This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followe... See more...

Aliases for UGT1A7 Gene

Aliases for UGT1A7 Gene

  • UDP Glucuronosyltransferase Family 1 Member A7 2 3 5
  • UGT1G 2 3 4
  • UDP Glycosyltransferase 1 Family, Polypeptide A7 2 3
  • UDP-Glucuronosyltransferase 1-7 3 4
  • UDP-Glucuronosyltransferase 1-G 3 4
  • UDP-Glucuronosyltransferase 1A7 3 4
  • EC 2.4.1.17 4 51
  • UDPGT 1-7 3 4
  • UGT1-07 3 4
  • UGT-1G 3 4
  • UGT1.7 3 4
  • GNT1 3 4
  • UGT1 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A7 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A7s 3
  • Bilirubin-Specific UDPGT Isozyme 1 3
  • UDP-Glucuronosyltransferase 1-1 3
  • UDP-Glucuronosyltransferase 1-A 3
  • UDP-Glucuronosyltransferase 1A1 3
  • UDPGT 1-1 3
  • UGT1-01 3
  • HUG-BR1 3
  • UGT-1A 3
  • UGT1.1 3
  • UGT1A1 3
  • UGT1A7 5
  • UGT1*7 4
  • UDPGT 3
  • UGT1A 3

External Ids for UGT1A7 Gene

Previous GeneCards Identifiers for UGT1A7 Gene

  • GC02U990247
  • GC02P234820
  • GC02P234883
  • GC02P234368
  • GC02P234372
  • GC02P234198
  • GC02P234209
  • GC02P234218
  • GC02P234255
  • GC02P234581
  • GC02P226390

Summaries for UGT1A7 Gene

Entrez Gene Summary for UGT1A7 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A7 Gene

UGT1A7 (UDP Glucuronosyltransferase Family 1 Member A7) is a Protein Coding gene. Diseases associated with UGT1A7 include Gilbert Syndrome and Bilirubin Metabolic Disorder. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A8.

UniProtKB/Swiss-Prot Summary for UGT1A7 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT1A7 Gene

Genomics for UGT1A7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT1A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233681 Promoter 0.3 EPDnew 600.7 -0.1 -56 0.1 UGT1A7 UGT1A6 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233682 Promoter 0.3 EPDnew 600.7 +0.8 794 0.1 UGT1A7 UGT1A1 UGT1A6 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233688 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 0.4 +9.1 9063 4.1 CREB1 SP1 CEBPB JUN RCOR1 YY1 ZBTB33 JUND EP300 FOSL2 UGT1A6 UGT1A1 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233699 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +17.6 17622 2.6 REST JUND MTA2 PHF21A MTA1 SP1 DPF2 HDAC1 SOX6 FOXJ2 USP40 UGT1A6 MROH2A ENSG00000224814 UGT1A5 UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233705 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +25.3 25263 3.6 REST FOXA1 SP1 CEBPB FOXA2 ATF3 YY1 GABPA ZBTB33 SIX5 ENSG00000224814 RPL17P11 USP40 UGT1A5 UGT1A6 UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT1A7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT1A7

Top Transcription factor binding sites by QIAGEN in the UGT1A7 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • COUP
  • HNF-4alpha2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for UGT1A7 Gene

Genomic Locations for UGT1A7 Gene
chr2:233,681,938-233,773,299
(GRCh38/hg38)
Size:
91,362 bases
Orientation:
Plus strand
chr2:234,590,584-234,681,945
(GRCh37/hg19)
Size:
91,362 bases
Orientation:
Plus strand

Genomic View for UGT1A7 Gene

Genes around UGT1A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A7 Gene

Proteins for UGT1A7 Gene

  • Protein details for UGT1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW7-UD17_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-7
    Protein Accession:
    Q9HAW7
    Secondary Accessions:
    • B8K293
    • O00473

    Protein attributes for UGT1A7 Gene

    Size:
    530 amino acids
    Molecular mass:
    59819 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A7 Gene

