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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]
UGT1A9 (UDP Glucuronosyltransferase Family 1 Member A9) is a Protein Coding gene. Diseases associated with UGT1A9 include Crigler-Najjar Syndrome, Type Ii and Gilbert Syndrome. Among its related pathways are Drug metabolism - cytochrome P450 and Estrogen metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001972 | retinoic acid binding | IDA | 20308471 |
GO:0015020 | glucuronosyltransferase activity | IEA,IDA | 18052087 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0016758 | transferase activity, transferring hexosyl groups | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA,IDA | 17179145 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 |
Benzo[a]pyrene metabolism
.01
|
|
2 | Porphyrin and chlorophyll metabolism |
.67
.67
|
|
3 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics |
Acetaminophen metabolism
.42
|
2-Naphthylamine and 2-Nitronaphtalene metabolism
.31
|
4 | Irinotecan Pathway, Pharmacokinetics | ||
5 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006805 | xenobiotic metabolic process | IDA | 1910331 |
GO:0019216 | regulation of lipid metabolic process | TAS | -- |
GO:0042573 | retinoic acid metabolic process | IC | 20308471 |
GO:0051552 | flavone metabolic process | IDA | 18052087 |
GO:0052695 | cellular glucuronidation | IDA | 22579593 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Propofol | Approved, Investigational, Vet_approved | Pharma | Enzyme, substrate | 1563 | ||
Irinotecan | Approved, Investigational | Pharma | Enzyme, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1414 | |
Mycophenolate mofetil | Approved, Investigational | Pharma | Enzyme, substrate | IMPDH inhibitor | 0 | |
Mycophenolic acid | Approved | Pharma | Enzyme, substrate | 1097 | ||
Sorafenib | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 779 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
SN38 glucuronide |
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(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide) |
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(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid |
|
99794-82-8 |
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(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid |
|
58814-71-4 |
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|||
(3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid |
|
99794-78-2 |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UGT1A9 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ugt1a8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ugt1a9 30 17 31 |
|
ManyToMany | |
Ugt1a10 17 31 |
|
ManyToMany | |||
Ugt1a7c 31 |
|
ManyToMany | |||
Ugt1a8 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | ugt1a7 31 |
|
ManyToMany | |
ugt1b1 31 |
|
ManyToMany | |||
ugt1b4 31 |
|
ManyToMany | |||
ugt1b5 31 |
|
ManyToMany | |||
ugt1b3 31 |
|
ManyToMany | |||
ugt1b2 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG11289 32 |
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|
Ugt86Dc 32 |
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Ugt86Da 32 |
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CG15661 32 |
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CG6475 32 |
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Ugt86Di 32 |
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Ugt86De 32 |
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Ugt37c1 32 |
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Ugt36Bb 32 |
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BEST:GH09393 32 |
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CG10168 32 |
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Ugt36Ba 32 |
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BEST:GH06505 32 |
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Ugt37a1 32 |
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Ugt86Dh 32 |
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Ugt37b1 32 |
|
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CG10178 32 |
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CG5724 32 |
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CG17323 32 |
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CG5999 32 |
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Dot 32 |
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CG10170 32 |
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CG16732 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | F39G3.1 32 |
|
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M88.1 32 |
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F35H8.6 32 |
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ZC443.5 32 |
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Y37E11AR.5 32 |
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C08F11.8 32 |
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C10H11.5 32 |
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C17G1.3 32 |
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AC3.2 32 |
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C10H11.4 32 |
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C08B6.1 32 |
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C44H9.1 32 |
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C33A12.6 32 |
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AC3.7 32 |
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F56B3.7 32 |
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C49A9.8 32 |
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C10H11.6 32 |
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F09G2.6 32 |
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K08B4.4 32 |
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T01G5.2 32 |
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R04B5.9 32 |
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F01D4.1 32 |
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ZC455.3 32 |
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F01D4.2 32 |
|
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AC3.8 32 |
|
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
549828 | Drug Response: Irinotecan response | 233,760,235(+) | TATATATATATATA/. | INTRON_VARIANT | |
708059 | Likely Benign: not provided | 233,767,102(+) | C/A | SYNONYMOUS_VARIANT | |
715222 | Benign: not provided | 233,713,840(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
724578 | Conflicting Interpretations: Crigler-Najjar syndrome; Lucey-Driscoll syndrome; Gilbert's syndrome; not provided | 233,767,133(+) | A/G | MISSENSE_VARIANT | |
728484 | Likely Benign: not provided | 233,760,959(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
crigler-najjar syndrome, type ii |
|
|
gilbert syndrome |
|
|
kernicterus |
|
|
crigler-najjar syndrome, type i |
|
|
bilirubin, serum level of, quantitative trait locus 1 |
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