The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous comp... See more...

Aliases for UGT2A1 Gene

Aliases for UGT2A1 Gene

  • UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus 2 3 5
  • UDP Glucuronosyltransferase 2 Family, Polypeptide A1, Complex Locus 2 3
  • UDP Glycosyltransferase 2 Family, Polypeptide A1 2 3
  • UDP-Glucuronosyltransferase 2A1 3 4
  • Uridine Diphosphate Glycosyltransferase 2 Family, Member A1 3
  • EC 2.4.1.17 4
  • UDPGT 2A1 4
  • UDPGT2A1 3
  • UGT2A1 5

External Ids for UGT2A1 Gene

Previous GeneCards Identifiers for UGT2A1 Gene

  • GC04P070020
  • GC04M070503
  • GC04M070704
  • GC04M070770
  • GC04M070635
  • GC04M070454

Summaries for UGT2A1 Gene

Entrez Gene Summary for UGT2A1 Gene

  • The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for UGT2A1 Gene

UGT2A1 (UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT2A2.

UniProtKB/Swiss-Prot Summary for UGT2A1 Gene

  • UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:19858781, PubMed:18719240, PubMed:19022937, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19858781, PubMed:19022937, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781).

Gene Wiki entry for UGT2A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT2A1 Gene

Genomics for UGT2A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J069653 Promoter 0.3 EPDnew 250.7 0.0 -18 0.1 UGT2A1 piR-33605-328 SULT1B1
GH04J069647 Promoter 0.3 EPDnew 250.4 +5.6 5595 0.1 UGT2A1 UGT2A2
GH04J069649 Enhancer 0.4 Ensembl 0.7 +3.9 3948 1.4 PRDM10 NRF1 GATA2 UGT2B4 UGT2A2 UGT2A1
GH04J069757 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.1 -106.3 -106254 4 ATF3 YY1 FOXA2 RXRA ZBTB33 JUND NFE2 SPI1 HNF4A FOXA1 SULT1B1 piR-36393-391 CSN1S1 HSALNG0034989 UGT2A1
GH04J069713 Enhancer 1 FANTOM5 Ensembl 0.2 -60.7 -60652 2.2 CEBPA ATF3 YY1 CEBPB THAP11 FOXA2 RXRA SAP130 MIER3 RARA SULT1B1 CSN1S1 HSALNG0034988 piR-32461-126 UGT2A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT2A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT2A1

Top Transcription factor binding sites by QIAGEN in the UGT2A1 gene promoter:
  • Cdc5
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C
  • STAT5A

Genomic Locations for UGT2A1 Gene

Latest Assembly
chr4:69,588,417-69,653,249
(GRCh38/hg38)
Size:
64,833 bases
Orientation:
Minus strand

Previous Assembly
chr4:70,454,135-70,518,965
(GRCh37/hg19 by Entrez Gene)
Size:
64,831 bases
Orientation:
Minus strand

chr4:70,454,135-70,518,965
(GRCh37/hg19 by Ensembl)
Size:
64,831 bases
Orientation:
Minus strand

Genomic View for UGT2A1 Gene

Genes around UGT2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT2A1 Gene

Proteins for UGT2A1 Gene

  • Protein details for UGT2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DTE4-UD2A1_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 2A1
    Protein Accession:
    P0DTE4
    Secondary Accessions:
    • B4E2F4
    • D3GER1
    • D3GER2
    • E9PDM7
    • J3KNA3
    • Q9Y4X1

    Protein attributes for UGT2A1 Gene

    Size:
    527 amino acids
    Molecular mass:
    59926 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • UGT2A1 isoform is part of the UGT2A complex locus which displays alternative use of promoters and exons. The locus is defined by 2 alternative promoters giving rise to 2 fonctionally active polypeptides UGT2A1 and UGT2A2. Alternative splicing of exons results in additional isoforms for each protein class.

