This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followe... See more...

Aliases for UGT1A4 Gene

Aliases for UGT1A4 Gene

  • UDP Glucuronosyltransferase Family 1 Member A4 2 3 5
  • HUG-BR2 2 3 4
  • UGT1D 2 3 4
  • UDP Glycosyltransferase 1 Family, Polypeptide A4 2 3
  • Bilirubin-Specific UDPGT Isozyme 2 3 4
  • UDP-Glucuronosyltransferase 1A4 3 4
  • UDP-Glucuronosyltransferase 1-4 3 4
  • UDP-Glucuronosyltransferase 1-D 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 1-4 3 4
  • UGT1-04 3 4
  • UGT-1D 3 4
  • UGT1.4 3 4
  • GNT1 3 4
  • UGT1 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A4 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A4s 3
  • Bilirubin UDP-Glucuronosyltransferase Isozyme 2 3
  • Bilirubin-Specific UDPGT Isozyme 1 3
  • UDP-Glucuronosyltransferase 1-1 3
  • UDP-Glucuronosyltransferase 1-A 3
  • UDP-Glucuronosyltransferase 1A1 3
  • UDPGT 1-1 3
  • UGT1-01 3
  • UGT1A4S 3
  • HUG-BR1 3
  • UGT-1A 3
  • UGT1.1 3
  • UGT1A1 3
  • UGT1A4 5
  • UGT1*4 4
  • UDPGT 3
  • UGT1A 3

External Ids for UGT1A4 Gene

Previous GeneCards Identifiers for UGT1A4 Gene

  • GC02U990252
  • GC02P234817
  • GC02P234880
  • GC02P234365
  • GC02P234409
  • GC02P234195
  • GC02P234205
  • GC02P234215
  • GC02P234292
  • GC02P234627
  • GC02P226427

Summaries for UGT1A4 Gene

Entrez Gene Summary for UGT1A4 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A4 Gene

UGT1A4 (UDP Glucuronosyltransferase Family 1 Member A4) is a Protein Coding gene. Diseases associated with UGT1A4 include Crigler-Najjar Syndrome, Type I and Gilbert Syndrome. Among its related pathways are Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A5.

UniProtKB/Swiss-Prot Summary for UGT1A4 Gene

  • [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842).
  • [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT1A4 Gene

Genomics for UGT1A4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT1A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233718 Promoter 0.8 EPDnew 250.7 +0.0 39 0.1 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 REST MAX UGT1A4 lnc-HJURP-5 UGT1A5 UGT1A3 UGT1A6 UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233688 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 12 -27.7 -27735 4.1 YY1 CEBPB EP300 RXRA ZBTB33 JUND SPI1 SMARCE1 HNF4A DPF2 UGT1A6 UGT1A1 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233867 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 9.9 +149.4 149365 1.8 MYC ZNF592 POLR2A ZIC2 SMAD5 MAX ZNF217 CTBP1 SIN3B HCFC1 MSL3P1 ENSG00000279809 TRPM8 UGT1A4 HJURP
GH02J233468 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -248.8 -248777 2.2 ZNF592 NFIC ZNF341 ZBTB33 NFIB L3MBTL2 SP1 NFIA MNT NR2F2 piR-53458 USP40 UGT1A4 HSALNG0023094 DGKD
GH02J233763 Enhancer 1 FANTOM5 Ensembl ENCODE 10.5 +45.7 45710 1.6 ATF3 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A MAFK FOXA1 RAD21 UGT1A4 UGT1A6 LOC100286922 DNAJB3 UGT1A1 MROH2A lnc-UGT1A8-1 UGT1A3 UGT1A5 UGT1A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT1A4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT1A4

Top Transcription factor binding sites by QIAGEN in the UGT1A4 gene promoter:
  • p53
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for UGT1A4 Gene

Latest Assembly
chr2:233,718,736-233,773,300
(GRCh38/hg38)
Size:
54,565 bases
Orientation:
Plus strand

Previous Assembly
chr2:234,627,382-234,681,946
(GRCh37/hg19 by Entrez Gene)
Size:
54,565 bases
Orientation:
Plus strand

chr2:234,627,424-234,681,945
(GRCh37/hg19 by Ensembl)
Size:
54,522 bases
Orientation:
Plus strand

