This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followe... See more...

Aliases for UGT1A3 Gene

Aliases for UGT1A3 Gene

  • UDP Glucuronosyltransferase Family 1 Member A3 2 3 5
  • UGT1C 2 3 4
  • UDP Glycosyltransferase 1 Family, Polypeptide A3 2 3
  • UDP-Glucuronosyltransferase 1-3 3 4
  • UDP-Glucuronosyltransferase 1-C 3 4
  • UDP-Glucuronosyltransferase 1A3 3 4
  • EC 2.4.1.17 4 51
  • UDPGT 1-3 3 4
  • UGT1-03 3 4
  • UGT-1C 3 4
  • UGT1.3 3 4
  • UGT1*3 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A3 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A3s 3
  • UDP-Glucuronosyltransferase 1A Isoform 3 4
  • UGT1A3S 3
  • UGT1A3 5
  • UDPGT 3
  • GNT1 4
  • UGT1 4

External Ids for UGT1A3 Gene

Previous GeneCards Identifiers for UGT1A3 Gene

  • GC02U990254
  • GC02P234816
  • GC02P234879
  • GC02P234364
  • GC02P234419
  • GC02P234194
  • GC02P234204
  • GC02P234214
  • GC02P234224
  • GC02P234302
  • GC02P234637
  • GC02P226437

Summaries for UGT1A3 Gene

Entrez Gene Summary for UGT1A3 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A3 Gene

UGT1A3 (UDP Glucuronosyltransferase Family 1 Member A3) is a Protein Coding gene. Diseases associated with UGT1A3 include Gilbert Syndrome and Bilirubin, Serum Level Of, Quantitative Trait Locus 1. Among its related pathways are Valproic acid pathway and Imipramine/Desipramine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A5.

UniProtKB/Swiss-Prot Summary for UGT1A3 Gene

  • [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucoronidation of endogenous estrogen hormones such as estradiol and estrone, and xenoestrogens such as epiestradiol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515).
  • [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGT1A3 Gene

Genomics for UGT1A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT1A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233729 Promoter 0.7 EPDnew 600.7 +0.0 23 0.1 SP1 ATF3 ZBTB33 JUND HNF4A RXRA MAX YY1 EGR1 UGT1A3 ENSG00000178836 ENSG00000248114 lnc-UGT1A1-2 DNAJB3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A9
GH02J233745 Promoter/Enhancer 1.3 EPDnew ENCODE 0.4 +16.5 16543 1 GATAD2A ATF7 REST TFE3 SOX13 NFKBIZ RCOR2 RXRB IRF2 SP1 DNAJB3 UGT1A2P UGT1A1 UGT1A6 UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10
GH02J233759 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 0.3 +32.0 31991 2.7 REST SP1 TOE1 FOXA2 RAD51 ZNF316 MAFF ATF3 YY1 MAFK UGT1A1 UGT1A6 MROH2A lnc-UGT1A8-1 UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10
GH02J233718 Promoter 0.8 EPDnew 0.4 -10.3 -10267 0.1 REST SP1 FOXA2 YY1 ZBTB33 JUND NR2F2 RAD21 HNF4A RXRA UGT1A4 lnc-HJURP-5 UGT1A5 UGT1A3 UGT1A6 UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233756 Enhancer 0.9 ENCODE 0.3 +27.9 27888 0.2 GATAD2A ATF7 REST TFE3 SOX13 NFKBIZ RCOR2 RXRB IRF2 SP1 ENSG00000178836 LOC100286922 lnc-HJURP-4 UGT1A1 DNAJB3 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT1A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT1A3

Top Transcription factor binding sites by QIAGEN in the UGT1A3 gene promoter:
  • PPAR-alpha
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for UGT1A3 Gene

Genomic Locations for UGT1A3 Gene
chr2:233,729,042-233,773,300
(GRCh38/hg38)
Size:
44,259 bases
Orientation:
Plus strand
chr2:234,637,754-234,681,945
(GRCh37/hg19)
Size:
44,192 bases
Orientation:
Plus strand

Genomic View for UGT1A3 Gene

Genes around UGT1A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A3 Gene

Proteins for UGT1A3 Gene

  • Protein details for UGT1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35503-UD13_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1A3
    Protein Accession:
    P35503
    Secondary Accessions:
    • B8K287

