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Aliases for UGT1A Gene

Aliases for UGT1A Gene

  • UDP Glucuronosyltransferase Family 1 Member A Complex Locus 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A Complex Locus 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A Cluster 2 3
  • UDP Glycosyltransferase 1 Family, Polypeptide A Cluster 2 3
  • UGT1A@ 3
  • UGT1 3
  • GNT1 3
  • UGT 3

External Ids for UGT1A Gene

Previous HGNC Symbols for UGT1A Gene

  • UGT1A@

Previous GeneCards Identifiers for UGT1A Gene

  • GC02U901997

Summaries for UGT1A Gene

Entrez Gene Summary for UGT1A Gene

  • This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]

CIViC summary for UGT1A Gene

GeneCards Summary for UGT1A Gene

UGT1A (UDP Glucuronosyltransferase Family 1 Member A Complex Locus) is a Protein Coding gene. Diseases associated with UGT1A include Crigler-Najjar Syndrome, Type I and Crigler-Najjar Syndrome, Type Ii.

Gene Wiki entry for UGT1A Gene

Additional gene information for UGT1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A Gene

Genomics for UGT1A Gene

GeneHancer (GH) Regulatory Elements for UGT1A Gene

Promoters and enhancers for UGT1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I233593 Enhancer 0.6 ENCODE 0.4 +7.9 7931 0.2 CBFB NR2F1 JUNB DPF2 BATF IRF4 BCL11A IKZF1 NBN RUNX3 USP40 UGT1A4 UGT1A UGT1A12P UGT1A11P
GH02I233671 Promoter 0.9 EPDnew 0.2 +86.4 86440 0.1 TAF1 MAX REST RAD21 YY1 JUND ATF3 HNF4G HNF4A ZBTB33 UGT1A9 UGT1A7 UGT1A10 UGT1A8 UGT1A
GH02I233617 Promoter 0.5 EPDnew 0.3 +32.2 32214 0.1 UGT1A8 UGT1A10 UGT1A
GH02I233759 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE 0.1 +175.5 175463 2.5 FOXA2 TAF1 MAX RAD21 YY1 ZNF316 HNF4G MAFK RXRA USF2 UGT1A1 UGT1A6 MROH2A UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10 UGT1A8
GH02I233688 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 0.1 +105.6 105562 4.1 NFIB JUN YY1 GATA3 RCOR1 FOSL2 FOS NFE2L2 SMARCE1 CEBPB UGT1A6 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UGT1A on UCSC Golden Path with GeneCards custom track

Genomic Locations for UGT1A Gene

Genomic Locations for UGT1A Gene
187,861 bases
Plus strand

Genomic View for UGT1A Gene

Genes around UGT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A Gene

Proteins for UGT1A Gene

Post-translational modifications for UGT1A Gene

No Post-translational modifications

No data available for DME Specific Peptides for UGT1A Gene

Domains & Families for UGT1A Gene

Gene Families for UGT1A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UGT1A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for UGT1A Gene

Function for UGT1A Gene

Phenotypes From GWAS Catalog for UGT1A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A Gene

Localization for UGT1A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UGT1A Gene

Pathways & Interactions for UGT1A Gene

SuperPathways for UGT1A Gene

No Data Available

Interacting Proteins for UGT1A Gene

Gene Ontology (GO) - Biological Process for UGT1A Gene


No data available for Pathways by source and SIGNOR curated interactions for UGT1A Gene

Drugs & Compounds for UGT1A Gene

(77) Drugs for UGT1A Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 1014
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1181
Bilirubin Pharma 129

(48) Additional Compounds for UGT1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UGT1A: view

Transcripts for UGT1A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A Gene

No ASD Table

Relevant External Links for UGT1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for UGT1A Gene

Expression for UGT1A Gene

NURSA nuclear receptor signaling pathways regulating expression of UGT1A Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A Gene

Orthologs for UGT1A Gene

No data available for Orthologs and Evolution for UGT1A Gene

Paralogs for UGT1A Gene

No data available for Paralogs for UGT1A Gene

Variants for UGT1A Gene

Additional Variant Information for UGT1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for UGT1A Gene

Disorders for UGT1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for UGT1A Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type i
  • hyperbilirubinemia, crigler-najjar type i; hblrcn1
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
irinotecan toxicity
brain stem glioma
  • brainstem neuroglial tumor
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards
Search UGT1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UGT1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UGT1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A Gene

Publications for UGT1A Gene

  1. A pilot genome-wide association study of early-onset breast cancer. (PMID: 18463975) Kibriya MG … Ahsan H (Breast cancer research and treatment 2009) 3 44 58
  2. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. (PMID: 18480185) Nakamura A … Yokoi T (Drug metabolism and disposition: the biological fate of chemicals 2008) 3 22 58
  3. [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. (PMID: 18478930) Wang Y … Li F (Zhonghua zhong liu za zhi [Chinese journal of oncology] 2007) 3 44 58
  4. Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. (PMID: 28049773) Audet-Delage Y … Guillemette C (Molecular pharmacology 2017) 3 58
  5. Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients. (PMID: 26010150) Lu L … Liu ZQ (PloS one 2015) 3 58

Products for UGT1A Gene

Sources for UGT1A Gene

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