    Alternative splice isoforms for UGT2A1 Gene

neXtProt entry for UGT2A1 Gene

Post-translational modifications for UGT2A1 Gene

  • Glycosylation at Asn49, Asn313, and Asn347

No data available for DME Specific Peptides for UGT2A1 Gene

Domains & Families for UGT2A1 Gene

Gene Families for UGT2A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UGT2A1 Gene

Suggested Antigen Peptide Sequences for UGT2A1 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 2A1 (UD2A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DTE4

UniProtKB/Swiss-Prot:

UD2A1_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT2A1: view

Function for UGT2A1 Gene

Molecular function for UGT2A1 Gene

UniProtKB/Swiss-Prot Function:
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:19858781, PubMed:18719240, PubMed:19022937, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19858781, PubMed:19022937, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:10359671, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19022937, ECO:0000269|PubMed:19858781, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52880, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87620, ChEBI:CHEBI:136886; Evidence={ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52920, ChEBI:CHEBI:15378, ChEBI:CHEBI:42156, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136884; Evidence={ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52872, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136642; Evidence={ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence={ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19858781, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence={ECO:0000269|PubMed:18719240};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52464, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:82961; Evidence={ECO:0000269|PubMed:18719240};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52456, ChEBI:CHEBI:15378, ChEBI:CHEBI:17347, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136639; Evidence={ECO:0000269|PubMed:19022937};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52568, ChEBI:CHEBI:15378, ChEBI:CHEBI:42534, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136673; Evidence={ECO:0000269|PubMed:19022937};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:53028, ChEBI:CHEBI:15378, ChEBI:CHEBI:29744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136965; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52952, ChEBI:CHEBI:29744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136902; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52948, ChEBI:CHEBI:23614, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136901; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52956, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:58875, ChEBI:CHEBI:136903; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52960, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:133661, ChEBI:CHEBI:136904; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=99 uM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=174 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=36 uM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:18719240}; KM=73 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:18719240}; KM=57 uM for estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:26220143}; KM=160 uM for 16alpha-hydroxyestrone (when assaying glucuronidation at position 16) {ECO:0000269|PubMed:26220143}; KM=38.7 uM for testosterone (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:19022937}; KM=11.6 uM for epitestosterone (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:19022937}; KM=251 uM for UDP-glucuronate (with 3-hydroxybiphenyl as substrate) {ECO:0000269|PubMed:10359671}; KM=274 uM for UDP-glucuronate (with S-(-)-b-citronellol as substrate) {ECO:0000269|PubMed:10359671}; KM=56.2 uM for testosterone {ECO:0000269|PubMed:10359671}; KM=75.4 uM for 3-hydroxybiphenyl {ECO:0000269|PubMed:10359671}; KM=59.5 uM for umbelliferone {ECO:0000269|PubMed:10359671}; KM=51.6 uM for S-(-)-b-citronellol {ECO:0000269|PubMed:10359671}; KM=170.1 uM for borneol {ECO:0000269|PubMed:10359671}; KM=39.5 uM for UDP-glucuronate (with 4-methyl-umbelliferone as substrate) {ECO:0000269|PubMed:19858781}; KM=303 uM for 4-nitrophenol {ECO:0000269|PubMed:19858781}; KM=32.3 uM for 4-methyl-umbelliferone {ECO:0000269|PubMed:19858781}; KM=0.6 uM for 4-phenylphenol {ECO:0000269|PubMed:19858781}; KM=619 uM for 4-phenylphenol {ECO:0000269|PubMed:19858781}; KM=2344 uM for cholate (when assaying glucuronidation at position 24) {ECO:0000269|PubMed:23756265}; KM=1744 uM for chenodeoxycholate (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:23756265}; KM=1397 uM for chenodeoxycholate (when assaying glucuronidation at position 24) {ECO:0000269|PubMed:23756265}; KM=102.2 uM for lithocholate (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:23756265}; KM=102.3 uM for lithocholate (when assaying glucuronidation at position 24) {ECO:0000269|PubMed:23756265}; KM=2405.6 uM for deoxycholate (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:23756265}; KM=917.9 uM for deoxycholate (when assaying glucuronidation at position 24) {ECO:0000269|PubMed:23756265}; KM=237.4 uM for hyodeoxycholate (when assaying glucuronidation at position 6) {ECO:0000269|PubMed:23756265}; KM=178.5 uM for hyodeoxycholate (when assaying glucuronidation at position 24) {ECO:0000269|PubMed:23756265}; KM=210.7 uM for hyocholate (when assaying glucuronidation at position 24) {ECO:0000269|PubMed:23756265}; Vmax=693 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=128 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=78.3 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=265 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=57.1 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=4.6 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=485 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=16.4 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=263 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 16-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=174 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=15.8 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=1.5 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=3.9 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=5.9 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=51 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:26220143}; Vmax=210 pmol/min/mg enzyme for the formation of 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) {ECO:0000269|PubMed:26220143}; Vmax=427 pmol/min/mg enzyme for the formation of testosterone 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:19022937}; Vmax=271 pmol/min/mg enzyme for the formation of epitestosterone 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:19022937}; Vmax=250 pmol/min/mg enzyme with testosterone as substrate {ECO:0000269|PubMed:10359671}; Vmax=2600 pmol/min/mg enzyme with 3-hydroxybiphenyl as substrate {ECO:0000269|PubMed:10359671}; Vmax=610 pmol/min/mg enzyme with umbelliferone as substrate {ECO:0000269|PubMed:10359671}; Vmax=1980 pmol/min/mg enzyme with S-(-)-b-citronellol as substrate {ECO:0000269|PubMed:10359671}; Vmax=1050 pmol/min/mg enzyme with borneol as substrate {ECO:0000269|PubMed:10359671}; Vmax=141 pmol/min/mg enzyme with 4-nitrophenol as substrate {ECO:0000269|PubMed:19858781}; Vmax=537 pmol/min/mg enzyme with 4-methyl-umbelliferone as substrate {ECO:0000269|PubMed:19858781}; Vmax=116 pmol/min/mg enzyme with 4-phenylphenol as substrate {ECO:0000269|PubMed:19858781}; Vmax=325 pmol/min/mg enzyme with 4-phenylphenol as substrate {ECO:0000269|PubMed:19858781}; Vmax=83.3 pmol/min/mg enzyme for the formation of choloyl-24-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=95 pmol/min/mg enzyme for the formation of chenodeoxycholoyl-3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=536.7 pmol/min/mg enzyme for the formation of chenodeoxycholoyl-24-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=685 pmol/min/mg enzyme for the formation of lithocholoyl-3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=305.2 pmol/min/mg enzyme for the formation of lithocholoyl24-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=83.3 pmol/min/mg enzyme for the formation of deoxycholoyl-3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=235.2 pmol/min/mg enzyme for the formation of deoxycholoyl-24-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=45.1 pmol/min/mg enzyme for the formation of hyodeoxycholate 6-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=805.1 pmol/min/mg enzyme for the formation of hyocholoyl-24-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265}; Vmax=495.1 pmol/min/mg enzyme for the formation of hyocholoyl-24-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23756265};
GENATLAS Biochemistry:
UDP glucoronosyltransferase 2 alpha 1,specific for the olfactory tissue

