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Aliases for UCP2 Gene

Aliases for UCP2 Gene

  • Uncoupling Protein 2 2 3 5
  • Uncoupling Protein 2 (Mitochondrial, Proton Carrier) 2 3
  • Solute Carrier Family 25 Member 8 3 4
  • SLC25A8 3 4
  • UCPH 3 4
  • Body Mass Index Quantitative Trait 4 2
  • Mitochondrial Uncoupling Protein 2 3
  • Body Mass Index QTL 4 2
  • BMIQ4 3
  • UCP 2 4

External Ids for UCP2 Gene

Previous HGNC Symbols for UCP2 Gene

  • BMIQ4

Previous GeneCards Identifiers for UCP2 Gene

  • GC11M076013
  • GC11M075225
  • GC11M073909
  • GC11M073412
  • GC11M073363
  • GC11M073685
  • GC11M069981

Summaries for UCP2 Gene

Entrez Gene Summary for UCP2 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

GeneCards Summary for UCP2 Gene

UCP2 (Uncoupling Protein 2) is a Protein Coding gene. Diseases associated with UCP2 include Body Mass Index Quantitative Trait Locus 4 and Hyperinsulinism Due To Ucp2 Deficiency. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot for UCP2 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Gene Wiki entry for UCP2 Gene

Additional gene information for UCP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCP2 Gene

Genomics for UCP2 Gene

GeneHancer (GH) Regulatory Elements for UCP2 Gene

Promoters and enhancers for UCP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J073968 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 659.7 +6.7 6744 16.9 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC UCP2 POLD3 ENSG00000206913 RNF169 UCP3 RN7SL239P MRPL48 DNAJB13 P4HA3 PPME1
GH11J074009 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -28.0 -28010 3 HDGF PKNOX1 ARNT IRF4 ZNF766 CBX5 E2F8 ZNF143 JUNB REST UCP3 ENSG00000206913 UCP2 POLD3 RNF169 FAM168A LIPT2 C2CD3 ENSG00000256098
GH11J074133 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 -155.0 -154950 10.2 FOXA2 ARID4B SIN3A BRCA1 GLIS2 ZFP91 FOS DEK REST ZNF592 PPME1 P4HA3 C2CD3 UCP3 UCP2 ENSG00000206913 ENSG00000256098
GH11J073778 Enhancer 1.6 FANTOM5 Ensembl ENCODE 6.1 +203.3 203331 2.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ENSG00000206913 MRPL48 POLD3 RNF169 RAB6A UCP2 FAM168A
GH11J074068 Enhancer 0.9 ENCODE 10.6 -86.8 -86830 3.4 PKNOX1 CLOCK ATF1 NEUROD1 TCF12 GATA2 FOS ATF7 NCOA1 ZNF592 PPME1 P4HA3 UCP3 UCP2 ENSG00000256098 C2CD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UCP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UCP2 gene promoter:
  • PPAR-alpha
  • GR-alpha
  • GR
  • NF-kappaB1
  • NF-kappaB
  • RelA
  • NF-1

Genomic Locations for UCP2 Gene

Genomic Locations for UCP2 Gene
8,641 bases
Minus strand
8,641 bases
Minus strand

Genomic View for UCP2 Gene

Genes around UCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCP2 Gene

Proteins for UCP2 Gene

  • Protein details for UCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial uncoupling protein 2
    Protein Accession:
    Secondary Accessions:
    • Q4PJH8
    • Q53HM3

    Protein attributes for UCP2 Gene

    309 amino acids
    Molecular mass:
    33229 Da
    Quaternary structure:
    • Acts as a dimer forming a proton channel.

neXtProt entry for UCP2 Gene

Post-translational modifications for UCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCP2 Gene

No data available for DME Specific Peptides for UCP2 Gene

Domains & Families for UCP2 Gene

Gene Families for UCP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for UCP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with UCP2: view

Function for UCP2 Gene

Molecular function for UCP2 Gene

UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
GENATLAS Biochemistry:
uncoupling protein of inner mitochondrial membrane 2,highly homolog to UCP1 and UCP3,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in adipose tissue and muscle,involved in the variation of energy metabolism with a reduced expression in skeletal muscle and intraperitoneal tissue (reduced gene expression in skeletal muscle of obese),regulated by PPARA and PPARG in mice

Gene Ontology (GO) - Molecular Function for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017077 oxidative phosphorylation uncoupler activity IBA --
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with UCP2: view
genes like me logo Genes that share phenotypes with UCP2: view

Human Phenotype Ontology for UCP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for UCP2 Gene

MGI Knock Outs for UCP2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for UCP2 Gene

Localization for UCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCP2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCP2 gene
Compartment Confidence
mitochondrion 5
peroxisome 3
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS,NAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with UCP2: view

Pathways & Interactions for UCP2 Gene

genes like me logo Genes that share pathways with UCP2: view

Gene Ontology (GO) - Biological Process for UCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IEA --
GO:0001666 response to hypoxia IDA 22292025
GO:0006839 mitochondrial transport IBA,IEA --
GO:0007565 female pregnancy IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with UCP2: view

No data available for SIGNOR curated interactions for UCP2 Gene

Drugs & Compounds for UCP2 Gene

(43) Drugs for UCP2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estradiol valerate Approved, Investigational, Vet_approved Pharma 1400
Polyestradiol phosphate Approved Pharma 1400
Adrenergic Agents Pharma 5713
Contraceptive Agents Pharma 2087

(37) Additional Compounds for UCP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCP2: view

Transcripts for UCP2 Gene

mRNA/cDNA for UCP2 Gene

Unigene Clusters for UCP2 Gene

Uncoupling protein 2 (mitochondrial, proton carrier):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - - - - - -
SP2: -
SP4: - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - -

Relevant External Links for UCP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCP2 Gene

This gene is overexpressed in Whole Blood (x14.7) and Spleen (x7.0).