Genomic View for UGT1A4 Gene

Genes around UGT1A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A4 Gene

Proteins for UGT1A4 Gene

  • Protein details for UGT1A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22310-UD14_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1A4
    Protein Accession:
    P22310
    Secondary Accessions:
    • B2R937
    • B8K288
    • Q5DT00

    Protein attributes for UGT1A4 Gene

    Size:
    534 amino acids
    Molecular mass:
    60025 Da
    Quaternary structure:
    • Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).
    Miscellaneous:
    • UGT1A4 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A4 Gene

Selected DME Specific Peptides for UGT1A4 Gene

P22310:
  • NTILVKWLPQNDL
  • PQNDLLGHP
  • AAHDLTW
  • MPNMVFIGGINC
  • PLFGDQMDNAKR
  • NALKAVIN
  • GAGVTLNVLEMT
  • DVIGFLL
  • DYPRPIMPNMVF
  • GKKGRVKKAHKSK
  • EPLDLAVFWVE
  • IADALGKIPQTVLWRYTG
  • FWVEFVM
  • VVFSLGSMV
  • VMRHKGA
  • KSYKENIMRLSSLHKDRP
  • QYHSLDV
  • CNGVPMV
  • HPMTRAF
  • PYASLASELFQREVS

Post-translational modifications for UGT1A4 Gene

  • Glycosylation at Asn119, Asn142, Asn296, and Asn348
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for UGT1A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A4 Gene

Gene Families for UGT1A4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for UGT1A4 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT1A4 Gene

GenScript: Design optimal peptide antigens:
  • UGT1A4 protein (A3KME6_HUMAN)
  • UDP-glucuronosyltransferase 1A4 (A9UKD7_HUMAN)
  • UDP-glucuronosyltransferase 1A4 (A9UKD8_HUMAN)
  • UDP-glucuronosyltransferase 1A4 (A9UKD9_HUMAN)
  • UDP-glucuronosyltransferase 1A4 (B8K2E8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22310

UniProtKB/Swiss-Prot:

UD14_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A4: view

Function for UGT1A4 Gene

Molecular function for UGT1A4 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:18177842, ECO:0000269|PubMed:24641623};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP; Xref=Rhea:RHEA:55840, ChEBI:CHEBI:15378, ChEBI:CHEBI:17933, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:139277; Evidence={ECO:0000269|PubMed:24641623};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP; Xref=Rhea:RHEA:55844, ChEBI:CHEBI:15378, ChEBI:CHEBI:17933, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:139278; Evidence={ECO:0000269|PubMed:24641623};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP; Xref=Rhea:RHEA:55836, ChEBI:CHEBI:15378, ChEBI:CHEBI:17823, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:139274; Evidence={ECO:0000269|PubMed:18177842};.
UniProtKB/Swiss-Prot Induction:
Induced by phenobarbital.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.39 uM for calcidiol (when assaying glucuronidation at position 25) {ECO:0000269|PubMed:24641623}; KM=2.16 uM for calcidiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:24641623}; KM=4.19 uM for 5,6-trans-calcidiol (when assaying glucuronidation at position 25) {ECO:0000269|PubMed:24641623}; KM=7.3 uM for calcitriol (when assaying glucuronidation at position 25) {ECO:0000269|PubMed:18177842}; KM=10.6 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:18719240}; KM=21.7 uM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:18719240}; Vmax=7.35 pmol/min/mg enzyme for the formation of calcidiol 25-O-(beta-D-glucuronate) {ECO:0000269|PubMed:24641623}; Vmax=0.93 pmol/min/mg enzyme for the formation of calcidiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:24641623}; Vmax=0.26 pmol/min/mg enzyme for the formation of 5,6-trans-calcidiol 25-O-(beta-D-glucuronate) {ECO:0000269|PubMed:24641623}; Vmax=33.7 pmol/min/mg enzyme for the formation of calcitriol 25-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18177842}; Vmax=14 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=41 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=5.5 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=4.1 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=1.9 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Vmax=6.1 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:23288867}; Note=Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values. {ECO:0000305|PubMed:18177842, ECO:0000305|PubMed:24641623};

Enzyme Numbers (IUBMB) for UGT1A4 Gene

Phenotypes From GWAS Catalog for UGT1A4 Gene

Gene Ontology (GO) - Molecular Function for UGT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 NOT retinoic acid binding IDA 20308471
GO:0008194 UDP-glycosyltransferase activity IEA --
GO:0015020 glucuronosyltransferase activity IEA,IDA 1898728
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with UGT1A4: view
genes like me logo Genes that share phenotypes with UGT1A4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A4 Gene