Enzyme Numbers (IUBMB) for UGT2A1 Gene

Phenotypes From GWAS Catalog for UGT2A1 Gene

Gene Ontology (GO) - Molecular Function for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008194 UDP-glycosyltransferase activity IEA --
GO:0015020 glucuronosyltransferase activity IEA,IDA 19858781
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT2A1: view
genes like me logo Genes that share phenotypes with UGT2A1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for UGT2A1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2A1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGT2A1 Gene

Localization for UGT2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT2A1 Gene

Membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT2A1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for UGT2A1 Gene

Pathways & Interactions for UGT2A1 Gene

genes like me logo Genes that share pathways with UGT2A1: view

Interacting Proteins for UGT2A1 Gene

Gene Ontology (GO) - Biological Process for UGT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007608 sensory perception of smell IEA --
GO:0008206 bile acid metabolic process IDA 23756265
GO:0050896 response to stimulus IEA --
GO:0052695 cellular glucuronidation IDA 19858781
genes like me logo Genes that share ontologies with UGT2A1: view

No data available for SIGNOR curated interactions for UGT2A1 Gene

Drugs & Compounds for UGT2A1 Gene

(18) Drugs for UGT2A1 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Codeine Approved, Illicit Pharma 98
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1160
Estriol Approved, Investigational, Vet_approved Pharma 0
Estrone Approved Pharma Estrogenic hormone 24

(76) Additional Compounds for UGT2A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-alpha-Estradiol-3-glucuronide
  • 17-a-Estradiol-3-glucuronide
  • 17-Α-estradiol-3-glucuronide
17-beta-Estradiol glucuronide
  • 17-b-Estradiol glucuronide
  • 17-Β-estradiol glucuronide
  • beta-Estradiol 17-beta-D-glucuronide
  • e(2)17g CPD
  • Estradiol-17 beta-glucuronide, monosodium salt
genes like me logo Genes that share compounds with UGT2A1: view

Transcripts for UGT2A1 Gene

mRNA/cDNA for UGT2A1 Gene

5 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT2A1

Alternative Splicing Database (ASD) splice patterns (SP) for UGT2A1 Gene

No ASD Table

Relevant External Links for UGT2A1 Gene

GeneLoc Exon Structure for
UGT2A1

Expression for UGT2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UGT2A1 Gene

This gene is overexpressed in Nasal epithelium (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGT2A1 Gene



Protein tissue co-expression partners for UGT2A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT2A1

SOURCE GeneReport for Unigene cluster for UGT2A1 Gene:

Hs.225950

mRNA Expression by UniProt/SwissProt for UGT2A1 Gene:

P0DTE4-UD2A1_HUMAN
Tissue specificity: Olfactory epithelium, brain and fetal lung (PubMed:10359671). Not present in liver (PubMed:10359671).
genes like me logo Genes that share expression patterns with UGT2A1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT2A1 Gene

Orthologs for UGT2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT2A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 99 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ugt2a1 29 16 30
  • 85.31 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Ugt2a1 29
  • 85.05 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 77 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 63 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 63 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 63 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii Dr.11419 29
Fruit Fly
(Drosophila melanogaster)
Insecta Ugt86Dc 31
  • 37 (a)
Ugt86Dd 31
  • 36 (a)
Ugt86Dg 31
  • 35 (a)
Ugt86Dj 31
  • 35 (a)
Ugt86Di 31
  • 35 (a)
Ugt35a 31
  • 34 (a)
Ugt86De 31
  • 34 (a)
CG6475 31
  • 33 (a)
BEST:GH09393 31
  • 32 (a)
Ugt35b 31
  • 32 (a)
Ugt86Da 31
  • 32 (a)
CG5999 31
  • 31 (a)
Ugt37c1 31
  • 30 (a)
BEST:GH06505 31
  • 30 (a)
Ugt37a1 31
  • 28 (a)
Ugt36Bb 31
  • 28 (a)
Ugt36Bc 31
  • 27 (a)
Ugt36Ba 31
  • 27 (a)
CG17323 31
  • 27 (a)
CG10168 31
  • 25 (a)
CG10170 31
  • 24 (a)
Worm
(Caenorhabditis elegans)
Secernentea F39G3.1 31
  • 32 (a)
M88.1 31
  • 32 (a)
C17G1.3 31
  • 28 (a)
T07C5.1a 31
  • 27 (a)
AC3.2 31
  • 27 (a)
C44H9.1 31
  • 27 (a)
F35H8.6 31
  • 27 (a)
F56B3.7 31
  • 27 (a)
C33A12.6 31
  • 26 (a)
ZC443.5 31
  • 25 (a)
C10H11.5 31
  • 25 (a)
C10H11.4 31
  • 25 (a)
R04B5.9 31
  • 25 (a)
T03D3.1 31
  • 25 (a)
F47C10.6 31
  • 24 (a)
T19H12.11 31
  • 24 (a)
F01D4.1 31
  • 24 (a)
C03A7.11 31
  • 23 (a)
C08B6.1 31
  • 23 (a)
F01D4.2 31
  • 23 (a)
Species where no ortholog for UGT2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for UGT2A1 Gene

