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Aliases for UCP3 Gene

Aliases for UCP3 Gene

  • Uncoupling Protein 3 2 3 5
  • Uncoupling Protein 3 (Mitochondrial, Proton Carrier) 2 3
  • Solute Carrier Family 25 Member 9 3 4
  • SLC25A9 3 4
  • Mitochondrial Uncoupling Protein 3 3
  • UCP 3 4

External Ids for UCP3 Gene

Previous GeneCards Identifiers for UCP3 Gene

  • GC11M076038
  • GC11M075251
  • GC11M073934
  • GC11M073437
  • GC11M073388
  • GC11M073711
  • GC11M070007

Summaries for UCP3 Gene

Entrez Gene Summary for UCP3 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

GeneCards Summary for UCP3 Gene

UCP3 (Uncoupling Protein 3) is a Protein Coding gene. Diseases associated with UCP3 include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are The fatty acid cycling model and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include transporter activity and oxidative phosphorylation uncoupler activity. An important paralog of this gene is UCP2.

UniProtKB/Swiss-Prot for UCP3 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

Gene Wiki entry for UCP3 Gene

Additional gene information for UCP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP3 Gene

Genomics for UCP3 Gene

GeneHancer (GH) Regulatory Elements for UCP3 Gene

Promoters and enhancers for UCP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I074009 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.9 -1882 3 HDGF PKNOX1 ARNT IRF4 ZNF766 CBX5 E2F8 ZNF143 JUNB REST UCP3 UCP2 FAM168A LIPT2 C2CD3 ENSG00000256098
GH11I074008 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 539 1 PRDM1 ZKSCAN1 UCP3 PPME1 LOC100421622
GH11I074010 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 0.0 -23 0.1 ZKSCAN1 UCP3 ENSG00000256098
GH11I073968 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.7 +32.9 32872 16.9 CLOCK ZFP64 DMAP1 IRF4 SLC30A9 E2F8 ZNF143 SP3 NFYC PPARGC1A UCP2 POLD3 ENSG00000206913 RNF169 UCP3 RN7SL239P MRPL48 DNAJB13 P4HA3 PPME1
GH11I074133 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 -128.8 -128822 10.2 FOXA2 ARID4B SIN3A BRCA1 GLIS2 FOS DEK REST ZNF592 MIER3 PPME1 P4HA3 C2CD3 UCP3 UCP2 ENSG00000206913 ENSG00000256098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UCP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UCP3 gene promoter:

Genomic Locations for UCP3 Gene

Genomic Locations for UCP3 Gene
9,155 bases
Minus strand

Genomic View for UCP3 Gene

Genes around UCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP3 Gene

Proteins for UCP3 Gene

  • Protein details for UCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial uncoupling protein 3
    Protein Accession:
    Secondary Accessions:
    • O60475
    • Q96HL3

    Protein attributes for UCP3 Gene

    312 amino acids
    Molecular mass:
    34216 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC51785.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UCP3 Gene


neXtProt entry for UCP3 Gene

Post-translational modifications for UCP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP3 Gene

No data available for DME Specific Peptides for UCP3 Gene

Domains & Families for UCP3 Gene

Gene Families for UCP3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for UCP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with UCP3: view

Function for UCP3 Gene

Molecular function for UCP3 Gene

GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37 residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity and in type 2 diabetes (NIDDM)
UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

Gene Ontology (GO) - Molecular Function for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9196039
GO:0005515 protein binding IPI 24008843
GO:0017077 oxidative phosphorylation uncoupler activity IBA --
genes like me logo Genes that share ontologies with UCP3: view
genes like me logo Genes that share phenotypes with UCP3: view

Animal Models for UCP3 Gene

MGI Knock Outs for UCP3:

miRNA for UCP3 Gene

miRTarBase miRNAs that target UCP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCP3 Gene

Localization for UCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP3 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCP3 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
peroxisome 2
nucleus 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9180264
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with UCP3: view

Pathways & Interactions for UCP3 Gene

genes like me logo Genes that share pathways with UCP3: view

SIGNOR curated interactions for UCP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for UCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IEA --
GO:0001666 response to hypoxia IEA --
GO:0006629 lipid metabolic process TAS 10935638
GO:0006631 fatty acid metabolic process IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with UCP3: view

Drugs & Compounds for UCP3 Gene

(24) Drugs for UCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(18) Additional Compounds for UCP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCP3: view

Transcripts for UCP3 Gene

Unigene Clusters for UCP3 Gene

Uncoupling protein 3 (mitochondrial, proton carrier):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCP3 Gene

No ASD Table

Relevant External Links for UCP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP3 Gene

This gene is overexpressed in Muscle - Skeletal (x40.9).

