Aliases for UGT1A5 Gene
External Ids for UGT1A5 Gene
Previous GeneCards Identifiers for UGT1A5 Gene
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]
GeneCards Summary for UGT1A5 Gene
UGT1A5 (UDP Glucuronosyltransferase Family 1 Member A5) is a Protein Coding gene. Diseases associated with UGT1A5 include Bilirubin, Serum Level Of, Quantitative Trait Locus 1 and Hyperbilirubinemia, Transient Familial Neonatal. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and glucuronosyltransferase activity. An important paralog of this gene is UGT1A3.
UniProtKB/Swiss-Prot Summary for UGT1A5 Gene
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18674515). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18674515). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515).
[Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.