This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followe... See more...

Aliases for UGT1A8 Gene

Aliases for UGT1A8 Gene

  • UDP Glucuronosyltransferase Family 1 Member A8 2 3 5
  • UGT1H 2 3 4
  • UDP Glycosyltransferase 1 Family, Polypeptide A8 2 3
  • UDP-Glucuronosyltransferase 1A8 3 4
  • UDP-Glucuronosyltransferase 1-8 3 4
  • UDP-Glucuronosyltransferase 1-H 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 1-8 3 4
  • UGT1-08 3 4
  • UGT-1H 3 4
  • UGT1.8 3 4
  • GNT1 3 4
  • UGT1 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A8 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A8s 3
  • Bilirubin-Specific UDPGT Isozyme 1 3
  • UDP-Glucuronosyltransferase 1-1 3
  • UDP-Glucuronosyltransferase 1-A 3
  • UDP-Glucuronosyltransferase 1A1 3
  • UDPGT 1-1 3
  • UGT1-01 3
  • UGT1A8S 3
  • HUG-BR1 3
  • UGT-1A 3
  • UGT1.1 3
  • UGT1A1 3
  • UGT1A8 5
  • UGT1*8 4
  • UDPGT 3
  • UGT1A 3

External Ids for UGT1A8 Gene

Previous GeneCards Identifiers for UGT1A8 Gene

  • GC02P232535
  • GC02U900011
  • GC02P234821
  • GC02P234884
  • GC02P234308
  • GC02P234199
  • GC02P234207
  • GC02P234213
  • GC02P234219
  • GC02P234225
  • GC02P234227
  • GC02P234526
  • GC02P226326

Summaries for UGT1A8 Gene

Entrez Gene Summary for UGT1A8 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A8 Gene

UGT1A8 (UDP Glucuronosyltransferase Family 1 Member A8) is a Protein Coding gene. Diseases associated with UGT1A8 include Bilirubin Metabolic Disorder and Gilbert Syndrome. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A10.

UniProtKB/Swiss-Prot Summary for UGT1A8 Gene

  • [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
  • [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT1A8 Gene

Genomics for UGT1A8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT1A8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233617 Promoter 0.3 EPDnew 250.7 +0.0 20 0.1 UGT1A8 UGT1A10 UGT1A
GH02J233688 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 0.2 +73.4 73368 4.1 YY1 CEBPB EP300 RXRA ZBTB33 JUND SPI1 SMARCE1 HNF4A DPF2 UGT1A6 UGT1A1 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233593 Enhancer 0.6 ENCODE 0.4 -24.3 -24263 0.2 BCL11A IRF4 CBFB BHLHE40 BATF NR2F1 JUNB IKZF1 CREM MTA2 USP40 UGT1A4 UGT1A UGT1A12P lnc-UGT1A8-2 UGT1A8
GH02J233699 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.2 +82.4 82389 1.7 NCOR1 ZNF592 ATF3 NFIC YY1 CEBPB HES1 BHLHE40 FEZF1 MAX ENSG00000224814 UGT1A6 UGT1A5 UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233705 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +89.4 89368 3.6 ATF3 YY1 CEBPB FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 ENSG00000224814 MROH2A RPL17P11 USP40 UGT1A5 UGT1A6 UGT1A7 UGT1A9 UGT1A10 UGT1A8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT1A8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT1A8

Top Transcription factor binding sites by QIAGEN in the UGT1A8 gene promoter:
  • LCR-F1
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for UGT1A8 Gene

Latest Assembly
chr2:233,617,633-233,773,310
(GRCh38/hg38)
Size:
155,678 bases
Orientation:
Plus strand

Previous Assembly
chr2:234,526,279-234,681,946
(GRCh37/hg19 by Entrez Gene)
Size:
155,668 bases
Orientation:
Plus strand

chr2:234,668,894-234,681,945
(GRCh37/hg19 by Ensembl)
Size:
13,052 bases
Orientation:
Plus strand

