This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followe... See more...

Aliases for UGT1A1 Gene

Aliases for UGT1A1 Gene

  • UDP Glucuronosyltransferase Family 1 Member A1 2 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A1 2 3
  • Bilirubin-Specific UDPGT Isozyme 1 3 4
  • UDP-Glucuronosyltransferase 1A1 3 4
  • EC 2.4.1.17 4 50
  • UDPGT 1-1 3 4
  • HUG-BR1 3 4
  • UGT1-01 3 4
  • UGT1*1 3 4
  • UGT1.1 3 4
  • UGT1A 2 3
  • GNT1 3 4
  • UGT1 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A1 3
  • Bilirubin UDP-Glucuronosyltransferase Isozyme 1 3
  • Bilirubin UDP-Glucuronosyltransferase 1-1 3
  • UDP-Glucuronosyltransferase 1A Isoform 1 4
  • Bilirubin UDP-Glucuronosyltranserase 3
  • UDP-Glucuronosyltransferase 1-A 3
  • UDP-Glucuronosyltransferase 1-1 4
  • UDP-Glucuronosyltransferase 1A 3
  • BILIQTL1 3
  • UGT-1A 3
  • UGT1A1 5
  • UDPGT 3

External Ids for UGT1A1 Gene

Previous HGNC Symbols for UGT1A1 Gene

  • UGT1
  • GNT1

Previous GeneCards Identifiers for UGT1A1 Gene

  • GC02U990253
  • GC02P234815
  • GC02P234878
  • GC02P234363
  • GC02P234450
  • GC02P234193
  • GC02P234203
  • GC02P234212
  • GC02P234223
  • GC02P234333
  • GC02P234668
  • GC02P226469
  • GC02P233619

Summaries for UGT1A1 Gene

Entrez Gene Summary for UGT1A1 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]

CIViC Summary for UGT1A1 Gene

GeneCards Summary for UGT1A1 Gene

UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1) is a Protein Coding gene. Diseases associated with UGT1A1 include Crigler-Najjar Syndrome, Type Ii and Crigler-Najjar Syndrome, Type I. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A5.

UniProtKB/Swiss-Prot Summary for UGT1A1 Gene

  • [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558).
  • [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A1 Gene

PharmGKB "VIP" Summary for UGT1A1 Gene

No data available for Tocris Summary , Rfam classification and piRNA Summary for UGT1A1 Gene

Genomics for UGT1A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UGT1A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233688 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 250.2 -69.3 -69269 4.1 YY1 CEBPB EP300 RXRA ZBTB33 JUND SPI1 SMARCE1 HNF4A DPF2 UGT1A6 UGT1A1 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
GH02J233759 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 250.7 +0.6 632 2.5 ATF3 YY1 RAD51 MAFF FOXA2 RXRA ZBTB33 ZNF316 JUND MAFK UGT1A1 UGT1A6 MROH2A lnc-UGT1A8-1 UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10
GH02J233745 Promoter/Enhancer 1.3 EPDnew ENCODE 250.4 -14.7 -14685 1 CEBPA ATF3 YY1 FOXA1 HOMEZ THAP11 FOXA2 KDM6A SMAD4 RXRA DNAJB3 UGT1A2P UGT1A1 UGT1A6 UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10
GH02J233757 Enhancer 0.4 ENCODE 250.7 -1.8 -1788 1.8 NFYC PPARG MIXL1 UGT1A1 LOC100286922 UGT1A6 USP40 DNAJB3 lnc-HJURP-4 UGT1A3 UGT1A4 UGT1A5 UGT1A7
GH02J233768 Promoter 0.3 EPDnew 250.4 +8.1 8125 0.1 UGT1A1 MROH2A lnc-UGT1A8-1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A9 UGT1A10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGT1A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGT1A1

Top Transcription factor binding sites by QIAGEN in the UGT1A1 gene promoter:
  • AML1a
  • Arnt
  • Cdc5
  • HNF-4alpha1
  • HOXA5
  • NRSF form 1
  • p300
  • p53

