT2B28 UGT2B11 UGT2B15 UGT2B10 LOC101927264
GH04I069095 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 5.3 -145.2 -145164 3.8 FOXA2 MLX ARID4B SIN3A DMAP1 ETS1 YY1 ATF7 FOS RXRA UGT2B7 UGT2B28 LOC105377267 UGT2A3 PIR54134 ENSG00000248763
GH04I068863 Enhancer 1.2 ENCODE dbSUPER 6.9 +86.3 86326 3.7 PKNOX1 SMAD1 FOXA2 ARNT ARID4B DMAP1 ZNF766 SP5 NFYC REST UGT2A3 ENSG00000272626 ENSG00000249235 ENSG00000251529
GH04I068903 Enhancer 1.1 Ensembl ENCODE dbSUPER 7 +44.1 44121 7.5 CTCF TAL1 CEBPG RAD21 ETS1 POLR2A CBFA2T2 NFE2 SMARCE1 TRIM22 ENSG00000272626 ENSG00000249985 UGT2A3 UGT2B28 UGT2B7
GH04I068870 Enhancer 1 ENCODE dbSUPER 7.7 +78.9 78929 4.6 ELF3 FOXA2 RAD21 YY1 NCOA2 CREM RXRA CEBPB PPARG TGIF2 LOC100422026 UGT2A3 ENSG00000272626 ENSG00000251529 ENSG00000249235
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UGT2A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UGT2A3 gene promoter:

Genomic Locations for UGT2A3 Gene

Genomic Locations for UGT2A3 Gene
chr4:68,928,459-68,951,798
(GRCh38/hg38)
Size:
23,340 bases
Orientation:
Minus strand
chr4:69,794,177-69,817,509
(GRCh37/hg19)

Genomic View for UGT2A3 Gene

Genes around UGT2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A3 Gene

Proteins for UGT2A3 Gene

  • Protein details for UGT2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM9-UD2A3_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A3
    Protein Accession:
    Q6UWM9
    Secondary Accessions:
    • Q9H6S4

    Protein attributes for UGT2A3 Gene

    Size:
    527 amino acids
    Molecular mass:
    60254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UGT2A3 Gene

Selected DME Specific Peptides for UGT2A3 Gene

Q6UWM9:
  • AFITHGG
  • SHWLNVK
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • AAHDLTW
  • KPLDRAVFWIE
  • YEAIYHG
  • RGHEVTVL
  • FVGGLHC
  • DVIGFLL
  • WIPQNDLLG
  • IPQKVLW
  • VMRHKGA
  • LSRIHHDQP
  • CGKVLVW

Post-translational modifications for UGT2A3 Gene

Other Protein References for UGT2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT2A3 Gene

Gene Families for UGT2A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT2A3 Gene

Suggested Antigen Peptide Sequences for UGT2A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWM9

UniProtKB/Swiss-Prot:

UD2A3_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A3: view

Function for UGT2A3 Gene

Molecular function for UGT2A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Enzyme Numbers (IUBMB) for UGT2A3 Gene

Phenotypes From GWAS Catalog for UGT2A3 Gene

Gene Ontology (GO) - Molecular Function for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015020 glucuronosyltransferase activity IDA,IEA 19858781
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2A3: view

Phenotypes for UGT2A3 Gene

GenomeRNAi human phenotypes for UGT2A3:
genes like me logo Genes that share phenotypes with UGT2A3: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2A3 Gene

Localization for UGT2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2A3 gene
Compartment Confidence
golgi apparatus 3
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with UGT2A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2A3 Gene

Pathways & Interactions for UGT2A3 Gene

genes like me logo Genes that share pathways with UGT2A3: view

Gene Ontology (GO) - Biological Process for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052695 cellular glucuronidation IDA 19858781
genes like me logo Genes that share ontologies with UGT2A3: view

No data available for SIGNOR curated interactions for UGT2A3 Gene

Drugs & Compounds for UGT2A3 Gene

(14) Drugs for UGT2A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma Full agonist, Agonist 83
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estriol Approved, Investigational, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 22
Morphine Approved, Investigational Pharma Full agonist, Agonist 1100

(81) Additional Compounds for UGT2A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT2A3: view

Transcripts for UGT2A3 Gene

mRNA/cDNA for UGT2A3 Gene

Unigene Clusters for UGT2A3 Gene

UDP glucuronosyltransferase 2 family, polypeptide A3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A3 Gene

No ASD Table

Relevant External Links for UGT2A3 Gene

GeneLoc Exon Structure for
UGT2A3
ECgene alternative splicing isoforms for
UGT2A3

Expression for UGT2A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT2A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2A3 Gene

This gene is overexpressed in Colon - Transverse (x16.4), Kidney - Cortex (x11.1), Small Intestine - Terminal Ileum (x10.2), Pancreas (x7.8), and Liver (x6.7).

Protein differential expression in normal tissues from HIPED for UGT2A3 Gene

This gene is overexpressed in Kidney (30.5), Pancreatic juice (13.6), and Rectum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGT2A3 Gene



Protein tissue co-expression partners for UGT2A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UGT2A3 Gene:

UGT2A3

SOURCE GeneReport for Unigene cluster for UGT2A3 Gene:

Hs.122583

Evidence on tissue expression from TISSUES for UGT2A3 Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with UGT2A3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2A3 Gene

Orthologs for UGT2A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT2A3 33 34
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia UGT2A1 33
  • 80.71 (n)
UGT2A3 34
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGT2A3 33 34
  • 80.01 (n)
mouse
(Mus musculus)
Mammalia Ugt2a3 33 16 34
  • 74.35 (n)
rat
(Rattus norvegicus)
Mammalia Ugt2a3 33
  • 74.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UGT2A3 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves UGT2A3 33
  • 64.27 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ugt2a1 33
  • 64.05 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC571561 33
  • 59.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ugt35b 33
  • 47.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006223 33
  • 45.87 (n)
Species where no ortholog for UGT2A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UGT2A3 Gene

ENSEMBL:
Gene Tree for UGT2A3 (if available)
TreeFam:
Gene Tree for UGT2A3 (if available)

Paralogs for UGT2A3 Gene

Variants for UGT2A3 Gene

Sequence variations from dbSNP and Humsavar for UGT2A3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000598 -- 68,945,205(-) A/C/T intron_variant
rs1000361683 -- 68,931,444(-) A/G intron_variant
rs10006282 -- 68,948,823(-) C/T intron_variant
rs1000692791 -- 68,930,395(-) T/C intron_variant
rs1000856432 -- 68,947,652(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UGT2A3 Gene

Variant ID Type Subtype PubMed ID
nsv999654 CNV gain 25217958
nsv980212 CNV duplication 23825009
nsv829962 CNV gain 17160897
nsv4372 CNV deletion 18451855
nsv436447 CNV deletion 17901297
nsv1145032 CNV deletion 24896259
nsv1122086 CNV deletion 24896259
nsv1074180 CNV deletion 25765185
nsv10519 CNV gain 18304495
esv3368609 OTHER inversion 20981092
esv2759258 CNV gain+loss 17122850
esv2727775 CNV deletion 23290073

Variation tolerance for UGT2A3 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2A3 Gene

Human Gene Mutation Database (HGMD)
UGT2A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2A3 Gene

Disorders for UGT2A3 Gene

Additional Disease Information for UGT2A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UGT2A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2A3 Gene

Publications for UGT2A3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. (PMID: 19858781) Sneitz N … Finel M (Pharmacogenetics and genomics 2009) 3 58

Products for UGT2A3 Gene

Sources for UGT2A3 Gene

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