Localization for UGT1A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A4 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A4 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
peroxisome 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UGT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS,IDA 17179145
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UGT1A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A4 Gene

Pathways & Interactions for UGT1A4 Gene

genes like me logo Genes that share pathways with UGT1A4: view

SIGNOR curated interactions for UGT1A4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UGT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006789 bilirubin conjugation TAS --
GO:0042167 heme catabolic process TAS --
GO:0045922 negative regulation of fatty acid metabolic process ISS --
GO:0052695 cellular glucuronidation TAS --
GO:0052696 flavonoid glucuronidation IBA 21873635
genes like me logo Genes that share ontologies with UGT1A4: view

Drugs & Compounds for UGT1A4 Gene

(79) Drugs for UGT1A4 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lamotrigine Approved, Investigational Pharma Enzyme, substrate 5-HT inhibitor 206
Trifluoperazine Approved, Investigational Pharma Enzyme, substrate 7
Anastrozole Approved, Investigational Pharma Enzyme, substrate Aromatase inhibitor, Potent aromatase (CYP19) inhibitor, Aromatase Inhibitors, Hormone therapy 354
Valproic acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 387
Estradiol Approved, Investigational, Vet_approved Pharma Enzyme, substrate, inducer Sex hormone 1160

(135) Additional Compounds for UGT1A4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(b-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(β-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
(3a,5b)-24-oxo-24-[(2-sulfoethyl)amino]cholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-Sulfoethyl)amino]cholan-3-yl-b-D-glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-Sulphoethyl)amino]cholan-3-yl-b-D-glucopyranosiduronate
  • (3a,5b)-24-oxo-24-[(2-Sulphoethyl)amino]cholan-3-yl-b-D-glucopyranosiduronic acid
  • (3a,5b)-24-oxo-24-[(2-Sulfoethyl)amino]cholan-3-yl-beta-delta-glucopyranosiduronate
  • Taurolithocholic acid 3-glucuronide
99794-82-8
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-glucopyranosiduronate
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
15-Hydroxynorandrostene-3,17-dione glucuronide
  • 15-HNADG
  • 15-Hydroxynorandrostene-3,17-dione glucuronoside
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronide
  • 15alpha-Hydroxynorandrost-4-ene-3,17-dione glucuronoside
  • Androst-4-ene-3,17-dione, 15-hydroxy glucuronide
131749-23-0
genes like me logo Genes that share compounds with UGT1A4: view

Transcripts for UGT1A4 Gene

mRNA/cDNA for UGT1A4 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A4

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A4 Gene

No ASD Table

Relevant External Links for UGT1A4 Gene

GeneLoc Exon Structure for
UGT1A4

Expression for UGT1A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A4 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A4 Gene

This gene is overexpressed in Liver (x52.0).

Protein differential expression in normal tissues from HIPED for UGT1A4 Gene

This gene is overexpressed in Liver (38.7) and Gallbladder (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT1A4 Gene



Protein tissue co-expression partners for UGT1A4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT1A4

mRNA Expression by UniProt/SwissProt for UGT1A4 Gene:

P22310-UD14_HUMAN
Tissue specificity: [Isoform 1]: Expressed in liver (PubMed:1339448, PubMed:18004212). Expressed in kidney, colon and small intestine (PubMed:18004212). Not expressed in esophagus (PubMed:18004212). Not expressed in skin (PubMed:1339448).

Evidence on tissue expression from TISSUES for UGT1A4 Gene

  • Liver(4.8)
  • Kidney(4.5)
  • Intestine(3.6)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with UGT1A4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A4 Gene

