UGT1A9 Gene (Protein Coding)

UDP Glucuronosyltransferase Family 1 Member A9

GC02P233671
GIFtS:
44
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followe... See more...

Aliases for UGT1A9 Gene

Aliases for UGT1A9 Gene

  • UDP Glucuronosyltransferase Family 1 Member A9 2 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A9 2 3
  • UDP-Glucuronosyltransferase 1A9 3 4
  • UDP-Glucuronosyltransferase 1-9 3 4
  • UDP-Glucuronosyltransferase 1-I 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 1-9 3 4
  • UGT1-09 3 4
  • HLUGP4 2 3
  • UGT-1I 3 4
  • UGT1.9 3 4
  • UGT1AI 2 3
  • LUGP4 2 3
  • UGT1I 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A9 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A9s 3
  • UGT1A9S 3
  • UGT1-9 3
  • UGT1A9 5
  • UGT1*9 4
  • UDPGT 3
  • LugP4 4
  • GNT1 4
  • UGT1 4

External Ids for UGT1A9 Gene

Previous GeneCards Identifiers for UGT1A9 Gene

  • GC02U990251
  • GC02P234822
  • GC02P234885
  • GC02P234369
  • GC02P234370
  • GC02P234200
  • GC02P234210
  • GC02P234220
  • GC02P234245
  • GC02P234580
  • GC02P226380

Summaries for UGT1A9 Gene

Entrez Gene Summary for UGT1A9 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A9 Gene

UGT1A9 (UDP Glucuronosyltransferase Family 1 Member A9) is a Protein Coding gene. Diseases associated with UGT1A9 include Crigler-Najjar Syndrome, Type Ii and Crigler-Najjar Syndrome, Type I. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A8.

UniProtKB/Swiss-Prot Summary for UGT1A9 Gene

  • [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
  • [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A9 Gene

Additional gene information for UGT1A9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT1A9 Gene

Genomics for UGT1A9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for UGT1A9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J233671 Promoter 0.8 EPDnew 250.7 0.0 -19 0.1 ATF3 YY1 RXRA ZBTB33 JUND HNF4A RAD21 REST MAX SP1 UGT1A9 UGT1A13P UGT1A10 UGT1A8 UGT1A
GH02J233688 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 0.4 +19.1 19103 4.1 YY1 CEBPB EP300 RXRA ZBTB33 JUND SPI1 SMARCE1 HNF4A DPF2 UGT1A6 UGT1A1 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233699 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.3 +28.1 28124 1.7 NCOR1 ZNF592 ATF3 NFIC YY1 CEBPB HES1 BHLHE40 FEZF1 MAX ENSG00000224814 UGT1A6 UGT1A5 UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233705 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +35.1 35103 3.6 ATF3 YY1 CEBPB FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 ENSG00000224814 MROH2A RPL17P11 USP40 UGT1A5 UGT1A6 UGT1A7 UGT1A9 UGT1A10 UGT1A8
GH02J233745 Promoter/Enhancer 1.3 EPDnew ENCODE 0.2 +73.7 73687 1 CEBPA ATF3 YY1 FOXA1 HOMEZ THAP11 FOXA2 KDM6A SMAD4 RXRA DNAJB3 UGT1A2P UGT1A1 UGT1A6 UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT1A9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT1A9

Top Transcription factor binding sites by QIAGEN in the UGT1A9 gene promoter:
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-gamma2

Genomic Locations for UGT1A9 Gene

Latest Assembly
chr2:233,671,898-233,773,300
(GRCh38/hg38)
Size:
101,403 bases
Orientation:
Plus strand

Previous Assembly
chr2:234,580,544-234,681,946
(GRCh37/hg19 by Entrez Gene)
Size:
101,403 bases
Orientation:
Plus strand

chr2:234,580,499-234,681,946
(GRCh37/hg19 by Ensembl)
Size:
101,448 bases
Orientation:
Plus strand

Genomic View for UGT1A9 Gene

Genes around UGT1A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UGT1A9 Gene

Proteins for UGT1A9 Gene

Products:

  1. Antibodies for research
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  • Protein details for UGT1A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60656-UD19_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1A9
    Protein Accession:
    O60656
    Secondary Accessions:
    • B8K285
    • P36509
    • Q9HAX0

    Protein attributes for UGT1A9 Gene

    Size:
    530 amino acids
    Molecular mass:
    59941 Da
    Quaternary structure:
    • Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 (PubMed:20610558).
    SequenceCaution:
    • Sequence=AAB19791.2; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • UGT1A9 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A9 Gene

Protein Expression for UGT1A9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for UGT1A9 Gene