Genomic View for UGT1A8 Gene

Genes around UGT1A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A8 Gene

Proteins for UGT1A8 Gene

  • Protein details for UGT1A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW9-UD18_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1A8
    Protein Accession:
    Q9HAW9
    Secondary Accessions:
    • B2R8S3
    • B8K290
    • O14928
    • Q8TEX4
    • Q8WTQ9
    • Q8WX85

    Protein attributes for UGT1A8 Gene

    Size:
    530 amino acids
    Molecular mass:
    59742 Da
    Quaternary structure:
    • Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 (PubMed:20610558).
    Miscellaneous:
    • UGT1A8 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A8 Gene

Selected DME Specific Peptides for UGT1A8 Gene

Q9HAW9:
  • NTILVKWLPQNDL
  • PQNDLLGHP
  • AAHDLTW
  • PLFGDQMDNAKR
  • YPKPVMPNMIFIGGINCHQGKP
  • NALKAVIN
  • GAGVTLNVLEMT
  • WLLRTDF
  • DVIGFLL
  • GKKGRVKKAHKSK
  • EPLDLAVFWVE
  • IADALGKIPQTVLWRYTG
  • PEVSWQL
  • FWVEFVM
  • FDAVFLDPFD
  • VVFSLGSMV
  • LVVPMDGS
  • VMRHKGA
  • KLVEYLK
  • KSYKENIMRLSSLHKDRP
  • QYHSLDV
  • ASEILQTPVT
  • CNGVPMV
  • HPMTRAF

Post-translational modifications for UGT1A8 Gene

  • Glycosylation at Asn71, Asn292, and Asn344
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for UGT1A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A8 Gene

Gene Families for UGT1A8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT1A8 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT1A8 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 1A8 (A9JQZ1_HUMAN)
  • UDP-glucuronosyltransferase 1A8 (A9JQZ2_HUMAN)
  • UDP-glucuronosyltransferase 1A8 (A9JQZ4_HUMAN)
  • UDP-glucuronosyltransferase 1 family polypeptide A8s (B8K290_HUMAN)
  • UDP-glucuronosyltransferase (Q13460_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HAW9

UniProtKB/Swiss-Prot:

UD18_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A8: view

Function for UGT1A8 Gene

Molecular function for UGT1A8 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18052087, PubMed:18004212, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18052087, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:20610558, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence={ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence={ECO:0000269|PubMed:18719240};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52476, ChEBI:CHEBI:15378, ChEBI:CHEBI:17263, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136634; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52924, ChEBI:CHEBI:15378, ChEBI:CHEBI:42156, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136882; Evidence={ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53004, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136931; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53032, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136933; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53048, ChEBI:CHEBI:1156, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136967; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53036, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62845, ChEBI:CHEBI:136936; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53040, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62845, ChEBI:CHEBI:136937; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53052, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87602, ChEBI:CHEBI:136969; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53060, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87602, ChEBI:CHEBI:136970; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53072, ChEBI:CHEBI:15378, ChEBI:CHEBI:28955, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136974; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53064, ChEBI:CHEBI:1189, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136971; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53080, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136975, ChEBI:CHEBI:136976; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53068, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136972, ChEBI:CHEBI:136973; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53000, ChEBI:CHEBI:15378, ChEBI:CHEBI:16330, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136914; Evidence={ECO:0000269|PubMed:16595710};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP; Xref=Rhea:RHEA:53388, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136914, ChEBI:CHEBI:136916; Evidence={ECO:0000269|PubMed:16595710};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63588, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147404; Evidence={ECO:0000269|PubMed:18052087};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63612, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147405; Evidence={ECO:0000269|PubMed:18052087};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP; Xref=Rhea:RHEA:63724, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149509, ChEBI:CHEBI:149522; Evidence={ECO:0000269|PubMed:18674515};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63704, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:62932, ChEBI:CHEBI:149486; Evidence={ECO:0000269|PubMed:15470161, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=61.7 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=10 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:18719240}; KM=38 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=55 uM for estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=20 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=102 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=40 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=52 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=118 uM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=105 uM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 4) {ECO:0000269|PubMed:15472229}; KM=184 uM for 4-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=431 uM for 4-hydroxy-estrone (when assaying glucuronidation at position 4) {ECO:0000269|PubMed:15472229}; KM=66 uM for 2-methoxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=69 uM for 2-methoxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=8 uM for 4-methoxy-17beta-estradiol(when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=111 uM for 4-methoxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=1.25 uM for genistein {ECO:0000269|PubMed:19545173}; KM=382.3 uM for 17beta-hydroxy-5alpha-androstan-3-one (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:16595710}; KM=1390 uM for mycophenolate (when assaying glucuronidation at position 7) {ECO:0000269|PubMed:15470161}; KM=20.3 uM for SN-38 (when assaying glucuronidation at position 10) {ECO:0000269|PubMed:12181437}; KM=128 uM for mycophenolate (when assaying glucuronidation at position 7) {ECO:0000269|PubMed:20610558}; Vmax=200 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=217 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=4.75 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=195 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=142 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=188 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=126 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=88 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=38 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=119 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=4723 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1975 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1538 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 4-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1050 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=749 pmol/min/mg enzyme for the formation of 2-methoxyestrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=218 pmol/min/mg enzyme for the formation of 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=275 pmol/min/mg enzyme for the formation of 4-methoxyestrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=3.3 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=16.3 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=78.6 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=47.9 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=15.6 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=0.24 nmol/min/mg enzyme for the formation of prunetin-5-O-(beta-D-glucuronoside) {ECO:0000269|PubMed:18052087}; Vmax=0.11 nmol/min/mg enzyme for the formation of prunetin-4'-O-(beta-D-glucuronoside) {ECO:0000269|PubMed:18052087}; Vmax=2.24 nmol/min/mg enzyme for the formation of genistein glucuronide {ECO:0000269|PubMed:19545173}; Vmax=0.047 pmol/min/mg enzyme with 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) as substrate, for the formation of 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] {ECO:0000269|PubMed:16595710}; Vmax=0.107 pmol/min/mg enzyme with 17beta-hydroxy-5alpha-androstan-3-one as substrate, for the formation of 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] {ECO:0000269|PubMed:16595710}; Vmax=1.9 nmol/min/mg enzyme for the formation of mycophenolate 7-O-glucuronide {ECO:0000269|PubMed:20610558}; Vmax=7.27 nmol/min/mg enzyme for the formation of mycophenolate 7-O-glucuronide {ECO:0000269|PubMed:15470161}; Vmax=5 pmol/min/mg enzyme for the formation of SN-38 glucuronide {ECO:0000269|PubMed:12181437}; Note=Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values. {ECO:0000305|PubMed:15470161, ECO:0000305|PubMed:16595710, ECO:0000305|PubMed:18052087, ECO:0000305|PubMed:19545173};

Enzyme Numbers (IUBMB) for UGT1A8 Gene

Phenotypes From GWAS Catalog for UGT1A8 Gene

Gene Ontology (GO) - Molecular Function for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IC 20308471
GO:0004857 enzyme inhibitor activity IDA 19996319
GO:0005496 steroid binding IDA 19996319
GO:0005504 fatty acid binding IDA 19996319
GO:0008144 drug binding IDA --
genes like me logo Genes that share ontologies with UGT1A8: view
genes like me logo Genes that share phenotypes with UGT1A8: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A8

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A8 Gene

Localization for UGT1A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A8 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A8 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17179145
GO:0005789 endoplasmic reticulum membrane NAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT1A8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A8 Gene

Pathways & Interactions for UGT1A8 Gene

genes like me logo Genes that share pathways with UGT1A8: view

Pathways by source for UGT1A8 Gene

SIGNOR curated interactions for UGT1A8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IC 19996319
GO:0008202 steroid metabolic process IC,IDA 15472229
GO:0009804 coumarin metabolic process IC 19996319
GO:0017144 drug metabolic process IDA --
GO:0042573 retinoic acid metabolic process IC 20308471
genes like me logo Genes that share ontologies with UGT1A8: view

