Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UGDH Gene

Aliases for UGDH Gene

  • UDP-Glucose 6-Dehydrogenase 2 3 5
  • UDP-Glucose Dehydrogenase 2 3
  • UDP-Glc Dehydrogenase 3 4
  • EC 4 56
  • UDP-GlcDH 3 4
  • UDPGDH 3 4
  • Uridine Diphospho-Glucose Dehydrogenase 3
  • GDH 3
  • UGD 3

External Ids for UGDH Gene

Previous GeneCards Identifiers for UGDH Gene

  • GC04M039674
  • GC04M039335
  • GC04M039397
  • GC04M039322
  • GC04M039176
  • GC04M038825

Summaries for UGDH Gene

Entrez Gene Summary for UGDH Gene

  • The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for UGDH Gene

UGDH (UDP-Glucose 6-Dehydrogenase) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include electron transfer activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.

UniProtKB/Swiss-Prot for UGDH Gene

  • Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Gene Wiki entry for UGDH Gene

Additional gene information for UGDH Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGDH Gene

Genomics for UGDH Gene

GeneHancer (GH) Regulatory Elements for UGDH Gene

Promoters and enhancers for UGDH Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I039525 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557 +0.5 547 4.1 HDGF PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 UGDH-AS1 UGDH LOC105374419 SMIM14 RPL9 GC04M039495
GH04I039515 Promoter 0.5 EPDnew 550.4 +14.1 14142 0.1 UGDH LOC105374419 SMIM14 GC04M039495 UGDH-AS1
GH04I039514 Enhancer 1.2 Ensembl ENCODE 5.6 +13.1 13100 1.8 CLOCK FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 LOC105374419 SMIM14 KLF3-AS1 WDR19 UGDH-AS1 LOC401127 UGDH RPL9 GC04M039495
GH04I039520 Enhancer 0.9 Ensembl ENCODE 5.1 +5.3 5283 4.6 FOXA2 SAP130 KLF6 SIN3A ZNF384 RARA ZNF335 SSRP1 JUND PRDM6 RPL9 LOC105374419 SMIM14 UGDH-AS1 UGDH GC04M039495
GH04I039501 Enhancer 0.6 FANTOM5 ENCODE 6 +25.8 25752 2.3 JUND FOS GC04M039495 RPL9 UGDH LOC401127
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UGDH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UGDH gene promoter:

Genomic Locations for UGDH Gene

Genomic Locations for UGDH Gene
29,557 bases
Minus strand

Genomic View for UGDH Gene

Genes around UGDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGDH Gene

Proteins for UGDH Gene

  • Protein details for UGDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucose 6-dehydrogenase
    Protein Accession:
    Secondary Accessions:
    • B3KUU2
    • B4DN25
    • O60589

    Protein attributes for UGDH Gene

    494 amino acids
    Molecular mass:
    55024 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for UGDH Gene

    Alternative splice isoforms for UGDH Gene


neXtProt entry for UGDH Gene

Selected DME Specific Peptides for UGDH Gene


Post-translational modifications for UGDH Gene

No Post-translational modifications

Domains & Families for UGDH Gene

Gene Families for UGDH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
  • Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
genes like me logo Genes that share domains with UGDH: view

Function for UGDH Gene

Molecular function for UGDH Gene

GENATLAS Biochemistry:
UDP-glucose dehydrogenase,converting UDP-glucose to UDP-glucuronate,involved in normal cell proliferation and migration,upregulated by androgens,playing a potentially important role in the control of sex steroid inactivation via glucuronidation in breast cancer cells
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Enzyme Numbers (IUBMB) for UGDH Gene

Phenotypes From GWAS Catalog for UGDH Gene

Gene Ontology (GO) - Molecular Function for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0003979 UDP-glucose 6-dehydrogenase activity TAS --
GO:0009055 electron transfer activity TAS 9737970
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with UGDH: view
genes like me logo Genes that share phenotypes with UGDH: view

Animal Model Products

miRNA for UGDH Gene

miRTarBase miRNAs that target UGDH

Clone Products

  • Addgene plasmids for UGDH

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGDH Gene

Localization for UGDH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGDH gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS,IBA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with UGDH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UGDH Gene

Pathways & Interactions for UGDH Gene

genes like me logo Genes that share pathways with UGDH: view

UniProtKB/Swiss-Prot O60701-UGDH_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Gene Ontology (GO) - Biological Process for UGDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0006011 UDP-glucose metabolic process TAS 9737970
GO:0006024 glycosaminoglycan biosynthetic process TAS 9737970
GO:0006065 UDP-glucuronate biosynthetic process TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with UGDH: view

