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This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]
UGCG (UDP-Glucose Ceramide Glucosyltransferase) is a Protein Coding gene. Diseases associated with UGCG include Sandhoff Disease and Fabry Disease. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include ceramide glucosyltransferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12873973 |
GO:0008120 | ceramide glucosyltransferase activity | TAS | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0102769 | dihydroceramide glucosyltransferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IBA | 21873635 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
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2 | Sphingolipid metabolism | ||
3 | IL2 signaling events mediated by PI3K |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006497 | protein lipidation | ISS | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006665 | sphingolipid metabolic process | IEA | -- |
GO:0006679 | glucosylceramide biosynthetic process | IDA | 8643456 |
GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Dihydroceramide |
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3-O-Sulfogalactosylceramide (d18:1/12:0) |
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852100-88-0 |
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3-O-Sulfogalactosylceramide (d18:1/14:0) |
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3-O-Sulfogalactosylceramide (d18:1/16:0) |
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862509-48-6 |
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3-O-Sulfogalactosylceramide (d18:1/18:0) |
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244215-65-4 |
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Compound | Action | Cas Number |
---|---|---|
Caspofungin Acetate | 179463-17-3 | |
Micafungin sodium | Inhibitor of β-(1,3)-D-glucan synthesis;fungicide | 208538-73-2 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UGCG 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | UGCG 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | UGCG 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UGCG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | UGCG 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ugcg 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ugcg 30 |
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Chicken (Gallus gallus) |
Aves | UGCG 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | UGCG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ugcg 30 |
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Str.20419 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.21362 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | ugcg 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012412 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | GlcT-1 30 31 |
|
OneToOne | |
CG6437 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | cgt-3 30 31 |
|
OneToMany | |
F59G1.1c 32 |
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F59G1.1a 32 |
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F59G1.1b 32 |
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F20B4.6 32 |
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T06C12.10 32 |
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cgt-2 31 |
|
OneToMany | |||
cgt-1 31 |
|
OneToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E02641g 30 |
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A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR207W 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9756 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01116 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14730 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1136125 | CNV | deletion | 17803354 |
esv3129366 | CNV | deletion | 24192839 |
esv3545326 | CNV | deletion | 23714750 |
nsv1110051 | CNV | deletion | 24896259 |
nsv1119606 | CNV | deletion | 24896259 |
nsv831690 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sandhoff disease |
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fabry disease |
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gaucher's disease |
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gaucher disease, type i |
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niemann-pick disease |
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