Selected DME Specific Peptides for UGT1A7 Gene

Q9HAW7:
  • NTILVKWLPQNDL
  • PQNDLLGHP
  • AAHDLTW
  • PLFGDQMDNAKR
  • YPKPVMPNMIFIGGINCHQGKP
  • NALKAVIN
  • GAGVTLNVLEMT
  • GIFCHYL
  • WLLRTDF
  • DVIGFLL
  • GKKGRVKKAHKSK
  • EPLDLAVFWVE
  • IADALGKIPQTVLWRYTG
  • PEVSWQL
  • FWVEFVM
  • FDAVFLDPFD
  • VVFSLGSMV
  • LVVPMDGS
  • VMRHKGA
  • KLVEYLK
  • KSYKENIMRLSSLHKDRP
  • QYHSLDV
  • ASEILQTPVT
  • CNGVPMV
  • HPMTRAF

Post-translational modifications for UGT1A7 Gene

  • Glycosylation at Asn71, Asn292, and Asn344
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for UGT1A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A7 Gene

Gene Families for UGT1A7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UGT1A7 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase
  • Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
ProtoNet:

Suggested Antigen Peptide Sequences for UGT1A7 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 1 family polypeptide A7s (B8K293_HUMAN)
  • UDP-glucuronosyltransferase (Q13407_HUMAN)
  • UDP-glucuronosyltransferase (Q4R0Z5_HUMAN)
  • UDP glycosyltransferase 1 family polypeptide A7 (Q5DSZ7_HUMAN)
  • UDP-glucuronosyltransferase (Q5K632_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HAW7

UniProtKB/Swiss-Prot:

UD17_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A7: view

Function for UGT1A7 Gene

Molecular function for UGT1A7 Gene

UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558};.

Enzyme Numbers (IUBMB) for UGT1A7 Gene

Phenotypes From GWAS Catalog for UGT1A7 Gene

Gene Ontology (GO) - Molecular Function for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0004857 enzyme inhibitor activity IDA 19996319
GO:0005080 protein kinase C binding IDA 18556656
GO:0015020 glucuronosyltransferase activity IEA,IDA 17179145
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UGT1A7: view
genes like me logo Genes that share phenotypes with UGT1A7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A7

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A7 Gene

Localization for UGT1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A7 Gene

Microsome. Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A7 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17179145
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with UGT1A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A7 Gene

Pathways & Interactions for UGT1A7 Gene

genes like me logo Genes that share pathways with UGT1A7: view

Gene Ontology (GO) - Biological Process for UGT1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007588 excretion IC 20056724
GO:0009804 coumarin metabolic process IC 19996319
GO:0017144 drug metabolic process IC 19996319
GO:0042573 retinoic acid metabolic process IC 20308471
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with UGT1A7: view

No data available for SIGNOR curated interactions for UGT1A7 Gene

Drugs & Compounds for UGT1A7 Gene

(46) Drugs for UGT1A7 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolic acid Approved Pharma Enzyme, substrate 1097
Ritonavir Approved, Investigational Pharma Enzyme, inducer HIV protease inhibitor 1023
Estradiol Approved, Investigational, Vet_approved Pharma Enzyme, substrate, inducer Sex hormone 1113
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 0
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1414

(90) Additional Compounds for UGT1A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SN38 glucuronide
  • sn-38g
  • 7-Ethyl-10-hydroxycamptothecin beta-glucuronide
  • sn 38g
  • 7-Ethyl-10-hydroxycamptothecin glucuronide
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-Cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-Cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-Hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
genes like me logo Genes that share compounds with UGT1A7: view

Transcripts for UGT1A7 Gene

mRNA/cDNA for UGT1A7 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A7

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A7 Gene

No ASD Table

Relevant External Links for UGT1A7 Gene

GeneLoc Exon Structure for
UGT1A7

Expression for UGT1A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for UGT1A7 Gene

This gene is overexpressed in Esophagus - Mucosa (x40.8) and Minor Salivary Gland (x5.5).

Protein differential expression in normal tissues from HIPED for UGT1A7 Gene

This gene is overexpressed in Kidney (42.3), Gallbladder (18.6), and Liver (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGT1A7 Gene



Protein tissue co-expression partners for UGT1A7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT1A7

mRNA Expression by UniProt/SwissProt for UGT1A7 Gene:

Q9HAW7-UD17_HUMAN
Tissue specificity: Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212).

