Aliases for UGT1A9 Gene
Aliases for UGT1A9 Gene
- UDP Glucuronosyltransferase Family 1 Member A9 2 3 5
- UDP Glycosyltransferase 1 Family, Polypeptide A9 2 3
- UDP-Glucuronosyltransferase 1-I 3 4
- UDP-Glucuronosyltransferase 1A9 3 4
- UDPGT 1-9 3 4
- UGT1-09 3 4
- UGT-1I 3 4
- UGT1.9 3 4
- UGT1I 3 4
- UDP Glucuronosyltransferase 1 Family, Polypeptide A9 3
- UDP-Glucuronosyltransferase 1 Family Polypeptide A9s 3
- UDP-Glucuronosyltransferase 1-9 3
External Ids for UGT1A9 Gene
- HGNC: 12541
- Entrez Gene: 54600
- Ensembl: ENSG00000241119
- OMIM: 606434
- UniProtKB: O60656
Previous GeneCards Identifiers for UGT1A9 Gene
- GC02U990251
- GC02P234822
- GC02P234885
- GC02P234369
- GC02P234370
- GC02P234200
- GC02P234210
- GC02P234220
- GC02P234245
- GC02P234580
- GC02P226380
Summaries for UGT1A9 Gene
-
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]
GeneCards Summary for UGT1A9 Gene
UGT1A9 (UDP Glucuronosyltransferase Family 1 Member A9) is a Protein Coding gene. Diseases associated with UGT1A9 include Crigler-Najjar Syndrome, Type Ii and Gilbert Syndrome. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A7.
UniProtKB/Swiss-Prot for UGT1A9 Gene
-
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Additional gene information for UGT1A9 Gene
- Monarch Initiative
- Search for UGT1A9 at DataMed
- Search for UGT1A9 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A9 Gene
Genomics for UGT1A9 Gene
GeneHancer (GH) Regulatory Elements for UGT1A9 Gene
Promoters and enhancers for UGT1A9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around UGT1A9 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the UGT1A9 gene promoter:
Regulatory Element Products
Genomic Locations for UGT1A9 Gene
Genomic Locations for UGT1A9 Gene
- chr2:233,671,853-233,773,305
- (GRCh38/hg38)
- Size:
- 101,453 bases
- Orientation:
- Plus strand
- chr2:234,580,499-234,681,951
- (GRCh37/hg19)
Genomic View for UGT1A9 Gene
Genes around UGT1A9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.1 by Entrez Gene
- 2q37.1 by HGNC
- 2q37.1 by Ensembl
UGT1A9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UGT1A9 Gene
Proteins for UGT1A9 Gene
-
Protein details for UGT1A9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60656-UD19_HUMAN
- Recommended name:
- UDP-glucuronosyltransferase 1-9
- Protein Accession:
- O60656
- B8K285
- P36509
- Q9HAX0
Protein attributes for UGT1A9 Gene
- Size:
- 530 amino acids
- Molecular mass:
- 59941 Da
- Quaternary structure:
-
- Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10.
- Miscellaneous:
-
- The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.
- SequenceCaution:
-
- Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82; Evidence={ECO:0000305};
Protein Expression for UGT1A9 Gene
Post-translational modifications for UGT1A9 Gene
Other Protein References for UGT1A9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for UGT1A9
- Invitrogen Antibodies for UGT1A9
- GeneTex UGT1A9 Antibody for UGT1A9
-
Boster Bio Antibodies for UGT1A9
-
Santa Cruz Biotechnology (SCBT) Antibodies for UGT1A9
Protein Products
-
OriGene Purified Proteins for UGT1A9
- Search Origene for MassSpec and Protein Over-expression Lysates for UGT1A9
- Origene Custom Protein Services for UGT1A9
- Search GeneTex for Proteins for UGT1A9
Assay Products
No data available for DME Specific Peptides for UGT1A9 Gene
Domains & Families for UGT1A9 Gene
Gene Families for UGT1A9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted membrane proteins
Protein Domains for UGT1A9 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UGT1A9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60656- Family:
-
- Belongs to the UDP-glycosyltransferase family.