Drugs & Compounds for UGT1A8 Gene

(53) Drugs for UGT1A8 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 0
Estradiol Approved, Investigational, Vet_approved Pharma Enzyme, substrate, inducer Sex hormone 1160
Morphine Approved, Investigational Pharma Enzyme, substrate 1511
raloxifene Approved, Investigational Pharma Enzyme, substrate 0
Valproic acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 387

(80) Additional Compounds for UGT1A8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
17-alpha-Estradiol-3-glucuronide
  • 17-a-Estradiol-3-glucuronide
  • 17-Α-estradiol-3-glucuronide
17-beta-Estradiol glucuronide
  • 17-b-Estradiol glucuronide
  • 17-Β-estradiol glucuronide
  • beta-Estradiol 17-beta-D-glucuronide
  • e(2)17g CPD
  • Estradiol-17 beta-glucuronide, monosodium salt
genes like me logo Genes that share compounds with UGT1A8: view

Transcripts for UGT1A8 Gene

mRNA/cDNA for UGT1A8 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A8

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A8 Gene

No ASD Table

Relevant External Links for UGT1A8 Gene

GeneLoc Exon Structure for
UGT1A8

Expression for UGT1A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT1A8 Gene

This gene is overexpressed in Liver (x49.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT1A8

mRNA Expression by UniProt/SwissProt for UGT1A8 Gene:

Q9HAW9-UD18_HUMAN
Tissue specificity: [Isoform 1]: Expressed in kidney, colon and small intestine (PubMed:18004212). Not expressed in liver (PubMed:18004212).

Evidence on tissue expression from TISSUES for UGT1A8 Gene

  • Liver(4.6)
  • Intestine(4.5)
  • Blood(4.5)
  • Urine(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with UGT1A8: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A8 Gene

Orthologs for UGT1A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UGT1A1 30
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ugt1a8 29
  • 81.57 (n)
Mouse
(Mus musculus)
Mammalia Ugt1a9 29
  • 80.59 (n)
Ugt1a1 30
  • 78 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia UGT1A6 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UGT1A1 30
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 66 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15808 29
Zebrafish
(Danio rerio)
Actinopterygii ugt1a7 30
  • 49 (a)
ManyToMany
ugt1b1 30
  • 48 (a)
ManyToMany
ugt1b5 30
  • 46 (a)
ManyToMany
ugt1b4 30
  • 46 (a)
ManyToMany
ugt1b3 30
  • 46 (a)
ManyToMany
ugt1b2 30
  • 45 (a)
ManyToMany
fads2 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG11289 31
  • 35 (a)
Ugt86Dc 31
  • 34 (a)
Ugt86Da 31
  • 33 (a)
Ugt86Di 31
  • 33 (a)
CG6475 31
  • 32 (a)
BEST:GH09393 31
  • 31 (a)
Ugt86De 31
  • 30 (a)
Ugt37c1 31
  • 30 (a)
Ugt36Bb 31
  • 29 (a)
BEST:GH06505 31
  • 28 (a)
Ugt36Ba 31
  • 28 (a)
Ugt86Dh 31
  • 27 (a)
Ugt37b1 31
  • 27 (a)
CG5724 31
  • 27 (a)
CG17323 31
  • 27 (a)
CG10178 31
  • 26 (a)
CG16732 31
  • 25 (a)
Dot 31
  • 25 (a)
CG10170 31
  • 24 (a)
Worm
(Caenorhabditis elegans)
Secernentea F39G3.1 31
  • 28 (a)
M88.1 31
  • 28 (a)
ZC443.5 31
  • 27 (a)
C08F11.8 31
  • 26 (a)
C10H11.5 31
  • 26 (a)
Y37E11AR.5 31
  • 26 (a)
AC3.2 31
  • 25 (a)
C08B6.1 31
  • 25 (a)
F09G2.6 31
  • 25 (a)
T01G5.2 31
  • 25 (a)
C49A9.8 31
  • 24 (a)
C10H11.4 31
  • 24 (a)
C10H11.6 31
  • 24 (a)
C17G1.3 31
  • 24 (a)
C33A12.6 31
  • 24 (a)
F01D4.1 31
  • 23 (a)
K08B4.4 31
  • 23 (a)
AC3.8 31
  • 22 (a)
ZC455.3 31
  • 22 (a)
F01D4.2 31
  • 22 (a)
Species where no ortholog for UGT1A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for UGT1A8 Gene