Evidence on tissue expression from TISSUES for UGT1A7 Gene

  • Liver(2.9)
  • Intestine(2.3)
  • Kidney(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with UGT1A7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A7 Gene

Orthologs for UGT1A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UGT1A7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UGT1A7 31
  • 99 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ugt1a8 30
  • 81.96 (n)
Mouse
(Mus musculus)
Mammalia Ugt1a9 30 31
  • 81.44 (n)
ManyToMany
Ugt1a10 31
  • 79 (a)
ManyToMany
Ugt1a8 31
  • 78 (a)
ManyToMany
Ugt1a7c 31
  • 78 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 65 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MGC152010 31
  • 43 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 59 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ugt1a7 31
  • 49 (a)
ManyToMany
ugt1b4 31
  • 46 (a)
ManyToMany
ugt1b1 31
  • 46 (a)
ManyToMany
ugt1b5 31
  • 45 (a)
ManyToMany
ugt1b3 31
  • 45 (a)
ManyToMany
ugt1b2 31
  • 45 (a)
ManyToMany
Species where no ortholog for UGT1A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for UGT1A7 Gene

ENSEMBL:
Gene Tree for UGT1A7 (if available)
TreeFam:
Gene Tree for UGT1A7 (if available)

Paralogs for UGT1A7 Gene

(31) SIMAP similar genes for UGT1A7 Gene using alignment to 16 proteins:

  • UD17_HUMAN
  • B8K293_HUMAN
  • H0Y8D7_HUMAN
  • Q4R0Z5_HUMAN
  • Q5DSZ7_HUMAN
  • Q5K632_HUMAN
  • Q5K672_HUMAN
  • Q5K673_HUMAN
  • Q5K674_HUMAN
  • Q96DH9_HUMAN
  • Q96PN9_HUMAN
  • Q96PP0_HUMAN
  • Q96PP1_HUMAN
  • Q9H3G0_HUMAN
  • Q9H3G1_HUMAN
  • Q9H3G2_HUMAN

Pseudogenes.org Pseudogenes for UGT1A7 Gene

genes like me logo Genes that share paralogs with UGT1A7: view

Variants for UGT1A7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A7 Gene

UD17_HUMAN-Q9HAW7
There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1, respectively, suggesting that these mutations confer slow glucuronidation phenotype.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT1A7 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
549828 Drug Response: Irinotecan response 233,760,235(+) TATATATATATATA/. INTRON_VARIANT
708059 Likely Benign: not provided 233,767,102(+) C/A SYNONYMOUS_VARIANT
715222 Benign: not provided 233,713,840(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
724578 Conflicting Interpretations: Crigler-Najjar syndrome; Lucey-Driscoll syndrome; Gilbert's syndrome; not provided 233,767,133(+) A/G MISSENSE_VARIANT
728484 Likely Benign: not provided 233,760,959(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for UGT1A7 Gene

Structural Variations from Database of Genomic Variants (DGV) for UGT1A7 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2661542 CNV deletion 23128226
esv2721666 CNV deletion 23290073
esv2721667 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3561178 CNV deletion 23714750
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv1138902 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963781 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv979185 CNV duplication 23825009
nsv979186 CNV duplication 23825009
nsv979187 CNV duplication 23825009

Variation tolerance for UGT1A7 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT1A7 Gene

Human Gene Mutation Database (HGMD)
UGT1A7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A7

Disorders for UGT1A7 Gene

MalaCards: The human disease database

(8) MalaCards diseases for UGT1A7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
bilirubin, serum level of, quantitative trait locus 1
  • biliqtl1
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT1A7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UGT1A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A7 Gene

Publications for UGT1A7 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Ménard V … Guillemette C (Human mutation 2009) 3 4 23 41
  2. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PMID: 11434514) Gong QH … Popescu NC (Pharmacogenetics 2001) 2 3 4 23
  3. [Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer]. (PMID: 20193274) Liu J … Song DK (Zhonghua yi xue za zhi 2009) 3 23 41
  4. Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers. (PMID: 19430315) Wang Y … Zheng Y (Journal of occupational and environmental medicine 2009) 3 23 41
  5. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PMID: 19303655) Lankisch TO … Strassburg CP (Journal of hepatology 2009) 3 23 41

Products for UGT1A7 Gene

Sources for UGT1A7 Gene