    Protein attributes for UGT1A3 Gene

    Size:
    534 amino acids
    Molecular mass:
    60338 Da
    Quaternary structure:
    • Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145).
    • [Isoform 1]: Interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
    • [Isoform 2]: Interacts with isoform 1/i1 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Also interacts with respective i1 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
    Miscellaneous:
    • UGT1A3 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A3 Gene

Selected DME Specific Peptides for UGT1A3 Gene

P35503:
  • NTILVKWLPQNDL
  • PQNDLLGHP
  • AAHDLTW
  • MPNMVFIGGINC
  • PLFGDQMDNAKR
  • NALKAVIN
  • GAGVTLNVLEMT
  • DVIGFLL
  • DYPRPIMPNMVF
  • GKKGRVKKAHKSK
  • EPLDLAVFWVE
  • IADALGKIPQTVLWRYTG
  • FWVEFVM
  • GSHWLSM
  • VVFSLGSMV
  • VMRHKGA
  • KSYKENIMRLSSLHKDRP
  • QYHSLDV
  • CNGVPMV
  • HPMTRAF
  • PYASLASELFQREVS

Post-translational modifications for UGT1A3 Gene

  • Glycosylation at Asn119, Asn142, Asn296, and Asn348
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for UGT1A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A3 Gene

Gene Families for UGT1A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT1A3 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase
ProtoNet:

Suggested Antigen Peptide Sequences for UGT1A3 Gene

GenScript: Design optimal peptide antigens:
  • UDP-glucuronosyltransferase 1A3 (A7E1U4_HUMAN)
  • UDP-glucuronosyltransferase 1A3 (A7E1U5_HUMAN)
  • UDP-glucuronosyltransferase 1A3 (A7E1U6_HUMAN)
  • UDP-glucuronosyltransferase 1A3 (A7E1U7_HUMAN)
  • UDP-glucuronosyltransferase 1A3 (A7E1U8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35503

UniProtKB/Swiss-Prot:

UD13_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A3: view

Function for UGT1A3 Gene

Molecular function for UGT1A3 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucoronidation of endogenous estrogen hormones such as estradiol and estrone, and xenoestrogens such as epiestradiol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence={ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence={ECO:0000269|PubMed:18719240};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52464, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:82961; Evidence={ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52476, ChEBI:CHEBI:15378, ChEBI:CHEBI:17263, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136634; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52940, ChEBI:CHEBI:36234, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136899; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52948, ChEBI:CHEBI:23614, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136901; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52952, ChEBI:CHEBI:29744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136902; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52956, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:58875, ChEBI:CHEBI:136903; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP; Xref=Rhea:RHEA:52960, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:133661, ChEBI:CHEBI:136904; Evidence={ECO:0000269|PubMed:23756265};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP; Xref=Rhea:RHEA:55840, ChEBI:CHEBI:15378, ChEBI:CHEBI:17933, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:139277; Evidence={ECO:0000269|PubMed:24641623};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=47 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=250 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=35 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:15472229}; KM=66.7 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17) {ECO:0000269|PubMed:18719240}; KM=34.2 uM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=77 uM for estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=479 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=32 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=587 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=222 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=49 uM for 2-methoxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=3.95 uM for calcidiol (when assaying glucuronidation at position 25) {ECO:0000269|PubMed:24641623}; KM=5.9 uM for calcidiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:24641623}; KM=9.35 uM for 5,6-trans-calcidiol (when assaying glucuronidation at position 25) {ECO:0000269|PubMed:24641623}; KM=35.9 uM for losartan (when assaying glucuronidation at position N2 of the tetrazole ring) {ECO:0000269|PubMed:18674515}; Vmax=39 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=653 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=13 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=86.1 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=683 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=26 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=50 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1342 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=39 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=41 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=28 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=154 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1.74 pmol/min/mg enzyme for the formation of calcidiol 25-O-(beta-D-glucuronate) {ECO:0000269|PubMed:24641623}; Vmax=0.56 pmol/min/mg enzyme for the formation of calcidiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:24641623}; Vmax=0.22 pmol/min/mg enzyme for the formation of 5,6-trans-calcidiol 25-O-(beta-D-glucuronate) {ECO:0000269|PubMed:24641623}; Vmax=225.7 pmol/min/mg enzyme for the formation of losartan N2-(beta-D-glucuronate) {ECO:0000269|PubMed:18674515};