ENSEMBL:
Gene Tree for UGT2A1 (if available)
TreeFam:
Gene Tree for UGT2A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT2A1: view image
Alliance of Genome Resources:
Additional Orthologs for UGT2A1

Paralogs for UGT2A1 Gene

(30) SIMAP similar genes for UGT2A1 Gene using alignment to 3 proteins:

  • UD2A1_HUMAN
  • D6RFW5_HUMAN
  • D6RHF3_HUMAN
genes like me logo Genes that share paralogs with UGT2A1: view

Variants for UGT2A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT2A1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs111696697 Likely Benign: not specified 69,647,069(-) A/T
NM_006798.5(UGT2A1):c.576T>A (p.Tyr192Ter)
NONSENSE
rs113894762 Benign: not provided 69,647,481(-) G/A
NM_006798.5(UGT2A1):c.164C>T (p.Ala55Val)
MISSENSE
rs139303872 Likely Benign: not provided 69,589,587(-) G/A
NM_001105677.2(UGT2A2):c.1396C>T (p.Arg466Ter)
NONSENSE
rs146749264 Benign: not provided 69,594,611(-) T/A
NM_001105677.2(UGT2A2):c.1197A>T (p.Gly399=)
SYNONYMOUS
rs146912371 Likely Benign: not provided 69,595,226(-) C/A
NM_001105677.2(UGT2A2):c.1047G>T (p.Lys349Asn)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT2A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT2A1 Gene

Variant ID Type Subtype PubMed ID
dgv146n73 CNV deletion 24416366
dgv5318n100 CNV loss 25217958
dgv659n27 CNV loss 19166990
dgv9119n54 CNV loss 21841781
dgv9120n54 CNV gain 21841781
dgv9121n54 CNV loss 21841781
dgv9122n54 CNV loss 21841781
dgv9123n54 CNV gain 21841781
dgv9124n54 CNV loss 21841781
dgv9125n54 CNV loss 21841781
dgv93n16 CNV deletion 17901297
esv1001272 CNV deletion 20482838
esv24189 CNV loss 19812545
esv2658506 CNV deletion 23128226
esv33983 CNV gain+loss 17666407
esv3564042 CNV deletion 23714750
esv3569511 CNV loss 25503493
esv3600917 CNV loss 21293372
esv3600919 CNV loss 21293372
nsv1009165 CNV loss 25217958
nsv1074182 CNV deletion 25765185
nsv1122088 CNV deletion 24896259
nsv292823 CNV deletion 16902084
nsv4377 CNV deletion 18451855
nsv461552 CNV loss 19166990
nsv476466 CNV novel sequence insertion 20440878
nsv499046 CNV loss 21111241
nsv510892 OTHER complex 20534489
nsv511264 CNV loss 21212237
nsv514225 CNV loss 21397061
nsv521416 CNV loss 19592680
nsv594616 CNV loss 21841781
nsv594630 CNV loss 21841781
nsv594636 CNV loss 21841781
nsv594637 CNV loss 21841781
nsv594640 CNV loss 21841781
nsv822601 CNV loss 20364138
nsv966281 CNV duplication 23825009
nsv998374 CNV gain 25217958

Variation tolerance for UGT2A1 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT2A1 Gene

Human Gene Mutation Database (HGMD)
UGT2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT2A1
Leiden Open Variation Database (LOVD)
UGT2A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT2A1 Gene

Disorders for UGT2A1 Gene

Additional Disease Information for UGT2A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for UGT2A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGT2A1 Gene

Publications for UGT2A1 Gene

  1. Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase. (PMID: 10359671) Jedlitschky G … Burchell B (The Biochemical journal 1999) 2 3 4
  2. The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation. (PMID: 23756265) Perreault M … Barbier O (Drug metabolism and disposition: the biological fate of chemicals 2013) 3 4
  3. UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. (PMID: 19022937) Sten T … Finel M (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 4
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 40
  5. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. (PMID: 19858781) Sneitz N … Finel M (Pharmacogenetics and genomics 2009) 3 4

Products for UGT2A1 Gene

Sources for UGT2A1 Gene