No data available for SIGNOR curated interactions for UGDH Gene

Drugs & Compounds for UGDH Gene

(14) Drugs for UGDH Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Copper Approved, Investigational Pharma Target 202
Water Approved Pharma 0
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine diphosphate glucose Experimental Pharma 0

(15) Additional Compounds for UGDH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with UGDH: view

Transcripts for UGDH Gene

Unigene Clusters for UGDH Gene

UDP-glucose 6-dehydrogenase:
Representative Sequences:

Clone Products

  • Addgene plasmids for UGDH

Alternative Splicing Database (ASD) splice patterns (SP) for UGDH Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP2: - - -
SP4: -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - -

Relevant External Links for UGDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGDH Gene

This gene is overexpressed in Liver (x6.4).

Protein differential expression in normal tissues from HIPED for UGDH Gene

This gene is overexpressed in Bone marrow stromal cell (19.2), Liver (6.3), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UGDH Gene

Protein tissue co-expression partners for UGDH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UGDH Gene:


SOURCE GeneReport for Unigene cluster for UGDH Gene:


mRNA Expression by UniProt/SwissProt for UGDH Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for UGDH Gene

  • Liver(4.7)
  • Skin(4.5)
  • Nervous system(3.1)
  • Intestine(2.4)
  • Kidney(2.4)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with UGDH: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UGDH Gene

Orthologs for UGDH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGDH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UGDH 33 34
  • 99.8 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
-- 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia UGDH 34
  • 97 (a)
(Canis familiaris)
Mammalia UGDH 33 34
  • 93.99 (n)
(Bos Taurus)
Mammalia UGDH 33 34
  • 93.45 (n)
(Mus musculus)
Mammalia Ugdh 33 16 34
  • 89.86 (n)
(Rattus norvegicus)
Mammalia Ugdh 33
  • 89.79 (n)
(Gallus gallus)
Aves UGDH 33 34
  • 82.25 (n)
(Anolis carolinensis)
Reptilia UGDH 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ugdh 33
  • 78 (n)
Str.1204 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52511 33
(Danio rerio)
Actinopterygii ugdh 33 34
  • 73.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta sgl 35 33 34
  • 61.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006532 33
  • 61.17 (n)
(Caenorhabditis elegans)
Secernentea sqv-4 33 34
  • 61.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39320 33
  • 60.45 (n)
(Glycine max)
eudicotyledons Gma.6350 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8544 33
(Oryza sativa)
Liliopsida Os03g0604200 33
  • 54.92 (n)
Os.10473 33
(Hordeum vulgare)
Liliopsida Hv.12401 33
(Triticum aestivum)
Liliopsida Ta.2657 33
(Zea mays)
Liliopsida Zm.4986 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8331 34
  • 68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.748 33
Species where no ortholog for UGDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGDH Gene

Gene Tree for UGDH (if available)
Gene Tree for UGDH (if available)

Paralogs for UGDH Gene

(2) SIMAP similar genes for UGDH Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with UGDH: view

No data available for Paralogs for UGDH Gene

Variants for UGDH Gene

Sequence variations from dbSNP and Humsavar for UGDH Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000084236 -- 39,502,551(-) A/G intron_variant
rs10001159 -- 39,519,608(-) G/A intron_variant
rs10004662 -- 39,504,233(-) A/G intron_variant
rs1000521950 -- 39,528,058(-) C/T upstream_transcript_variant
rs1000567123 -- 39,498,547(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UGDH Gene

Variant ID Type Subtype PubMed ID
nsv1010784 CNV gain 25217958
nsv1010189 CNV gain 25217958

Variation tolerance for UGDH Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGDH Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGDH Gene

Disorders for UGDH Gene

Additional Disease Information for UGDH

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UGDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGDH Gene

Publications for UGDH Gene

  1. Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. (PMID: 9737970) Spicer AP … Seldin MF (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. (PMID: 10575217) Marcu O … Marsh JL (Cytogenetics and cell genetics 1999) 2 3 22 58
  3. cDNA cloning and expression analysis of the human UDPglucose dehydrogenase. (PMID: 9850599) Peng HL … Chang HY (Proceedings of the National Science Council, Republic of China. Part B, Life sciences 1998) 3 4 22 58
  4. Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates. (PMID: 22123821) Egger S … Nidetzky B (The Journal of biological chemistry 2012) 3 4 58
  5. Conformational flexibility in the allosteric regulation of human UDP-α-D-glucose 6-dehydrogenase. (PMID: 21961565) Sennett NC … Wood ZA (Biochemistry 2011) 3 4 58

Products for UGDH Gene

Sources for UGDH Gene

Loading form....