Enzyme Numbers (IUBMB) for UGT1A3 Gene

Phenotypes From GWAS Catalog for UGT1A3 Gene

Gene Ontology (GO) - Molecular Function for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0015020 glucuronosyltransferase activity IEA,IDA 17179145
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016758 transferase activity, transferring hexosyl groups IEA --
genes like me logo Genes that share ontologies with UGT1A3: view
genes like me logo Genes that share phenotypes with UGT1A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A3 Gene

Localization for UGT1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A3 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A3 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 17179145
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with UGT1A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A3 Gene

Pathways & Interactions for UGT1A3 Gene

genes like me logo Genes that share pathways with UGT1A3: view

Pathways by source for UGT1A3 Gene

Gene Ontology (GO) - Biological Process for UGT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042573 retinoic acid metabolic process IC 20308471
GO:0052695 cellular glucuronidation IDA 17179145
GO:0052696 flavonoid glucuronidation IDA 20056724
GO:0052697 xenobiotic glucuronidation IDA 20056724
genes like me logo Genes that share ontologies with UGT1A3: view

No data available for SIGNOR curated interactions for UGT1A3 Gene

Drugs & Compounds for UGT1A3 Gene

(81) Drugs for UGT1A3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Morphine Approved, Investigational Pharma Agonist, Full agonist, Partial agonist, Enzyme, substrate 1406
Atorvastatin Approved Pharma Inhibitor, Competitive, Enzyme, substrate 893
Deferasirox Approved, Investigational Pharma Enzyme, inhibitor Oral iron chelator 100
Ritonavir Approved, Investigational Pharma Enzyme, inducer HIV protease inhibitor 1023
Valproic acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 377

(88) Additional Compounds for UGT1A3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-Dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-Dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-Dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-Cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-Cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-Hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-HPG
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-oxo-Etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A3: view

Transcripts for UGT1A3 Gene

mRNA/cDNA for UGT1A3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A3

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A3 Gene

No ASD Table

Relevant External Links for UGT1A3 Gene

GeneLoc Exon Structure for
UGT1A3

Expression for UGT1A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A3 Gene

Protein differential expression in normal tissues from HIPED for UGT1A3 Gene

This gene is overexpressed in Liver (43.9) and Gallbladder (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT1A3 Gene



Protein tissue co-expression partners for UGT1A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT1A3

mRNA Expression by UniProt/SwissProt for UGT1A3 Gene:

P35503-UD13_HUMAN
Tissue specificity: [Isoform 1]: Expressed in liver, kidney, colon, esophagus and small intestine.

Evidence on tissue expression from TISSUES for UGT1A3 Gene

  • Liver(4.5)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with UGT1A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A3 Gene

Orthologs for UGT1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A3 Gene

Organism Taxonomy Gene Similarity Type Details
Rat
(Rattus norvegicus)
Mammalia Ugt1a2 30
  • 81.11 (n)
Mouse
(Mus musculus)
Mammalia Ugt1a2 30 17 31
  • 79.61 (n)
ManyToMany
Ugt1a5 31
  • 76 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 70 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 60 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ugt1a7 31
  • 51 (a)
ManyToMany
ugt1b1 31
  • 48 (a)
ManyToMany
ugt1b2 31
  • 46 (a)
ManyToMany
ugt1b3 31
  • 46 (a)
ManyToMany
ugt1b5 31
  • 46 (a)
ManyToMany
ugt1b4 31
  • 46 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ugt36Bb 30
  • 44.03 (n)
Ugt37c1 32
  • 30 (a)
Ugt37a1 32
  • 29 (a)
CG5724 32
  • 29 (a)
Ugt36Ba 32
  • 29 (a)
CG17323 32
  • 29 (a)
BEST:GH06505 32
  • 28 (a)
Ugt37b1 32
  • 26 (a)
CG10178 32
  • 26 (a)
Dot 32
  • 26 (a)
CG16732 32
  • 24 (a)
CG5999 32
  • 23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011564 30
  • 43 (n)
Worm
(Caenorhabditis elegans)
Secernentea F39G3.1 32
  • 30 (a)
AC3.2 32
  • 28 (a)
F35H8.6 32
  • 28 (a)
C08F11.8 32
  • 27 (a)
F10D2.5 32
  • 27 (a)
T07C5.1a 32
  • 26 (a)
ZC443.5 32
  • 26 (a)
C10H11.5 32
  • 26 (a)
C17G1.3 32
  • 25 (a)
F09G2.6 32
  • 25 (a)
K08B4.4 32
  • 25 (a)
C33A12.6 32
  • 25 (a)
C03A7.11 32
  • 24 (a)
C08B6.1 32
  • 24 (a)
C44H9.1 32
  • 24 (a)
C10H11.6 32
  • 24 (a)
F47C10.6 32
  • 23 (a)
R04B5.9 32
  • 23 (a)
F01D4.1 32
  • 23 (a)
F01D4.2 32
  • 23 (a)
T01G5.2 32
  • 23 (a)
Species where no ortholog for UGT1A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for UGT1A3 Gene

