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This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014] See more...
Aliases for UGCG Gene
Aliases for UGCG Gene
External Ids for UGCG Gene
- HGNC: 12524
- Entrez Gene: 7357
- Ensembl: ENSG00000148154
- OMIM: 602874
- UniProtKB: Q16739
Previous GeneCards Identifiers for UGCG Gene
- GC09P105457
- GC09P106391
- GC09P108116
- GC09P110039
- GC09P111738
- GC09P113698
- GC09P114659
- GC09P084257
Summaries for UGCG Gene
-
This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]
GeneCards Summary for UGCG Gene
UGCG (UDP-Glucose Ceramide Glucosyltransferase) is a Protein Coding gene. Diseases associated with UGCG include Gaucher Disease, Type I and Sandhoff Disease. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include ceramide glucosyltransferase activity.
UniProtKB/Swiss-Prot Summary for UGCG Gene
-
Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (PubMed:8643456, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity).
Additional gene information for UGCG Gene
- HGNC(12524)
- Entrez Gene(7357)
- Ensembl(ENSG00000148154)
- OMIM(602874)
- UniProtKB(Q16739)
- Open Targets Platform(ENSG00000148154)
- Search for UGCG at DataMed
- Search for UGCG at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UGCG Gene
Genomics for UGCG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UGCG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UGCG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UGCG
- Top Transcription factor binding sites by QIAGEN in the UGCG gene promoter:
-
- AML1a
- C/EBPbeta
- HEN1
- Lmo2
- MRF-2
- NF-kappaB
- NF-kappaB1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Genomic Locations for UGCG Gene
Genomic Locations for UGCG Gene
- chr9:111,896,766-111,935,369
- (GRCh38/hg38)
- Size:
- 38,604 bases
- Orientation:
- Plus strand
- chr9:114,659,046-114,697,649
- (GRCh37/hg19)
- Size:
- 38,604 bases
- Orientation:
- Plus strand
Genomic View for UGCG Gene
Genes around UGCG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.3 by HGNC
- 9q31.3 by Entrez Gene
- 9q31.3 by Ensembl
UGCG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UGCG Gene
Proteins for UGCG Gene
-
Protein details for UGCG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16739-CEGT_HUMAN
- Recommended name:
- Ceramide glucosyltransferase
- Protein Accession:
- Q16739
- Q5T258
Protein attributes for UGCG Gene
- Size:
- 394 amino acids
- Molecular mass:
- 44854 Da
- Quaternary structure:
-
- Interacts with RTN1; regulates the ceramide glucosyltransferase activity of UGCG.
Protein Expression for UGCG Gene
Post-translational modifications for UGCG Gene
Other Protein References for UGCG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-UGCG monoclonal antibody
- Creative Biolabs Recombinant Anti-Human UGCG Antibody and Mouse Anti-UGCG Recombinant Antibody (CBCNC-745)
- Novus Biologicals Antibodies for UGCG
-
Abcam antibodies for UGCG
- Invitrogen Antibodies for UGCG (AFLGC-UGCG)
-
Biorbyt antibodies for UGCG
-
Boster Bio Antibodies for UGCG
-
Santa Cruz Biotechnology (SCBT) Antibodies for UGCG
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for UGCG
- Origene Custom Protein Services for UGCG
- antibodies-online: Show 8 available UGCG Proteins ranked by validation data
- Compare Top UGCG Proteins
-
Quality Products:
-
Abcam proteins for UGCG
Assay Products
No data available for DME Specific Peptides for UGCG Gene
Domains & Families for UGCG Gene
Gene Families for UGCG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for UGCG Gene
- InterPro:
- Blocks:
-
- Glycosyl transferase, family 2
- ProtoNet:
Suggested Antigen Peptide Sequences for UGCG Gene
- GenScript: Design optimal peptide antigens:
-
- UDP-glucose:N-acylsphingosine D-glucosyltransferase (CEGT_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16739UniProtKB/Swiss-Prot:
CEGT_HUMAN :- The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.
- Belongs to the glycosyltransferase 2 family.
- Domain:
-
- The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.