Orthologs for UGT1A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 95 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Ugt1a5 29
  • 80.31 (n)
Mouse
(Mus musculus)
Mammalia Ugt1a5 29 16 30
  • 78.16 (n)
ManyToMany
Ugt1a2 30
  • 75 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 67 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 38 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 40 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 60 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ugt1a7 30
  • 50 (a)
ManyToMany
ugt1b1 30
  • 47 (a)
ManyToMany
ugt1b3 30
  • 46 (a)
ManyToMany
ugt1b5 30
  • 46 (a)
ManyToMany
ugt1b4 30
  • 46 (a)
ManyToMany
ugt1b2 30
  • 45 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ugt36Ba 31
  • 30 (a)
Ugt37c1 31
  • 29 (a)
BEST:GH06505 31
  • 29 (a)
CG5724 31
  • 29 (a)
CG17323 31
  • 27 (a)
Ugt86Dh 31
  • 26 (a)
CG10178 31
  • 25 (a)
Dot 31
  • 25 (a)
Worm
(Caenorhabditis elegans)
Secernentea C10H11.5 31
  • 29 (a)
F35H8.6 31
  • 29 (a)
AC3.2 31
  • 28 (a)
C08F11.8 31
  • 28 (a)
ZC443.5 31
  • 27 (a)
T07C5.1a 31
  • 26 (a)
F09G2.6 31
  • 26 (a)
C33A12.6 31
  • 26 (a)
C03A7.11 31
  • 25 (a)
R04B5.9 31
  • 25 (a)
C17G1.3 31
  • 25 (a)
K08B4.4 31
  • 25 (a)
C10H11.6 31
  • 24 (a)
T01G5.2 31
  • 24 (a)
F47C10.6 31
  • 23 (a)
C10H11.4 31
  • 23 (a)
F01D4.1 31
  • 23 (a)
F01D4.2 31
  • 23 (a)
Species where no ortholog for UGT1A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for UGT1A4 Gene

ENSEMBL:
Gene Tree for UGT1A4 (if available)
TreeFam:
Gene Tree for UGT1A4 (if available)
Alliance of Genome Resources:
Additional Orthologs for UGT1A4

Paralogs for UGT1A4 Gene

(31) SIMAP similar genes for UGT1A4 Gene using alignment to 14 proteins:

  • UD14_HUMAN
  • A3KME6_HUMAN
  • A9UKD7_HUMAN
  • A9UKD8_HUMAN
  • A9UKD9_HUMAN
  • B8K2E8_HUMAN
  • B8K2E9_HUMAN
  • B8K2F1_HUMAN
  • B8K2F4_HUMAN
  • B8K2F8_HUMAN
  • Q0VAJ1_HUMAN
  • Q8WX86_HUMAN
  • Q8WX87_HUMAN
  • Q8WX88_HUMAN
genes like me logo Genes that share paralogs with UGT1A4: view

Variants for UGT1A4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT1A4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
549828 Drug Response: Irinotecan response 233,760,235(+) TATATATATATATA/.
UGT1A1*1
INTRON
895439 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,312(+) C/T
NM_000463.3(UGT1A1):c.25C>T (p.Arg9Cys)
MISSENSE_VARIANT,INTRON
895502 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,648(+) G/C
NM_000463.3(UGT1A1):c.361G>C (p.Ala121Pro)
MISSENSE_VARIANT,INTRON
895576 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,768,315(+) T/C
NM_000463.3(UGT1A1):c.1180T>C (p.Phe394Leu)
MISSENSE
895638 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,772,692(+) G/A
NM_000463.3(UGT1A1):c.*133G>A
THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT1A4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT1A4 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2661542 CNV deletion 23128226
esv2721667 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3561178 CNV deletion 23714750
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv979187 CNV duplication 23825009

Variation tolerance for UGT1A4 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT1A4 Gene

Human Gene Mutation Database (HGMD)
UGT1A4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A4
Leiden Open Variation Database (LOVD)
UGT1A4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A4 Gene

Disorders for UGT1A4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for UGT1A4 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
bilirubin, serum level of, quantitative trait locus 1
  • biliqtl1
hyperbilirubinemia, transient familial neonatal
  • hblrtfn
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT1A4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT1A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A4 Gene

Publications for UGT1A4 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Ménard V … Guillemette C (Human mutation 2009) 3 4 22 40
  2. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PMID: 18161889) Berkhout M … Peters WH (The British journal of surgery 2008) 3 22 40
  3. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. (PMID: 17179145) Operaña TN … Tukey RH (The Journal of biological chemistry 2007) 3 4 22
  4. Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases. (PMID: 15855726) Yamanaka H … Yokoi T (Drug metabolism and pharmacokinetics 2005) 3 22 40
  5. UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. (PMID: 15708967) Mori A … Takeuchi Y (Drug metabolism and disposition: the biological fate of chemicals 2005) 3 22 40

Products for UGT1A4 Gene

Sources for UGT1A4 Gene