Protein differential expression in normal tissues from HIPED for UCP2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UCP2 Gene

Protein tissue co-expression partners for UCP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UCP2 Gene:


SOURCE GeneReport for Unigene cluster for UCP2 Gene:


mRNA Expression by UniProt/SwissProt for UCP2 Gene:

Tissue specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Evidence on tissue expression from TISSUES for UCP2 Gene

  • Lung(4.8)
  • Muscle(4.8)
  • Spleen(4.6)
  • Nervous system(3.9)
  • Intestine(3.1)
  • Blood(3)
  • Pancreas(3)
  • Liver(2.9)
  • Heart(2.7)
  • Thyroid gland(2.6)
  • Kidney(2.3)
  • Lymph node(2.3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with UCP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UCP2 Gene

Orthologs for UCP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UCP2 34 33
  • 99.68 (n)
(Canis familiaris)
Mammalia UCP2 34 33
  • 92.34 (n)
(Bos Taurus)
Mammalia UCP2 34 33
  • 90.4 (n)
(Monodelphis domestica)
Mammalia UCP2 34
  • 90 (a)
(Mus musculus)
Mammalia Ucp2 16 34 33
  • 89.97 (n)
(Rattus norvegicus)
Mammalia Ucp2 33
  • 88.67 (n)
(Ornithorhynchus anatinus)
Mammalia UCP2 34
  • 81 (a)
(Anolis carolinensis)
Reptilia UCP2 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ucp2 33
  • 74.48 (n)
MGC75881 33
African clawed frog
(Xenopus laevis)
Amphibia ucp2-prov 33
(Danio rerio)
Actinopterygii ucp2 34 33 33
  • 73.6 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8891 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011676 33
  • 61.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dic2 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 34
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PUMP1 33
  • 53.9 (n)
(Oryza sativa)
Liliopsida Os11g0707800 33
  • 56.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10779 34
  • 37 (a)
Species where no ortholog for UCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCP2 Gene

Gene Tree for UCP2 (if available)
Gene Tree for UCP2 (if available)
Evolutionary constrained regions (ECRs) for UCP2: view image

Paralogs for UCP2 Gene

(11) SIMAP similar genes for UCP2 Gene using alignment to 5 proteins:

  • F5GX45_HUMAN
  • F5H312_HUMAN
genes like me logo Genes that share paralogs with UCP2: view

Variants for UCP2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UCP2 Gene

Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIM:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals.

Sequence variations from dbSNP and Humsavar for UCP2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs659366 risk-factor, Body mass index quantitative trait locus 4 73,983,709(-) C/T upstream_transcript_variant
rs371789455 conflicting-interpretations-of-pathogenicity, not specified 73,976,909(-) C/T coding_sequence_variant, missense_variant
rs660339 conflicting-interpretations-of-pathogenicity, not specified 73,978,059(-) G/A coding_sequence_variant, missense_variant
rs148253207 likely-benign, not specified 73,978,264(-) C/G/T coding_sequence_variant, missense_variant
rs45490393 likely-benign, not specified 73,975,503(-) G/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for UCP2 Gene

Variant ID Type Subtype PubMed ID
esv3626827 CNV loss 21293372
nsv520299 CNV loss 19592680

Variation tolerance for UCP2 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.18; 90.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UCP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for UCP2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for UCP2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 4
  • obesity
hyperinsulinism due to ucp2 deficiency
  • hyperinsulinemic hypoglycemia due to ucp2 deficiency
acute insulin response
  • air
neovascular glaucoma
  • secondary angle-closure glaucoma with rubeosis
- elite association - COSMIC cancer census association via MalaCards
Search UCP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UCP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCP2 Gene

Publications for UCP2 Gene

  1. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. (PMID: 11381268) Esterbauer H … Patsch W (Nature genetics 2001) 2 3 4 22 44 58
  2. Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain. (PMID: 19833146) Heidema AG … Mariman EC (Physiology & behavior 2010) 3 22 44 58
  3. Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. (PMID: 19889414) Salpea KD … Humphries SE (Atherosclerosis 2010) 3 22 44 58
  4. Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus. (PMID: 19681913) Crispim D … Canani LH (Clinical endocrinology 2010) 3 22 44 58
  5. Uncoupling protein 2 polymorphisms as risk factors for NTDs. (PMID: 19137581) Mitchell A … Mills JL (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 22 44 58

Products for UCP2 Gene

Sources for UCP2 Gene

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