O60656:
  • IADALGKIPQTVLWRYTG
  • NTILVKWLPQNDL
  • PEVSWQL
  • FWVEFVM
  • PQNDLLGHP
  • FDAVFLDPFD
  • AAHDLTW
  • VVFSLGSMV
  • LVVPMDGS
  • VMRHKGA
  • KLVEYLK
  • PLFGDQMDNAKR
  • YPKPVMPNMIFIGGINCHQGKP
  • NALKAVIN
  • GAGVTLNVLEMT
  • KSYKENIMRLSSLHKDRP
  • WLLRTDF
  • QYHSLDV
  • DVIGFLL
  • ASEILQTPVT
  • GKKGRVKKAHKSK
  • CNGVPMV
  • HPMTRAF
  • EPLDLAVFWVE

Post-translational modifications for UGT1A9 Gene

  • Glycosylation at Asn71, Asn292, and Asn344
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for UGT1A9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A9 Gene

Gene Families for UGT1A9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT1A9 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT1A9 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 1A9 (A9UKF4_HUMAN)
  • UDP-glucuronosyltransferase 1A9 (A9UKF7_HUMAN)
  • UDP-glucuronosyltransferase 1 family polypeptide A9s (B8K285_HUMAN)
  • UDP-glucuronosyltransferase 1A9 (Q330M4_HUMAN)
  • UDP-glucuronosyltransferase variant (Q4R0Z6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60656

UniProtKB/Swiss-Prot:

UD19_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A9: view

Function for UGT1A9 Gene

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  2. CRISPR products for research
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  6. Cell Lines for research

Molecular function for UGT1A9 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:19545173};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53004, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136931; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53040, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62845, ChEBI:CHEBI:136937; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53048, ChEBI:CHEBI:1156, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136967; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53060, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87602, ChEBI:CHEBI:136970; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63612, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147405; Evidence={ECO:0000269|PubMed:18052087};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP; Xref=Rhea:RHEA:63724, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149509, ChEBI:CHEBI:149522; Evidence={ECO:0000269|PubMed:18674515};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63696, ChEBI:CHEBI:8988, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149482; Evidence={ECO:0000269|PubMed:12181437};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63704, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62932, ChEBI:CHEBI:149486; Evidence={ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:18004212};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4 uM for estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=17 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=24 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=43 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=58 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=53 uM for 2-methoxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=126 uM for 2-methoxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=55 uM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=53 uM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 4) {ECO:0000269|PubMed:15472229}; KM=241 uM for 4-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=142 uM for 4-hydroxy-estrone (when assaying glucuronidation at position 4) {ECO:0000269|PubMed:15472229}; KM=2.09 uM for genistein {ECO:0000269|PubMed:19545173}; KM=0.7 uM for SN-38 (when assaying glucuronidation at position 10) {ECO:0000269|PubMed:12181437}; KM=160 uM for mycophenolate (when assaying glucuronidation at position 7) {ECO:0000269|PubMed:15470161}; Vmax=4 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=6 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=145 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=11 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=118 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=7 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=41 pmol/min/mg enzyme for the formation of 2-methoxyestrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=17 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1673 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=63 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=524 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 4-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=5.3 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=3.5 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=1.29 nmol/min/mg enzyme for the formation of genistein glucuronide {ECO:0000269|PubMed:19545173}; Vmax=0.25 nmol/min/mg enzyme for the formation of prunetin-5-O-(beta-D-glucuronoside) {ECO:0000269|PubMed:18052087}; Vmax=0.012 pmol/min/mg enzyme with 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) as substrate, for the formation of 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] {ECO:0000269|PubMed:16595710}; Vmax=2.4 pmol/min/mg enzyme for the formation of SN-38 glucuronide {ECO:0000269|PubMed:12181437}; Vmax=11.82 nmol/min/mg enzyme for the formation of mycophenolate 7-O-glucuronide {ECO:0000269|PubMed:15470161}; Note=Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values. {ECO:0000305|PubMed:15470161, ECO:0000305|PubMed:16595710, ECO:0000305|PubMed:18052087};

Enzyme Numbers (IUBMB) for UGT1A9 Gene

Phenotypes From GWAS Catalog for UGT1A9 Gene

Gene Ontology (GO) - Molecular Function for UGT1A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0008194 UDP-glycosyltransferase activity IEA --
GO:0015020 glucuronosyltransferase activity ISS,IDA 18052087
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT1A9: view
genes like me logo Genes that share phenotypes with UGT1A9: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A9

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A9 Gene

Localization for UGT1A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A9 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A9 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UGT1A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17179145
GO:0005789 endoplasmic reticulum membrane NAS,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT1A9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A9 Gene