Genomic Locations for UGT1A1 Gene

Latest Assembly
chr2:233,760,270-233,773,300
(GRCh38/hg38)
Size:
13,031 bases
Orientation:
Plus strand

Previous Assembly
chr2:234,668,916-234,681,946
(GRCh37/hg19 by Entrez Gene)
Size:
13,031 bases
Orientation:
Plus strand

chr2:234,526,291-234,681,956
(GRCh37/hg19 by Ensembl)
Size:
155,666 bases
Orientation:
Plus strand

Genomic View for UGT1A1 Gene

Genes around UGT1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A1 Gene

Proteins for UGT1A1 Gene

  • Protein details for UGT1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22309-UD11_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1A1
    Protein Accession:
    P22309
    Secondary Accessions:
    • A6NJC3
    • B8K286

    Protein attributes for UGT1A1 Gene

    Size:
    533 amino acids
    Molecular mass:
    59591 Da
    Quaternary structure:
    • Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2 (PubMed:17187418, PubMed:20610558). Isoform 1 also interacts with respective i2 isoforms of UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).
    SequenceCaution:
    • Sequence=AAA61247.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF03522.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • UGT1A1 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A1 Gene

Selected DME Specific Peptides for UGT1A1 Gene

P22309:
  • NTILVKWLPQNDL
  • PQNDLLGHP
  • AAHDLTW
  • PLFGDQMDNAKR
  • NALKAVIN
  • GAGVTLNVLEMT
  • DVIGFLL
  • DYPRPIMPNMVF
  • GKKGRVKKAHKSK
  • EPLDLAVFWVE
  • IADALGKIPQTVLWRYTG
  • FWVEFVM
  • GSHWLSM
  • VVFSLGSMV
  • VMRHKGA
  • KSYKENIMRLSSLHKDRP
  • QYHSLDV
  • CNGVPMV
  • HPMTRAF

Post-translational modifications for UGT1A1 Gene

  • Glycosylation at Asn102, Asn295, and Asn347
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for UGT1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A1 Gene

Gene Families for UGT1A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for UGT1A1 Gene

InterPro:
Blocks:
  • UDP-glucoronosyl/UDP-glucosyl transferase

Suggested Antigen Peptide Sequences for UGT1A1 Gene

GenScript: Design optimal peptide antigens:
  • Bilirubin UDP-glucuronosyltransferase 1 A1 (B6EBF5_HUMAN)
  • UDP-glucuronosyltransferase 1A4 (Q53QD2_HUMAN)
  • cDNA FLJ75264, highly similar to Human bilirubin UDP-glucuronosyltransferase isozyme 1 mRNA (Q5DT03_HUMAN)
  • Bilirubin UDP-glucronosyltrasferase 1-1 (Q9BX76_HUMAN)
  • UDP-glucuronosyltransferase (Q9H3F9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22309

UniProtKB/Swiss-Prot:

UD11_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A1: view

Function for UGT1A1 Gene

Molecular function for UGT1A1 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19830808, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136641; Evidence={ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:19830808, ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53048, ChEBI:CHEBI:1156, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136967; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53004, ChEBI:CHEBI:15378, ChEBI:CHEBI:28744, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136931; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:53072, ChEBI:CHEBI:15378, ChEBI:CHEBI:28955, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:136974; Evidence={ECO:0000269|PubMed:15472229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52868, ChEBI:CHEBI:15378, ChEBI:CHEBI:17160, ChEBI:CHEBI:57529, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223; Evidence={ECO:0000269|PubMed:18719240};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP; Xref=Rhea:RHEA:52880, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:87620, ChEBI:CHEBI:136886; Evidence={ECO:0000269|PubMed:23288867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63720, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149504, ChEBI:CHEBI:149507; Evidence={ECO:0000269|PubMed:18674515};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63588, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:147403, ChEBI:CHEBI:147404; Evidence={ECO:0000269|PubMed:18052087};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP; Xref=Rhea:RHEA:63696, ChEBI:CHEBI:8988, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:149482; Evidence={ECO:0000269|PubMed:12181437, ECO:0000269|PubMed:18004212};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.26 uM for bilirubin {ECO:0000269|PubMed:18004206}; KM=70 uM for 4-methylumbelliferone {ECO:0000269|PubMed:18004206}; KM=23 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=38 uM for estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=165 uM for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; KM=15 uM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2) {ECO:0000269|PubMed:15472229}; KM=19 uM for 2-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=38 uM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=74 uM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 4) {ECO:0000269|PubMed:15472229}; KM=21 uM for 4-hydroxy-estrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=19 uM for 4-hydroxy-estrone (when assaying glucuronidation at position 4) {ECO:0000269|PubMed:15472229}; KM=49 uM for 2-methoxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=49 uM for 2-methoxyestrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=14 uM for 4-methoxy-17beta-estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=103 uM for 4-methoxyestrone (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:15472229}; KM=60.6 uM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=11.2 uM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3) {ECO:0000269|PubMed:18719240}; KM=21.5 uM for losartan (when assaying glucuronidation at position N2 of the tetrazole ring) {ECO:0000269|PubMed:18674515}; KM=7.5 uM for SN-38 (when assaying glucuronidation at position 10) {ECO:0000269|PubMed:12181437}; KM=410 uM for mycophenolate (when assaying glucuronidation at position 7) {ECO:0000269|PubMed:15470161}; KM=320 uM for mycophenolate (when assaying glucuronidation at position 6') {ECO:0000269|PubMed:15470161}; Vmax=1080 pmol/min/mg enzyme with bilirubin as substrate {ECO:0000269|PubMed:18004206}; Vmax=255 pmol/min/mg enzyme with 4-methylumbelliferone as substrate {ECO:0000269|PubMed:18004206}; Vmax=274 pmol/min/mg enzyme with 1-naphthol as substrate {ECO:0000269|PubMed:18004206}; Vmax=767 pmol/min/mg enzyme with 17beta-estradiol as substrate {ECO:0000269|PubMed:18004206}; Vmax=93 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=3 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=1037 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=36 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=326 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=19 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=42 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=34 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=11 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 4-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=222 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=39 pmol/min/mg enzyme for the formation of 2-methoxyestrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=19 pmol/min/mg enzyme for the formation of 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=4 pmol/min/mg enzyme for the formation of 4-methoxyestrone 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:15472229}; Vmax=704 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=115 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18719240}; Vmax=32.2 pmol/min/mg enzyme for the formation of losartan N2-(beta-D-glucuronate) {ECO:0000269|PubMed:18674515}; Vmax=40 pmol/min/mg enzyme for the formation of prunetin-4'-O-(beta-D-glucuronate) {ECO:0000269|PubMed:18052087}; Vmax=0.014 pmol/min/mg enzyme with 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) as substrate, for the formation of 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] {ECO:0000269|PubMed:16595710}; Vmax=33.4 pmol/min/mg enzyme for the formation of SN-38 glucuronide {ECO:0000269|PubMed:12181437}; Vmax=110 pmol/min/mg enzyme for the formation of mycophenolate 7-O-glucuronide {ECO:0000269|PubMed:15470161}; Vmax=30 pmol/min/mg enzyme for the formation of mycophenolic acid O-acyl-glucuronide {ECO:0000269|PubMed:15470161}; Note=Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values. {ECO:0000305|PubMed:16595710, ECO:0000305|PubMed:18052087};

Enzyme Numbers (IUBMB) for UGT1A1 Gene

Phenotypes From GWAS Catalog for UGT1A1 Gene

Gene Ontology (GO) - Molecular Function for UGT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 20308471
GO:0004857 enzyme inhibitor activity IDA 19996319
GO:0005496 steroid binding IDA 19996319
GO:0008194 UDP-glycosyltransferase activity IEA --
GO:0015020 glucuronosyltransferase activity IEA,IDA 1898728
genes like me logo Genes that share ontologies with UGT1A1: view
genes like me logo Genes that share phenotypes with UGT1A1: view