- Family:
-
- Belongs to the glycosyltransferase 2 family.
Function for UGCG Gene
Molecular function for UGCG Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (PubMed:8643456, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP; Xref=Rhea:RHEA:12088, ChEBI:CHEBI:15378, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.80; Evidence={ECO:0000269|PubMed:8643456};.
- GENATLAS Biochemistry:
- UDP-glucose-ceramide glycosyltransferase,catalyzing the first glycosylation step of glycosphingolipid synthesis
Enzyme Numbers (IUBMB) for UGCG Gene
Phenotypes From GWAS Catalog for UGCG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12873973 |
| GO:0008120 | ceramide glucosyltransferase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0102769 | dihydroceramide glucosyltransferase activity | IEA | -- |
Phenotypes for UGCG Gene
- MGI mutant phenotypes for UGCG:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for UGCG:
-
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability ratio
- Synthetic lethal with Ras
- shRNA abundance <= 25%
- Decreased viability
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased virus production
Animal Models for UGCG Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UGCG - Select products 50% OFF >
- * UGCG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UGCG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UGCG
-
Santa Cruz Biotechnology (SCBT) CRISPR for UGCG
miRNA for UGCG Gene
- miRTarBase miRNAs that target UGCG
-
- mmu-miR-17-5p (MIRT010005)
- mmu-miR-340-5p (MIRT010504)
- mmu-miR-24-3p (MIRT013911)
- mmu-miR-149-5p (MIRT014688)
- hsa-miR-335-5p (MIRT019137)
- hsa-miR-375 (MIRT020053)
- hsa-miR-633 (MIRT464454)
- hsa-miR-8079 (MIRT464455)
- hsa-miR-8062 (MIRT464456)
- hsa-miR-1245a (MIRT464457)
- hsa-miR-510-5p (MIRT464458)
- hsa-miR-548x-3p (MIRT464459)
- hsa-miR-548j-3p (MIRT464460)
- hsa-miR-548aq-3p (MIRT464461)
- hsa-miR-548am-3p (MIRT464462)
- hsa-miR-548aj-3p (MIRT464463)
- hsa-miR-548ah-3p (MIRT464464)
- hsa-miR-548ae-3p (MIRT464465)
- hsa-miR-548z (MIRT464466)
- hsa-miR-548h-3p (MIRT464467)
- hsa-miR-548d-3p (MIRT464468)
- hsa-miR-548bb-3p (MIRT464469)
- hsa-miR-548ac (MIRT464470)
- hsa-miR-27b-3p (MIRT464471)
- hsa-miR-27a-3p (MIRT464472)
- hsa-miR-513a-5p (MIRT464473)
- hsa-miR-5591-3p (MIRT464474)
- hsa-miR-324-5p (MIRT464475)
- hsa-miR-586 (MIRT464476)
- hsa-miR-660-5p (MIRT464477)
- hsa-miR-328-3p (MIRT464478)
- hsa-miR-223-5p (MIRT464479)
- hsa-miR-7155-3p (MIRT464480)
- hsa-miR-3136-3p (MIRT464481)
- hsa-miR-3919 (MIRT464482)
- hsa-miR-511-3p (MIRT464483)
- hsa-miR-8066 (MIRT464484)
- hsa-miR-4482-3p (MIRT491996)
- hsa-miR-7159-3p (MIRT491997)
- hsa-miR-4284 (MIRT491998)
- hsa-miR-8057 (MIRT491999)
- hsa-miR-219a-2-3p (MIRT492000)
- hsa-miR-4797-3p (MIRT492001)
- hsa-miR-219b-3p (MIRT492002)
- hsa-miR-545-5p (MIRT492003)
- hsa-miR-1252-3p (MIRT492004)
- hsa-miR-3646 (MIRT492005)
- hsa-miR-4796-3p (MIRT492006)
- hsa-miR-93-5p (MIRT492007)
- hsa-miR-526b-3p (MIRT492008)
- hsa-miR-519d-3p (MIRT492009)
- hsa-miR-20b-5p (MIRT492010)
- hsa-miR-20a-5p (MIRT492011)
- hsa-miR-17-5p (MIRT492012)
- hsa-miR-106b-5p (MIRT492013)
- hsa-miR-106a-5p (MIRT492014)
- hsa-miR-3609 (MIRT492015)
- hsa-miR-548ah-5p (MIRT492016)
- hsa-miR-548t-5p (MIRT492017)
- hsa-miR-548az-5p (MIRT492018)
- hsa-miR-24-3p (MIRT492019)
- hsa-miR-6504-3p (MIRT553067)
- hsa-miR-3120-3p (MIRT553068)
- hsa-miR-216a-3p (MIRT553069)
- hsa-miR-128-3p (MIRT553070)
- hsa-miR-3681-3p (MIRT553071)
- hsa-miR-335-3p (MIRT612315)
- hsa-miR-5096 (MIRT612316)
- hsa-miR-5683 (MIRT612317)
- hsa-miR-576-3p (MIRT638128)
- hsa-miR-1273h-3p (MIRT736845)
- hsa-miR-2467-3p (MIRT739319)
- hsa-miR-3678-3p (MIRT742174)
- hsa-miR-4684-3p (MIRT746947)
- hsa-miR-4797-5p (MIRT748989)
- hsa-miR-6501-3p (MIRT752907)