ENSEMBL:
Gene Tree for UGT1A8 (if available)
TreeFam:
Gene Tree for UGT1A8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT1A8: view image
Alliance of Genome Resources:
Additional Orthologs for UGT1A8

Paralogs for UGT1A8 Gene

(31) SIMAP similar genes for UGT1A8 Gene using alignment to 5 proteins:

  • UD18_HUMAN
  • A9JQZ1_HUMAN
  • A9JQZ2_HUMAN
  • A9JQZ4_HUMAN
  • Q5DSZ6_HUMAN
genes like me logo Genes that share paralogs with UGT1A8: view

Variants for UGT1A8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT1A8 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
549828 Drug Response: Irinotecan response 233,760,235(+) TATATATATATATA/.
UGT1A1*1
INTRON
895439 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,312(+) C/T
NM_000463.3(UGT1A1):c.25C>T (p.Arg9Cys)
MISSENSE_VARIANT,INTRON
895502 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,648(+) G/C
NM_000463.3(UGT1A1):c.361G>C (p.Ala121Pro)
MISSENSE_VARIANT,INTRON
895576 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,768,315(+) T/C
NM_000463.3(UGT1A1):c.1180T>C (p.Phe394Leu)
MISSENSE
895638 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,772,692(+) G/A
NM_000463.3(UGT1A1):c.*133G>A
THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT1A8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT1A8 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv22295 CNV loss 19812545
esv2422005 CNV deletion 20811451
esv24647 CNV gain 19812545
esv25622 CNV loss 19812545
esv2657145 CNV deletion 23128226
esv2661542 CNV deletion 23128226
esv2721663 CNV deletion 23290073
esv2721664 CNV deletion 23290073
esv2721665 CNV deletion 23290073
esv2721666 CNV deletion 23290073
esv2721667 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv2762307 CNV gain 21179565
esv3561177 CNV deletion 23714750
esv3561178 CNV deletion 23714750
esv3594678 CNV loss 21293372
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv3893573 CNV gain 25118596
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv1138902 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584704 CNV loss 21841781
nsv584705 CNV loss 21841781
nsv7336 OTHER inversion 18451855
nsv961572 CNV duplication 23825009
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963781 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv979184 CNV duplication 23825009
nsv979185 CNV duplication 23825009
nsv979186 CNV duplication 23825009
nsv979187 CNV duplication 23825009

Variation tolerance for UGT1A8 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT1A8 Gene

Human Gene Mutation Database (HGMD)
UGT1A8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A8
Leiden Open Variation Database (LOVD)
UGT1A8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A8 Gene

Disorders for UGT1A8 Gene

MalaCards: The human disease database

(21) MalaCards diseases for UGT1A8 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
bilirubin, serum level of, quantitative trait locus 1
  • biliqtl1
hyperbilirubinemia, transient familial neonatal
  • hblrtfn
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT1A8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT1A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A8 Gene

Publications for UGT1A8 Gene

  1. Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors. (PMID: 18568343) Johnson LA … Jacobson PA (European journal of clinical pharmacology 2008) 3 22 40
  2. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. (PMID: 17179145) Operaña TN … Tukey RH (The Journal of biological chemistry 2007) 3 4 22
  3. The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. (PMID: 17339869) Lévesque E … Guillemette C (Clinical pharmacology and therapeutics 2007) 3 22 40
  4. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. (PMID: 18052087) Joseph TB … Hu M (Molecular pharmaceutics 2007) 3 4 22
  5. Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. (PMID: 16397224) Thibaudeau J … Guillemette C (Cancer research 2006) 3 22 40

Products for UGT1A8 Gene

Sources for UGT1A8 Gene