Human Phenotype Ontology for UGT1A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A1

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A1 Gene

Localization for UGT1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A1 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UGT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum NAS,IDA 17179145
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with UGT1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A1 Gene

Pathways & Interactions for UGT1A1 Gene

genes like me logo Genes that share pathways with UGT1A1: view

SIGNOR curated interactions for UGT1A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UGT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006789 bilirubin conjugation TAS --
GO:0006953 acute-phase response IEA --
GO:0007584 response to nutrient IEA --
GO:0008202 steroid metabolic process IC 19996319
genes like me logo Genes that share ontologies with UGT1A1: view

Drugs & Compounds for UGT1A1 Gene

(283) Drugs for UGT1A1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Enzyme, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1504
Indacaterol Approved Pharma Enzyme, substrate β2-agonist 0
Nilotinib Approved, Investigational Pharma Transporter, inhibitor Kinase Inhibitors 0
Atazanavir Approved, Investigational Pharma Enzyme, inhibitor HIV protease inhibitor,highly potent 0
Carvedilol Approved, Investigational Pharma Enzyme, substrate 207

(2320) Additional Compounds for UGT1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-methylumbelliferone
  • 4-Methyl-7-hydroxycoumarin
  • 4-MU
  • 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran
  • 7-Hydroxy-4-methyl-2-oxo-3-chromene
  • 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one
Morphine-3-glucuronide
  • Morphine 3-glucuronide(minor)
  • Morphine-3beta-D-glucuronide
20290-09-9
Scopoletin
  • 6-Methoxy-7-hydroxycoumarin
  • 6-Methylesculetin
  • 6-O-Methylesculetin
  • 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one
  • 7-Hydroxy-6-methoxycoumarin
92-61-5
SN38 glucuronide
  • sn-38g
  • 7-Ethyl-10-hydroxycamptothecin beta-glucuronide
  • sn 38g
  • 7-Ethyl-10-hydroxycamptothecin glucuronide
(+)-12a-Hydroxypachyrrhizone
  • 12a-Hydroxypachyrrhizone
28768-44-7
genes like me logo Genes that share compounds with UGT1A1: view

Transcripts for UGT1A1 Gene

mRNA/cDNA for UGT1A1 Gene

1 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGT1A1

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A1 Gene

No ASD Table

Relevant External Links for UGT1A1 Gene

GeneLoc Exon Structure for
UGT1A1

Expression for UGT1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UGT1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGT1A1 Gene

This gene is overexpressed in Colon - Transverse (x22.9), Bladder (x17.0), and Small Intestine - Terminal Ileum (x5.8).

Protein differential expression in normal tissues from HIPED for UGT1A1 Gene

This gene is overexpressed in Liver (43.0) and Gallbladder (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UGT1A1 Gene



Protein tissue co-expression partners for UGT1A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGT1A1

SOURCE GeneReport for Unigene cluster for UGT1A1 Gene:

Hs.554822

mRNA Expression by UniProt/SwissProt for UGT1A1 Gene:

P22309-UD11_HUMAN
Tissue specificity: [Isoform 1]: Expressed in liver, colon and small intestine. Not expressed in kidney, esophagus and skin.

Evidence on tissue expression from TISSUES for UGT1A1 Gene

  • Liver(4.6)
  • Intestine(4.5)
  • Blood(4.5)
  • Urine(2.2)
  • Kidney(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • mouth
Abdomen:
  • liver
General:
  • skin
genes like me logo Genes that share expression patterns with UGT1A1: view