Pathways & Interactions for UGT1A9 Gene

genes like me logo Genes that share pathways with UGT1A9: view

SIGNOR curated interactions for UGT1A9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UGT1A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process IDA 1910331
GO:0019216 regulation of lipid metabolic process TAS --
GO:0042573 retinoic acid metabolic process IC 20308471
GO:0051552 flavone metabolic process IDA 18052087
GO:0052695 cellular glucuronidation ISS,IDA 22579593
genes like me logo Genes that share ontologies with UGT1A9: view

Drugs & Compounds for UGT1A9 Gene

Products:

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(127) Drugs for UGT1A9 Gene - From: DrugBank, PharmGKB, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propofol Approved, Investigational, Vet_approved Pharma Enzyme, substrate 1708
Irinotecan Approved, Investigational Pharma Enzyme, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1504
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 0
Mycophenolic acid Approved Pharma Enzyme, substrate 1134
Sorafenib Approved, Investigational Pharma Enzyme, substrate, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 801

(139) Additional Compounds for UGT1A9 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SN38 glucuronide
  • sn-38g
  • 7-Ethyl-10-hydroxycamptothecin beta-glucuronide
  • sn 38g
  • 7-Ethyl-10-hydroxycamptothecin glucuronide
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-Sulfoethyl)amino]cholan-3-yl-b-D-glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-Sulphoethyl)amino]cholan-3-yl-b-D-glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-Sulphoethyl)amino]cholan-3-yl-b-D-glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-Sulfoethyl)amino]cholan-3-yl-beta-delta-glucopyranosiduronate
  • Taurolithocholic acid 3-glucuronide
 99794-82-8
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-glucopyranosiduronate
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
 58814-71-4
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
 77710-64-6
genes like me logo Genes that share compounds with UGT1A9: view

Transcripts for UGT1A9 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for UGT1A9 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A9

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A9 Gene

No ASD Table

Relevant External Links for UGT1A9 Gene

GeneLoc Exon Structure for
UGT1A9

Expression for UGT1A9 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A9 Gene

mRNA expression in normal human tissues for UGT1A9 Gene
mRNA expression by BioGPS for UGT1A9 GenemRNA expression by GTEx for UGT1A9 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A9 Gene

This gene is overexpressed in Kidney - Cortex (x41.9) and Liver (x10.1).

Protein differential expression in normal tissues from HIPED for UGT1A9 Gene

This gene is overexpressed in Kidney (32.8), Liver (20.6), and Gallbladder (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT1A9 Gene



Protein tissue co-expression partners for UGT1A9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT1A9

mRNA Expression by UniProt/SwissProt for UGT1A9 Gene:

O60656-UD19_HUMAN
Tissue specificity: [Isoform 1]: Expressed in liver, kidney, colon, esophagus and small intestine.

Evidence on tissue expression from TISSUES for UGT1A9 Gene

  • Liver(4.5)
  • Kidney(4.4)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with UGT1A9: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A9 Gene

Orthologs for UGT1A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia UGT1A9 30
  • 99 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ugt1a8 29
  • 82.09 (n)
Mouse
(Mus musculus)
 Mammalia Ugt1a9 29 16 30
  • 81.11 (n)
 ManyToMany
Ugt1a10 16 30
  • 79 (a)
 ManyToMany
Ugt1a7c 30
  • 79 (a)
 ManyToMany
Ugt1a8 30
  • 78 (a)
 ManyToMany
Dog
(Canis familiaris)
 Mammalia -- 30
  • 68 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia -- 30
  • 43 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves -- 30
  • 60 (a)
 ManyToMany
-- 30
  • 44 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 38 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii ugt1a7 30
  • 50 (a)
 ManyToMany
ugt1b1 30
  • 46 (a)
 ManyToMany
ugt1b4 30
  • 46 (a)
 ManyToMany
ugt1b5 30
  • 45 (a)
 ManyToMany
ugt1b3 30
  • 45 (a)
 ManyToMany
ugt1b2 30
  • 45 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG11289 31
  • 35 (a)
Ugt86Dc 31
  • 34 (a)
Ugt86Da 31
  • 33 (a)
CG15661 31
  • 32 (a)
CG6475 31
  • 32 (a)
Ugt86Di 31
  • 32 (a)
Ugt86De 31
  • 30 (a)
Ugt37c1 31
  • 30 (a)
Ugt36Bb 31
  • 30 (a)
BEST:GH09393 31
  • 29 (a)
CG10168 31
  • 29 (a)
Ugt36Ba 31
  • 29 (a)
BEST:GH06505 31
  • 28 (a)
Ugt37a1 31
  • 27 (a)
Ugt86Dh 31
  • 27 (a)
Ugt37b1 31
  • 27 (a)
CG10178 31
  • 27 (a)
CG5724 31
  • 27 (a)
CG17323 31
  • 27 (a)
CG5999 31
  • 26 (a)
Dot 31
  • 26 (a)
CG10170 31
  • 25 (a)
CG16732 31
  • 24 (a)
Worm
(Caenorhabditis elegans)
 Secernentea F39G3.1 31
  • 29 (a)
M88.1 31
  • 29 (a)
F35H8.6 31
  • 29 (a)
ZC443.5 31
  • 27 (a)
Y37E11AR.5 31
  • 27 (a)
C08F11.8 31
  • 26 (a)
C10H11.5 31
  • 26 (a)
C17G1.3 31
  • 26 (a)
AC3.2 31
  • 25 (a)
C10H11.4 31
  • 25 (a)
C08B6.1 31
  • 25 (a)
C44H9.1 31
  • 25 (a)
C33A12.6 31
  • 25 (a)
AC3.7 31
  • 25 (a)
F56B3.7 31
  • 25 (a)
C49A9.8 31
  • 24 (a)
C10H11.6 31
  • 24 (a)
F09G2.6 31
  • 24 (a)
K08B4.4 31
  • 24 (a)
T01G5.2 31
  • 24 (a)
R04B5.9 31
  • 23 (a)
F01D4.1 31
  • 23 (a)
ZC455.3 31
  • 22 (a)
F01D4.2 31
  • 22 (a)
AC3.8 31
  • 21 (a)
Species where no ortholog for UGT1A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for UGT1A9 Gene

