Aliases for UGT2A3 Gene

Aliases for UGT2A3 Gene

  • UDP Glucuronosyltransferase Family 2 Member A3 2 3 5
  • UDP Glucuronosyltransferase 2 Family, Polypeptide A3 2 3
  • UDP-Glucuronosyltransferase 2A3 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 2A3 3 4
  • FLJ21934 2
  • UGT2A3 5

External Ids for UGT2A3 Gene

Previous GeneCards Identifiers for UGT2A3 Gene

  • GC04M069975
  • GC04M069828
  • GC04M065589

Summaries for UGT2A3 Gene

GeneCards Summary for UGT2A3 Gene

UGT2A3 (UDP Glucuronosyltransferase Family 2 Member A3) is a Protein Coding gene. Diseases associated with UGT2A3 include Crigler-Najjar Syndrome, Type I and Gilbert Syndrome. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot Summary for UGT2A3 Gene

  • UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT2A3 Gene

Genomics for UGT2A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT2A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT2A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT2A3

Top Transcription factor binding sites by QIAGEN in the UGT2A3 gene promoter:
  • E4BP4
  • Gfi-1
  • HNF-1
  • HNF-1A
  • HOXA3
  • IRF-2
  • POU2F1
  • POU2F1a
  • SRF (504 AA)
  • YY1

Genomic Locations for UGT2A3 Gene

Latest Assembly
chr4:68,928,460-68,951,804
(GRCh38/hg38)
Size:
23,345 bases
Orientation:
Minus strand

Previous Assembly
chr4:69,794,181-69,817,522
(GRCh37/hg19 by Entrez Gene)
Size:
23,342 bases
Orientation:
Minus strand

chr4:69,794,181-69,817,509
(GRCh37/hg19 by Ensembl)
Size:
23,329 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr4(ALT_REF_LOCI_1):504,482-527,823 (-)

Genomic View for UGT2A3 Gene

Genes around UGT2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A3 Gene

Proteins for UGT2A3 Gene

  • Protein details for UGT2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM9-UD2A3_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A3
    Protein Accession:
    Q6UWM9
    Secondary Accessions:
    • Q9H6S4

    Protein attributes for UGT2A3 Gene

    Size:
    527 amino acids
    Molecular mass:
    60254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15179.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for UGT2A3 Gene

Selected DME Specific Peptides for UGT2A3 Gene

Q6UWM9:
  • AFITHGG
  • SHWLNVK
  • HKGAKHLR
  • LLGHPKT
  • PQNDLLGHP
  • FVQSSGE
  • AAHDLTW
  • KPLDRAVFWIE
  • YEAIYHG
  • RGHEVTVL
  • FVGGLHC
  • DVIGFLL
  • WIPQNDLLG
  • IPQKVLW
  • VMRHKGA
  • LSRIHHDQP
  • CGKVLVW

Post-translational modifications for UGT2A3 Gene

  • Glycosylation at Asn313
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT2A3 Gene

Domains & Families for UGT2A3 Gene

Gene Families for UGT2A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT2A3 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT2A3 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 2A3 (UD2A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWM9

UniProtKB/Swiss-Prot:

UD2A3_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A3: view

Function for UGT2A3 Gene

Molecular function for UGT2A3 Gene

UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;.

Enzyme Numbers (IUBMB) for UGT2A3 Gene

Phenotypes From GWAS Catalog for UGT2A3 Gene

Gene Ontology (GO) - Molecular Function for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IEA,IBA 21873635
GO:0015020 glucuronosyltransferase activity IEA,IDA 19858781
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2A3: view
genes like me logo Genes that share phenotypes with UGT2A3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2A3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT2A3 Gene

Localization for UGT2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A3 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT2A3 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with UGT2A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT2A3 Gene

Pathways & Interactions for UGT2A3 Gene

genes like me logo Genes that share pathways with UGT2A3: view

Gene Ontology (GO) - Biological Process for UGT2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052695 cellular glucuronidation IDA 19858781
genes like me logo Genes that share ontologies with UGT2A3: view