Primer products for research

Orthologs for UGT1A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia UGT1A1 29
  • 83.49 (n)
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Ugt1a1 29
  • 82.68 (n)
Mouse
(Mus musculus)
Mammalia Ugt1a1 29 16
  • 81.64 (n)
Ugt1a5 30
  • 76 (a)
ManyToMany
Ugt1a2 30
  • 76 (a)
ManyToMany
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 32 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves UGT1A1 29
  • 66.27 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 60 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ugt1a1 29
  • 58.3 (n)
ugt1a7 30
  • 51 (a)
ManyToMany
ugt1b1 30
  • 48 (a)
ManyToMany
ugt1b5 30
  • 46 (a)
ManyToMany
ugt1b3 30
  • 46 (a)
ManyToMany
ugt1b2 30
  • 46 (a)
ManyToMany
ugt1b4 30
  • 46 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG10178 29 31
  • 47.54 (n)
Ugt36Bb 31
  • 39 (a)
CG11289 31
  • 34 (a)
Ugt37c1 31
  • 30 (a)
Ugt86Dj 31
  • 29 (a)
BEST:GH06505 31
  • 28 (a)
Ugt86Dh 31
  • 27 (a)
Ugt36Ba 31
  • 27 (a)
Ugt37b1 31
  • 25 (a)
Dot 31
  • 25 (a)
CG3797 31
  • 24 (a)
CG5724 31
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008401 29
  • 47.33 (n)
Worm
(Caenorhabditis elegans)
Secernentea C08F11.8 31
  • 28 (a)
C10H11.5 31
  • 28 (a)
C17G1.3 31
  • 28 (a)
ZC443.5 31
  • 27 (a)
C10H11.6 31
  • 26 (a)
F09G2.6 31
  • 26 (a)
C03A7.11 31
  • 25 (a)
R11A8.3 31
  • 25 (a)
AC3.2 31
  • 25 (a)
R04B5.9 31
  • 25 (a)
K08B4.4 31
  • 24 (a)
T01G5.2 31
  • 24 (a)
C10H11.4 31
  • 23 (a)
ZC455.3 31
  • 23 (a)
AC3.8 31
  • 22 (a)
F01D4.1 31
  • 22 (a)
F01D4.2 31
  • 21 (a)
Species where no ortholog for UGT1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for UGT1A1 Gene

ENSEMBL:
Gene Tree for UGT1A1 (if available)
TreeFam:
Gene Tree for UGT1A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UGT1A1: view image
Alliance of Genome Resources:
Additional Orthologs for UGT1A1

Paralogs for UGT1A1 Gene

(31) SIMAP similar genes for UGT1A1 Gene using alignment to 6 proteins:

  • UD11_HUMAN
  • A6NJC3_HUMAN
  • B6EBF5_HUMAN
  • Q5DT03_HUMAN
  • Q9BX76_HUMAN
  • Q9H3F9_HUMAN
genes like me logo Genes that share paralogs with UGT1A1: view

Variants for UGT1A1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A1 Gene

UD11_HUMAN-P22309
Genetic variation in UGT1A1 defines the bilirubin serum levels quantitative trait locus 1 (BILIQTL1) [MIM:601816]. Variation in serum bilirubin is associated with altered cardiovascular disease risk and drug metabolism.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGT1A1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
549828 Drug Response: Irinotecan response 233,760,235(+) TATATATATATATA/.
UGT1A1*1
INTRON
895439 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,312(+) C/T
NM_000463.3(UGT1A1):c.25C>T (p.Arg9Cys)
MISSENSE_VARIANT,INTRON
895502 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,760,648(+) G/C
NM_000463.3(UGT1A1):c.361G>C (p.Ala121Pro)
MISSENSE_VARIANT,INTRON
895576 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,768,315(+) T/C
NM_000463.3(UGT1A1):c.1180T>C (p.Phe394Leu)
MISSENSE
895638 Uncertain Significance: Gilbert's syndrome; Crigler-Najjar syndrome; Lucey-Driscoll syndrome 233,772,692(+) G/A
NM_000463.3(UGT1A1):c.*133G>A
THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UGT1A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UGT1A1 Gene

Variant ID Type Subtype PubMed ID
nsv1013712 CNV loss 25217958
nsv3215 CNV deletion 18451855

Variation tolerance for UGT1A1 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGT1A1 Gene