ENSEMBL:
Gene Tree for UGT1A3 (if available)
TreeFam:
Gene Tree for UGT1A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT1A3: view image

Paralogs for UGT1A3 Gene

(31) SIMAP similar genes for UGT1A3 Gene using alignment to 18 proteins:

  • UD13_HUMAN
  • A7E1U4_HUMAN
  • A7E1U5_HUMAN
  • A7E1U6_HUMAN
  • A7E1U7_HUMAN
  • A7E1U8_HUMAN
  • A7E1U9_HUMAN
  • A7ISW3_HUMAN
  • A9UKC8_HUMAN
  • A9UKC9_HUMAN
  • A9UKD1_HUMAN
  • B1MV79_HUMAN
  • Q5DT01_HUMAN
  • Q75XT3_HUMAN
  • Q75XT5_HUMAN
  • Q8WX89_HUMAN
  • Q8WX90_HUMAN
  • Q8WX91_HUMAN

Pseudogenes.org Pseudogenes for UGT1A3 Gene

genes like me logo Genes that share paralogs with UGT1A3: view

Variants for UGT1A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT1A3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
549828 Drug Response: Irinotecan response 233,760,235(+) TATATATATATATA/. INTRON_VARIANT
708059 Likely Benign: not provided 233,767,102(+) C/A SYNONYMOUS_VARIANT
724578 Conflicting Interpretations: Crigler-Najjar syndrome; Lucey-Driscoll syndrome; Gilbert's syndrome; not provided 233,767,133(+) A/G MISSENSE_VARIANT
728484 Likely Benign: not provided 233,760,959(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
729124 Benign: not provided 233,743,622(+) C/T MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for UGT1A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for UGT1A3 Gene

Variant ID Type Subtype PubMed ID
dgv769e199 CNV deletion 23128226
esv2422005 CNV deletion 20811451
esv25622 CNV loss 19812545
esv2721667 CNV deletion 23290073
esv2721669 CNV deletion 23290073
esv2760613 CNV loss 21179565
esv2760615 CNV loss 21179565
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584705 CNV loss 21841781
nsv961573 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv963782 CNV duplication 23825009

Variation tolerance for UGT1A3 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT1A3 Gene

Human Gene Mutation Database (HGMD)
UGT1A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A3 Gene

Disorders for UGT1A3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for UGT1A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
bilirubin, serum level of, quantitative trait locus 1
  • biliqtl1
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
drug-induced hepatitis
  • drug-induced chronic hepatitis
autosomal dominant non-syndromic intellectual disability 3
  • mrd3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UGT1A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UGT1A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A3 Gene

Publications for UGT1A3 Gene

  1. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. (PMID: 19204906) Ménard V … Guillemette C (Human mutation 2009) 3 4 23 41
  2. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (PMID: 19303655) Lankisch TO … Strassburg CP (Journal of hepatology 2009) 3 23 41
  3. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (PMID: 18161889) Berkhout M … Peters WH (The British journal of surgery 2008) 3 23 41
  4. Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene. (PMID: 18677463) Lankisch TO … Strassburg CP (Archives of toxicology 2008) 3 23 41
  5. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. (PMID: 17179145) Operaña TN … Tukey RH (The Journal of biological chemistry 2007) 3 4 23

Products for UGT1A3 Gene

Sources for UGT1A3 Gene