Function for UGT1A9 Gene
Molecular function for UGT1A9 Gene
- UniProtKB/Swiss-Prot Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Enzyme Numbers (IUBMB) for UGT1A9 Gene
Phenotypes From GWAS Catalog for UGT1A9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001972 | retinoic acid binding | IDA | 20308471 |
| GO:0008194 | UDP-glycosyltransferase activity | IBA | -- |
| GO:0015020 | glucuronosyltransferase activity | IEA,IDA | 18052087 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for UGT1A9 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for UGT1A9
-
CRISPR Products
-
OriGene CRISPR knockouts for UGT1A9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UGT1A9
- genomics-online: gRNA clones - Search results for available UGT1A9 gene related products
- Applied Biological Materials CRISPR for UGT1A9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UGT1A9
- GenScript: Design CRISPR guide RNA sequences for UGT1A9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGT1A9
- Browse OriGene Inhibitory RNA Products For UGT1A9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A9
- genomics-online: shRNA clones - Search results for available UGT1A9 gene related products
Clone Products
- Sino Biological Human cDNA Clone for UGT1A9
- VectorBuilder custom plasmid, inducible vectors for UGT1A9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UGT1A9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGT1A9
- genomics-online: cdna clones - Search results for available UGT1A9 gene related products
- orf clones - Search results for available UGT1A9 gene related products
- Applied Biological Materials Clones for UGT1A9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for UGT1A9
Cell Line Products
-
Horizon Cell Lines for UGT1A9
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A9 Gene
Localization for UGT1A9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UGT1A9 Gene
- Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 17179145 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IBA,IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A9 Gene
Pathways & Interactions for UGT1A9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Porphyrin and chlorophyll metabolism |
.67
.67
|
|
| 3 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics | ||
| 4 | Irinotecan Pathway | ||
| 5 | Metabolism |
.37
|
|
Pathways by source for UGT1A9 Gene
10 BioSystems pathways for UGT1A9 Gene
8 Reactome pathways for UGT1A9 Gene
10 KEGG pathways for UGT1A9 Gene
3 GeneGo (Thomson Reuters) pathways for UGT1A9 Gene
1 Cell Signaling Technology pathway for UGT1A9 Gene
Interacting Proteins for UGT1A9 Gene
GPS-Prot Interaction Network for UGT1A9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006805 | xenobiotic metabolic process | IDA | 1910331 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0019216 | regulation of lipid metabolic process | TAS | -- |
| GO:0042573 | retinoic acid metabolic process | IC | 20308471 |
| GO:0051552 | flavone metabolic process | IDA | 18052087 |
No data available for SIGNOR curated interactions for UGT1A9 Gene
Drugs & Compounds for UGT1A9 Gene
(100) Drugs for UGT1A9 Gene - From: DrugBank, PharmGKB, ClinicalTrials, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Propofol | Approved, Investigational, Vet_approved | Pharma | Enzyme, substrate | 1189 | ||
| Irinotecan | Approved, Investigational | Pharma | Enzyme, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1181 | |
| Mycophenolate mofetil | Approved, Investigational | Pharma | Enzyme, substrate | IMPDH inhibitor | 987 | |
| Mycophenolic acid | Approved | Pharma | Enzyme, substrate | 987 | ||
| Sorafenib | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 717 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SN38 glucuronide |
|
|||||
| (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide) |
|
|
||||
| (3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid |
|
99794-82-8 |
|
|||
| (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid |
|
58814-71-4 |
|
|||
| (3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid |
|
99794-78-2 |
|
Transcripts for UGT1A9 Gene
mRNA/cDNA for UGT1A9 Gene
- (271) Selected AceView cDNA sequences:
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000354728 2416 bps (uc002vus.4)
CRISPR Products
-
OriGene CRISPR knockouts for UGT1A9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UGT1A9
- genomics-online: gRNA clones - Search results for available UGT1A9 gene related products
- Applied Biological Materials CRISPR for UGT1A9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UGT1A9
- GenScript: Design CRISPR guide RNA sequences for UGT1A9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGT1A9
- Browse OriGene Inhibitory RNA Products For UGT1A9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A9
- genomics-online: shRNA clones - Search results for available UGT1A9 gene related products
Clone Products
- Sino Biological Human cDNA Clone for UGT1A9
- VectorBuilder custom plasmid, inducible vectors for UGT1A9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UGT1A9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGT1A9
- genomics-online: cdna clones - Search results for available UGT1A9 gene related products
- orf clones - Search results for available UGT1A9 gene related products
- Applied Biological Materials Clones for UGT1A9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for UGT1A9
Expression for UGT1A9 Gene
mRNA differential expression in normal tissues according to GTEx for UGT1A9 Gene
This gene is overexpressed in Kidney - Cortex (x41.9) and Liver (x10.1).
This gene is overexpressed in Kidney (32.8), Liver (20.6), and Gallbladder (15.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT1A9 Gene
NURSA nuclear receptor signaling pathways regulating expression of UGT1A9 Gene:
UGT1A9mRNA Expression by UniProt/SwissProt for UGT1A9 Gene:
O60656-UD19_HUMAN
Tissue specificity:
Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine.