Human Gene Mutation Database (HGMD)
UGT1A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UGT1A1
Leiden Open Variation Database (LOVD)
UGT1A1

SNP Genotyping and Copy Number Assays for research

Disorders for UGT1A1 Gene

MalaCards: The human disease database

(40) MalaCards diseases for UGT1A1 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
gilbert syndrome
  • hyperbilirubinemia, gilbert type; hblrg
hyperbilirubinemia, transient familial neonatal
  • hblrtfn
bilirubin, serum level of, quantitative trait locus 1
  • biliqtl1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

UD11_HUMAN
  • Gilbert syndrome (GILBS) [MIM:143500]: Occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague non-specific complaints. {ECO:0000269 PubMed:11013440, ECO:0000269 PubMed:12139570, ECO:0000269 PubMed:17496722, ECO:0000269 PubMed:7715297, ECO:0000269 PubMed:9627603}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Transient familial neonatal hyperbilirubinemia (HBLRTFN) [MIM:237900]: A condition characterized by excessive concentration of bilirubin in the blood, which may lead to jaundice. Breast milk jaundice is a common problem in nursing infants. {ECO:0000269 PubMed:11061796}. Note=The disease may be caused by variants affecting the gene represented in this entry. The defect has been ascribed to various breast milk substances, but the component or combination of components that is responsible remains unclear. Defects of UGT1A1 are an underlying cause of the prolonged unconjugated hyperbilirubinemia associated with breast milk. One or more components in the milk may trigger the jaundice in infants who have such mutations. Mutations are identical to those detected in patients with Gilbert syndrome, a risk factor of neonatal non-physiologic hyperbilirubinemia and a genetic factor in fasting hyperbilirubinemia.
  • Crigler-Najjar syndrome 1 (CN1) [MIM:218800]: Patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive. {ECO:0000269 PubMed:11013440, ECO:0000269 PubMed:15712364, ECO:0000269 PubMed:1634050, ECO:0000269 PubMed:17229650, ECO:0000269 PubMed:19830808, ECO:0000269 PubMed:23992562, ECO:0000269 PubMed:7906695, ECO:0000269 PubMed:7989045, ECO:0000269 PubMed:7989595, ECO:0000269 PubMed:8226884}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Crigler-Najjar syndrome 2 (CN2) [MIM:606785]: Patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant. {ECO:0000269 PubMed:11013440, ECO:0000269 PubMed:11370628, ECO:0000269 PubMed:12402338, ECO:0000269 PubMed:14550264, ECO:0000269 PubMed:15712364, ECO:0000269 PubMed:17229650, ECO:0000269 PubMed:18004206, ECO:0000269 PubMed:19830808, ECO:0000269 PubMed:23099197, ECO:0000269 PubMed:23992562, ECO:0000269 PubMed:7989595, ECO:0000269 PubMed:8276413, ECO:0000269 PubMed:8280139, ECO:0000269 PubMed:8706880, ECO:0000269 PubMed:9621515, ECO:0000269 PubMed:9639672}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for UGT1A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UGT1A1: view

No data available for Genatlas for UGT1A1 Gene

Publications for UGT1A1 Gene

  1. Genome-wide association meta-analysis for total serum bilirubin levels. (PMID: 19414484) Johnson AD … Witteman JC (Human molecular genetics 2009) 3 4 22 40
  2. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. (PMID: 18004206) Udomuksorn W … Miners JO (Pharmacogenetics and genomics 2007) 3 4 22 72
  3. Global gene expression as a function of germline genetic variation. (PMID: 15857854) French D … Relling MV (Human molecular genetics 2005) 3 22 40 72
  4. Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene. (PMID: 11061796) Maruo Y … Shimada M (Pediatrics 2000) 3 4 22 72
  5. Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men. (PMID: 20308029) Karatzas A … Tsezou A (Cancer epidemiology 2010) 3 22 40

Products for UGT1A1 Gene

Sources for UGT1A1 Gene