ENSEMBL:
Gene Tree for UGT1A9 (if available)
TreeFam:
Gene Tree for UGT1A9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT1A9: view image
Alliance of Genome Resources:
Additional Orthologs for UGT1A9

Paralogs for UGT1A9 Gene

Paralogs for UGT1A9 Gene

(31) SIMAP similar genes for UGT1A9 Gene using alignment to 8 proteins:

  • UD19_HUMAN
  • A9UKF4_HUMAN
  • A9UKF7_HUMAN
  • Q330M4_HUMAN
  • Q4R0Z6_HUMAN
  • Q4R0Z7_HUMAN
  • Q53E75_HUMAN
  • Q5DSZ5_HUMAN

Pseudogenes.org Pseudogenes for UGT1A9 Gene

genes like me logo Genes that share paralogs with UGT1A9: view

Variants for UGT1A9 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT1A9 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
549828 Drug Response: Irinotecan response 233,760,235(+) TATATATATATATA/.
UGT1A1*1 		INTRON
895439 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,312(+) C/T
NM_000463.3(UGT1A1):c.25C>T (p.Arg9Cys) 		MISSENSE_VARIANT,INTRON
895502 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,648(+) G/C
NM_000463.3(UGT1A1):c.361G>C (p.Ala121Pro) 		MISSENSE_VARIANT,INTRON
895576 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,768,315(+) T/C
NM_000463.3(UGT1A1):c.1180T>C (p.Phe394Leu) 		MISSENSE
895638 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,772,692(+) G/A
NM_000463.3(UGT1A1):c.*133G>A 		THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT1A9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT1A9 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2661542 CNV deletion 23128226
esv2721664 CNV deletion 23290073
esv2721666 CNV deletion 23290073
esv2721667 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3561178 CNV deletion 23714750
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv1138902 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963781 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv979184 CNV duplication 23825009
nsv979185 CNV duplication 23825009
nsv979186 CNV duplication 23825009
nsv979187 CNV duplication 23825009

Variation tolerance for UGT1A9 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT1A9 Gene

Human Gene Mutation Database (HGMD)
UGT1A9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A9
Leiden Open Variation Database (LOVD)
UGT1A9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A9 Gene

Disorders for UGT1A9 Gene

MalaCards: The human disease database

(10) MalaCards diseases for UGT1A9 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
bilirubin, serum level of, quantitative trait locus 1
  • biliqtl1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT1A9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT1A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A9 Gene

Publications for UGT1A9 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Ménard V … Guillemette C (Human mutation 2009) 3 4 22 40
  2. Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). (PMID: 18816295) Takahashi H … Takeuchi Y (Basic & clinical pharmacology & toxicology 2008) 3 22 25 40
  3. N-Glycosylation plays a role in protein folding of human UGT1A9. (PMID: 19951703) Nakajima M … Yokoi T (Biochemical pharmacology 2010) 3 4 22
  4. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. (PMID: 19364970) Cecchin E … Toffoli G (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009) 3 22 40
  5. The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients. (PMID: 19715905) Sánchez-Fructuoso AI … Barrientos A (Transplantation proceedings 2009) 3 22 40

ExternalLinks

View latest publications for UGT1A9 gene in Mastermind

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