Protein differential expression in normal tissues from HIPED for UCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCP3 Gene

Protein tissue co-expression partners for UCP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of UCP3 Gene:


SOURCE GeneReport for Unigene cluster for UCP3 Gene:


mRNA Expression by UniProt/SwissProt for UCP3 Gene:

Tissue specificity: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.

Evidence on tissue expression from TISSUES for UCP3 Gene

  • Muscle(4.8)
  • Liver(2.4)
  • Nervous system(2.3)
  • Thyroid gland(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with UCP3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UCP3 Gene

Orthologs for UCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UCP3 33 34
  • 98.72 (n)
(Canis familiaris)
Mammalia UCP3 33
  • 89.39 (n)
(Bos Taurus)
Mammalia UCP3 33 34
  • 88.75 (n)
(Rattus norvegicus)
Mammalia Ucp3 33
  • 85.82 (n)
(Mus musculus)
Mammalia Ucp3 33 16 34
  • 85.28 (n)
(Monodelphis domestica)
Mammalia UCP3 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia UCP3 34
  • 80 (a)
(Gallus gallus)
Aves UCP3 33 34
  • 71.68 (n)
(Anolis carolinensis)
Reptilia UCP3 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ucp1 33
  • 69.9 (n)
(Danio rerio)
Actinopterygii ucp3 34
  • 72 (a)
ucp1 33
  • 70.46 (n)
zgc55824 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 34
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UCP2 33
  • 50.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 34
  • 37 (a)
Species where no ortholog for UCP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP3 Gene

Gene Tree for UCP3 (if available)
Gene Tree for UCP3 (if available)

Paralogs for UCP3 Gene

(9) SIMAP similar genes for UCP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UCP3: view

Variants for UCP3 Gene

Sequence variations from dbSNP and Humsavar for UCP3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs104894319 pathogenic, Obesity, severe, and type II diabetes 74,005,844(-) G/A coding_sequence_variant, stop_gained
rs17848368 pathogenic, Obesity, severe, and type II diabetes 74,006,298(-) G/A coding_sequence_variant, missense_variant
rs2229707 benign, pathogenic, UCP3 POLYMORPHISM G/A, Obesity, severe, and type II diabetes, Obesity (OBESITY) [MIM:601665] 74,006,202(-) C/T coding_sequence_variant, missense_variant
rs192655642 uncertain-significance, not specified 74,006,232(-) C/T coding_sequence_variant, missense_variant
rs370829405 uncertain-significance, not specified 74,006,304(-) T/C coding_sequence_variant, missense_variant

Variation tolerance for UCP3 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UCP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UCP3 Gene

Disorders for UCP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UCP3 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search UCP3 in MalaCards View complete list of genes associated with diseases


  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:9769326, ECO:0000269 Ref.9}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Additional Disease Information for UCP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UCP3: view

No data available for Genatlas for UCP3 Gene

Publications for UCP3 Gene

  1. Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. (PMID: 19155787) Matsunaga T … Nishiyama T (Journal of hypertension 2009) 3 22 44 58
  2. Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study. (PMID: 19769793) Salopuro T … Uusitupa M (BMC medical genetics 2009) 3 22 44 58
  3. Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 gene. (PMID: 18348082) de Luis DA … Conde R (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2008) 3 22 44 58
  4. Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes. (PMID: 18426825) van Abeelen AF … van der Schouw YT (European journal of endocrinology 2008) 3 22 44 58
  5. UCP2 A55V variant is associated with obesity and related phenotypes in an aboriginal community in Taiwan. (PMID: 17502873) Wang TN … Ko YC (International journal of obesity (2005) 2007) 3 22 44 58

Products for UCP3 Gene

Sources for UCP3 Gene

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