Aliases for UGT1A8 Gene
- UDP Glucuronosyltransferase Family 1 Member A8 2 3 5
- UGT1H 2 3 4
- UDP Glycosyltransferase 1 Family, Polypeptide A8 2 3
- UDP-Glucuronosyltransferase 1A8 3 4
- UDP-Glucuronosyltransferase 1-8 3 4
- UDP-Glucuronosyltransferase 1-H 3 4
- EC 126.96.36.199 4 51
- UDPGT 1-8 3 4
- UGT1-08 3 4
- UGT-1H 3 4
- UGT1.8 3 4
- GNT1 3 4
- UGT1 3 4
- UDP Glucuronosyltransferase 1 Family, Polypeptide A8 3
- UDP-Glucuronosyltransferase 1 Family Polypeptide A8s 3
External Ids for UGT1A8 Gene
Previous GeneCards Identifiers for UGT1A8 Gene
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]
GeneCards Summary for UGT1A8 Gene
UGT1A8 (UDP Glucuronosyltransferase Family 1 Member A8) is a Protein Coding gene. Diseases associated with UGT1A8 include Gilbert Syndrome and Cholelithiasis. Among its related pathways are Codeine and Morphine Metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A10.
UniProtKB/Swiss-Prot Summary for UGT1A8 Gene
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
[Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.