No data available for SIGNOR curated interactions for UGT2A3 Gene

Drugs & Compounds for UGT2A3 Gene

(17) Drugs for UGT2A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Codeine Approved, Illicit Pharma 98
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1160
Estriol Approved, Investigational, Vet_approved Pharma 0
Estrone Approved Pharma Estrogenic hormone 24
Morphine Approved, Investigational Pharma 1511

(76) Additional Compounds for UGT2A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-alpha-Estradiol-3-glucuronide
  • 17-a-Estradiol-3-glucuronide
  • 17-Α-estradiol-3-glucuronide
17-beta-Estradiol glucuronide
  • 17-b-Estradiol glucuronide
  • 17-Β-estradiol glucuronide
  • beta-Estradiol 17-beta-D-glucuronide
  • e(2)17g CPD
  • Estradiol-17 beta-glucuronide, monosodium salt
genes like me logo Genes that share compounds with UGT2A3: view

Transcripts for UGT2A3 Gene

mRNA/cDNA for UGT2A3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2A3

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A3 Gene

No ASD Table

Relevant External Links for UGT2A3 Gene

GeneLoc Exon Structure for
UGT2A3

Expression for UGT2A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT2A3 Gene

This gene is overexpressed in Colon - Transverse (x16.4), Kidney - Cortex (x11.1), Small Intestine - Terminal Ileum (x10.2), Pancreas (x7.8), and Liver (x6.7).

Protein differential expression in normal tissues from HIPED for UGT2A3 Gene

This gene is overexpressed in Kidney (30.5), Pancreatic juice (13.6), and Rectum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGT2A3 Gene



Protein tissue co-expression partners for UGT2A3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT2A3

SOURCE GeneReport for Unigene cluster for UGT2A3 Gene:

Hs.122583

Evidence on tissue expression from TISSUES for UGT2A3 Gene

  • Liver(4.5)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with UGT2A3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2A3 Gene

Orthologs for UGT2A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UGT2A3 29 30
  • 99.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UGT2A1 29
  • 80.71 (n)
UGT2A3 30
  • 73 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia UGT2A3 29 30
  • 80.01 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ugt2a3 29 16 30
  • 74.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ugt2a3 29
  • 74.32 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia UGT2A3 30
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves UGT2A3 29
  • 64.27 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ugt2a1 29
  • 64.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC571561 29
  • 59.95 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Ugt35b 29
  • 47.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006223 29
  • 45.87 (n)
Species where no ortholog for UGT2A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for UGT2A3 Gene

ENSEMBL:
Gene Tree for UGT2A3 (if available)
TreeFam:
Gene Tree for UGT2A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT2A3: view image
Alliance of Genome Resources:
Additional Orthologs for UGT2A3

Paralogs for UGT2A3 Gene

(31) SIMAP similar genes for UGT2A3 Gene using alignment to 3 proteins:

  • UD2A3_HUMAN
  • D6RBL8_HUMAN
  • F5GY78_HUMAN
genes like me logo Genes that share paralogs with UGT2A3: view

Variants for UGT2A3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT2A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT2A3 Gene

Variant ID Type Subtype PubMed ID
esv2727775 CNV deletion 23290073
esv2759258 CNV gain+loss 17122850
esv3368609 OTHER inversion 20981092
nsv10519 CNV gain 18304495
nsv1074180 CNV deletion 25765185
nsv1122086 CNV deletion 24896259
nsv1145032 CNV deletion 24896259
nsv436447 CNV deletion 17901297
nsv4372 CNV deletion 18451855
nsv829962 CNV gain 17160897
nsv980212 CNV duplication 23825009
nsv999654 CNV gain 25217958

Variation tolerance for UGT2A3 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2A3 Gene

Human Gene Mutation Database (HGMD)
UGT2A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2A3
Leiden Open Variation Database (LOVD)
UGT2A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT2A3 Gene

Disorders for UGT2A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UGT2A3 Gene - From: COP

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT2A3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT2A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT2A3 Gene

Publications for UGT2A3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 40
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. (PMID: 25798074) Basei FL … Kobarg J (Proteome science 2015) 3

Products for UGT2A3 Gene

Sources for UGT2A3 Gene