- hsa-miR-6773-3p (MIRT755331)
- hsa-miR-744-3p (MIRT759354)
- hsa-miR-8068 (MIRT760078)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGCG
- Browse OriGene Inhibitory RNA Products For UGCG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGCG
Clone Products
- Applied Biological Materials (abm): Clones for UGCG - Select products 50% OFF >
- * UGCG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UGCG
- Addgene plasmids for UGCG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGCG
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UGCG Gene
Localization for UGCG Gene
Subcellular locations from UniProtKB/Swiss-Prot for UGCG Gene
- Golgi apparatus membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| endoplasmic reticulum | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IBA | 21873635 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGCG Gene
Pathways & Interactions for UGCG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Sphingolipid metabolism | ||
| 3 | IL2 signaling events mediated by PI3K | ||
Pathways by source for UGCG Gene
1 BioSystems pathway for UGCG Gene
4 Reactome pathways for UGCG Gene
2 KEGG pathways for UGCG Gene
UniProtKB/Swiss-Prot Q16739-CEGT_HUMAN
- Pathway: Lipid metabolism; sphingolipid metabolism.
Interacting Proteins for UGCG Gene
GPS-Prot Interaction Network for UGCG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006497 | protein lipidation | ISS | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006665 | sphingolipid metabolic process | IEA | -- |
| GO:0006679 | glucosylceramide biosynthetic process | IDA | 8643456 |
| GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
Drugs & Compounds for UGCG Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Dihydroceramide |
|
|||||
| glucosylceramide |
|
|||||
| 3-O-Sulfogalactosylceramide (d18:1/12:0) |
|
852100-88-0 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/14:0) |
|
|
||||
| 3-O-Sulfogalactosylceramide (d18:1/16:0) |
|
862509-48-6 |
|
(2) ApexBio Compounds for UGCG Gene
| Compound | Action | Cas Number |
|---|---|---|
| Caspofungin Acetate | 179463-17-3 | |
| Micafungin sodium | Inhibitor of β-(1,3)-D-glucan synthesis;fungicide | 208538-73-2 |
Transcripts for UGCG Gene
mRNA/cDNA for UGCG Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374279 3959 nts (view in UCSC)
- ENST00000474306 468 nts (view in UCSC)
- ENST00000489355 526 nts (view in UCSC)
- ENST00000490110 581 nts (view in UCSC)
- ENST00000495085 772 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UGCG - Select products 50% OFF >
- * UGCG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UGCG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UGCG
-
Santa Cruz Biotechnology (SCBT) CRISPR for UGCG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGCG
- Browse OriGene Inhibitory RNA Products For UGCG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGCG
Clone Products
- Applied Biological Materials (abm): Clones for UGCG - Select products 50% OFF >
- * UGCG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UGCG
- Addgene plasmids for UGCG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGCG
Relevant External Links for UGCG Gene
- GeneLoc Exon Structure for
- UGCG
Expression for UGCG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Natural Killer Cells Peripheral Blood
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Adrenal Gland (Endocrine System)
This gene is overexpressed in Monocytes (52.5) and Heart (16.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGCG Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UGCG
SOURCE GeneReport for Unigene cluster for UGCG Gene:
Hs.304249mRNA Expression by UniProt/SwissProt for UGCG Gene:
Q16739-CEGT_HUMAN
Tissue specificity:
Found in all tissues examined.