Evidence on tissue expression from TISSUES for UGT1A9 Gene
- Liver(4.5)
- Kidney(4.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for UGT1A9
-
OriGene qPCR primer pairs for UGT1A9
- genomics-online: primer clones - Search results for available UGT1A9 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A9 Gene
Orthologs for UGT1A9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | UGT1A9 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ugt1a8 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ugt1a9 16 34 33 |
|
||
| Ugt1a10 34 |
|
ManyToMany | |||
| Ugt1a7c 34 |
|
ManyToMany | |||
| Ugt1a8 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ugt1a7 34 |
|
ManyToMany | |
| ugt1b1 34 |
|
ManyToMany | |||
| ugt1b4 34 |
|
ManyToMany | |||
| ugt1b5 34 |
|
ManyToMany | |||
| ugt1b3 34 |
|
ManyToMany | |||
| ugt1b2 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11289 35 |
|
|
|
| Ugt86Dc 35 |
|
|
|||
| Ugt86Da 35 |
|
|
|||
| CG15661 35 |
|
|
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| CG6475 35 |
|
|
|||
| Ugt86Di 35 |
|
|
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| Ugt36Bb 35 |
|
|
|||
| Ugt86De 35 |
|
|
|||
| Ugt37c1 35 |
|
|
|||
| CG10168 35 |
|
|
|||
| BEST:GH09393 35 |
|
|
|||
| Ugt36Ba 35 |
|
|
|||
| BEST:GH06505 35 |
|
|
|||
| CG10178 35 |
|
|
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| Ugt37a1 35 |
|
|
|||
| CG5724 35 |
|
|
|||
| Ugt37b1 35 |
|
|
|||
| Ugt86Dh 35 |
|
|
|||
| CG17323 35 |
|
|
|||
| Dot 35 |
|
|
|||
| CG5999 35 |
|
|
|||
| CG10170 35 |
|
|
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| CG16732 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | F35H8.6 35 |
|
|
|
| M88.1 35 |
|
|
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| F39G3.1 35 |
|
|
|||
| ZC443.5 35 |
|
|
|||
| Y37E11AR.5 35 |
|
|
|||
| C17G1.3 35 |
|
|
|||
| C08F11.8 35 |
|
|
|||
| C10H11.5 35 |
|
|
|||
| C08B6.1 35 |
|
|
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| C33A12.6 35 |
|
|
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| C10H11.4 35 |
|
|
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| AC3.2 35 |
|
|
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| C44H9.1 35 |
|
|
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| F56B3.7 35 |
|
|
|||
| AC3.7 35 |
|
|
|||
| C10H11.6 35 |
|
|
|||
| F09G2.6 35 |
|
|
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| K08B4.4 35 |
|
|
|||
| C49A9.8 35 |
|
|
|||
| T01G5.2 35 |
|
|
|||
| R04B5.9 35 |
|
|
|||
| F01D4.1 35 |
|
|
|||
| F01D4.2 35 |
|
|
|||
| ZC455.3 35 |
|
|
|||
| AC3.8 35 |
|
|
- Species where no ortholog for UGT1A9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for UGT1A9 Gene
- ENSEMBL:
- Gene Tree for UGT1A9 (if available)
- TreeFam:
- Gene Tree for UGT1A9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UGT1A9: view image
Paralogs for UGT1A9 Gene
(31) SIMAP similar genes for UGT1A9 Gene using alignment to 8 proteins:
- UD19_HUMAN
- A9UKF4_HUMAN
- A9UKF7_HUMAN
- Q330M4_HUMAN
- Q4R0Z6_HUMAN
- Q4R0Z7_HUMAN
- Q53E75_HUMAN
- Q5DSZ5_HUMAN
Pseudogenes.org Pseudogenes for UGT1A9 Gene
Variants for UGT1A9 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1042640 | benign, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, Gilbert's syndrome | 233,772,898(+) | G/C/T | 3_prime_UTR_variant | |
| rs10929303 | benign, Gilbert's syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome | 233,772,770(+) | T/C | 3_prime_UTR_variant | |
| rs111033539 | pathogenic, Crigler Najjar syndrome, type 1 | 233,767,160(+) | C/T | coding_sequence_variant, stop_gained | |
| rs111033541 | pathogenic, Crigler-Najjar syndrome, type II | 233,760,331(+) | T/G | intron_variant | |
| rs138183896 | uncertain-significance, Lucey-Driscoll syndrome, Gilbert's syndrome, Crigler-Najjar syndrome | 233,760,581(+) | T/C | intron_variant |
Residual Variation Intolerance Score:
78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.25;
25.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UGT1A9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A9 Gene
Disorders for UGT1A9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| crigler-najjar syndrome, type ii |
|
|
| gilbert syndrome |
|
|
| crigler-najjar syndrome, type i |
|
|
| bilirubin, serum level of, quantitative trait locus 1 |
|
|
| kernicterus |
|
|
Search UGT1A9 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UGT1A9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A9 Gene
Publications for UGT1A9 Gene
- Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). (PMID: 18816295) Takahashi H … Takeuchi Y (Basic & clinical pharmacology & toxicology 2008) 3 22 25 44 58
- N-Glycosylation plays a role in protein folding of human UGT1A9. (PMID: 19951703) Nakajima M … Yokoi T (Biochemical pharmacology 2010) 3 4 22 58
- Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Ménard V … Guillemette C (Human mutation 2009) 3 4 44 58
- Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. (PMID: 19364970) Cecchin E … Toffoli G (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009) 3 22 44 58
- UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients. (PMID: 19494809) van Schaik RH … van Gelder T (Clinical pharmacology and therapeutics 2009) 3 22 44 58
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- GeneTex UGT1A9 Antibody for UGT1A9
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Sources for UGT1A9 Gene
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