Aliases for UFSP2 Gene
External Ids for UFSP2 Gene
Previous HGNC Symbols for UFSP2 Gene
Previous GeneCards Identifiers for UFSP2 Gene
This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for UFSP2 Gene
UFSP2 (UFM1 Specific Peptidase 2) is a Protein Coding gene. Diseases associated with UFSP2 include Beukes Hip Dysplasia and Spondyloepimetaphyseal Dysplasia, Di Rocco Type. Gene Ontology (GO) annotations related to this gene include thiolester hydrolase activity and ubiquitin-like protein-specific protease activity. An important paralog of this gene is UFSP1.
UniProtKB/Swiss-Prot Summary for UFSP2 Gene
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.