Evidence on tissue expression from TISSUES for UGCG Gene
- Nervous system(3.9)
- Lung(3.3)
- Kidney(3.2)
- Spleen(3.1)
- Skin(3.1)
- Heart(2.9)
- Liver(2.7)
- Bone marrow(2.7)
- Intestine(2.6)
- Pancreas(2.5)
- Lymph node(2.5)
- Adrenal gland(2.4)
- Blood(2.2)
- Stomach(2.2)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for UGCG
-
OriGene qPCR primer pairs and template standards for UGCG
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGCG Gene
Orthologs for UGCG Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UGCG 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UGCG 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | UGCG 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UGCG 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UGCG 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ugcg 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ugcg 30 |
|
||
| Chicken (Gallus gallus) |
Aves | UGCG 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UGCG 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ugcg 30 |
|
||
| Str.20419 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21362 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ugcg 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012412 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | GlcT-1 30 31 |
|
OneToOne | |
| CG6437 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | cgt-3 30 31 |
|
OneToMany | |
| F59G1.1c 32 |
|
|
|||
| F59G1.1a 32 |
|
|
|||
| F59G1.1b 32 |
|
|
|||
| F20B4.6 32 |
|
|
|||
| T06C12.10 32 |
|
|
|||
| cgt-2 31 |
|
OneToMany | |||
| cgt-1 31 |
|
OneToMany | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E02641g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR207W 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9756 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01116 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14730 30 |
|
- Species where no ortholog for UGCG was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UGCG Gene
- ENSEMBL:
- Gene Tree for UGCG (if available)
- TreeFam:
- Gene Tree for UGCG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UGCG: view image
Paralogs for UGCG Gene
No data available for Paralogs for UGCG Gene
Variants for UGCG Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1136125 | CNV | deletion | 17803354 |
| esv3129366 | CNV | deletion | 24192839 |
| esv3545326 | CNV | deletion | 23714750 |
| nsv1110051 | CNV | deletion | 24896259 |
| nsv1119606 | CNV | deletion | 24896259 |
| nsv831690 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UGCG Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UGCG
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UGCG Gene
Disorders for UGCG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gaucher disease, type i |
|
|
| sandhoff disease |
|
|
| fabry disease |
|
|
| gaucher's disease |
|
|
| gm1 gangliosidosis |
|
|
Search UGCG in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UGCG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UGCG Gene
Publications for UGCG Gene
- Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. (PMID: 8643456) Ichikawa S … Hirabayashi Y (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 23
- Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation. (PMID: 9545298) Watanabe R … Pagano RE (The Journal of biological chemistry 1998) 3 4 23
- Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization. (PMID: 9605861) Ichikawa S … Hirabayashi Y (Cytogenetics and cell genetics 1997) 2 3 23
- Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. (PMID: 8901638) Ichikawa S … Hirabayashi Y (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23
- Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer. (PMID: 18560890) Ruckhäberle E … Rody A (Journal of cancer research and clinical oncology 2009) 3 23
ExternalLinks
Products for UGCG Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for UGCG
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- Novus Biologicals proteins and lysates for UGCG
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- VectorBuilder Virus packaging for UGCG CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UGCG
- Addgene plasmids for UGCG
- antibodies-online: Show 11 available UGCG Antibodies ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for UGCG
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- Horizon Cell Lines for UGCG
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UGCG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UGCG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UGCG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGCG
- Boster Bio Antibodies for UGCG
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for UGCG
Sources for UGCG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
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- (143) Applied Biosystems
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- (145) Aminode
- (146) GeneCopoeia
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- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (177) snoDB
- (178) MirGeneDB